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O57472

- CHRD_DANRE

UniProt

O57472 - CHRD_DANRE

Protein

Chordin

Gene

chd

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: ZFIN

    GO - Biological processi

    1. anterior/posterior axis specification Source: ZFIN
    2. caudal fin morphogenesis Source: ZFIN
    3. determination of heart left/right asymmetry Source: ZFIN
    4. determination of left/right symmetry Source: ZFIN
    5. determination of ventral identity Source: ZFIN
    6. dorsal/ventral pattern formation Source: ZFIN
    7. dorsal convergence Source: ZFIN
    8. embryonic heart tube morphogenesis Source: ZFIN
    9. embryonic hemopoiesis Source: ZFIN
    10. heart looping Source: ZFIN
    11. Kupffer's vesicle development Source: ZFIN
    12. negative regulation of BMP signaling pathway Source: ZFIN
    13. otic placode formation Source: ZFIN
    14. regulation of BMP signaling pathway involved in heart jogging Source: ZFIN
    15. somitogenesis Source: ZFIN
    16. specification of organ position Source: ZFIN

    Keywords - Molecular functioni

    Developmental protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chordin
    Alternative name(s):
    Protein chordino
    Gene namesi
    Name:chd
    Synonyms:chrd
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-990415-33. chd.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 940921ChordinPRO_0000005366Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi430 – 4301N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiO57472.

    Expressioni

    Tissue specificityi

    During gastrulation, levels are highest in the organizer region. Also present in the developing brain and in paraxial mesoderm and ectoderm.1 Publication

    Developmental stagei

    First detected shortly after the midbastula transition. Levels increase during gastrulation, persist through early somatogenesis, but then decrease and are gone by 24 hours.1 Publication

    Interactioni

    Subunit structurei

    Interacts with twsg1 and/or bmp4.By similarity

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000045109.

    Structurei

    3D structure databases

    ProteinModelPortaliO57472.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini42 – 11877VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini162 – 277116CHRD 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini279 – 398120CHRD 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini404 – 519116CHRD 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini525 – 652128CHRD 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini689 – 74860VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini767 – 83670VWFC 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini855 – 91965VWFC 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the chordin family.Curated
    Contains 4 CHRD domains.PROSITE-ProRule annotation
    Contains 4 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG85639.
    HOGENOMiHOG000234370.
    HOVERGENiHBG005330.
    InParanoidiO57472.
    KOiK04657.
    PhylomeDBiO57472.

