Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ultraviolet-sensitive opsin

Gene
N/A
Organism
Melopsittacus undulatus (Budgerigar) (Psittacus undulatus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

Absorptioni

Abs(max)=371 nm2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

Chromophore

Names & Taxonomyi

Protein namesi
Recommended name:
Ultraviolet-sensitive opsin
Alternative name(s):
Ultraviolet cone photoreceptor pigment
OrganismiMelopsittacus undulatus (Budgerigar) (Psittacus undulatus)
Taxonomic identifieri13146 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePsittaciformesPsittaculidaeMelopsittacus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737ExtracellularBy similarityAdd
BLAST
Transmembranei38 – 5821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini59 – 6911CytoplasmicBy similarityAdd
BLAST
Transmembranei70 – 9021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini91 – 10616ExtracellularBy similarityAdd
BLAST
Transmembranei107 – 12721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini128 – 14720CytoplasmicBy similarityAdd
BLAST
Transmembranei148 – 16821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini169 – 19729ExtracellularBy similarityAdd
BLAST
Transmembranei198 – 21821Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini219 – 24729CytoplasmicBy similarityAdd
BLAST
Transmembranei248 – 26821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini269 – 28214ExtracellularBy similarityAdd
BLAST
Transmembranei283 – 30321Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini304 – 34744CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347Ultraviolet-sensitive opsinPRO_0000197769Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi12 – 121N-linked (GlcNAc...)Sequence analysis
Disulfide bondi105 ↔ 182PROSITE-ProRule annotation
Modified residuei291 – 2911N6-(retinylidene)lysineBy similarity
Lipidationi317 – 3171S-palmitoyl cysteineSequence analysis

Post-translational modificationi

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Expressioni

Tissue specificityi

Cone photoreceptor cells.1 Publication

Structurei

3D structure databases

ProteinModelPortaliO57605.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG107442.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR001521. Opsin_blue.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00238. OPSIN.
PR00574. OPSINBLUE.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O57605-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGEEEFYLF KNGSIGGPWD GPQYHIAPPW AFYLQTAFMG FVFMVGTPLN
60 70 80 90 100
AIVLVVTIKY KKLRQPLNYI LVNISFCGFL ACIICIFTVF VSSSQGYFVF
110 120 130 140 150
GKHVCAFEGF MGATAGLVTG WSLAFLAFER YIVICKPLGN FRFTAKHALV
160 170 180 190 200
VVVATWVIGI GVAIPPFFGW SRYVPEGLQC SCGPDWYTVG TKYRSEYYTW
210 220 230 240 250
FLFIFCFIVP LSLIIFSYSQ LLSALRAVAA QQQESATTQK AEREVSRMVV
260 270 280 290 300
VMVGSFCVCY VPYAALAMYM VNNREHGIDL RLVTIPAFFS KSSCVYNPII
310 320 330 340
YCFMNKQFRG CIMEMVCGKP MTDDSDMSSS AQRTEVSSVS SSQVSPS
Length:347
Mass (Da):38,791
Last modified:June 1, 1998 - v1
Checksum:iC272A8690F228E4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11787 mRNA. Translation: CAA72483.1.
RefSeqiNP_001298010.1. NM_001311081.1.

Genome annotation databases

GeneIDi101869469.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11787 mRNA. Translation: CAA72483.1.
RefSeqiNP_001298010.1. NM_001311081.1.

3D structure databases

ProteinModelPortaliO57605.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101869469.

Phylogenomic databases

HOVERGENiHBG107442.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR001521. Opsin_blue.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00238. OPSIN.
PR00574. OPSINBLUE.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The molecular basis for UV vision in birds: spectral characteristics, cDNA sequence and retinal localization of the UV-sensitive visual pigment of the budgerigar (Melopsittacus undulatus)."
    Wilkie S.E., Vissers P.M.A.M., Das D., DeGrip W.J., Bowmaker J.K., Hunt D.M.
    Biochem. J. 330:541-547(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES.
    Tissue: Retina.
  2. "Visual pigments and oil droplets from six classes of photoreceptor in the retinas of birds."
    Bowmaker J.K., Heath L.A., Wilkie S.E., Hunt D.M.
    Vision Res. 37:2183-2194(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: BIOPHYSICOCHEMICAL PROPERTIES.
    Tissue: Retina.

Entry informationi

Entry nameiOPSUV_MELUD
AccessioniPrimary (citable) accession number: O57605
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 1998
Last modified: November 11, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.