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Protein

Thermosome subunit

Gene

ths

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-20-MONOMER.
BRENDAi3.6.4.B10. 5244.

Names & Taxonomyi

Protein namesi
Recommended name:
Thermosome subunit
Alternative name(s):
Chaperonin subunit
Gene namesi
Name:ths
Ordered Locus Names:PH0017
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Thermosome subunitPRO_0000128396Add
BLAST

Interactioni

Subunit structurei

Forms an oligomeric complex of eight-membered rings.By similarity

Protein-protein interaction databases

DIPiDIP-29172N.
IntActiO57762. 1 interaction.
MINTiMINT-1501887.
STRINGi70601.PH0017.

Structurei

3D structure databases

ProteinModelPortaliO57762.
SMRiO57762. Positions 10-524.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiarCOG01257. Archaea.
COG0459. LUCA.
HOGENOMiHOG000226730.
OMAiHAAMPKR.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
IPR012714. Thermosome_arc.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02339. thermosome_arch. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O57762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLAGQPIL ILPEGTQRYV GRDAQRMNIL AARIIAETVR TTLGPKGMDK
60 70 80 90 100
MLVDSLGDIV ITNDGATILD EMDIQHPAAK MMVEVAKTQD KEAGDGTTTA
110 120 130 140 150
VVIAGELLKK AEELLDQNIH PSIIIKGYTL ASQKAQEILD SIAKEVKPDD
160 170 180 190 200
EEVLLKAAMT AITGKAAEEE REYLAKLAVE AVKLVAEEKD GKLKVDIDNI
210 220 230 240 250
KLEKKEGGAV RDTRLIRGVV IDKEVVHPGM PKRIENAKIA LINDALEVKE
260 270 280 290 300
TETDAEIRIT SPEQLQAFLE QEEKMLKEMV DKIKEVGANV VFVQKGIDDL
310 320 330 340 350
AQHYLAKYGI LAVRRVKKSD MEKLAKATGA KIVTNIRDLT PEDLGEAELV
360 370 380 390 400
EERKVAGENM IFVEGCKNPK AVTILIRGGT EHVVDEVERA LEDAIKVVKD
410 420 430 440 450
ILEDGKIIAG GGASEIELSI KLDEYAKEVG GKEQLAIEAF AEALKVIPRT
460 470 480 490 500
LAENAGLDPI ETLVKVIAAH KEKGQTIGID VYEGEPADMM ERGVIEPVRV
510 520 530 540
KKQAIKSASE AAIMILRIDD VIAASKLEKE KEGEKGGGSE EFSGSSDLD
Length:549
Mass (Da):59,693
Last modified:August 1, 1998 - v1
Checksum:i9A451CA8C6CFEB4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29085.1.
PIRiF71219.
RefSeqiWP_010884137.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA29085; BAA29085; BAA29085.
GeneIDi1443919.
KEGGipho:PH0017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29085.1.
PIRiF71219.
RefSeqiWP_010884137.1. NC_000961.1.

3D structure databases

ProteinModelPortaliO57762.
SMRiO57762. Positions 10-524.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29172N.
IntActiO57762. 1 interaction.
MINTiMINT-1501887.
STRINGi70601.PH0017.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA29085; BAA29085; BAA29085.
GeneIDi1443919.
KEGGipho:PH0017.

Phylogenomic databases

eggNOGiarCOG01257. Archaea.
COG0459. LUCA.
HOGENOMiHOG000226730.
OMAiHAAMPKR.

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-20-MONOMER.
BRENDAi3.6.4.B10. 5244.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
IPR012714. Thermosome_arc.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02339. thermosome_arch. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

Entry informationi

Entry nameiTHS_PYRHO
AccessioniPrimary (citable) accession number: O57762
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 11, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.