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O57525

- CP17A_RANDY

UniProt

O57525 - CP17A_RANDY

Protein

Steroid 17-alpha-hydroxylase/17,20 lyase

Gene

CYP17A1

Organism
Rana dybowskii (Dybovsky's frog) (Korean brown frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction.

    Catalytic activityi

    A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.
    17-alpha-hydroxyprogesterone = androst-4-ene-3,17-dione + acetaldehyde.

    Cofactori

    Heme group.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi455 – 4551Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. 17-alpha-hydroxyprogesterone aldolase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. steroid 17-alpha-monooxygenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. steroid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase, Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Steroidogenesis

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00062.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.99.9, EC:4.1.2.30)
    Alternative name(s):
    17-alpha-hydroxyprogesterone aldolase
    CYPXVII
    Cytochrome P450 17A1
    Cytochrome P450-C17
    Short name:
    Cytochrome P450c17
    Gene namesi
    Name:CYP17A1
    Synonyms:CYP17
    OrganismiRana dybowskii (Dybovsky's frog) (Korean brown frog)
    Taxonomic identifieri71582 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaeRanaRana

    Subcellular locationi

    Membrane Curated

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 519519Steroid 17-alpha-hydroxylase/17,20 lyasePRO_0000051948Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO57525.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG106944.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O57525-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLCFFLLIF IRSFLLFKIK LVRTSEKKWR MGSRSHGDVK HPKSLPSLPV    50
    IGSLLHLGKK LPPHILFCNL QKKYGSLYSF MMGSHYVVVV NNHEDAREVL 100
    LKKGKTFGGR PRTVTTDILT RDGKDIAFAD YSPTWKFHRK MVHSALCMFG 150
    EGTVAIEQII SREAASLCQT LTSFQRIPLD MAPELIRAVT NVVCSLCFNT 200
    RYKRGDAEFE TMLKYSKGIV DTVAKDSLVD IFPWLQIFPN KDLDILRQSV 250
    AARDQLLQKK INEHKDAFCG ETVKDLVDAL LKAKLNMENN NSNVSQDVGL 300
    TEDHILMTVG DIFGAGVETT STVLKWAVAY LLHYPEVQKK IQEELDVKVG 350
    FGRYPLLSDR KILHYTEAAI SEVLRIRPVS PLLIPHVALK ESSIGEYTIP 400
    KEARVVINLW SLHHDEKEWV NPHLFSPDRF LDENGNRVYS PSPSFLPFGA 450
    GIRVCLGEAL AKMEVFLFLS WILQRFTLEV PEGDPLPDLE GKFGVVIQVK 500
    PFKVIAKLRE VWKNIEIVT 519
    Length:519
    Mass (Da):58,948
    Last modified:June 1, 1998 - v1
    Checksum:iFDF866CF15593A2E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF042278 mRNA. Translation: AAB97686.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF042278 mRNA. Translation: AAB97686.1 .

    3D structure databases

    ProteinModelPortali O57525.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106944.

    Enzyme and pathway databases

    UniPathwayi UPA00062 .

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of cDNA encoding 17-alpha-hydroxylase/17,20 lyase (P450c17) in amphibia (Rana dybowskii)."
      Choi H.H., Kang H.M., Choi H.S., Kwon H.B.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCP17A_RANDY
    AccessioniPrimary (citable) accession number: O57525
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3