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Protein

RNA 2',3'-cyclic phosphodiesterase

Gene

PH0099

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei40Proton donorUniRule annotation1
Active sitei125Proton acceptorUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-99-MONOMER
BRENDAi6.5.1.B3 5244

Names & Taxonomyi

Protein namesi
Recommended name:
RNA 2',3'-cyclic phosphodiesteraseUniRule annotation (EC:3.1.4.-UniRule annotation)
Short name:
RNA 2',3'-CPDaseUniRule annotation
Gene namesi
Ordered Locus Names:PH0099
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001389651 – 184RNA 2',3'-cyclic phosphodiesteraseAdd BLAST184

Interactioni

Protein-protein interaction databases

STRINGi70601.PH0099

Structurei

Secondary structure

1184
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 8Combined sources7
Helixi11 – 24Combined sources14
Beta strandi26 – 33Combined sources8
Helixi36 – 38Combined sources3
Beta strandi40 – 48Combined sources9
Helixi51 – 65Combined sources15
Beta strandi71 – 82Combined sources12
Beta strandi84 – 95Combined sources12
Helixi98 – 112Combined sources15
Turni113 – 115Combined sources3
Beta strandi125 – 135Combined sources11
Helixi137 – 146Combined sources10
Turni147 – 149Combined sources3
Beta strandi151 – 157Combined sources7
Beta strandi159 – 168Combined sources10
Beta strandi171 – 181Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VDXX-ray2.40A1-184[»]
1VGJX-ray1.94A1-184[»]
ProteinModelPortaliO57823
SMRiO57823
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO57823

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 43HXTX 1UniRule annotation1 Publication4
Motifi125 – 128HXTX 2UniRule annotation1 Publication4

Sequence similaritiesi

Belongs to the 2H phosphoesterase superfamily. ThpR family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01736 Archaea
COG1514 LUCA
HOGENOMiHOG000226389
KOiK01975
OMAiLTPRGPI
OrthoDBiPOG093Z0B37

Family and domain databases

HAMAPiMF_01940 RNA_CPDase, 1 hit
InterProiView protein in InterPro
IPR009097 cNuc_Pdiesterase
IPR014051 Phosphoesterase_HXTX
IPR004175 RNA_CPDase
PANTHERiPTHR35561 PTHR35561, 1 hit
PfamiView protein in Pfam
PF02834 LigT_PEase, 2 hits
SUPFAMiSSF55144 SSF55144, 1 hit
TIGRFAMsiTIGR02258 2_5_ligase, 1 hit

Sequencei

Sequence statusi: Complete.

O57823-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAFIAIDVN ESVRDSLVRA QDYIGSKEAK IKFVERENLH ITLKFLGEIT
60 70 80 90 100
EEQAEEIKNI LKKIAEKYKK HEVKVKGIGV FPNPNYIRVI WAGIENDEII
110 120 130 140 150
REMAREIEDE LAKLGFKKEG NFVAHITLGR VKFVKDKLGL TMKLKELANE
160 170 180
DFGSFVVDAI ELKKSTLTPK GPIYETLARF ELSE
Length:184
Mass (Da):21,096
Last modified:August 1, 1998 - v1
Checksum:iF9C5C5D6BA897CE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA29168.1
PIRiA71230
RefSeqiWP_010884220.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA29168; BAA29168; BAA29168
GeneIDi1444002
KEGGipho:PH0099

Similar proteinsi

Entry informationi

Entry nameiTHPR_PYRHO
AccessioniPrimary (citable) accession number: O57823
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health