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O57764

- CAPPA_PYRHO

UniProt

O57764 - CAPPA_PYRHO

Protein

Phosphoenolpyruvate carboxylase

Gene

ppcA

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 2 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

    Catalytic activityi

    Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbon fixation Source: UniProtKB-HAMAP
    2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
    3. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Carbon dioxide fixation

    Keywords - Ligandi

    Magnesium

    Enzyme and pathway databases

    BioCyciPHOR70601:GJWR-19-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
    Short name:
    PEPCUniRule annotation
    Short name:
    PEPCaseUniRule annotation
    Gene namesi
    Name:ppcAUniRule annotation
    Ordered Locus Names:PH0016
    OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
    Taxonomic identifieri70601 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000000752: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 469469Phosphoenolpyruvate carboxylasePRO_0000309613Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi70601.PH0016.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PEPCase type 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1892.
    HOGENOMiHOG000038601.
    KOiK01595.

    Family and domain databases

    HAMAPiMF_01904. PEPcase_type2.
    InterProiIPR007566. PEP_COase_arc-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PfamiPF14010. PEPcase_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006677. UCP006677. 1 hit.
    SUPFAMiSSF51621. SSF51621. 1 hit.
    TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O57764-1 [UniParc]FASTAAdd to Basket

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    MIPRIMSTQH PDNYSIPFFA SSPILGGEDE ITEAFYAFSV LGADEQMWDF    50
    EGKEVDEFVV KKLLERYPTF FKENILGEDL RLTPRVPNPS VEKAEAKLLL 100
    ETLQGITRAA DYARVFYLDN IAPIFEVILP MTTSLAEMLR VHELYRKIVS 150
    LSGEVIYDVT VKEWIGEFYP KEINVIPLFE TKVALLKSGR IIREYIGRKR 200
    PEYLRVFFAR SDPAMNYGLL SAVTYVKKAL EQVGEVEEET STPIYPIIGV 250
    GSPPFRGGMR PENVKKVLKE YPSVQTYTIQ SSFKYDHPTK DVVKAVEIVK 300
    SKKREAPDPL DIPEFIQLYE IEYQKQLKIL APYIRNIVTR IPDRRKRKLH 350
    IGLFGYSRNV GGLSLPRVIK FTASLYSIGL PPELLGLNEL SDNQLDSISE 400
    YYKNLYDDLE FAMRFFSFKV AERVGLRELS EKVKEFKPDI DDEYVREAEL 450
    VFRGQGDVMK LAQIRGFLG 469
    Length:469
    Mass (Da):53,953
    Last modified:November 13, 2007 - v2
    Checksum:i8244B4BEF29D2D74
    GO

    Sequence cautioni

    The sequence BAA29084.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000001 Genomic DNA. Translation: BAA29084.1. Different initiation.
    PIRiE71219.
    RefSeqiNP_142039.1. NC_000961.1.

    Genome annotation databases

    EnsemblBacteriaiBAA29084; BAA29084; BAA29084.
    GeneIDi1443918.
    KEGGipho:PH0016.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000001 Genomic DNA. Translation: BAA29084.1 . Different initiation.
    PIRi E71219.
    RefSeqi NP_142039.1. NC_000961.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 70601.PH0016.

    Protocols and materials databases

    DNASUi 1443918.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA29084 ; BAA29084 ; BAA29084 .
    GeneIDi 1443918.
    KEGGi pho:PH0016.

    Phylogenomic databases

    eggNOGi COG1892.
    HOGENOMi HOG000038601.
    KOi K01595.

    Enzyme and pathway databases

    BioCyci PHOR70601:GJWR-19-MONOMER.

    Family and domain databases

    HAMAPi MF_01904. PEPcase_type2.
    InterProi IPR007566. PEP_COase_arc-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    Pfami PF14010. PEPcase_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006677. UCP006677. 1 hit.
    SUPFAMi SSF51621. SSF51621. 1 hit.
    TIGRFAMsi TIGR02751. PEPCase_arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

    Entry informationi

    Entry nameiCAPPA_PYRHO
    AccessioniPrimary (citable) accession number: O57764
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 73 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3