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O57429

- UBP2_CHICK

UniProt

O57429 - UBP2_CHICK

Protein

Ubiquitin carboxyl-terminal hydrolase 2

Gene

USP2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Possesses both ubiquitin-specific peptidase and isopeptidase activities By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei28 – 281NucleophilePROSITE-ProRule annotation
    Metal bindingi177 – 1771ZincBy similarity
    Metal bindingi180 – 1801ZincBy similarity
    Metal bindingi228 – 2281ZincBy similarity
    Metal bindingi231 – 2311ZincBy similarity
    Active sitei309 – 3091Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ubiquitin-specific protease activity Source: Roslin

    GO - Biological processi

    1. protein deubiquitination Source: Roslin
    2. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiC19.013.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 2 (EC:3.4.19.12)
    Alternative name(s):
    41 kDa ubiquitin-specific protease
    Deubiquitinating enzyme 2
    Ubiquitin thioesterase 2
    Ubiquitin-specific-processing protease 2
    Gene namesi
    Name:USP2
    Synonyms:UBP41
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmperinuclear region By similarity

    GO - Cellular componenti

    1. perinuclear region of cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 357357Ubiquitin carboxyl-terminal hydrolase 2PRO_0000080618Add
    BLAST

    Proteomic databases

    PaxDbiO57429.

    Interactioni

    Subunit structurei

    Homooligomer.By similarity

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000010901.

    Structurei

    3D structure databases

    ProteinModelPortaliO57429.
    SMRiO57429. Positions 16-352.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 351333USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family. USP2 subfamily.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5560.
    HOVERGENiHBG011164.
    PhylomeDBiO57429.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O57429-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAARMAPTPR SSKVVQGLTG LRNLGNTCFM NSILQCLSNT KELRDYCLQN    50
    QYLRDLNNNS RMRTALMSEF AKLIQLLWTS SPNDSVSPSE FKTQIQRYAP 100
    RFVGYNQQDA QEFLRFLLDG LHGEVNRVLV RPRANADTLD HLPDDEKSRQ 150
    MWRRYQERED SRVSDLFVGQ LKSSLTCSEC GYCSTAFDPF WDLSLPIPKK 200
    GYGEVTLMDC LRLFTKEDVL DGDEKPTCCR CKARTRCTKK FSIQKFPKIL 250
    VLHLKRFSEA RIRASKLTTF VNFPLKDLDL REFASQSCNH AVYNLYAVSN 300
    HSGTTMGGHY TAYCKSPISS EWHSFNDSRV TPMSSSHVRS SDAYLLFYEL 350
    ASPSSRM 357
    Length:357
    Mass (Da):40,932
    Last modified:June 1, 1998 - v1
    Checksum:iEC39E6454937C455
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF016107 mRNA. Translation: AAC13729.1.
    UniGeneiGga.454.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF016107 mRNA. Translation: AAC13729.1 .
    UniGenei Gga.454.

    3D structure databases

    ProteinModelPortali O57429.
    SMRi O57429. Positions 16-352.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000010901.

    Protein family/group databases

    MEROPSi C19.013.

    Proteomic databases

    PaxDbi O57429.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG5560.
    HOVERGENi HBG011164.
    PhylomeDBi O57429.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a novel ubiquitin-specific protease, UBP41, with isopeptidase activity in chick skeletal muscle."
      Baek S., Choi K.S., Yoo Y.J., Cho J.M., Baker R.T., Tanaka K., Chung C.H.
      J. Biol. Chem. 272:25560-25565(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skeletal muscle.

    Entry informationi

    Entry nameiUBP2_CHICK
    AccessioniPrimary (citable) accession number: O57429
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3