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O57656 (GPDA_TAKRU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

Short name=GPD-C
Short name=GPDH-C
EC=1.1.1.8
Gene names
Name:gpd1
Synonyms:lg3p
OrganismTakifugu rubripes (Japanese pufferfish) (Fugu rubripes) [Reference proteome]
Taxonomic identifier31033 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiEuteleosteiNeoteleosteiAcanthomorphaAcanthopterygiiPercomorphaTetraodontiformesTetradontoideaTetraodontidaeTakifugu

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
PRO_0000138078

Regions

Nucleotide binding11 – 166NAD By similarity
Region271 – 2722Substrate binding By similarity

Sites

Active site2051Proton acceptor By similarity
Binding site981NAD By similarity
Binding site1211NAD; via amide nitrogen By similarity
Binding site1211Substrate By similarity
Binding site1541NAD; via amide nitrogen By similarity
Binding site2711NAD By similarity
Binding site3001NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
O57656 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 4A56E07FE3A5D966

FASTA35138,078
        10         20         30         40         50         60 
MAAPKKVCII GSGNWGSAIA KIVGANAAQN SKFDKTVKMW VFEETVNGRK LTEIINTEHE 

        70         80         90        100        110        120 
NVKYLPGHKL PTNVLAVPDL VEASKDADIL VFVIPHQFIG KVCDTMSGNI KKEAIGISLI 

       130        140        150        160        170        180 
KGVDEGPDGL KLISDVIQEK LGITMSVLMG ANIANEVADE KFCETTIGCK NKSHGPLLKE 

       190        200        210        220        230        240 
LMQTINFRVT VVEEYDVVEI CGALKNIVAV GAGFCDGLGF GDNTKAAVIR LGLMEMIAFA 

       250        260        270        280        290        300 
RIFCTAGPVS SATFLESCGV ADLITTCYGG RNRKVAKAFV KTGKSIEELE KEMLEGQKLQ 

       310        320        330        340        350 
GPATAAEVYR ILKHKNLIDK FPLFNAVYQI CYQGHPVSEF ISCLQNHPEH M 

« Hide

References

[1]"Sequencing of a 62kb region of Fugu rubripes around the G6PD locus."
Riboldi Tunnicliffe G.R., Nyakatura G., Bauer D., Elgar G.S., Perret X., Brenner S., Rosenthal A.
Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U72484 Genomic DNA. Translation: AAB96364.1.
RefSeqXP_003963492.1. XM_003963443.1.

3D structure databases

ProteinModelPortalO57656.
SMRO57656. Positions 3-351.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING31033.ENSTRUP00000003849.

Proteomic databases

PRIDEO57656.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSTRUT00000003869; ENSTRUP00000003849; ENSTRUG00000001679.
GeneID101071719.
KEGGtru:101071719.

Phylogenomic databases

eggNOGCOG0240.
GeneTreeENSGT00390000003114.
InParanoidO57656.
KOK00006.
OMAHILPFAR.
OrthoDBEOG7ZKSBS.
TreeFamTF300836.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11728. PTHR11728. 1 hit.
PfamPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSPR00077. GPDHDRGNASE.
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR03376. glycerol3P_DH. 1 hit.
PROSITEPS00957. NAD_G3PDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPDA_TAKRU
AccessionPrimary (citable) accession number: O57656
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: February 19, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families