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Protein

Nucleoside diphosphate kinase

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).By similarity

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei13 – 131ATPBy similarity
Binding sitei61 – 611ATPBy similarity
Binding sitei89 – 891ATPBy similarity
Binding sitei95 – 951ATPBy similarity
Binding sitei106 – 1061ATPBy similarity
Binding sitei116 – 1161ATPBy similarity
Active sitei119 – 1191Pros-phosphohistidine intermediateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinase (EC:2.7.4.6)
Short name:
NDK
Short name:
NDP kinase
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153Nucleoside diphosphate kinasePRO_0000250203Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO57535.
PRIDEiO57535.

Expressioni

Gene expression databases

BgeeiENSGALG00000002932.

Interactioni

Protein-protein interaction databases

BioGridi676189. 2 interactions.
IntActiO57535. 1 interaction.
STRINGi9031.ENSGALP00000034078.

Structurei

3D structure databases

ProteinModelPortaliO57535.
SMRiO57535. Positions 3-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.Curated

Phylogenomic databases

eggNOGiKOG0888. Eukaryota.
COG0105. LUCA.
GeneTreeiENSGT00760000119146.
HOGENOMiHOG000224564.
HOVERGENiHBG000423.
InParanoidiO57535.
KOiK00940.
OMAiWFEDKEL.
OrthoDBiEOG091G0PLD.
PhylomeDBiO57535.
TreeFamiTF106373.

Family and domain databases

HAMAPiMF_00451. NDP_kinase. 1 hit.
InterProiIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
PROSITEiPS00469. NDP_KINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O57535-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANCERTFI AIKPDGVQRG LVGEIIKRFE QKGFRLVAMK FVHASEDLLK
60 70 80 90 100
QHYIDLKDRP FYPGLVKYMN SGPVVAMVWE GLNVVKTGRV MLGETNPADS
110 120 130 140 150
KPGTIRGDFC IQVGRNIIHG SDSVESAQKE ISLWFKPAEL IDYRSCAHDW

VYE
Length:153
Mass (Da):17,288
Last modified:June 1, 1998 - v1
Checksum:i939DDD61D329E008
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043542 mRNA. Translation: AAB99856.1.
RefSeqiNP_990378.1. NM_205047.1.
UniGeneiGga.2020.

Genome annotation databases

EnsembliENSGALT00000034721; ENSGALP00000034078; ENSGALG00000002932.
GeneIDi395916.
KEGGigga:395916.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043542 mRNA. Translation: AAB99856.1.
RefSeqiNP_990378.1. NM_205047.1.
UniGeneiGga.2020.

3D structure databases

ProteinModelPortaliO57535.
SMRiO57535. Positions 3-153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676189. 2 interactions.
IntActiO57535. 1 interaction.
STRINGi9031.ENSGALP00000034078.

Proteomic databases

PaxDbiO57535.
PRIDEiO57535.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000034721; ENSGALP00000034078; ENSGALG00000002932.
GeneIDi395916.
KEGGigga:395916.

Organism-specific databases

CTDi4831.

Phylogenomic databases

eggNOGiKOG0888. Eukaryota.
COG0105. LUCA.
GeneTreeiENSGT00760000119146.
HOGENOMiHOG000224564.
HOVERGENiHBG000423.
InParanoidiO57535.
KOiK00940.
OMAiWFEDKEL.
OrthoDBiEOG091G0PLD.
PhylomeDBiO57535.
TreeFamiTF106373.

Enzyme and pathway databases

ReactomeiR-GGA-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Miscellaneous databases

PROiO57535.

Gene expression databases

BgeeiENSGALG00000002932.

Family and domain databases

HAMAPiMF_00451. NDP_kinase. 1 hit.
InterProiIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
PROSITEiPS00469. NDP_KINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDK_CHICK
AccessioniPrimary (citable) accession number: O57535
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.