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Protein

Nucleoside diphosphate kinase

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).By similarity

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei13ATPBy similarity1
Binding sitei61ATPBy similarity1
Binding sitei89ATPBy similarity1
Binding sitei95ATPBy similarity1
Binding sitei106ATPBy similarity1
Binding sitei116ATPBy similarity1
Active sitei119Pros-phosphohistidine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide metabolism
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinase (EC:2.7.4.6)
Short name:
NDK
Short name:
NDP kinase
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: AgBase
  • lamellipodium Source: AgBase
  • mitochondrion Source: AgBase
  • plasma membrane Source: UniProtKB-SubCell
  • ruffle Source: AgBase

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002502031 – 153Nucleoside diphosphate kinaseAdd BLAST153

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO57535.
PRIDEiO57535.

Expressioni

Gene expression databases

BgeeiENSGALG00000002932.
ExpressionAtlasiO57535. baseline.

Interactioni

Protein-protein interaction databases

BioGridi676189. 2 interactors.
IntActiO57535. 1 interactor.
STRINGi9031.ENSGALP00000034078.

Structurei

3D structure databases

ProteinModelPortaliO57535.
SMRiO57535.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.Curated

Phylogenomic databases

eggNOGiKOG0888. Eukaryota.
COG0105. LUCA.
HOGENOMiHOG000224564.
HOVERGENiHBG000423.
InParanoidiO57535.
KOiK00940.
OMAiWFEDKEL.
OrthoDBiEOG091G0PLD.
PhylomeDBiO57535.
TreeFamiTF106373.

Family and domain databases

HAMAPiMF_00451. NDP_kinase. 1 hit.
InterProiView protein in InterPro
IPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
PfamiView protein in Pfam
PF00334. NDK. 1 hit.
PRINTSiPR01243. NUCDPKINASE.
SMARTiView protein in SMART
SM00562. NDK. 1 hit.
PROSITEiView protein in PROSITE
PS00469. NDP_KINASES. 1 hit.

Sequencei

Sequence statusi: Complete.

O57535-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANCERTFI AIKPDGVQRG LVGEIIKRFE QKGFRLVAMK FVHASEDLLK
60 70 80 90 100
QHYIDLKDRP FYPGLVKYMN SGPVVAMVWE GLNVVKTGRV MLGETNPADS
110 120 130 140 150
KPGTIRGDFC IQVGRNIIHG SDSVESAQKE ISLWFKPAEL IDYRSCAHDW

VYE
Length:153
Mass (Da):17,288
Last modified:June 1, 1998 - v1
Checksum:i939DDD61D329E008
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043542 mRNA. Translation: AAB99856.1.
RefSeqiNP_990378.1. NM_205047.1.
UniGeneiGga.2020.

Genome annotation databases

GeneIDi395916.
KEGGigga:395916.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043542 mRNA. Translation: AAB99856.1.
RefSeqiNP_990378.1. NM_205047.1.
UniGeneiGga.2020.

3D structure databases

ProteinModelPortaliO57535.
SMRiO57535.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676189. 2 interactors.
IntActiO57535. 1 interactor.
STRINGi9031.ENSGALP00000034078.

Proteomic databases

PaxDbiO57535.
PRIDEiO57535.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395916.
KEGGigga:395916.

Organism-specific databases

CTDi4831.

Phylogenomic databases

eggNOGiKOG0888. Eukaryota.
COG0105. LUCA.
HOGENOMiHOG000224564.
HOVERGENiHBG000423.
InParanoidiO57535.
KOiK00940.
OMAiWFEDKEL.
OrthoDBiEOG091G0PLD.
PhylomeDBiO57535.
TreeFamiTF106373.

Miscellaneous databases

PROiO57535.

Gene expression databases

BgeeiENSGALG00000002932.
ExpressionAtlasiO57535. baseline.

Family and domain databases

HAMAPiMF_00451. NDP_kinase. 1 hit.
InterProiView protein in InterPro
IPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
PfamiView protein in Pfam
PF00334. NDK. 1 hit.
PRINTSiPR01243. NUCDPKINASE.
SMARTiView protein in SMART
SM00562. NDK. 1 hit.
PROSITEiView protein in PROSITE
PS00469. NDP_KINASES. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNDK_CHICK
AccessioniPrimary (citable) accession number: O57535
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: June 1, 1998
Last modified: March 15, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.