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Protein

Melanopsin-B

Gene

opn4b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Photoreceptor implicated in non-image-forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

Keywords - Biological processi

Keywords - Ligandi

Chromophore

Protein family/group databases

TCDBi9.A.14.1.7. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanopsin-B
Alternative name(s):
Opsin-4B
Short name:
xMOP
Gene namesi
Name:opn4bBy similarity
Synonyms:mopImported
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5957217. LOC100485437.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence analysisAdd
BLAST
Transmembranei33 – 5321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini54 – 6411CytoplasmicSequence analysisAdd
BLAST
Transmembranei65 – 8521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini86 – 10217ExtracellularSequence analysisAdd
BLAST
Transmembranei103 – 12321Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini124 – 14623CytoplasmicSequence analysisAdd
BLAST
Transmembranei147 – 16721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini168 – 19831ExtracellularSequence analysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini220 – 25031CytoplasmicSequence analysisAdd
BLAST
Transmembranei251 – 27121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini272 – 28615ExtracellularSequence analysisAdd
BLAST
Transmembranei287 – 30721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini308 – 534227CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 534534Melanopsin-BPRO_0000271892Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi100 ↔ 178PROSITE-ProRule annotation
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence analysis
Modified residuei294 – 2941N6-(retinylidene)lysineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Highest level in the iris, high level in the inner nuclear layer, possibly in horizontal cells, and lowest level in retinal pigment epithelium. Expressed in melanophore cells of the skin.1 Publication

Structurei

3D structure databases

ProteinModelPortaliO57422.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG007871.
KOiK04255.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00238. OPSIN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O57422-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLGKTVEYG THRQDAIAQI DVPDQVLYTI GSFILIIGSV GIIGNMLVLY
60 70 80 90 100
AFYRNKKLRT APNYFIINLA ISDFLMSATQ APVCFLSSLH REWILGDIGC
110 120 130 140 150
NVYAFCGALF GITSMMTLLA ISINRYIVIT KPLQSIQWSS KKRTSQIIVL
160 170 180 190 200
VWMYSLMWSL APLLGWSSYV PEGLRISCTW DYVTSTMSNR SYTMMLCCCV
210 220 230 240 250
FFIPLIVISH CYLFMFLAIR STGRNVQKLG SYGRQSFLSQ SMKNEWKMAK
260 270 280 290 300
IAFVIIIVFV LSWSPYACVT LIAWAGHGKS LTPYSKTVPA VIAKASAIYN
310 320 330 340 350
PIIYGIIHPK YRETIHKTVP CLRFLIREPK KDIFESSVRG SIYGRQSASR
360 370 380 390 400
KKNSFISTVS TAETVSSHIW DNTPNGHWDR KSLSQTMSNL CSPLLQDPNS
410 420 430 440 450
SHTLEQTLTW PDDPSPKEIL LPSSLKSVTY PIGLESIVKD EHTNNSCVRN
460 470 480 490 500
HRVDKSGGLD WIINATLPRI VIIPTSESNI SETKEEHDNN SEEKSKRTEE
510 520 530
EEDFFNFHVD TSLLNLEGLN SSTDLYEVVE RFLS
Length:534
Mass (Da):60,344
Last modified:June 1, 1998 - v1
Checksum:iA453F7ED39D1B87E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014797 mRNA. Translation: AAC41235.1.
RefSeqiNP_001079143.1. NM_001085674.1.
UniGeneiXl.310.

Genome annotation databases

GeneIDi373689.
KEGGixla:373689.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014797 mRNA. Translation: AAC41235.1.
RefSeqiNP_001079143.1. NM_001085674.1.
UniGeneiXl.310.

3D structure databases

ProteinModelPortaliO57422.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi9.A.14.1.7. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi373689.
KEGGixla:373689.

Organism-specific databases

CTDi100884131.
XenbaseiXB-GENE-5957217. LOC100485437.

Phylogenomic databases

HOVERGENiHBG007871.
KOiK04255.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00238. OPSIN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Skin1 Publication.

Entry informationi

Entry nameiOPN4B_XENLA
AccessioniPrimary (citable) accession number: O57422
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 1998
Last modified: May 11, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.