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O57429 (UBP2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 2

EC=3.4.19.12
Alternative name(s):
41 kDa ubiquitin-specific protease
Deubiquitinating enzyme 2
Ubiquitin thioesterase 2
Ubiquitin-specific-processing protease 2
Gene names
Name:USP2
Synonyms:UBP41
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Possesses both ubiquitin-specific peptidase and isopeptidase activities By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Cofactor

Binds 1 zinc ion By similarity.

Subunit structure

Homooligomer By similarity.

Subcellular location

Cytoplasm By similarity. Cytoplasmperinuclear region By similarity.

Sequence similarities

Belongs to the peptidase C19 family. USP2 subfamily.

Contains 1 USP domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 357357Ubiquitin carboxyl-terminal hydrolase 2
PRO_0000080618

Regions

Domain19 – 351333USP

Sites

Active site281Nucleophile By similarity
Active site3091Proton acceptor By similarity
Metal binding1771Zinc By similarity
Metal binding1801Zinc By similarity
Metal binding2281Zinc By similarity
Metal binding2311Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
O57429 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: EC39E6454937C455

FASTA35740,932
        10         20         30         40         50         60 
MAARMAPTPR SSKVVQGLTG LRNLGNTCFM NSILQCLSNT KELRDYCLQN QYLRDLNNNS 

        70         80         90        100        110        120 
RMRTALMSEF AKLIQLLWTS SPNDSVSPSE FKTQIQRYAP RFVGYNQQDA QEFLRFLLDG 

       130        140        150        160        170        180 
LHGEVNRVLV RPRANADTLD HLPDDEKSRQ MWRRYQERED SRVSDLFVGQ LKSSLTCSEC 

       190        200        210        220        230        240 
GYCSTAFDPF WDLSLPIPKK GYGEVTLMDC LRLFTKEDVL DGDEKPTCCR CKARTRCTKK 

       250        260        270        280        290        300 
FSIQKFPKIL VLHLKRFSEA RIRASKLTTF VNFPLKDLDL REFASQSCNH AVYNLYAVSN 

       310        320        330        340        350 
HSGTTMGGHY TAYCKSPISS EWHSFNDSRV TPMSSSHVRS SDAYLLFYEL ASPSSRM 

« Hide

References

[1]"Molecular cloning of a novel ubiquitin-specific protease, UBP41, with isopeptidase activity in chick skeletal muscle."
Baek S., Choi K.S., Yoo Y.J., Cho J.M., Baker R.T., Tanaka K., Chung C.H.
J. Biol. Chem. 272:25560-25565(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skeletal muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF016107 mRNA. Translation: AAC13729.1.
UniGeneGga.454.

3D structure databases

ProteinModelPortalO57429.
SMRO57429. Positions 16-352.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000010901.

Protein family/group databases

MEROPSC19.013.

Proteomic databases

PaxDbO57429.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG5560.
HOVERGENHBG011164.
PhylomeDBO57429.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBP2_CHICK
AccessionPrimary (citable) accession number: O57429
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries