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Protein
Submitted name:

Potassium channel xKv4.3

Gene

kcnd3

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channelSAAS annotation, Voltage-gated channelSAAS annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium channel xKv4.3Imported
Gene namesi
Name:kcnd3Imported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5867986 kcnd3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei181 – 202HelicalSequence analysisAdd BLAST22
Transmembranei222 – 246HelicalSequence analysisAdd BLAST25
Transmembranei258 – 275HelicalSequence analysisAdd BLAST18
Transmembranei325 – 346HelicalSequence analysisAdd BLAST22
Transmembranei358 – 374HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_500415903617 – 659Sequence analysisAdd BLAST643

Structurei

3D structure databases

ProteinModelPortaliO57662
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 107BTBInterPro annotationAdd BLAST70

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili137 – 157Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the potassium channel family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG106687
KOiK04893

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003975 K_chnl_volt-dep_Kv4
IPR004056 K_chnl_volt-dep_Kv4.3
IPR024587 K_chnl_volt-dep_Kv4_C
IPR021645 Shal-type_N
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 2 hits
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF11879 DUF3399, 1 hit
PF00520 Ion_trans, 1 hit
PF11601 Shal-type, 1 hit
PRINTSiPR00169 KCHANNEL
PR01518 KV43CHANNEL
PR01491 KVCHANNEL
PR01497 SHALCHANNEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequencei

Sequence statusi: Complete.

O57662-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGVAAWLP FARAAAIGWM PVANCPMPLA PADKNKKQDE VIILNVSGRR
60 70 80 90 100
FQTWRTTLER YPDNLLGRPE KEFFFNEETK EYFFDRDPEV FRSILNFYRT
110 120 130 140 150
GKLHYPRYEY ISAYDEELSF YGILPEIIGD CCYEEYKDRK RENAERLMDD
160 170 180 190 200
NEFENKQEAM PSLNLRETMW RAFENPHTST LALVFYYVTG FFIAVSVIAN
210 220 230 240 250
VVETVPCGTV PGNKELPCGE RYQVAFFCLD TACVMIFTVE YLLRLFAAPS
260 270 280 290 300
RYRFMRSVMR SVMSIDVVAI MPYYIGLVMT NINEDVSGAF VTLRVFRVFR
310 320 330 340 350
IFKFSRHSQG LRILGYTLKS CASELGFLLF SLTMAIIIFA TVMFYAEKGS
360 370 380 390 400
TSSKFTSIPA SFWYTIVTMT TLGYGDMVPK TIAGKIFEFH LTSLSGVLVI
410 420 430 440 450
ALPDPVMVSN FSRIYHQNQR ADKRRAQKKA RLARIRVAKT GSSTAYLHSK
460 470 480 490 500
RNGLLNEALE LMGSTEEPHI GKSASLIESQ HHHLLHCLEK TTGLSYLVDD
510 520 530 540 550
PLLSVRTSDH EEPCSLWMSQ MFEQNCRENS CKNYPSTATA SLSSHHGLTT
560 570 580 590 600
SCCSRRNKKT THLPNSNVPA TRLRTMQELS TIHIQCSDQP SLTASRSSLN
610 620 630 640 650
LKSEDEMRSN CKASQITTAI ISIPTPPALT PEGETRPGSP PGRSTNIHST

SNIVKVSAL
Length:659
Mass (Da):74,516
Last modified:June 1, 1998 - v1
Checksum:i73F5CF339C6A0F47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89265 mRNA Translation: AAB94379.1
RefSeqiNP_001079287.1, NM_001085818.1
UniGeneiXl.236

Genome annotation databases

GeneIDi378574
KEGGixla:378574

Similar proteinsi

Entry informationi

Entry nameiO57662_XENLA
AccessioniPrimary (citable) accession number: O57662
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: February 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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