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Protein

Keratin, type I cytoskeletal 18

Gene

krt18

Organism
Scyliorhinus stellaris (Nursehound) (Greater spotted dogfish)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

When phosphorylated, plays a role in filament reorganization.By similarity

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei318StutterSequence analysis1

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 18
Alternative name(s):
Cytokeratin-18
Short name:
CK-18
Keratin-18
Short name:
K18
Gene namesi
Name:krt18By similarity
OrganismiScyliorhinus stellaris (Nursehound) (Greater spotted dogfish)
Taxonomic identifieri68454 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiGaleomorphiiGaleoideaCarcharhiniformesScyliorhinidaeScyliorhinus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002890762 – 415Keratin, type I cytoskeletal 18By similarityAdd BLAST414

Post-translational modificationi

Phosphorylated.By similarity
Proteolytically cleaved by caspases during epithelial cell apoptosis.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei225 – 226Cleavage; by caspasesBy similarity2

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO57611

Expressioni

Tissue specificityi

Expressed in stratified and complex epithelia such as epidermis, mouth and pharyngeal mucosa, mucosa of anterior esophagus, rectal mucosa and gland canals, gill mucosae, gill squamous epithelium and secondary lamellae, uterus mucosa, cornea, conjunctiva, outermost layer of Sclera and in olfactory epithelium. Also expressed in simple epithelia and epitheloid cells such as lateral line canal (mantle cells, neuromast), dura mater (meninges) and ampullae of Lorenzini.2 Publications

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Keratin-18 associates with keratin-8 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliO57611
SMRiO57611
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 378IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 66HeadSequence analysisAdd BLAST65
Regioni67 – 102Coil 1ASequence analysisAdd BLAST36
Regioni103 – 119Linker 1Sequence analysisAdd BLAST17
Regioni120 – 211Coil 1BSequence analysisAdd BLAST92
Regioni212 – 235Linker 12Sequence analysisAdd BLAST24
Regioni236 – 373Coil 2Sequence analysisAdd BLAST138
Regioni374 – 415TailSequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi8 – 55Ser-richSequence analysisAdd BLAST48

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG013015

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR027695 Keratin-18
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PTHR23239:SF35 PTHR23239:SF35, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O57611-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYRGYTSLS SHSGPMSIRR SMPLQSSASS ISGYGQRMAV SRISRVASLG
60 70 80 90 100
SSSSSAAGIG MGGVGNQKET MQDLNDRLAT YLEKVHSLET GNAKLELQIK
110 120 130 140 150
EHLDARGPSF RDWSIYEKPL NELRKEVYDM TVDNARLILQ IDNARLAADD
160 170 180 190 200
FRVKWESELS IRQSVENDIN GLRKVIDDTN IGRLHLETEI ESLKEELIYI
210 220 230 240 250
RKNHDEEVKA LRSQVADSSV HVEVDSAPGP DLSKVLAEIR KEYEGVAQKN
260 270 280 290 300
KDDAEIWYKN QMDGYKVEVK HNTDELCSAK VQVTELHRQI QSLEVELESL
310 320 330 340 350
LSMKNSLEGT LRDTELRYEM ELQTINGMIA KLEADLHQIR GDMQAQVREY
360 370 380 390 400
EILLNIKMKL EAEIATYRRL LDGEDINTLV ESTSGVTSQT IKKTIVTTQK
410
VVDGKIVSDE TVQIN
Length:415
Mass (Da):46,792
Last modified:June 1, 1998 - v1
Checksum:iD02F98DF51095D30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14647 mRNA Translation: CAA74980.1

Similar proteinsi

Entry informationi

Entry nameiK1C18_SCYST
AccessioniPrimary (citable) accession number: O57611
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

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