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O57472

- CHRD_DANRE

UniProt

O57472 - CHRD_DANRE

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Protein

Chordin

Gene
chd, chrd
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes By similarity.1 Publication

GO - Molecular functioni

  1. protein binding Source: ZFIN

GO - Biological processi

  1. anterior/posterior axis specification Source: ZFIN
  2. caudal fin morphogenesis Source: ZFIN
  3. determination of heart left/right asymmetry Source: ZFIN
  4. determination of left/right symmetry Source: ZFIN
  5. determination of ventral identity Source: ZFIN
  6. dorsal/ventral pattern formation Source: ZFIN
  7. dorsal convergence Source: ZFIN
  8. embryonic heart tube morphogenesis Source: ZFIN
  9. embryonic hemopoiesis Source: ZFIN
  10. heart looping Source: ZFIN
  11. Kupffer's vesicle development Source: ZFIN
  12. negative regulation of BMP signaling pathway Source: ZFIN
  13. otic placode formation Source: ZFIN
  14. regulation of BMP signaling pathway involved in heart jogging Source: ZFIN
  15. somitogenesis Source: ZFIN
  16. specification of organ position Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Chordin
Alternative name(s):
Protein chordino
Gene namesi
Name:chd
Synonyms:chrd
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-990415-33. chd.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed predictionAdd
BLAST
Chaini20 – 940921ChordinPRO_0000005366Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi347 – 3471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi430 – 4301N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development By similarity.

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiO57472.

Expressioni

Tissue specificityi

During gastrulation, levels are highest in the organizer region. Also present in the developing brain and in paraxial mesoderm and ectoderm.1 Publication

Developmental stagei

First detected shortly after the midbastula transition. Levels increase during gastrulation, persist through early somatogenesis, but then decrease and are gone by 24 hours.1 Publication

Interactioni

Subunit structurei

Interacts with twsg1 and/or bmp4 By similarity.

Protein-protein interaction databases

STRINGi7955.ENSDARP00000045109.

Structurei

3D structure databases

ProteinModelPortaliO57472.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 11877VWFC 1Add
BLAST
Domaini162 – 277116CHRD 1Add
BLAST
Domaini279 – 398120CHRD 2Add
BLAST
Domaini404 – 519116CHRD 3Add
BLAST
Domaini525 – 652128CHRD 4Add
BLAST
Domaini689 – 74860VWFC 2Add
BLAST
Domaini767 – 83670VWFC 3Add
BLAST
Domaini855 – 91965VWFC 4Add
BLAST

Sequence similaritiesi

Belongs to the chordin family.
Contains 4 CHRD domains.
Contains 4 VWFC domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG85639.
HOGENOMiHOG000234370.
HOVERGENiHBG005330.
InParanoidiO57472.
KOiK04657.
PhylomeDBiO57472.

Family and domain databases

InterProiIPR016353. Chordin.
IPR010895. CHRD.
IPR001007. VWF_C.
[Graphical view]
PfamiPF07452. CHRD. 4 hits.
PF00093. VWC. 4 hits.
[Graphical view]
PIRSFiPIRSF002496. Chordin. 1 hit.
SMARTiSM00754. CHRD. 4 hits.
SM00214. VWC. 4 hits.
[Graphical view]
PROSITEiPS50933. CHRD. 4 hits.
PS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O57472-1 [UniParc]FASTAAdd to Basket

