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Protein

Paired box protein Pax-2-A

Gene

pax2-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable transcription factor. Involved in kidney development, acting synergistically with lhx1/lim-1 in pronephric morphogenesis during the tailbud stages (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Segmentation polarity protein
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-2-A
Short name:
xPax-2a
Gene namesi
Name:pax2-a
Synonyms:pax-2aImported
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-486805 pax2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002891321 – 497Paired box protein Pax-2-AAdd BLAST497

Expressioni

Tissue specificityi

Expression becomes spatially localized at mid-gastrula stages and is confined to the nervous system (midbrain, hindbrain, spinal cord), sensory organs (optic vesicle and stalk, otic vesicle), visceral arches, developing excretory system (pronephros, pronephric duct, rectal diverticulum, proctodaeum) and thyroid gland. Splicing does not appear to be tissue-specific and tissues displayed the same spectrum of splice variants.3 Publications

Developmental stagei

Splicing is temporally regulated. Isoform 5 is expressed both maternally and zygotically, whereas isoform 1, isoform 2, isoform 3 and isoform 4 are exclusively zygotic. Expression is highest in embryos from stage 12 on, with expression levels remaining constant throughout embryogenesis.1 Publication

Inductioni

By activin. Weakly by bFGF.1 Publication

Structurei

3D structure databases

ProteinModelPortaliO57685
SMRiO57685
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 142PairedPROSITE-ProRule annotationAdd BLAST127

Keywords - Domaini

Paired box

Phylogenomic databases

HOVERGENiHBG009115
KOiK15608

Family and domain databases

CDDicd00131 PAX, 1 hit
Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001523 Paired_dom
IPR022130 Pax2_C
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00292 PAX, 1 hit
PF12403 Pax2_C, 2 hits
PRINTSiPR00027 PAIREDBOX
SMARTiView protein in SMART
SM00351 PAX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00034 PAIRED_1, 1 hit
PS51057 PAIRED_2, 1 hit

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O57685-1) [UniParc]FASTAAdd to basket
Also known as: 41 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDMHCKADPF SAMHPGHGGV NQLGGVFVNG RPLPDVVRQR IVELAHQGVR
60 70 80 90 100
PCDISRQLRV SHGCVSKILG RYYETGSIKP GVIGGSKPKV ATPKVVDKIA
110 120 130 140 150
EYKRQNPTMF AWEIRDRLLA EGICDNDTVP SVSSINRIIR TKVQQPFHPT
160 170 180 190 200
PDGSGTPVGT PGHTLVPSTA SPPVSSASND PVGSYSINGI LGIPRSNGEK
210 220 230 240 250
RKRDEDGSDG SGPNGDSQSS VESLRKHLRA DNFTQQQLEA LDRVFERPSY
260 270 280 290 300
PDVFQTAEHI KSEQASEYSL PALTPGLDEV KSSLSASGNA DLGSNVSGPQ
310 320 330 340 350
SYPVVTESFA SHLYVKQEPH EASLTPFTPS SLASSGLADI QPFQMALTVD
360 370 380 390 400
ASTPTYSSFT HHGPHYGQFG SQPLIAGRDM SSTTLPGYPP HVPPTGQGSY
410 420 430 440 450
PTSTLAGMVP GTNVSVHHSV QPVECCSCLS SSKPCLFHCR TGSGSEFSGN
460 470 480 490
PYSHPQYTTY NEAWRFSNPA LLSSPYYYSA TSRGSAPPTA ATAYDRH
Length:497
Mass (Da):53,204
Last modified:May 29, 2007 - v2
Checksum:i2815A8C329878237
GO
Isoform 2 (identifier: O57685-2) [UniParc]FASTAAdd to basket
Also known as: 11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     307-376: Missing.
     412-444: Missing.

Show »
Length:394
Mass (Da):42,229
Checksum:iBC81726C6E51EDF2
GO
Isoform 31 Publication (identifier: O57685-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     307-376: Missing.

Show »
Length:427
Mass (Da):45,702
Checksum:i7E6EF01E04E062C1
GO
Isoform 4 (identifier: O57685-4) [UniParc]FASTAAdd to basket
Also known as: 51 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     166-205: Missing.
     307-376: Missing.
     412-444: Missing.

Show »
Length:354
Mass (Da):38,106
Checksum:i059AC72416A555F7
GO
Isoform 5 (identifier: O57685-5) [UniParc]FASTAAdd to basket
Also known as: 71 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     206-376: Missing.
     445-445: S → FLGS

Show »
Length:329
Mass (Da):35,283
Checksum:i81DE1C10F3CED0A4
GO
Isoform 6 (identifier: O57685-6) [UniParc]FASTAAdd to basket
Also known as: 10

The sequence of this isoform differs from the canonical sequence as follows:
     166-376: Missing.
     412-444: Missing.
     445-445: S → FLGS

Note: No experimental confirmation available.
Show »
Length:256
Mass (Da):27,687
Checksum:i4B225AC9EAA7BF6D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91A → T in CAA71208 (PubMed:9486533).Curated1
Sequence conflicti144Q → R in CAA71208 (PubMed:9486533).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_052436166 – 376Missing in isoform 6. 1 PublicationAdd BLAST211
Alternative sequenceiVSP_052435166 – 205Missing in isoform 4. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_052437206 – 376Missing in isoform 5. 1 PublicationAdd BLAST171
Alternative sequenceiVSP_052438307 – 376Missing in isoform 2, isoform 3 and isoform 4. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_052439412 – 444Missing in isoform 2, isoform 4 and isoform 6. 2 PublicationsAdd BLAST33
Alternative sequenceiVSP_052440445S → FLGS in isoform 5 and isoform 6. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10119 mRNA Translation: CAA71205.1
Y10121 mRNA Translation: CAA71207.1
Y10122 mRNA Translation: CAA71208.1
Y10123 mRNA Translation: CAA71209.1
AJ000667 mRNA Translation: CAA04223.1
BC055960 mRNA Translation: AAH55960.1
RefSeqiNP_001079830.1, NM_001086361.1 [O57685-3]
XP_018079766.1, XM_018224277.1 [O57685-1]
XP_018079772.1, XM_018224283.1 [O57685-2]
XP_018079775.1, XM_018224286.1 [O57685-4]
UniGeneiXl.1130

Genome annotation databases

GeneIDi379520
KEGGixla:379520

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPAX2A_XENLA
AccessioniPrimary (citable) accession number: O57685
Secondary accession number(s): O57677
, O57680, O57681, O57684, Q7SZU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: March 28, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health