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O57472

- CHRD_DANRE

UniProt

O57472 - CHRD_DANRE

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Protein

Chordin

Gene

chd

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity).By similarity

GO - Biological processi

  1. anterior/posterior axis specification Source: ZFIN
  2. caudal fin morphogenesis Source: ZFIN
  3. determination of heart left/right asymmetry Source: ZFIN
  4. determination of left/right symmetry Source: ZFIN
  5. determination of ventral identity Source: ZFIN
  6. dorsal/ventral pattern formation Source: ZFIN
  7. dorsal convergence Source: ZFIN
  8. embryonic heart tube morphogenesis Source: ZFIN
  9. embryonic hemopoiesis Source: ZFIN
  10. heart looping Source: ZFIN
  11. Kupffer's vesicle development Source: ZFIN
  12. negative regulation of BMP signaling pathway Source: ZFIN
  13. otic placode formation Source: ZFIN
  14. regulation of BMP signaling pathway involved in heart jogging Source: ZFIN
  15. somitogenesis Source: ZFIN
  16. specification of organ position Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Chordin
Alternative name(s):
Protein chordino
Gene namesi
Name:chd
Synonyms:chrd
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-990415-33. chd.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 940921ChordinPRO_0000005366Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi430 – 4301N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiO57472.

Expressioni

Tissue specificityi

During gastrulation, levels are highest in the organizer region. Also present in the developing brain and in paraxial mesoderm and ectoderm.1 Publication

Developmental stagei

First detected shortly after the midbastula transition. Levels increase during gastrulation, persist through early somatogenesis, but then decrease and are gone by 24 hours.1 Publication

Interactioni

Subunit structurei

Interacts with twsg1 and/or bmp4.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000045109.

Structurei

3D structure databases

ProteinModelPortaliO57472.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 11877VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini162 – 277116CHRD 1PROSITE-ProRule annotationAdd
BLAST
Domaini279 – 398120CHRD 2PROSITE-ProRule annotationAdd
BLAST
Domaini404 – 519116CHRD 3PROSITE-ProRule annotationAdd
BLAST
Domaini525 – 652128CHRD 4PROSITE-ProRule annotationAdd
BLAST
Domaini689 – 74860VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini767 – 83670VWFC 3PROSITE-ProRule annotationAdd
BLAST
Domaini855 – 91965VWFC 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the chordin family.Curated
Contains 4 CHRD domains.PROSITE-ProRule annotation
Contains 4 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG85639.
HOGENOMiHOG000234370.
HOVERGENiHBG005330.
InParanoidiO57472.
KOiK04657.
PhylomeDBiO57472.

