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Protein

Paired box protein Pax-2-A

Gene

pax2-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transcription factor. Involved in kidney development, acting synergistically with lhx1/lim-1 in pronephric morphogenesis during the tailbud stages (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Segmentation polarity protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-2-A
Short name:
xPax-2a
Gene namesi
Name:pax2-a
Synonyms:pax-2aImported
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-486805. pax2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotationBy similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002891321 – 497Paired box protein Pax-2-AAdd BLAST497

Expressioni

Tissue specificityi

Expression becomes spatially localized at mid-gastrula stages and is confined to the nervous system (midbrain, hindbrain, spinal cord), sensory organs (optic vesicle and stalk, otic vesicle), visceral arches, developing excretory system (pronephros, pronephric duct, rectal diverticulum, proctodaeum) and thyroid gland. Splicing does not appear to be tissue-specific and tissues displayed the same spectrum of splice variants.3 Publications

Developmental stagei

Splicing is temporally regulated. Isoform 5 is expressed both maternally and zygotically, whereas isoform 1, isoform 2, isoform 3 and isoform 4 are exclusively zygotic. Expression is highest in embryos from stage 12 on, with expression levels remaining constant throughout embryogenesis.1 Publication

Inductioni

By activin. Weakly by bFGF.1 Publication

Structurei

3D structure databases

ProteinModelPortaliO57685.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 142PairedPROSITE-ProRule annotationAdd BLAST127

Sequence similaritiesi

Contains 1 paired domain.PROSITE-ProRule annotation

Keywords - Domaini

Paired box

Phylogenomic databases

HOVERGENiHBG009115.
KOiK15608.

Family and domain databases

CDDicd00131. PAX. 1 hit.
Gene3Di1.10.10.10. 2 hits.
1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR022130. Pax2_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00292. PAX. 1 hit.
PF12403. Pax2_C. 2 hits.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O57685-1) [UniParc]FASTAAdd to basket
Also known as: 41 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDMHCKADPF SAMHPGHGGV NQLGGVFVNG RPLPDVVRQR IVELAHQGVR
60 70 80 90 100
PCDISRQLRV SHGCVSKILG RYYETGSIKP GVIGGSKPKV ATPKVVDKIA
110 120 130 140 150
EYKRQNPTMF AWEIRDRLLA EGICDNDTVP SVSSINRIIR TKVQQPFHPT
160 170 180 190 200
PDGSGTPVGT PGHTLVPSTA SPPVSSASND PVGSYSINGI LGIPRSNGEK
210 220 230 240 250
RKRDEDGSDG SGPNGDSQSS VESLRKHLRA DNFTQQQLEA LDRVFERPSY
260 270 280 290 300
PDVFQTAEHI KSEQASEYSL PALTPGLDEV KSSLSASGNA DLGSNVSGPQ
310 320 330 340 350
SYPVVTESFA SHLYVKQEPH EASLTPFTPS SLASSGLADI QPFQMALTVD
360 370 380 390 400
ASTPTYSSFT HHGPHYGQFG SQPLIAGRDM SSTTLPGYPP HVPPTGQGSY
410 420 430 440 450
PTSTLAGMVP GTNVSVHHSV QPVECCSCLS SSKPCLFHCR TGSGSEFSGN
460 470 480 490
PYSHPQYTTY NEAWRFSNPA LLSSPYYYSA TSRGSAPPTA ATAYDRH
Length:497
Mass (Da):53,204
Last modified:May 29, 2007 - v2
Checksum:i2815A8C329878237
GO
Isoform 2 (identifier: O57685-2) [UniParc]FASTAAdd to basket
Also known as: 11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     307-376: Missing.
     412-444: Missing.

Show »
Length:394
Mass (Da):42,229
Checksum:iBC81726C6E51EDF2
GO
Isoform 31 Publication (identifier: O57685-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     307-376: Missing.

Show »
Length:427
Mass (Da):45,702
Checksum:i7E6EF01E04E062C1
GO
Isoform 4 (identifier: O57685-4) [UniParc]FASTAAdd to basket
Also known as: 51 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     166-205: Missing.
     307-376: Missing.
     412-444: Missing.

Show »
Length:354
Mass (Da):38,106
Checksum:i059AC72416A555F7
GO
Isoform 5 (identifier: O57685-5) [UniParc]FASTAAdd to basket
Also known as: 71 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     206-376: Missing.
     445-445: S → FLGS

Show »
Length:329
Mass (Da):35,283
Checksum:i81DE1C10F3CED0A4
GO
Isoform 6 (identifier: O57685-6) [UniParc]FASTAAdd to basket
Also known as: 10

The sequence of this isoform differs from the canonical sequence as follows:
     166-376: Missing.
     412-444: Missing.
     445-445: S → FLGS

Note: No experimental confirmation available.
Show »
Length:256
Mass (Da):27,687
Checksum:i4B225AC9EAA7BF6D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91A → T in CAA71208 (PubMed:9486533).Curated1
Sequence conflicti144Q → R in CAA71208 (PubMed:9486533).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_052436166 – 376Missing in isoform 6. 1 PublicationAdd BLAST211
Alternative sequenceiVSP_052435166 – 205Missing in isoform 4. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_052437206 – 376Missing in isoform 5. 1 PublicationAdd BLAST171
Alternative sequenceiVSP_052438307 – 376Missing in isoform 2, isoform 3 and isoform 4. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_052439412 – 444Missing in isoform 2, isoform 4 and isoform 6. 2 PublicationsAdd BLAST33
Alternative sequenceiVSP_052440445S → FLGS in isoform 5 and isoform 6. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10119 mRNA. Translation: CAA71205.1.
Y10121 mRNA. Translation: CAA71207.1.
Y10122 mRNA. Translation: CAA71208.1.
Y10123 mRNA. Translation: CAA71209.1.
AJ000667 mRNA. Translation: CAA04223.1.
BC055960 mRNA. Translation: AAH55960.1.
RefSeqiNP_001079830.1. NM_001086361.1. [O57685-3]
UniGeneiXl.1130.

Genome annotation databases

GeneIDi379520.
KEGGixla:379520.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10119 mRNA. Translation: CAA71205.1.
Y10121 mRNA. Translation: CAA71207.1.
Y10122 mRNA. Translation: CAA71208.1.
Y10123 mRNA. Translation: CAA71209.1.
AJ000667 mRNA. Translation: CAA04223.1.
BC055960 mRNA. Translation: AAH55960.1.
RefSeqiNP_001079830.1. NM_001086361.1. [O57685-3]
UniGeneiXl.1130.

3D structure databases

ProteinModelPortaliO57685.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi379520.
KEGGixla:379520.

Organism-specific databases

CTDi379520.
XenbaseiXB-GENE-486805. pax2.

Phylogenomic databases

HOVERGENiHBG009115.
KOiK15608.

Family and domain databases

CDDicd00131. PAX. 1 hit.
Gene3Di1.10.10.10. 2 hits.
1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR022130. Pax2_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00292. PAX. 1 hit.
PF12403. Pax2_C. 2 hits.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAX2A_XENLA
AccessioniPrimary (citable) accession number: O57685
Secondary accession number(s): O57677
, O57680, O57681, O57684, Q7SZU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: November 30, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.