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Protein

D-aminoacyl-tRNA deacylase

Gene

dtdA

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.UniRule annotation

Catalytic activityi

A D-aminoacyl-tRNA + H2O = a D-amino acid + tRNA.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-8-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
D-aminoacyl-tRNA deacylaseUniRule annotation (EC:3.1.1.96UniRule annotation)
Alternative name(s):
D-tyrosyl-tRNA(Tyr) deacylase
Gene namesi
Name:dtdAUniRule annotation
Ordered Locus Names:PH0006
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001589721 – 274D-aminoacyl-tRNA deacylaseAdd BLAST274

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi70601.PH0006

Structurei

Secondary structure

1274
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 7Combined sources6
Helixi11 – 23Combined sources13
Beta strandi27 – 33Combined sources7
Beta strandi36 – 41Combined sources6
Beta strandi44 – 51Combined sources8
Helixi59 – 67Combined sources9
Beta strandi72 – 81Combined sources10
Beta strandi88 – 92Combined sources5
Beta strandi95 – 98Combined sources4
Beta strandi101 – 104Combined sources4
Helixi114 – 127Combined sources14
Beta strandi133 – 136Combined sources4
Beta strandi148 – 158Combined sources11
Helixi159 – 162Combined sources4
Helixi165 – 185Combined sources21
Turni186 – 188Combined sources3
Beta strandi190 – 195Combined sources6
Helixi202 – 210Combined sources9
Beta strandi211 – 219Combined sources9
Helixi221 – 223Combined sources3
Helixi228 – 235Combined sources8
Beta strandi238 – 240Combined sources3
Beta strandi244 – 249Combined sources6
Helixi254 – 267Combined sources14
Beta strandi270 – 274Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GFQX-ray1.75A/B/C1-274[»]
ProteinModelPortaliO57774
SMRiO57774
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO57774

Family & Domainsi

Sequence similaritiesi

Belongs to the DtdA deacylase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01616 Archaea
COG1650 LUCA
HOGENOMiHOG000015484
KOiK09716
OMAiCYEATHH
OrthoDBiPOG093Z07LR

Family and domain databases

HAMAPiMF_00562 Deacylase_DtdA, 1 hit
InterProiView protein in InterPro
IPR018033 Deacylase_DtdA_archaea
IPR007508 DtdA
PANTHERiPTHR34667 PTHR34667, 1 hit
PfamiView protein in Pfam
PF04414 tRNA_deacylase, 1 hit
PIRSFiPIRSF016210 UCP016210, 1 hit

Sequencei

Sequence statusi: Complete.

O57774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVIMTTKVD KASMNIMNKL IENFGFKETE YVFDGNPVYK RGDVLILTTN
60 70 80 90 100
DEMIYYDYLD REIENQLGFK PEIIAFASRH SSKQKLPALT THVTGNWGKA
110 120 130 140 150
MYGGKDESFA VAIPSAMKLS LLKMSELNDL GWTVCYEATH HGPTELEVPS
160 170 180 190 200
FFIEIGSSEE EWINDRAGEI IAETIIYVLD NYEKGRSKFK VALGIGGGHY
210 220 230 240 250
APKQTKRALE GDLAFGHILP KYAQPVSRDV MIKALNRFGE KVEAIYVDWK
260 270
GSRGETRQLA KSLAQELGLE FIKD
Length:274
Mass (Da):30,890
Last modified:August 1, 1998 - v1
Checksum:i53BC968C224DCBB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA29074.1
PIRiC71218
RefSeqiWP_010884126.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA29074; BAA29074; BAA29074
GeneIDi1443908
KEGGipho:PH0006

Similar proteinsi

Entry informationi

Entry nameiDTDA_PYRHO
AccessioniPrimary (citable) accession number: O57774
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health