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Protein

RNA 2',3'-cyclic phosphodiesterase

Gene

PH0099

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei40Proton donorUniRule annotation1
Active sitei125Proton acceptorUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-103-MONOMER.
BRENDAi6.5.1.B3. 5244.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA 2',3'-cyclic phosphodiesteraseUniRule annotation (EC:3.1.4.-UniRule annotation)
Short name:
RNA 2',3'-CPDaseUniRule annotation
Gene namesi
Ordered Locus Names:PH0099
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001389651 – 184RNA 2',3'-cyclic phosphodiesteraseAdd BLAST184

Interactioni

Protein-protein interaction databases

STRINGi70601.PH0099.

Structurei

Secondary structure

1184
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 8Combined sources7
Helixi11 – 24Combined sources14
Beta strandi26 – 33Combined sources8
Helixi36 – 38Combined sources3
Beta strandi40 – 48Combined sources9
Helixi51 – 65Combined sources15
Beta strandi71 – 82Combined sources12
Beta strandi84 – 95Combined sources12
Helixi98 – 112Combined sources15
Turni113 – 115Combined sources3
Beta strandi125 – 135Combined sources11
Helixi137 – 146Combined sources10
Turni147 – 149Combined sources3
Beta strandi151 – 157Combined sources7
Beta strandi159 – 168Combined sources10
Beta strandi171 – 181Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VDXX-ray2.40A1-184[»]
1VGJX-ray1.94A1-184[»]
ProteinModelPortaliO57823.
SMRiO57823.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO57823.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 43HXTX 1UniRule annotation1 Publication4
Motifi125 – 128HXTX 2UniRule annotation1 Publication4

Sequence similaritiesi

Belongs to the 2H phosphoesterase superfamily. ThpR family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01736. Archaea.
COG1514. LUCA.
HOGENOMiHOG000226389.
KOiK01975.
OMAiIGVFPNP.

Family and domain databases

Gene3Di3.90.1140.10. 1 hit.
HAMAPiMF_01940. RNA_CPDase. 1 hit.
InterProiIPR014051. Phosphoesterase_HXTX.
IPR004175. RNA_CPDase.
IPR009097. RNA_ligase/cNuc_Pdiesterase.
[Graphical view]
PfamiPF02834. LigT_PEase. 2 hits.
[Graphical view]
SUPFAMiSSF55144. SSF55144. 1 hit.
TIGRFAMsiTIGR02258. 2_5_ligase. 1 hit.

Sequencei

Sequence statusi: Complete.

O57823-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAFIAIDVN ESVRDSLVRA QDYIGSKEAK IKFVERENLH ITLKFLGEIT
60 70 80 90 100
EEQAEEIKNI LKKIAEKYKK HEVKVKGIGV FPNPNYIRVI WAGIENDEII
110 120 130 140 150
REMAREIEDE LAKLGFKKEG NFVAHITLGR VKFVKDKLGL TMKLKELANE
160 170 180
DFGSFVVDAI ELKKSTLTPK GPIYETLARF ELSE
Length:184
Mass (Da):21,096
Last modified:August 1, 1998 - v1
Checksum:iF9C5C5D6BA897CE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29168.1.
PIRiA71230.
RefSeqiWP_010884220.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA29168; BAA29168; BAA29168.
GeneIDi1444002.
KEGGipho:PH0099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29168.1.
PIRiA71230.
RefSeqiWP_010884220.1. NC_000961.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VDXX-ray2.40A1-184[»]
1VGJX-ray1.94A1-184[»]
ProteinModelPortaliO57823.
SMRiO57823.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH0099.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA29168; BAA29168; BAA29168.
GeneIDi1444002.
KEGGipho:PH0099.

Phylogenomic databases

eggNOGiarCOG01736. Archaea.
COG1514. LUCA.
HOGENOMiHOG000226389.
KOiK01975.
OMAiIGVFPNP.

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-103-MONOMER.
BRENDAi6.5.1.B3. 5244.

Miscellaneous databases

EvolutionaryTraceiO57823.

Family and domain databases

Gene3Di3.90.1140.10. 1 hit.
HAMAPiMF_01940. RNA_CPDase. 1 hit.
InterProiIPR014051. Phosphoesterase_HXTX.
IPR004175. RNA_CPDase.
IPR009097. RNA_ligase/cNuc_Pdiesterase.
[Graphical view]
PfamiPF02834. LigT_PEase. 2 hits.
[Graphical view]
SUPFAMiSSF55144. SSF55144. 1 hit.
TIGRFAMsiTIGR02258. 2_5_ligase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTHPR_PYRHO
AccessioniPrimary (citable) accession number: O57823
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.