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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-1930-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:PH1994
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001670291 – 502Probable glycine dehydrogenase (decarboxylating) subunit 2Add BLAST502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei273N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi70601.PH1994

Structurei

3D structure databases

ProteinModelPortaliO57709
SMRiO57709
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00076 Archaea
COG1003 LUCA
HOGENOMiHOG000239368
KOiK00283
OMAiMHINLHK
OrthoDBiPOG093Z01WJ

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_00713 GcvPB, 1 hit
InterProiView protein in InterPro
IPR023012 GcvPB
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

O57709-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRQARWDEP LIFELSRPGR VGYTLPKPIE DVKVEIPEKL KRKTPLELPE
60 70 80 90 100
VSEPEVVKHY TRLSEMNYGV DSGIYPLGSC TMKYNPKINE EIANHPKVAF
110 120 130 140 150
IHPYQDERTV QGALKIMWEL EQWLKEITGM DRFTLQPAAG ANGEFTGVMI
160 170 180 190 200
IKAYHLDRGD TQRTEILVPD SAHGTNPASA SMAGFKVVEI PSNENGTVDL
210 220 230 240 250
EALENAVSER TAGLMLTNPN TLGIFEDEIE EIAKIVHKVG GLLYYDGANL
260 270 280 290 300
NGILGKVRPG DMGFDIVHLN LHKTFSTPHG GGGPGAGPVG VKEFLKDYLP
310 320 330 340 350
VPLVSYDEEN DRYYLDYNVP KSIGKVKELF GNFAVLVKAL TYLKIMGKEG
360 370 380 390 400
LREVSEVAVL NANYLARKLK GTRGYELPHK ELRKHEVVFS AEPMKKETGV
410 420 430 440 450
RTLDVAKRLL DFGLHAPTIY FPLIVHEALM IEPTESVSKE ELDAYVEALK
460 470 480 490 500
KISEEAYTNP EIVKSAPHNT AVRRVDDVLA AKKPVITWKM YKELKEKGEI

DY
Length:502
Mass (Da):56,275
Last modified:August 1, 1998 - v1
Checksum:i003E8623B58828FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA31121.1
PIRiB71216
RefSeqiWP_010886055.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA31121; BAA31121; BAA31121
GeneIDi1442837
KEGGipho:PH1994

Similar proteinsi

Entry informationi

Entry nameiGCSPB_PYRHO
AccessioniPrimary (citable) accession number: O57709
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health