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Protein

Non-specific serine/threonine protein kinase

Gene

akt1

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotationImported, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseSAAS annotation (EC:2.7.11.1SAAS annotation)
Gene namesi
Name:akt1Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KCNMA1Q8AYS82EBI-4306384,EBI-1635766

Protein-protein interaction databases

IntActiO57513, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliO57513
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 108PHInterPro annotationAdd BLAST104
Domaini150 – 408Protein kinaseInterPro annotationAdd BLAST259
Domaini409 – 480AGC-kinase C-terminalInterPro annotationAdd BLAST72

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili96 – 116Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0598 Eukaryota
ENOG410XNPH LUCA
HOGENOMiHOG000233033
HOVERGENiHBG108317
KOiK04456
PhylomeDBiO57513

Family and domain databases

CDDicd05594 STKc_PKB_alpha, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR034676 Akt1
IPR011009 Kinase-like_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR017892 Pkinase_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00069 Pkinase, 1 hit
PF00433 Pkinase_C, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

O57513-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEVAIVKEG WLHKRGEYIK TWRPRYFLLK NDGTFIGYKE RPQDVDQRES
60 70 80 90 100
PLNNFSVAQC QLMKTERPKP NTFIIRCLQW TTVIERTFHV ETPEEREEWT
110 120 130 140 150
KAIQTVADSL KKQEEEMMDF RSGSPSDNSG AEEMEVSMTK PKHKVTMNEF
160 170 180 190 200
EYLKLLGKGT FGKVILVKEK ATGRYYAMKI LKKEVIVAKD EVAHTLTENR
210 220 230 240 250
VLQNSRHPFL TALKYSFQTH DRLCFVMEYA NGGELFFHLS RERVFSEDRA
260 270 280 290 300
RFYGAEIVSA LDYLHSEKNV VYRDLKLENL MLDKDGHIKI TDFGLCKEGI
310 320 330 340 350
KDGATMKTFC GTPEYLAPEV LEDNDYGRAV DWWGLGVVMY EMMCGRLPFY
360 370 380 390 400
NQDHEKLFEL ILMEEIRFPR TLSPEAKSLL SGLLKKDPKQ RLGGGPDDAK
410 420 430 440 450
EIMQHKFFAG IVWQDVYGKK LVPPFKPQVT SETDTRYFDE EFTAQMITIT
460 470 480
PPDQDDSMDC VDNERRPHFP QFSYSASGTA
Length:480
Mass (Da):55,724
Last modified:June 1, 1998 - v1
Checksum:i3B83A47FD6689626
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039943 mRNA Translation: AAB94767.1
RefSeqiNP_990386.1, NM_205055.1
UniGeneiGga.3875

Genome annotation databases

GeneIDi395928
KEGGigga:395928

Similar proteinsi

Entry informationi

Entry nameiO57513_CHICK
AccessioniPrimary (citable) accession number: O57513
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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