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Protein

Cell division protein FtsZ 1

Gene

ftsZ1

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei169GTPUniRule annotation1
Binding sitei173GTPUniRule annotation1
Binding sitei216GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi51 – 55GTPUniRule annotation5
Nucleotide bindingi138 – 140GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Septation
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-5-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZ 1UniRule annotation
Gene namesi
Name:ftsZ1UniRule annotation
Ordered Locus Names:PH0003
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001144061 – 372Cell division protein FtsZ 1Add BLAST372

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi70601.PH0003

Structurei

3D structure databases

ProteinModelPortaliO57776
SMRiO57776
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02201 Archaea
COG0206 LUCA
HOGENOMiHOG000049094
KOiK03531
OMAiMRAVKGI
OrthoDBiPOG093Z0942

Family and domain databases

CDDicd02201 FtsZ_type1, 1 hit
Gene3Di3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
HAMAPiMF_00909 FtsZ, 1 hit
InterProiView protein in InterPro
IPR000158 Cell_div_FtsZ
IPR020805 Cell_div_FtsZ_CS
IPR024757 FtsZ_C
IPR008280 Tub_FtsZ_C
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR003008 Tubulin_FtsZ_GTPase
PfamiView protein in Pfam
PF12327 FtsZ_C, 1 hit
PF00091 Tubulin, 1 hit
PRINTSiPR00423 CELLDVISFTSZ
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
TIGRFAMsiTIGR00065 ftsZ, 1 hit
PROSITEiView protein in PROSITE
PS01134 FTSZ_1, 1 hit
PS01135 FTSZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

O57776-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKLVENVVE RVSSEETKVQ EVQVPQSSID EELKKIVEQI KARIHVVGVG
60 70 80 90 100
GAGCNTVNRM MEVGVTGAKI IAVNTDAQDL LKVKAHQKIL IGKEITRGLG
110 120 130 140 150
AGNDPKIGEE AAKESEREIR EALEGADMVF VTCGLGGGTG TGAAPVIAEM
160 170 180 190 200
ARKMGALTVS VVTLPFTMEG IRRAKNAEYG LKRLAKASDT VIVIPNDKLL
210 220 230 240 250
EVAPKLPIQM AFKVADEILV QAVKGITELI TKPGLVNLDF NDVRAVMKDG
260 270 280 290 300
GVAMIGIGES DSEKRALEAA EQALNSPLLD VDISGAKGAL ISISGADVKL
310 320 330 340 350
EEAQQIIEYV TRNVDPKAQV IWGIQLEPEL EKTIRVMVIV TGITSRYVTF
360 370
QEETPAPSEE ETTPVKIDIP EL
Length:372
Mass (Da):39,877
Last modified:August 1, 1998 - v1
Checksum:i0DEE5681EA93651E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA29071.1
PIRiH71217
RefSeqiWP_010884123.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA29071; BAA29071; BAA29071
GeneIDi1443905
KEGGipho:PH0003

Similar proteinsi

Entry informationi

Entry nameiFTSZ1_PYRHO
AccessioniPrimary (citable) accession number: O57776
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health