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Protein

Paired box protein Pax-2-B

Gene

pax2-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transcription factor. Involved in kidney development, acting synergistically with lhx1/lim-1 in pronephric morphogenesis during the tailbud stages.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Segmentation polarity protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-2-B
Short name:
xPax-2b
Gene namesi
Name:pax2-b
Synonyms:pax-2B
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

  • Nucleus PROSITE-ProRule annotationBy similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Paired box protein Pax-2-BPRO_0000289133Add
BLAST

Expressioni

Tissue specificityi

Expression becomes spatially localized at mid-gastrula stages and is localized to the nervous system (midbrain, hindbrain, spinal cord), sensory organs (optic vesicle and stalk, otic vesicle), visceral arches, developing excretory system (pronephros, pronephric duct, rectal diverticulum, proctodaeum) and thryoid gland. Splicing does not appear to be tissue-specific.5 Publications

Developmental stagei

Splicing is temporally regulated. Isoform 3 is expressed both maternally and zygotically, whereas isoform 2 is exclusively zygotic. Expression is highest in embryos from stage 12 on, with expression levels remaining constant throughout embryogenesis.1 Publication

Inductioni

By activin. Weakly by bFGF.1 Publication

Structurei

3D structure databases

ProteinModelPortaliO57682.
SMRiO57682. Positions 18-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 141127PairedPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 paired domain.PROSITE-ProRule annotation

Keywords - Domaini

Paired box

Phylogenomic databases

HOVERGENiHBG009115.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR022130. Pax2_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00292. PAX. 1 hit.
PF12403. Pax2_C. 2 hits.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O57682-1) [UniParc]FASTAAdd to basket
Also known as: 121 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDMHCKADPF SAMHRHGGVN QLGGVFVNGR PLPDVVRQRI VELAHQGVRP
60 70 80 90 100
CDISRQLRVS HGCVSKILGR YYETGSIKPG VIGGSKPKVA TPKVVDKIAD
110 120 130 140 150
YKRQNPTMFA WEIRDRLLAE GICDNDTVPS VSSINRIIRT KVQQPFHPTP
160 170 180 190 200
DGTPVSTPGH TLVPSTASPP VSSASNDPVG SYSINGILGI PRSNGEKRKR
210 220 230 240 250
DEDGSDGSGP NGDSQSSVES LRKHLRADNF TQQQLEALDR VFERPSYPDV
260 270 280 290 300
FQSAEHIKSE QASEYSLPAL TPGLDEVKSS LSASGNADLG SNVSGPQSYP
310 320 330 340 350
VVTESFASHL YLKQEPHEAS LTPFTPSSLA SSGLADIQPF QMALTVDAST
360 370 380 390 400
PTYSSFTHHG PPYGQFGSQP LIAGRDMSST TLPGYPPHVP PTGQGSYPTS
410 420 430 440 450
TLAGMVPGTN VSVHHSVQPV ECCSCLSSSK PCLFHCRTGS GSEFSGNPYS
460 470 480 490
HPQYTTYNEA WRFSNPALLS SPYYYSATSR GSAPPTAATA YDRH
Length:494
Mass (Da):53,038
Last modified:May 29, 2007 - v2
Checksum:i7D319E30BF0C7B55
GO
Isoform 21 Publication (identifier: O57682-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-15: R → PG
     408-440: Missing.

Show »
Length:462
Mass (Da):49,563
Checksum:i4F99F772A35E7596
GO
Isoform 3 (identifier: O57682-3) [UniParc]FASTAAdd to basket
Also known as: 81 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     203-373: Missing.
     408-440: Missing.

Show »
Length:290
Mass (Da):31,366
Checksum:i51EC64276F6DAA4B
GO
Isoform 4 (identifier: O57682-4) [UniParc]FASTAAdd to basket
Also known as: 11

The sequence of this isoform differs from the canonical sequence as follows:
     15-15: R → PG
     203-373: Missing.
     408-440: Missing.

Note: No Experimental confirmation available.
Show »
Length:291
Mass (Da):31,364
Checksum:i2AA7F5C73860BA7E
GO

Sequence cautioni

The sequence AAD52680 differs from that shown. Reason: Frameshift at positions 335 and 362. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei15 – 151R → PG in isoform 2 and isoform 4. 2 PublicationsVSP_052441
Alternative sequencei203 – 373171Missing in isoform 3 and isoform 4. 2 PublicationsVSP_052442Add
BLAST
Alternative sequencei408 – 44033Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsVSP_052443Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10120 mRNA. Translation: CAA71206.1.
AJ000668 mRNA. Translation: CAA04224.1.
AF179300 mRNA. Translation: AAD52680.1. Frameshift.
BC077463 mRNA. Translation: AAH77463.1.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10120 mRNA. Translation: CAA71206.1.
AJ000668 mRNA. Translation: CAA04224.1.
AF179300 mRNA. Translation: AAD52680.1. Frameshift.
BC077463 mRNA. Translation: AAH77463.1.

3D structure databases

ProteinModelPortaliO57682.
SMRiO57682. Positions 18-141.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG009115.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR022130. Pax2_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00292. PAX. 1 hit.
PF12403. Pax2_C. 2 hits.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAX2B_XENLA
AccessioniPrimary (citable) accession number: O57682
Secondary accession number(s): O57678, Q6AZQ6, Q9PUK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: December 9, 2015
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.