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Protein

Homeobox protein HMX3

Gene

HMX3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi181 – 240HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein HMX3
Alternative name(s):
Homeobox protein H6 family member 3
Homeobox protein Nkx-5.1
Short name:
cNkx5-1
Gene namesi
Name:HMX3
Synonyms:NKX-5.1, NKX5-1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003413831 – 308Homeobox protein HMX3Add BLAST308

Proteomic databases

PaxDbiO57601.

Expressioni

Developmental stagei

Expressed in the otic placode beginning at stage 10 and exhibits a dynamic expression pattern during formation and further differentiation of the otic vesicle.1 Publication

Inductioni

Regulated by DAN in inner ear.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011796.

Structurei

3D structure databases

ProteinModelPortaliO57601.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi8 – 40Pro-richAdd BLAST33
Compositional biasi276 – 281Poly-Gly6

Sequence similaritiesi

Belongs to the HMX homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0485. Eukaryota.
ENOG4111R8D. LUCA.
HOGENOMiHOG000231923.
HOVERGENiHBG098273.
InParanoidiO57601.
KOiK09349.
PhylomeDBiO57601.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O57601-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPETGQEPPS APPPPPPPKE SFYIKNLLNG DPPKAAPKQP RALFAPSGKA
60 70 80 90 100
DGSGFALSQV GDLSFPRFEI PAPRFALSAH CLERAQTWWY PYALTPAGAH
110 120 130 140 150
LPRTEAAEKS LLRDSSPASG TDRDSPEPLL QGGDAEQKER DPKSPAEIVL
160 170 180 190 200
EESDSEEGKK EGGAEDWKKR EESPEKKPCR KKKTRTVFSR SQVFQLESTF
210 220 230 240 250
DMKRYLSSSE RAGLAASLHL TETQVKIWFQ NRRNKWKRQL AAELEAANLS
260 270 280 290 300
HAAAQRIVRV PILYHENSGA ESSAAGGGGP GPQPLLTFPH PVYYSHPSVT

SVPLLRPV
Length:308
Mass (Da):33,787
Last modified:June 1, 1998 - v1
Checksum:i568B77CBF9C4968B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15989 Genomic DNA. Translation: CAA75921.1.
RefSeqiNP_001007986.1. NM_001007985.1.
UniGeneiGga.22889.

Genome annotation databases

GeneIDi429199.
KEGGigga:429199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15989 Genomic DNA. Translation: CAA75921.1.
RefSeqiNP_001007986.1. NM_001007985.1.
UniGeneiGga.22889.

3D structure databases

ProteinModelPortaliO57601.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011796.

Proteomic databases

PaxDbiO57601.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi429199.
KEGGigga:429199.

Organism-specific databases

CTDi340784.

Phylogenomic databases

eggNOGiKOG0485. Eukaryota.
ENOG4111R8D. LUCA.
HOGENOMiHOG000231923.
HOVERGENiHBG098273.
InParanoidiO57601.
KOiK09349.
PhylomeDBiO57601.

Miscellaneous databases

PROiO57601.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHMX3_CHICK
AccessioniPrimary (citable) accession number: O57601
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 1, 1998
Last modified: June 8, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.