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O57656

- GPDA_TAKRU

UniProt

O57656 - GPDA_TAKRU

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Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

Gene
gpd1, lg3p
Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981NAD By similarity
Binding sitei121 – 1211NAD; via amide nitrogen By similarity
Binding sitei121 – 1211Substrate By similarity
Binding sitei154 – 1541NAD; via amide nitrogen By similarity
Active sitei205 – 2051Proton acceptor By similarity
Binding sitei271 – 2711NAD By similarity
Binding sitei300 – 3001NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NAD By similarity

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (EC:1.1.1.8)
Short name:
GPD-C
Short name:
GPDH-C
Gene namesi
Name:gpd1
Synonyms:lg3p
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
ProteomesiUP000005226: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmicPRO_0000138078Add
BLAST

Proteomic databases

PRIDEiO57656.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000003849.

Structurei

3D structure databases

ProteinModelPortaliO57656.
SMRiO57656. Positions 3-351.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni271 – 2722Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0240.
GeneTreeiENSGT00390000003114.
InParanoidiO57656.
KOiK00006.
OMAiPVGEFIH.
OrthoDBiEOG7ZKSBS.
TreeFamiTF300836.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O57656-1 [UniParc]FASTAAdd to Basket

« Hide

MAAPKKVCII GSGNWGSAIA KIVGANAAQN SKFDKTVKMW VFEETVNGRK    50
LTEIINTEHE NVKYLPGHKL PTNVLAVPDL VEASKDADIL VFVIPHQFIG 100
KVCDTMSGNI KKEAIGISLI KGVDEGPDGL KLISDVIQEK LGITMSVLMG 150
ANIANEVADE KFCETTIGCK NKSHGPLLKE LMQTINFRVT VVEEYDVVEI 200
CGALKNIVAV GAGFCDGLGF GDNTKAAVIR LGLMEMIAFA RIFCTAGPVS 250
SATFLESCGV ADLITTCYGG RNRKVAKAFV KTGKSIEELE KEMLEGQKLQ 300
GPATAAEVYR ILKHKNLIDK FPLFNAVYQI CYQGHPVSEF ISCLQNHPEH 350
M 351
Length:351
Mass (Da):38,078
Last modified:June 1, 1998 - v1
Checksum:i4A56E07FE3A5D966
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U72484 Genomic DNA. Translation: AAB96364.1.
RefSeqiXP_003963492.1. XM_003963443.1.

Genome annotation databases

EnsembliENSTRUT00000003869; ENSTRUP00000003849; ENSTRUG00000001679.
GeneIDi101071719.
KEGGitru:101071719.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U72484 Genomic DNA. Translation: AAB96364.1 .
RefSeqi XP_003963492.1. XM_003963443.1.

3D structure databases

ProteinModelPortali O57656.
SMRi O57656. Positions 3-351.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 31033.ENSTRUP00000003849.

Proteomic databases

PRIDEi O57656.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSTRUT00000003869 ; ENSTRUP00000003849 ; ENSTRUG00000001679 .
GeneIDi 101071719.
KEGGi tru:101071719.

Phylogenomic databases

eggNOGi COG0240.
GeneTreei ENSGT00390000003114.
InParanoidi O57656.
KOi K00006.
OMAi PVGEFIH.
OrthoDBi EOG7ZKSBS.
TreeFami TF300836.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11728. PTHR11728. 1 hit.
Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSi PR00077. GPDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
PROSITEi PS00957. NAD_G3PDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequencing of a 62kb region of Fugu rubripes around the G6PD locus."
    Riboldi Tunnicliffe G.R., Nyakatura G., Bauer D., Elgar G.S., Perret X., Brenner S., Rosenthal A.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGPDA_TAKRU
AccessioniPrimary (citable) accession number: O57656
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: June 11, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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