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Protein

Trk system potassium uptake protein TrkA homolog

Gene

trkA

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of a potassium transport system.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei30 – 301NADBy similarity
Binding sitei51 – 511NADBy similarity
Binding sitei98 – 981NAD; shared with dimeric partnerBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 115NADBy similarity
Nucleotide bindingi73 – 742NADBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

NAD, Potassium

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1986-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Trk system potassium uptake protein TrkA homolog
Short name:
K(+)-uptake protein TrkA homolog
Gene namesi
Name:trkA
Ordered Locus Names:PH1984
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Trk system potassium uptake protein TrkA homologPRO_0000148728Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi70601.PH1984.

Structurei

3D structure databases

ProteinModelPortaliO57719.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 130129RCK N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini141 – 22383RCK C-terminalPROSITE-ProRule annotationAdd
BLAST

Domaini

The RCK N-terminal domain binds NAD and possibly other effectors. This is expected to cause a conformation change that regulates potassium transport (By similarity).By similarity

Sequence similaritiesi

Contains 1 RCK C-terminal domain.PROSITE-ProRule annotation
Contains 1 RCK N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiarCOG01957. Archaea.
COG0569. LUCA.
HOGENOMiHOG000243320.
KOiK03499.
OMAiTMENPQE.

Family and domain databases

Gene3Di3.30.70.1450. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR006036. K_uptake_TrkA.
IPR016040. NAD(P)-bd_dom.
IPR006037. RCK_C.
IPR003148. RCK_N.
[Graphical view]
PfamiPF02080. TrkA_C. 1 hit.
PF02254. TrkA_N. 1 hit.
[Graphical view]
PRINTSiPR00335. KUPTAKETRKA.
SUPFAMiSSF116726. SSF116726. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS51202. RCK_C. 1 hit.
PS51201. RCK_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O57719-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYIVIMGAGR IGTLVARMLE SEGHDVAIIE MNRERAREIS EYISGLVIEG
60 70 80 90 100
DATDQKVLEN ANIKNANAFA ALTGKDDANI LACILAKHLN PNIMTILRIT
110 120 130 140 150
DPGKKKIFED VKELKTYFDI VVSPEDIAAN YIFRTLVTPG FNRVLLPREG
160 170 180 190 200
AEIIQFQIDE DCEVAGKPVK ELNLPKDSLI IAVYDEKGNL TIPSGDTIIP
210 220
KKGQVIIFAK NSALQEVKKI MEKKKKEQ
Length:228
Mass (Da):25,323
Last modified:August 1, 1998 - v1
Checksum:iF64E2D14EFE3FFD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA31111.1.
PIRiH71214.
RefSeqiWP_010886046.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA31111; BAA31111; BAA31111.
GeneIDi1442828.
KEGGipho:PH1984.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA31111.1.
PIRiH71214.
RefSeqiWP_010886046.1. NC_000961.1.

3D structure databases

ProteinModelPortaliO57719.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH1984.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA31111; BAA31111; BAA31111.
GeneIDi1442828.
KEGGipho:PH1984.

Phylogenomic databases

eggNOGiarCOG01957. Archaea.
COG0569. LUCA.
HOGENOMiHOG000243320.
KOiK03499.
OMAiTMENPQE.

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1986-MONOMER.

Family and domain databases

Gene3Di3.30.70.1450. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR006036. K_uptake_TrkA.
IPR016040. NAD(P)-bd_dom.
IPR006037. RCK_C.
IPR003148. RCK_N.
[Graphical view]
PfamiPF02080. TrkA_C. 1 hit.
PF02254. TrkA_N. 1 hit.
[Graphical view]
PRINTSiPR00335. KUPTAKETRKA.
SUPFAMiSSF116726. SSF116726. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS51202. RCK_C. 1 hit.
PS51201. RCK_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

Entry informationi

Entry nameiTRKA_PYRHO
AccessioniPrimary (citable) accession number: O57719
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: December 9, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.