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Protein

Keratin, type I cytoskeletal 18

Gene

krt18

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

When phosphorylated, plays a role in filament reorganization.By similarity

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei279StutterSequence analysis1
Sitei340StutterSequence analysis1

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 18
Alternative name(s):
Cytokeratin-18
Short name:
CK-18
Keratin-18
Short name:
K18
Simple type I keratin
Gene namesi
Name:krt18
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002890732 – 438Keratin, type I cytoskeletal 18By similarityAdd BLAST437

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO57607

Expressioni

Tissue specificityi

Expressed in all tissues examined, including epidermal keratinocytes, tongue mucosa, corneal epithelium, Meninges cells, epidermal goblet and Merkel cells, gill mucosa, basal cells of gill secondary lamellae, hepatocytes and bile canaliculi, bile duct, intestinal mucosa, blood vessel endothelial and muscle cells, interstitial cells, fibroblasts, scale-associated cells, ovary stroma and follicle, optic nerve glia, eye ciliary body, chondrocytes and kidney tubules.1 Publication

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Keratin-18 associates with keratin-8 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliO57607
SMRiO57607
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 400IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 88HeadSequence analysisAdd BLAST87
Regioni89 – 124Coil 1ASequence analysisAdd BLAST36
Regioni125 – 141Linker 1Sequence analysisAdd BLAST17
Regioni142 – 233Coil 1BSequence analysisAdd BLAST92
Regioni234 – 257Linker 12Sequence analysisAdd BLAST24
Regioni258 – 395Coil 2Sequence analysisAdd BLAST138
Regioni396 – 438TailSequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 68Gly-richSequence analysisAdd BLAST34

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG013015

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O57607-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVKRSSVRG PGSGYGYSIT HNSTAPTYRA ASTYGGAGGQ GTRISSVSYS
60 70 80 90 100
GVRSGMGGMG VGMGGSGGSM SSSIQVSTSG DTAHIMGNEK FAMQNLNDRL
110 120 130 140 150
ASYLEMVRNL EQANGKLELK IREAMEKRGP DVNDYSRYNA ILDDLRKKVF
160 170 180 190 200
DATTDNARMC LQIDNARLAA DDFRVKFESE LSIRQSVEAD IVGLRKVIDD
210 220 230 240 250
TNMGRMNLES EIEALKEELI FLKKNHDNEV MEMRNMISQS GVQVDVDAPK
260 270 280 290 300
GQDLAAIMAE VRAKYEKEAL KNQEELKAWH ETRITEVQSV VSQNTEALQG
310 320 330 340 350
AHTEINDLRR QLQTLEIELD SQKSLKGSLE GTLRDTEMRY NMEMESLNKI
360 370 380 390 400
LVGLESELTN LRSNIQQQTQ EYEHLLNIKM KLEAEIATYR RLLDGGDFKL
410 420 430
QDALEDQRTV KTKVMTVTQT LVDGKVVSSS TETKERNL
Length:438
Mass (Da):48,779
Last modified:June 1, 1998 - v1
Checksum:i06EF8C4EEEAD841B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14289 mRNA Translation: CAA74664.1
RefSeqiNP_001118196.1, NM_001124724.1
UniGeneiOmy.34894

Genome annotation databases

GeneIDi100136778

Similar proteinsi

Entry informationi

Entry nameiK1C18_ONCMY
AccessioniPrimary (citable) accession number: O57607
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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