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Protein

Paired box protein Pax-2-B

Gene

pax2-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable transcription factor. Involved in kidney development, acting synergistically with lhx1/lim-1 in pronephric morphogenesis during the tailbud stages.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Segmentation polarity protein
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-2-B
Short name:
xPax-2b
Gene namesi
Name:pax2-b
Synonyms:pax-2B
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002891331 – 494Paired box protein Pax-2-BAdd BLAST494

Expressioni

Tissue specificityi

Expression becomes spatially localized at mid-gastrula stages and is localized to the nervous system (midbrain, hindbrain, spinal cord), sensory organs (optic vesicle and stalk, otic vesicle), visceral arches, developing excretory system (pronephros, pronephric duct, rectal diverticulum, proctodaeum) and thryoid gland. Splicing does not appear to be tissue-specific.5 Publications

Developmental stagei

Splicing is temporally regulated. Isoform 3 is expressed both maternally and zygotically, whereas isoform 2 is exclusively zygotic. Expression is highest in embryos from stage 12 on, with expression levels remaining constant throughout embryogenesis.1 Publication

Inductioni

By activin. Weakly by bFGF.1 Publication

Structurei

3D structure databases

ProteinModelPortaliO57682
SMRiO57682
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 141PairedPROSITE-ProRule annotationAdd BLAST127

Keywords - Domaini

Paired box

Phylogenomic databases

HOVERGENiHBG009115

Family and domain databases

CDDicd00131 PAX, 1 hit
Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001523 Paired_dom
IPR022130 Pax2_C
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00292 PAX, 1 hit
PF12403 Pax2_C, 2 hits
PRINTSiPR00027 PAIREDBOX
SMARTiView protein in SMART
SM00351 PAX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00034 PAIRED_1, 1 hit
PS51057 PAIRED_2, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O57682-1) [UniParc]FASTAAdd to basket
Also known as: 121 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDMHCKADPF SAMHRHGGVN QLGGVFVNGR PLPDVVRQRI VELAHQGVRP
60 70 80 90 100
CDISRQLRVS HGCVSKILGR YYETGSIKPG VIGGSKPKVA TPKVVDKIAD
110 120 130 140 150
YKRQNPTMFA WEIRDRLLAE GICDNDTVPS VSSINRIIRT KVQQPFHPTP
160 170 180 190 200
DGTPVSTPGH TLVPSTASPP VSSASNDPVG SYSINGILGI PRSNGEKRKR
210 220 230 240 250
DEDGSDGSGP NGDSQSSVES LRKHLRADNF TQQQLEALDR VFERPSYPDV
260 270 280 290 300
FQSAEHIKSE QASEYSLPAL TPGLDEVKSS LSASGNADLG SNVSGPQSYP
310 320 330 340 350
VVTESFASHL YLKQEPHEAS LTPFTPSSLA SSGLADIQPF QMALTVDAST
360 370 380 390 400
PTYSSFTHHG PPYGQFGSQP LIAGRDMSST TLPGYPPHVP PTGQGSYPTS
410 420 430 440 450
TLAGMVPGTN VSVHHSVQPV ECCSCLSSSK PCLFHCRTGS GSEFSGNPYS
460 470 480 490
HPQYTTYNEA WRFSNPALLS SPYYYSATSR GSAPPTAATA YDRH
Length:494
Mass (Da):53,038
Last modified:May 29, 2007 - v2
Checksum:i7D319E30BF0C7B55
GO
Isoform 21 Publication (identifier: O57682-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-15: R → PG
     408-440: Missing.

Show »
Length:462
Mass (Da):49,563
Checksum:i4F99F772A35E7596
GO
Isoform 3 (identifier: O57682-3) [UniParc]FASTAAdd to basket
Also known as: 81 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     203-373: Missing.
     408-440: Missing.

Show »
Length:290
Mass (Da):31,366
Checksum:i51EC64276F6DAA4B
GO
Isoform 4 (identifier: O57682-4) [UniParc]FASTAAdd to basket
Also known as: 11

The sequence of this isoform differs from the canonical sequence as follows:
     15-15: R → PG
     203-373: Missing.
     408-440: Missing.

Note: No Experimental confirmation available.
Show »
Length:291
Mass (Da):31,364
Checksum:i2AA7F5C73860BA7E
GO

Sequence cautioni

The sequence AAD52680 differs from that shown. Reason: Frameshift at positions 335 and 362.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05244115R → PG in isoform 2 and isoform 4. 2 Publications1
Alternative sequenceiVSP_052442203 – 373Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST171
Alternative sequenceiVSP_052443408 – 440Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10120 mRNA Translation: CAA71206.1
AJ000668 mRNA Translation: CAA04224.1
AF179300 mRNA Translation: AAD52680.1 Frameshift.
BC077463 mRNA Translation: AAH77463.1
RefSeqiXP_018083072.1, XM_018227583.1 [O57682-2]
UniGeneiXl.1130
Xl.85122

Genome annotation databases

GeneIDi108697493

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPAX2B_XENLA
AccessioniPrimary (citable) accession number: O57682
Secondary accession number(s): O57678, Q6AZQ6, Q9PUK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: March 28, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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