O57480 (O57480_CHICK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Guanylate cyclase RuleBase RU003431
EC=4.6.1.2 RuleBase RU003431

Gene names

Name:

GC1 EMBL AAC24500.1

Organism

Gallus gallus (Chicken) EMBL AAC24500.1

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	1068 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	GTP = 3',5'-cyclic GMP + diphosphate. RuleBase RU003431
Sequence similarities	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Ontologies

Keywords
Biological process	cGMP biosynthesis RuleBase RU003431
Ligand	Nucleotide-binding SAAS SAAS001054
Molecular function	Lyase SAAS SAAS001054 RuleBase RU003431 Receptor EMBL AAC24500.1
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro guanylate cyclase activity Inferred from electronic annotation. Source: EC protein kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAC24500.1

Sequences

	Sequence		Length	Mass (Da)
	O57480 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 3F4C693E1597174B	FASTA	1,068	118,289
	10 20 30 40 50 60 VGVLGPWLCD PVASRALPEL ASRLAVARLN RDPELSRGYW WDAVLLPEPC QTPQAVTALL 70 80 90 100 110 120 GAERYAAGLV GPLNPAVCGA AELLAAAWNK PLVSWSCVGD GEGERETLVE PMPAPGAVLH 130 140 150 160 170 180 AVLSYFRWAH VAVVTAPQDA WREVGRGLAQ EMRARGPPVT VVTPVGTREE EAGEALRRVR 190 200 210 220 230 240 RADGVRVVVM CMHSVLLGGE EQRVLLEKAE DMGMTDGTYV FIPYDALTFP LPYHRVPYPI 250 260 270 280 290 300 LANSTKLRLA YDAVLTITID SPEVSFHEAL RQAQEAYEIP AHIDPTQVHP LFATIYNSIY 310 320 330 340 350 360 FLANAVEATR RSGRWVMGSS VAENARDFQM EGFCQPFSVT EDGDVNVPYV VLDTDGKGDR 370 380 390 400 410 420 LWPVYGLEPG IRGLAYRGHS VHWPHSSSPG TDSGCWFESG SICNGGMDAS FVLLIFILVS 430 440 450 460 470 480 ALVAAGAALA CFIRRRIQQA QLMKGPNKII LTMEDLTFIN TQSNKRVDGS RTSLAGRSTG 490 500 510 520 530 540 DTKSIRSVTA APDTTNVAIA EGNETPPGAN SHLPLLLLLF NQQGLVASVQ GDWVWLKKFP 550 560 570 580 590 600 GDQHSEVKPA TKLAFCKLRD LRHENVNLFL GFFHDCGIFA IVSEHCSRGS LEDLLRNQDM 610 620 630 640 650 660 KLDWMFKSSL LIDLIKGMRY LHHRDVVHGR RKSRNCVVDG RFVLKVTDHG YNELLEAQRV 670 680 690 700 710 720 PTPTPQPQER LWTAPELLRD AALERRGSFR GDVYGIGIIM QEVICRSAPY CMLGLPPEEI 730 740 750 760 770 780 IEKVARPPPL CRPAVSADQA PLECIHLMKQ CWSEQPERRP NIDQIFDQFK GINKGRKTNI 790 800 810 820 830 840 IDSMLRMLEQ YSSNLEDLIR ERTEELEIEK QKTDKLLTQM LPPSVAEALK MGTPVEPEYF 850 860 870 880 890 900 EEVTLYFSDI VGFTTISAMS EPIEVVDLLN DLYTLFDVII GAHDVYKVET IGDAYMVASG 910 920 930 940 950 960 LPKRNGNRHA GEIANMSLDI LSSVGTFKMR HMPEVPVRIR IGLHSGPCVA GVVGLTMPRY 970 980 990 1000 1010 1020 CLFGDTVNTA SRMESTGLPY RIHVNARTVA ILRALQEGFK LDIRGKTELK GKGVEDTYWL 1030 1040 1050 1060 VGREGFTKPI PTPPDLLPGA SNHGISLDEI PAERRRKLEK ARPGQVLK

References

[1]

"A null mutation in the photoreceptor guanylate cyclase gene causes the retinal degeneration chicken phenotype." Semple-Rowland S.L., Lee N.R., Van Hooser J.P., Palczewski K., Baehr W. Proc. Natl. Acad. Sci. U.S.A. 95:1271-1276(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Rhode Island Red EMBL AAC24500.1. Tissue: Retina-pigment epithelium-choroid EMBL AAC24500.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF036942 mRNA. Translation: AAC24500.1.
IPI	IPI00883115.
PIR	T42382.
UniGene	Gga.510.
3D structure databases
HSSP	HSSP built from PDB template 1AZS based on UniProtKB P26769.
ProteinModelPortal	O57480.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG098487.
Family and domain databases
Gene3D	3.30.70.1230. 1 hit.
InterPro	IPR001054. A/G_cyclase. IPR018297. A/G_cyclase_CS. IPR001828. ANF_lig-bd_rcpt. IPR011645. Haem_no_assoc-bd. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. [Graphical view]
Pfam	PF01094. ANF_receptor. 1 hit. PF00211. Guanylate_cyc. 1 hit. PF07701. HNOBA. 1 hit. PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
SMART	SM00044. CYCc. 1 hit. [Graphical view]
SUPFAM	SSF55073. A/G_cyclase. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS00452. GUANYLATE_CYCLASE_1. 1 hit. PS50125. GUANYLATE_CYCLASE_2. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O57480_CHICK

Accession

Primary (citable) accession number: O57480

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 1998
Last sequence update:	June 1, 1998
Last modified:	April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)