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O57764 (CAPPA_PYRHO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoenolpyruvate carboxylase
Short name=PEPC
Short name=PEPCase
EC=4.1.1.31
Gene names
Name:ppcA
Ordered Locus Names:PH0016
OrganismPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) [Complete proteome] [HAMAP]
Taxonomic identifier70601 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus ›

Protein attributes

Sequence length469 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity. HAMAP-Rule MF_01904

Catalytic activity

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-. HAMAP-Rule MF_01904

Cofactor

Magnesium By similarity.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the PEPCase type 2 family.

Sequence caution

The sequence BAA29084.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 469469Phosphoenolpyruvate carboxylase HAMAP-Rule MF_01904
PRO_0000309613

Sequences

Sequence LengthMass (Da)Tools
O57764 [UniParc].

Last modified November 13, 2007. Version 2.
Checksum: 8244B4BEF29D2D74

FASTA46953,953
        10         20         30         40         50         60 
MIPRIMSTQH PDNYSIPFFA SSPILGGEDE ITEAFYAFSV LGADEQMWDF EGKEVDEFVV 

        70         80         90        100        110        120 
KKLLERYPTF FKENILGEDL RLTPRVPNPS VEKAEAKLLL ETLQGITRAA DYARVFYLDN 

       130        140        150        160        170        180 
IAPIFEVILP MTTSLAEMLR VHELYRKIVS LSGEVIYDVT VKEWIGEFYP KEINVIPLFE 

       190        200        210        220        230        240 
TKVALLKSGR IIREYIGRKR PEYLRVFFAR SDPAMNYGLL SAVTYVKKAL EQVGEVEEET 

       250        260        270        280        290        300 
STPIYPIIGV GSPPFRGGMR PENVKKVLKE YPSVQTYTIQ SSFKYDHPTK DVVKAVEIVK 

       310        320        330        340        350        360 
SKKREAPDPL DIPEFIQLYE IEYQKQLKIL APYIRNIVTR IPDRRKRKLH IGLFGYSRNV 

       370        380        390        400        410        420 
GGLSLPRVIK FTASLYSIGL PPELLGLNEL SDNQLDSISE YYKNLYDDLE FAMRFFSFKV 

       430        440        450        460 
AERVGLRELS EKVKEFKPDI DDEYVREAEL VFRGQGDVMK LAQIRGFLG

« Hide

References

[1]"Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3."
Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T. expand/collapse author list , Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T., Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.
DNA Res. 5:55-76(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000001 Genomic DNA. Translation: BAA29084.1. Different initiation.
PIRE71219.
RefSeqNP_142039.1. NC_000961.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING70601.PH0016.

Protocols and materials databases

DNASU1443918.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA29084; BAA29084; BAA29084.
GeneID1443918.
KEGGpho:PH0016.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1892.
HOGENOMHOG000038601.
KOK01595.
ProtClustDBPRK13655.

Enzyme and pathway databases

BioCycPHOR70601:GJWR-19-MONOMER.

Family and domain databases

HAMAPMF_01904. PEPcase_type2.
InterProIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase.
[Graphical view]
PIRSFPIRSF006677. UCP006677. 1 hit.
SUPFAMSSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
TIGRFAMsTIGR02751. PEPCase_arch. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCAPPA_PYRHO
AccessionPrimary (citable) accession number: O57764
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: May 1, 2013
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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