« Hide

MMEGLLWILL SVIIASVHGS RLKTPALPIQ PEREPMISKG LSGCSFGGRF    50
YSLEDTWHPD LGEPFGVMHC VMCHCEPQRS RRGKVFGKVS CRNMKQDCPD 100
PTCDDPVLLP GHCCKTCPKG DSGRKEVESL FDFFQEKDDD LHKSYNDRSY 150
ISSEDTSTRD STTTDFVALL TGVTDSWLPS SSGVARARFT LSRTSLTFSI 200
TFQRINRPSL IAFLDTDGNT AFEFRVPQAD NDMICGIWKN VPKPHMRQLE 250
AEQLHVSMTT ADNRKEELQG RIIKHRALFA ETFSAILTSD EVHSGMGGIA 300
MLTLSDTENN LHFILIMQGL VPPGSSKVPV RVKLQYRQHL LREIRANITA 350
DDSDFAEVLA DLNSRELFWL SRGQLQISVQ TEGQTLRHIS GFISGRRSCD 400
TLQSVLSSGA ALTAGQTGGV GSAVFTLHPN GSLDYQLLVA GLSSAVLSVS 450
IEMKPRRRNK RSVLYELSAV FTDQRAAGSC GRVEARHTHM LLQNELFINI 500
ATALQPDGEL RGQIRLLPYN GLDARRNELP VPLAGVLVSP PVRTGAAGHA 550
WVSVDPQCHL HYEIIVNGLS KSEDASISAH LHGLAEIGEM DDSSTNHKRL 600
LTGFYGQQAQ GVLKDISVEL LRHLNEGTAY LQVSTKMNPR GEIRGRIHVP 650
NHCESPAPRA EFLEEPEFED LLFTREPTEL RKDTHTHVHS CFFEGEQHTH 700
GSQWTPQYNT CFTCTCQKKT VICDPVMCPT LSCTHTVQPE DQCCPICEEK 750
KESKETAAVE KVEENPEGCY FEGDQKMHAP GTTWHPFVPP FGYIKCAVCT 800
CKGSTGEVHC EKVTCPPLTC SRPIRRNPSD CCKECPPEET PPLEDEEMMQ 850
ADGTRLCKFG KNYYQNSEHW HPSVPLVGEM KCITCWCDHG VTKCQRKQCP 900
LLSCRNPIRT EGKCCPECIE DFMEKEEMAK MAEKKKSWRH 940
Length:940
Mass (Da):104,999
Last modified:June 1, 1998 - v1
Checksum:iB855CAF84F4623AC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF034606 mRNA. Translation: AAB93485.1.
AB043968 Genomic DNA. Translation: BAB18642.1.
RefSeqiNP_571048.1. NM_130973.2.
UniGeneiDr.75804.

Genome annotation databases

GeneIDi30161.
KEGGidre:30161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF034606 mRNA. Translation: AAB93485.1 .
AB043968 Genomic DNA. Translation: BAB18642.1 .
RefSeqi NP_571048.1. NM_130973.2.
UniGenei Dr.75804.

3D structure databases

ProteinModelPortali O57472.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000045109.

Proteomic databases

PRIDEi O57472.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 30161.
KEGGi dre:30161.

Organism-specific databases

CTDi 30161.
ZFINi ZDB-GENE-990415-33. chd.

Phylogenomic databases

eggNOGi NOG85639.
HOGENOMi HOG000234370.
HOVERGENi HBG005330.
InParanoidi O57472.
KOi K04657.
PhylomeDBi O57472.

Miscellaneous databases

NextBioi 20806631.
PROi O57472.

Family and domain databases

InterProi IPR016353. Chordin.
IPR010895. CHRD.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF07452. CHRD. 4 hits.
PF00093. VWC. 4 hits.
[Graphical view ]
PIRSFi PIRSF002496. Chordin. 1 hit.
SMARTi SM00754. CHRD. 4 hits.
SM00214. VWC. 4 hits.
[Graphical view ]
PROSITEi PS50933. CHRD. 4 hits.
PS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Differential regulation of chordin expression domains in mutant zebrafish."
    Miller-Bertoglio V.E., Fisher S., Sanchez A., Mullins M.C., Halpern M.E.
    Dev. Biol. 192:537-550(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Embryo.
  2. "Regulation of chordino."
    Fujii R., Hibi M., Hirano T., Shimizu T.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42.

Entry informationi

Entry nameiCHRD_DANRE
AccessioniPrimary (citable) accession number: O57472
Secondary accession number(s): Q9DED8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 1998
Last modified: June 11, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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