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Protein
Submitted name:

Transcription factor PAX3

Gene

pax3a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • developmental pigmentation Source: ZFIN
  • enteric nervous system development Source: ZFIN
  • muscle organ development Source: InterPro
  • neural crest cell migration Source: ZFIN
  • neural crest formation Source: InterPro
  • regulation of transcription from RNA polymerase II promoter Source: InterPro
  • transcription, DNA-templated Source: UniProtKB-KW
  • xanthophore differentiation Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-DRE-3214847. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Submitted name:
Transcription factor PAX3Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:pax3aImported
Synonyms:pax3Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 2

Organism-specific databases

ZFINiZDB-GENE-980526-52. pax3a.

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

  • nucleus Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000010192.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000037761.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 161PairedInterPro annotationAdd BLAST128
Domaini218 – 278Homeobox DNA-bindingInterPro annotationAdd BLAST61

Sequence similaritiesi

Contains 1 paired domain.UniRule annotation

Keywords - Domaini

HomeoboxUniRule annotation, Paired boxUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0849. Eukaryota.
ENOG410XS01. LUCA.
GeneTreeiENSGT00680000099553.
HOGENOMiHOG000230939.
HOVERGENiHBG009115.
KOiK09381.
OMAiVHQSTLP.
OrthoDBiEOG091G0S4E.
TreeFamiTF351610.

Family and domain databases

CDDicd00131. PAX. 1 hit.
Gene3Di1.10.10.10. 2 hits.
1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR033038. Pax3.
IPR022106. Pax7_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR24329:SF307. PTHR24329:SF307. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
PF12360. Pax7. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O57416-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTALAGGISR MMRPTPPQNY PRGGYSLEVS TPLGQGRVNQ LGGVFINGRP
60 70 80 90 100
LPNHIRHKIV EMAHHGIRPC VISRQLRVSH GCVSKILCRY QETGSIRPGA
110 120 130 140 150
IGGSKPKQST TPDVEKKIEE YKRENPGMFS WEIRDKLLKD GICDRNNVPS
160 170 180 190 200
VSSISRMLRC KFGGNGDEDE DDDEVEKREI EENERRAKHS IDGILGDRSS
210 220 230 240 250
HSDEGSDVDS EPGLPLKRKQ RRSRTTFTAE QLEELERAFE RTHYPDIYTR
260 270 280 290 300
EELAQRAKLT EARVQVWFSN RRARWRKQAG ANQLMAFNHL IPGGFPPSAM
310 320 330 340 350
SSLQPYQLAD SPYPPSSISQ VSEQPSTVHR PQPLPPTSVH QSGLGSGPGA
360 370 380 390 400
QEGSSAYCLS SGRHGFSGYS DGYVAAPGHA NPVNPSISNG LPSQVMGLLN
410 420 430 440 450
PGAVPHQPQS DFALSPLTGG LEPSTGMPAS CHSSQRLEAL PGLPSMPALP
460 470 480 490 500
SSQSYCPSSY SSPGYSVDHV ASYQYSQYGQ SKVNTSTVTT VERLSRVYPL

KRASFGLVE
Length:509
Mass (Da):55,671
Last modified:June 1, 1998 - v1
Checksum:i44F67FC287617F1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX085193 Genomic DNA. No translation available.
AF014366 mRNA. Translation: AAC41253.1.
RefSeqiNP_571352.1. NM_131277.1.
UniGeneiDr.75806.

Genome annotation databases

EnsembliENSDART00000038828; ENSDARP00000037761; ENSDARG00000010192.
GeneIDi30532.
KEGGidre:30532.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX085193 Genomic DNA. No translation available.
AF014366 mRNA. Translation: AAC41253.1.
RefSeqiNP_571352.1. NM_131277.1.
UniGeneiDr.75806.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000037761.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000038828; ENSDARP00000037761; ENSDARG00000010192.
GeneIDi30532.
KEGGidre:30532.

Organism-specific databases

CTDi30532.
ZFINiZDB-GENE-980526-52. pax3a.

Phylogenomic databases

eggNOGiKOG0849. Eukaryota.
ENOG410XS01. LUCA.
GeneTreeiENSGT00680000099553.
HOGENOMiHOG000230939.
HOVERGENiHBG009115.
KOiK09381.
OMAiVHQSTLP.
OrthoDBiEOG091G0S4E.
TreeFamiTF351610.

Enzyme and pathway databases

ReactomeiR-DRE-3214847. HATs acetylate histones.

Gene expression databases

BgeeiENSDARG00000010192.

Family and domain databases

CDDicd00131. PAX. 1 hit.
Gene3Di1.10.10.10. 2 hits.
1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR033038. Pax3.
IPR022106. Pax7_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR24329:SF307. PTHR24329:SF307. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
PF12360. Pax7. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO57416_DANRE
AccessioniPrimary (citable) accession number: O57416
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.