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O57764

- CAPPA_PYRHO

UniProt

O57764 - CAPPA_PYRHO

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Protein
Phosphoenolpyruvate carboxylase
Gene
ppcA, PH0016
Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-19-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylase (EC:4.1.1.31)
Short name:
PEPC
Short name:
PEPCase
Gene namesi
Name:ppcA
Ordered Locus Names:PH0016
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000752: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Phosphoenolpyruvate carboxylaseUniRule annotation
PRO_0000309613Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi70601.PH0016.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 2 family.

Phylogenomic databases

eggNOGiCOG1892.
HOGENOMiHOG000038601.
KOiK01595.

Family and domain databases

HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

O57764-1 [UniParc]FASTAAdd to Basket

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MIPRIMSTQH PDNYSIPFFA SSPILGGEDE ITEAFYAFSV LGADEQMWDF    50
EGKEVDEFVV KKLLERYPTF FKENILGEDL RLTPRVPNPS VEKAEAKLLL 100
ETLQGITRAA DYARVFYLDN IAPIFEVILP MTTSLAEMLR VHELYRKIVS 150
LSGEVIYDVT VKEWIGEFYP KEINVIPLFE TKVALLKSGR IIREYIGRKR 200
PEYLRVFFAR SDPAMNYGLL SAVTYVKKAL EQVGEVEEET STPIYPIIGV 250
GSPPFRGGMR PENVKKVLKE YPSVQTYTIQ SSFKYDHPTK DVVKAVEIVK 300
SKKREAPDPL DIPEFIQLYE IEYQKQLKIL APYIRNIVTR IPDRRKRKLH 350
IGLFGYSRNV GGLSLPRVIK FTASLYSIGL PPELLGLNEL SDNQLDSISE 400
YYKNLYDDLE FAMRFFSFKV AERVGLRELS EKVKEFKPDI DDEYVREAEL 450
VFRGQGDVMK LAQIRGFLG 469
Length:469
Mass (Da):53,953
Last modified:November 13, 2007 - v2
Checksum:i8244B4BEF29D2D74
GO

Sequence cautioni

The sequence BAA29084.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000001 Genomic DNA. Translation: BAA29084.1. Different initiation.
PIRiE71219.
RefSeqiNP_142039.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA29084; BAA29084; BAA29084.
GeneIDi1443918.
KEGGipho:PH0016.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000001 Genomic DNA. Translation: BAA29084.1 . Different initiation.
PIRi E71219.
RefSeqi NP_142039.1. NC_000961.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 70601.PH0016.

Protocols and materials databases

DNASUi 1443918.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA29084 ; BAA29084 ; BAA29084 .
GeneIDi 1443918.
KEGGi pho:PH0016.

Phylogenomic databases

eggNOGi COG1892.
HOGENOMi HOG000038601.
KOi K01595.

Enzyme and pathway databases

BioCyci PHOR70601:GJWR-19-MONOMER.

Family and domain databases

HAMAPi MF_01904. PEPcase_type2.
InterProi IPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF14010. PEPcase_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF006677. UCP006677. 1 hit.
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR02751. PEPCase_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

Entry informationi

Entry nameiCAPPA_PYRHO
AccessioniPrimary (citable) accession number: O57764
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi