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Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

Gene

gpd1

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981NADBy similarity
Binding sitei121 – 1211NAD; via amide nitrogenBy similarity
Binding sitei121 – 1211SubstrateBy similarity
Binding sitei154 – 1541NAD; via amide nitrogenBy similarity
Active sitei205 – 2051Proton acceptorBy similarity
Binding sitei271 – 2711NADBy similarity
Binding sitei300 – 3001NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NADBy similarity

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (EC:1.1.1.8)
Short name:
GPD-C
Short name:
GPDH-C
Gene namesi
Name:gpd1
Synonyms:lg3p
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
ProteomesiUP000005226: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmicPRO_0000138078Add
BLAST

Proteomic databases

PRIDEiO57656.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000003849.

Structurei

3D structure databases

ProteinModelPortaliO57656.
SMRiO57656. Positions 3-351.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni271 – 2722Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0240.
GeneTreeiENSGT00390000003114.
InParanoidiO57656.
KOiK00006.
OMAiEVANDNF.
OrthoDBiEOG7ZKSBS.
TreeFamiTF300836.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O57656-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAPKKVCII GSGNWGSAIA KIVGANAAQN SKFDKTVKMW VFEETVNGRK
60 70 80 90 100
LTEIINTEHE NVKYLPGHKL PTNVLAVPDL VEASKDADIL VFVIPHQFIG
110 120 130 140 150
KVCDTMSGNI KKEAIGISLI KGVDEGPDGL KLISDVIQEK LGITMSVLMG
160 170 180 190 200
ANIANEVADE KFCETTIGCK NKSHGPLLKE LMQTINFRVT VVEEYDVVEI
210 220 230 240 250
CGALKNIVAV GAGFCDGLGF GDNTKAAVIR LGLMEMIAFA RIFCTAGPVS
260 270 280 290 300
SATFLESCGV ADLITTCYGG RNRKVAKAFV KTGKSIEELE KEMLEGQKLQ
310 320 330 340 350
GPATAAEVYR ILKHKNLIDK FPLFNAVYQI CYQGHPVSEF ISCLQNHPEH

M
Length:351
Mass (Da):38,078
Last modified:June 1, 1998 - v1
Checksum:i4A56E07FE3A5D966
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72484 Genomic DNA. Translation: AAB96364.1.
RefSeqiXP_003963492.1. XM_003963443.1.

Genome annotation databases

EnsembliENSTRUT00000003869; ENSTRUP00000003849; ENSTRUG00000001679.
GeneIDi101071719.
KEGGitru:101071719.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72484 Genomic DNA. Translation: AAB96364.1.
RefSeqiXP_003963492.1. XM_003963443.1.

3D structure databases

ProteinModelPortaliO57656.
SMRiO57656. Positions 3-351.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000003849.

Proteomic databases

PRIDEiO57656.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSTRUT00000003869; ENSTRUP00000003849; ENSTRUG00000001679.
GeneIDi101071719.
KEGGitru:101071719.

Phylogenomic databases

eggNOGiCOG0240.
GeneTreeiENSGT00390000003114.
InParanoidiO57656.
KOiK00006.
OMAiEVANDNF.
OrthoDBiEOG7ZKSBS.
TreeFamiTF300836.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequencing of a 62kb region of Fugu rubripes around the G6PD locus."
    Riboldi Tunnicliffe G.R., Nyakatura G., Bauer D., Elgar G.S., Perret X., Brenner S., Rosenthal A.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGPDA_TAKRU
AccessioniPrimary (citable) accession number: O57656
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: January 7, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.