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Protein
Submitted name:

Potassium channel xKv4.3

Gene

kcnd3

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channelSAAS annotation, Voltage-gated channelSAAS annotation

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium channel xKv4.3Imported
Gene namesi
Name:kcnd3Imported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5867986. kcnd3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei181 – 20222HelicalSequence analysisAdd
BLAST
Transmembranei222 – 24625HelicalSequence analysisAdd
BLAST
Transmembranei258 – 27518HelicalSequence analysisAdd
BLAST
Transmembranei325 – 34622HelicalSequence analysisAdd
BLAST
Transmembranei358 – 37417HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 659643Sequence analysisPRO_5004159036Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO57662.
SMRiO57662. Positions 3-140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 10770BTB (POZ)InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the potassium channel family.SAAS annotation
Contains 1 BTB (POZ) domain.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG106687.
KOiK04893.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003975. K_chnl_volt-dep_Kv4.
IPR004056. K_chnl_volt-dep_Kv4.3.
IPR024587. K_chnl_volt-dep_Kv4_C.
IPR021645. Shal-type_N.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 2 hits.
PfamiPF02214. BTB_2. 1 hit.
PF11879. DUF3399. 1 hit.
PF00520. Ion_trans. 1 hit.
PF11601. Shal-type. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01518. KV43CHANNEL.
PR01491. KVCHANNEL.
PR01497. SHALCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O57662-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGVAAWLP FARAAAIGWM PVANCPMPLA PADKNKKQDE VIILNVSGRR
60 70 80 90 100
FQTWRTTLER YPDNLLGRPE KEFFFNEETK EYFFDRDPEV FRSILNFYRT
110 120 130 140 150
GKLHYPRYEY ISAYDEELSF YGILPEIIGD CCYEEYKDRK RENAERLMDD
160 170 180 190 200
NEFENKQEAM PSLNLRETMW RAFENPHTST LALVFYYVTG FFIAVSVIAN
210 220 230 240 250
VVETVPCGTV PGNKELPCGE RYQVAFFCLD TACVMIFTVE YLLRLFAAPS
260 270 280 290 300
RYRFMRSVMR SVMSIDVVAI MPYYIGLVMT NINEDVSGAF VTLRVFRVFR
310 320 330 340 350
IFKFSRHSQG LRILGYTLKS CASELGFLLF SLTMAIIIFA TVMFYAEKGS
360 370 380 390 400
TSSKFTSIPA SFWYTIVTMT TLGYGDMVPK TIAGKIFEFH LTSLSGVLVI
410 420 430 440 450
ALPDPVMVSN FSRIYHQNQR ADKRRAQKKA RLARIRVAKT GSSTAYLHSK
460 470 480 490 500
RNGLLNEALE LMGSTEEPHI GKSASLIESQ HHHLLHCLEK TTGLSYLVDD
510 520 530 540 550
PLLSVRTSDH EEPCSLWMSQ MFEQNCRENS CKNYPSTATA SLSSHHGLTT
560 570 580 590 600
SCCSRRNKKT THLPNSNVPA TRLRTMQELS TIHIQCSDQP SLTASRSSLN
610 620 630 640 650
LKSEDEMRSN CKASQITTAI ISIPTPPALT PEGETRPGSP PGRSTNIHST

SNIVKVSAL
Length:659
Mass (Da):74,516
Last modified:June 1, 1998 - v1
Checksum:i73F5CF339C6A0F47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89265 mRNA. Translation: AAB94379.1.
RefSeqiNP_001079287.1. NM_001085818.1.
UniGeneiXl.236.

Genome annotation databases

GeneIDi378574.
KEGGixla:378574.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89265 mRNA. Translation: AAB94379.1.
RefSeqiNP_001079287.1. NM_001085818.1.
UniGeneiXl.236.

3D structure databases

ProteinModelPortaliO57662.
SMRiO57662. Positions 3-140.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi378574.
KEGGixla:378574.

Organism-specific databases

CTDi3752.
XenbaseiXB-GENE-5867986. kcnd3.

Phylogenomic databases

HOVERGENiHBG106687.
KOiK04893.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003975. K_chnl_volt-dep_Kv4.
IPR004056. K_chnl_volt-dep_Kv4.3.
IPR024587. K_chnl_volt-dep_Kv4_C.
IPR021645. Shal-type_N.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 2 hits.
PfamiPF02214. BTB_2. 1 hit.
PF11879. DUF3399. 1 hit.
PF00520. Ion_trans. 1 hit.
PF11601. Shal-type. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01518. KV43CHANNEL.
PR01491. KVCHANNEL.
PR01497. SHALCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "xKv4.3."
    Lautermilch N.J., Spitzer N.C.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO57662_XENLA
AccessioniPrimary (citable) accession number: O57662
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: May 11, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.