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Protein

Keratin, type I cytoskeletal 18

Gene

krt18

Organism
Scyliorhinus stellaris (Nursehound) (Greater spotted dogfish)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

When phosphorylated, plays a role in filament reorganization.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei318StutterSequence analysis1

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 18
Alternative name(s):
Cytokeratin-18
Short name:
CK-18
Keratin-18
Short name:
K18
Gene namesi
Name:krt18By similarity
OrganismiScyliorhinus stellaris (Nursehound) (Greater spotted dogfish)
Taxonomic identifieri68454 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiGaleomorphiiGaleoideaCarcharhiniformesScyliorhinidaeScyliorhinus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002890762 – 415Keratin, type I cytoskeletal 18By similarityAdd BLAST414

Post-translational modificationi

Phosphorylated.By similarity
Proteolytically cleaved by caspases during epithelial cell apoptosis.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei225 – 226Cleavage; by caspasesBy similarity2

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO57611.

Expressioni

Tissue specificityi

Expressed in stratified and complex epithelia such as epidermis, mouth and pharyngeal mucosa, mucosa of anterior esophagus, rectal mucosa and gland canals, gill mucosae, gill squamous epithelium and secondary lamellae, uterus mucosa, cornea, conjuctiva, outermost layer of Sclera and in olfactory epithelium. Also expressed in simple epithelia and epitheloid cells such as lateral line canal (mantle cells, neuromast), dura mater (meninges) and ampullae of Lorenzini.2 Publications

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Keratin-18 associates with keratin-8 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliO57611.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 66HeadSequence analysisAdd BLAST65
Regioni67 – 373RodSequence analysisAdd BLAST307
Regioni67 – 102Coil 1ASequence analysisAdd BLAST36
Regioni103 – 119Linker 1Sequence analysisAdd BLAST17
Regioni120 – 211Coil 1BSequence analysisAdd BLAST92
Regioni212 – 235Linker 12Sequence analysisAdd BLAST24
Regioni236 – 373Coil 2Sequence analysisAdd BLAST138
Regioni374 – 415TailSequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi8 – 55Ser-richSequence analysisAdd BLAST48

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG013015.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O57611-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYRGYTSLS SHSGPMSIRR SMPLQSSASS ISGYGQRMAV SRISRVASLG
60 70 80 90 100
SSSSSAAGIG MGGVGNQKET MQDLNDRLAT YLEKVHSLET GNAKLELQIK
110 120 130 140 150
EHLDARGPSF RDWSIYEKPL NELRKEVYDM TVDNARLILQ IDNARLAADD
160 170 180 190 200
FRVKWESELS IRQSVENDIN GLRKVIDDTN IGRLHLETEI ESLKEELIYI
210 220 230 240 250
RKNHDEEVKA LRSQVADSSV HVEVDSAPGP DLSKVLAEIR KEYEGVAQKN
260 270 280 290 300
KDDAEIWYKN QMDGYKVEVK HNTDELCSAK VQVTELHRQI QSLEVELESL
310 320 330 340 350
LSMKNSLEGT LRDTELRYEM ELQTINGMIA KLEADLHQIR GDMQAQVREY
360 370 380 390 400
EILLNIKMKL EAEIATYRRL LDGEDINTLV ESTSGVTSQT IKKTIVTTQK
410
VVDGKIVSDE TVQIN
Length:415
Mass (Da):46,792
Last modified:June 1, 1998 - v1
Checksum:iD02F98DF51095D30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14647 mRNA. Translation: CAA74980.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14647 mRNA. Translation: CAA74980.1.

3D structure databases

ProteinModelPortaliO57611.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO57611.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG013015.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1C18_SCYST
AccessioniPrimary (citable) accession number: O57611
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 1998
Last modified: May 11, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.