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Protein

Nuclear receptor coactivator 3

Gene

ncoa3

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, probably via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as retinoids (RAR and RXR), thyroid hormone (TR) and orphan nuclear receptor (hepatocyte nuclear receptor 4 (HNF4) and constitutive androstane receptor (CAR)). Displays histone acetyltransferase activity.

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Acyltransferase, Transferase
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor coactivator 3 (EC:2.3.1.48)
Alternative name(s):
Retinoid X receptor-interacting coactivator xSRC-3
Gene namesi
Name:ncoa3
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865628 ncoa3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi622L → A: Weakly impairs interaction with nuclear receptors. 1 Publication1
Mutagenesisi683L → A: Strongly impairs interaction with nuclear receptors. 1 Publication1
Mutagenesisi739L → A: Strongly impairs interaction with nuclear receptors. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000944091 – 1391Nuclear receptor coactivator 3Add BLAST1391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei614N6-acetyllysineBy similarity1
Modified residuei617N6-acetyllysineBy similarity1
Modified residuei618N6-acetyllysineBy similarity1

Post-translational modificationi

Phosphorylated and acetylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiO57539

Expressioni

Tissue specificityi

Highly expressed in liver and in early stages of oocyte development.

Developmental stagei

Expressed only in early stages of oocyte development. Expression is more prominent in stage I, strongly decreases in stage II and then, gradually disappears.

Interactioni

Subunit structurei

Interacts with the histone acetyltransferase protein EP300.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ncoa3O57539-12EBI-301587,EBI-301595

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliO57539
SMRiO57539
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 84bHLHPROSITE-ProRule annotationAdd BLAST58
Domaini112 – 182PASPROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1088 – 1274AcetyltransferaseAdd BLAST187

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi680 – 684LXXLL motif 15
Motifi736 – 740LXXLL motif 25
Motifi1048 – 1052LXXLL motif 35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi503 – 666Ser-richAdd BLAST164
Compositional biasi515 – 522Poly-Ser8
Compositional biasi968 – 971Poly-Gln4
Compositional biasi1241 – 1248Poly-Gln8

Domaini

Contains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the association with nuclear receptors, and constitute the RID domain (Receptor-interacting domain).

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG052583
KOiK11256

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 1 hit
Gene3Di1.10.287.1070, 1 hit
4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR010011 DUF1518
IPR032565 DUF4927
IPR036638 HLH_DNA-bd_sf
IPR028818 NCOA3
IPR009110 Nuc_rcpt_coact
IPR014920 Nuc_rcpt_coact_Ncoa-typ
IPR037077 Nuc_rcpt_coact_Ncoa_int_sf
IPR017426 Nuclear_rcpt_coactivator
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR014935 SRC/p160_LXXLL
PANTHERiPTHR10684 PTHR10684, 1 hit
PTHR10684:SF3 PTHR10684:SF3, 1 hit
PfamiView protein in Pfam
PF07469 DUF1518, 1 hit
PF16279 DUF4927, 1 hit
PF08815 Nuc_rec_co-act, 1 hit
PF00989 PAS, 1 hit
PF08832 SRC-1, 1 hit
PIRSFiPIRSF038181 Nuclear_receptor_coactivator, 1 hit
SMARTiView protein in SMART
SM01151 DUF1518, 1 hit
SM00353 HLH, 1 hit
SM00091 PAS, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
SSF69125 SSF69125, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 1 hit