    Family and domain databases

    InterProiIPR016353. Chordin.
    IPR010895. CHRD.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF07452. CHRD. 4 hits.
    PF00093. VWC. 4 hits.
    [Graphical view]
    PIRSFiPIRSF002496. Chordin. 1 hit.
    SMARTiSM00754. CHRD. 4 hits.
    SM00214. VWC. 4 hits.
    [Graphical view]
    PROSITEiPS50933. CHRD. 4 hits.
    PS01208. VWFC_1. 3 hits.
    PS50184. VWFC_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O57472-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMEGLLWILL SVIIASVHGS RLKTPALPIQ PEREPMISKG LSGCSFGGRF    50
    YSLEDTWHPD LGEPFGVMHC VMCHCEPQRS RRGKVFGKVS CRNMKQDCPD 100
    PTCDDPVLLP GHCCKTCPKG DSGRKEVESL FDFFQEKDDD LHKSYNDRSY 150
    ISSEDTSTRD STTTDFVALL TGVTDSWLPS SSGVARARFT LSRTSLTFSI 200
    TFQRINRPSL IAFLDTDGNT AFEFRVPQAD NDMICGIWKN VPKPHMRQLE 250
    AEQLHVSMTT ADNRKEELQG RIIKHRALFA ETFSAILTSD EVHSGMGGIA 300
    MLTLSDTENN LHFILIMQGL VPPGSSKVPV RVKLQYRQHL LREIRANITA 350
    DDSDFAEVLA DLNSRELFWL SRGQLQISVQ TEGQTLRHIS GFISGRRSCD 400
    TLQSVLSSGA ALTAGQTGGV GSAVFTLHPN GSLDYQLLVA GLSSAVLSVS 450
    IEMKPRRRNK RSVLYELSAV FTDQRAAGSC GRVEARHTHM LLQNELFINI 500
    ATALQPDGEL RGQIRLLPYN GLDARRNELP VPLAGVLVSP PVRTGAAGHA 550
    WVSVDPQCHL HYEIIVNGLS KSEDASISAH LHGLAEIGEM DDSSTNHKRL 600
    LTGFYGQQAQ GVLKDISVEL LRHLNEGTAY LQVSTKMNPR GEIRGRIHVP 650
    NHCESPAPRA EFLEEPEFED LLFTREPTEL RKDTHTHVHS CFFEGEQHTH 700
    GSQWTPQYNT CFTCTCQKKT VICDPVMCPT LSCTHTVQPE DQCCPICEEK 750
    KESKETAAVE KVEENPEGCY FEGDQKMHAP GTTWHPFVPP FGYIKCAVCT 800
    CKGSTGEVHC EKVTCPPLTC SRPIRRNPSD CCKECPPEET PPLEDEEMMQ 850
    ADGTRLCKFG KNYYQNSEHW HPSVPLVGEM KCITCWCDHG VTKCQRKQCP 900
    LLSCRNPIRT EGKCCPECIE DFMEKEEMAK MAEKKKSWRH 940
    Length:940
    Mass (Da):104,999
    Last modified:June 1, 1998 - v1
    Checksum:iB855CAF84F4623AC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF034606 mRNA. Translation: AAB93485.1.
    AB043968 Genomic DNA. Translation: BAB18642.1.
    RefSeqiNP_571048.1. NM_130973.2.
    UniGeneiDr.75804.

    Genome annotation databases

    GeneIDi30161.
    KEGGidre:30161.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF034606 mRNA. Translation: AAB93485.1 .
    AB043968 Genomic DNA. Translation: BAB18642.1 .
    RefSeqi NP_571048.1. NM_130973.2.
    UniGenei Dr.75804.

    3D structure databases

    ProteinModelPortali O57472.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000045109.

    Proteomic databases

    PRIDEi O57472.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 30161.
    KEGGi dre:30161.

    Organism-specific databases

    CTDi 30161.
    ZFINi ZDB-GENE-990415-33. chd.

    Phylogenomic databases

    eggNOGi NOG85639.
    HOGENOMi HOG000234370.
    HOVERGENi HBG005330.
    InParanoidi O57472.
    KOi K04657.
    PhylomeDBi O57472.

    Miscellaneous databases

    NextBioi 20806631.
    PROi O57472.

    Family and domain databases

    InterProi IPR016353. Chordin.
    IPR010895. CHRD.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF07452. CHRD. 4 hits.
    PF00093. VWC. 4 hits.
    [Graphical view ]
    PIRSFi PIRSF002496. Chordin. 1 hit.
    SMARTi SM00754. CHRD. 4 hits.
    SM00214. VWC. 4 hits.
    [Graphical view ]
    PROSITEi PS50933. CHRD. 4 hits.
    PS01208. VWFC_1. 3 hits.
    PS50184. VWFC_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential regulation of chordin expression domains in mutant zebrafish."
      Miller-Bertoglio V.E., Fisher S., Sanchez A., Mullins M.C., Halpern M.E.
      Dev. Biol. 192:537-550(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Embryo.
    2. "Regulation of chordino."
      Fujii R., Hibi M., Hirano T., Shimizu T.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42.

    Entry informationi

    Entry nameiCHRD_DANRE
    AccessioniPrimary (citable) accession number: O57472
    Secondary accession number(s): Q9DED8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3