Family and domain databases

InterProiIPR016353. Chordin.
IPR010895. CHRD.
IPR001007. VWF_C.
[Graphical view]
PfamiPF07452. CHRD. 4 hits.
PF00093. VWC. 4 hits.
[Graphical view]
PIRSFiPIRSF002496. Chordin. 1 hit.
SMARTiSM00754. CHRD. 4 hits.
SM00214. VWC. 4 hits.
[Graphical view]
PROSITEiPS50933. CHRD. 4 hits.
PS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O57472-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMEGLLWILL SVIIASVHGS RLKTPALPIQ PEREPMISKG LSGCSFGGRF
60 70 80 90 100
YSLEDTWHPD LGEPFGVMHC VMCHCEPQRS RRGKVFGKVS CRNMKQDCPD
110 120 130 140 150
PTCDDPVLLP GHCCKTCPKG DSGRKEVESL FDFFQEKDDD LHKSYNDRSY
160 170 180 190 200
ISSEDTSTRD STTTDFVALL TGVTDSWLPS SSGVARARFT LSRTSLTFSI
210 220 230 240 250
TFQRINRPSL IAFLDTDGNT AFEFRVPQAD NDMICGIWKN VPKPHMRQLE
260 270 280 290 300
AEQLHVSMTT ADNRKEELQG RIIKHRALFA ETFSAILTSD EVHSGMGGIA
310 320 330 340 350
MLTLSDTENN LHFILIMQGL VPPGSSKVPV RVKLQYRQHL LREIRANITA
360 370 380 390 400
DDSDFAEVLA DLNSRELFWL SRGQLQISVQ TEGQTLRHIS GFISGRRSCD
410 420 430 440 450
TLQSVLSSGA ALTAGQTGGV GSAVFTLHPN GSLDYQLLVA GLSSAVLSVS
460 470 480 490 500
IEMKPRRRNK RSVLYELSAV FTDQRAAGSC GRVEARHTHM LLQNELFINI
510 520 530 540 550
ATALQPDGEL RGQIRLLPYN GLDARRNELP VPLAGVLVSP PVRTGAAGHA
560 570 580 590 600
WVSVDPQCHL HYEIIVNGLS KSEDASISAH LHGLAEIGEM DDSSTNHKRL
610 620 630 640 650
LTGFYGQQAQ GVLKDISVEL LRHLNEGTAY LQVSTKMNPR GEIRGRIHVP
660 670 680 690 700
NHCESPAPRA EFLEEPEFED LLFTREPTEL RKDTHTHVHS CFFEGEQHTH
710 720 730 740 750
GSQWTPQYNT CFTCTCQKKT VICDPVMCPT LSCTHTVQPE DQCCPICEEK
760 770 780 790 800
KESKETAAVE KVEENPEGCY FEGDQKMHAP GTTWHPFVPP FGYIKCAVCT
810 820 830 840 850
CKGSTGEVHC EKVTCPPLTC SRPIRRNPSD CCKECPPEET PPLEDEEMMQ
860 870 880 890 900
ADGTRLCKFG KNYYQNSEHW HPSVPLVGEM KCITCWCDHG VTKCQRKQCP
910 920 930 940
LLSCRNPIRT EGKCCPECIE DFMEKEEMAK MAEKKKSWRH
Length:940
Mass (Da):104,999
Last modified:June 1, 1998 - v1
Checksum:iB855CAF84F4623AC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF034606 mRNA. Translation: AAB93485.1.
AB043968 Genomic DNA. Translation: BAB18642.1.
RefSeqiNP_571048.1. NM_130973.2.
UniGeneiDr.75804.

Genome annotation databases

GeneIDi30161.
KEGGidre:30161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF034606 mRNA. Translation: AAB93485.1 .
AB043968 Genomic DNA. Translation: BAB18642.1 .
RefSeqi NP_571048.1. NM_130973.2.
UniGenei Dr.75804.

3D structure databases

ProteinModelPortali O57472.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000045109.

Proteomic databases

PRIDEi O57472.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 30161.
KEGGi dre:30161.

Organism-specific databases

CTDi 30161.
ZFINi ZDB-GENE-990415-33. chd.

Phylogenomic databases

eggNOGi NOG85639.
HOGENOMi HOG000234370.
HOVERGENi HBG005330.
InParanoidi O57472.
KOi K04657.
PhylomeDBi O57472.

Miscellaneous databases

NextBioi 20806631.
PROi O57472.

Family and domain databases

InterProi IPR016353. Chordin.
IPR010895. CHRD.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF07452. CHRD. 4 hits.
PF00093. VWC. 4 hits.
[Graphical view ]
PIRSFi PIRSF002496. Chordin. 1 hit.
SMARTi SM00754. CHRD. 4 hits.
SM00214. VWC. 4 hits.
[Graphical view ]
PROSITEi PS50933. CHRD. 4 hits.
PS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Differential regulation of chordin expression domains in mutant zebrafish."
    Miller-Bertoglio V.E., Fisher S., Sanchez A., Mullins M.C., Halpern M.E.
    Dev. Biol. 192:537-550(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Embryo.
  2. "Regulation of chordino."
    Fujii R., Hibi M., Hirano T., Shimizu T.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42.

Entry informationi

Entry nameiCHRD_DANRE
AccessioniPrimary (citable) accession number: O57472
Secondary accession number(s): Q9DED8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3