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms may be produced.
Isoform 1 (identifier: O57539-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGLGENSLD PLASETRKRK PSSCDTPGPG LTCSGEKRRR EQESKYIEEL
60 70 80 90 100
ADLISANLSD IDNFNVKPDK CAILKETVRQ IRQIKEQGKA SSNDDDVQKA
110 120 130 140 150
DVSSTGQGVI DKDSLGPLLL QALDGFLYVV NREGSIVFVS ENVTQYLQYK
160 170 180 190 200
QEDLVNTSVY SILHEEDRKD FLKNLPKSTV NGVPWFSETP RQKSHTFNCR
210 220 230 240 250
MLVKTSHDHL EDGSNLDARQ RYETMQCFAL SQPRAMIEEG EDLQSCMICV
260 270 280 290 300
ARRITTAERA FSANPESFIT RHDLTGKVVN IDANSLRSSM RPGFEDTIRR
310 320 330 340 350
CIQRFLFHSE GQPWTYKRHY QEAYVHGLSE TPLYRFSLAD GTMVTAQTKS
360 370 380 390 400
KLFRNPVTND PHGFVSTHFL QREQNGYRPN PNPMAQGIRP QMNPNLPNTM
410 420 430 440 450
NSMPPQAMQQ QNRNYGMGDP NSMAQMQGMR YKSPGNMAPV NQAPGVQQSP
460 470 480 490 500
YQNNSNYGLN MNSPPHGSPG MNANQPNLMV SPRNRASPKM ASNQFSPVPG
510 520 530 540 550
MNSPMGSSGN AGGGSFSSSS LSALHAISEG VGSSLLSSLS SPGQKVENNS
560 570 580 590 600
NMNMPQQGKI CNQDCKSPSG LYCEQGQVES SVCQSSGREH LGEKDVKENI
610 620 630 640 650
FEGSESQRSQ AESKGHKKLL QLLTCFTEER GQSLMSSSSM DCKDSSNVTS
660 670 680 690 700
PSGVSSSTSI GVSSTSNLHG SMLQEKHRIL HKLLQNGNSP AEVAKITAEA
710 720 730 740 750
TGKDVFQETV SSAPCTEATV KREQLSPKKK ENNALLRHLL DKDDWKDPLA
760 770 780 790 800
KDIKPKVEHM DIKMGSCSSS NVPTSSQDKE VKIKTEPGEE VPGDLDNLDA
810 820 830 840 850
ILGDLAGSDF YSNSMSSRAS DLGPKQPVFQ DSPTLAMRSP DSMQGSRPPF
860 870 880 890 900
NRAMSLDSRS STPPVRNVNS FPMLPKQGMI GSPRMMDGQD NFGVMMGSGP
910 920 930 940 950
NRSMNQHPGG DWAMQNSAVN RLEPPNVGSV GRPGPDYSSA MTRPAMGGNM
960 970 980 990 1000
PGLLTRSNSI PGSRPVMQQQ QHILPMRPND MAMSMGSNPY GQQAPSNPPG
1010 1020 1030 1040 1050
SWPDAIMMNQ GRGGAQNRQL GRNSLDDLLC PPSTVEGQTD EIALLDQLHT
1060 1070 1080 1090 1100
LLSNTDATGL EEIDRALGIP DLVSQGQALE PQPDSYQPQG SPVMIDQKPP
1110 1120 1130 1140 1150
MYGQHYAGQG AAMSAGGFNN MQGQHPPFNT VMGQMNQQQG MHPLQGMHPR
1160 1170 1180 1190 1200
ANLIRPRNNI PKQLRMQLQQ RLQGQQFLNQ NRQALEMKVD PMNPGGAGVM
1210 1220 1230 1240 1250
RPVMQTPVSQ QGFLNAQMVA QKNRELISHQ IRQHRMAMMM QQQQGQPQAF
1260 1270 1280 1290 1300
SPPPNVTASA SMDNPLGGPP MPQAPPQQFS YPPNYGINQQ TDPTFGRVSS
1310 1320 1330 1340 1350
PPNAMMSSRM APSQNPHPQT TQMYPSPDMK GWPSGNMARP NSFPQQQYSH
1360 1370 1380 1390
QTNPATYNMM HMNGNGNHMG QMNINSLPMS GMPMGPDQKY C
Length:1,391
Mass (Da):152,532
Last modified:June 1, 1998 - v1
Checksum:iAD28F5CD934AC33D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044080 mRNA Translation: AAC12927.1
RefSeqiNP_001081732.1, NM_001088263.1 [O57539-1]
UniGeneiXl.268

Genome annotation databases

GeneIDi398021
KEGGixla:398021

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNCOA3_XENLA
AccessioniPrimary (citable) accession number: O57539
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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