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Protein

Ras-responsive element-binding protein 1

Gene

RREB1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri47 – 69C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri78 – 100C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri106 – 128C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri189 – 211C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 239C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri297 – 319C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri622 – 644C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri650 – 672C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri732 – 754C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri763 – 788C2H2-type 10PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1170 – 1192C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1298 – 1320C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1419 – 1441C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1447 – 1469C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-responsive element-binding protein 1
Short name:
RREB-1
Gene namesi
Name:RREB1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002951561 – 1615Ras-responsive element-binding protein 1Add BLAST1615

Proteomic databases

PaxDbiO57415.
PRIDEiO57415.

Expressioni

Tissue specificityi

Broadly expressed, except in brain.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020854.

Structurei

3D structure databases

ProteinModelPortaliO57415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi463 – 528Pro-richAdd BLAST66

Sequence similaritiesi

Contains 14 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri47 – 69C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri78 – 100C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri106 – 128C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri189 – 211C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 239C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri297 – 319C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri622 – 644C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri650 – 672C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri732 – 754C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri763 – 788C2H2-type 10PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1170 – 1192C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1298 – 1320C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1419 – 1441C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1447 – 1469C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000154195.
HOVERGENiHBG108418.
InParanoidiO57415.
KOiK20210.
PhylomeDBiO57415.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 15 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O57415-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSAVMNVGK IAENGGTSQT VKSPSKSPAP NRIGRRNQET KEEKSSYTCP
60 70 80 90 100
LCEKICTTQH QLTMHIRQHN TDTGGTDHSC SICGKSLSSA SSLDRHMLVH
110 120 130 140 150
SGERPYKCSV CGQSFTTNGN MHRHMKIHEK DPNSTASTTP PSPLKAKRLS
160 170 180 190 200
SKRKFSQDAE MDREERTPAK KVVEDGQYGE GDRKEDDAYH CPVCFKDFFC
210 220 230 240 250
KYALESHMET HPDNSLRCDI CCITFRTHRG LLRHNAVIHK QLPRDPTGKP
260 270 280 290 300
FIQNNPSIPA GFHDLGFTDF SCRKFPRISQ VWCETNLRRC ISEFHRFICE
310 320 330 340 350
TCNKAFPMLL ALKLHTETHV MDQGRDKHKL QSTSLPSENP DQKAFMASLG
360 370 380 390 400
LQYTKDIKPV KQEDDTQDEV QEMRLRALKS NLPQEPGSTG LLSLSPLEAA
410 420 430 440 450
TMGGPFSVLP PTKENIKLLS LQPFQKGFII QPDSSIVVKP ISNESAIELA
460 470 480 490 500
DIQQILKMAS SAPPQISLPP LSKAPSVPVQ SIFKHMPPLK PKPLVTPRTV
510 520 530 540 550
VATSTPPPLI SAQQASPGCI SPSLPPPPLR LIKNSVETSS NSHLSQPGAK
560 570 580 590 600
SSPSSQLLLQ PKVEPLTQHE MKTQLEQDSI IEALLPLNME AKIKQEVTEG
610 620 630 640 650
DLKAIIAGAA NKKAPTMRKV LYPCRFCDQV FAFSGVLRAH IRSHLGISPY
660 670 680 690 700
QCNICDYIAA DKAALIRHLR THSGERPYIC KICHYPGTVK ANCERHLRKK
710 720 730 740 750
HLKVTRKDIE KNIEYVTSNA AEMVDAFCSP DTVCKLCGED LKHYRALRIH
760 770 780 790 800
MRTHSGCQKK KPFECKECGT AFSAKRNCIH HILKQHLHVQ EREIENYILV
810 820 830 840 850
VDCSAQESHT DAPLLEDSTY MDCKPITPFL EPQNGFLLGT SSHVPIKLEP
860 870 880 890 900
MGNFPMDFDE PLDFSQKSKN LSAVQVKQEN LLVSSPLSFY DCSMEPIDLS
910 920 930 940 950
IPKVLKRDND IPGEARNQEL ASSVITDNAY NWQQCPLGFG ANGNSEKNRA
960 970 980 990 1000
VGHPQPLKGS LHLTVPIISP ALLGNSALLR PLRPKPPPQP LLPKPPVTKE
1010 1020 1030 1040 1050
LPPLASIAQI ISSVSSAPAL LKTEAADASP KAASSSTGCD KSGNAKAKMT
1060 1070 1080 1090 1100
IVTAIQRDSN LPSDLTQACD PEPSPIADTG LTKKRGRKKG TKNKPKLSSG
1110 1120 1130 1140 1150
VDLESSGEFA SIEKMLATTD TNKFSPFLQS TDNFKEESGQ NGTSEDEKET
1160 1170 1180 1190 1200
PEDKLLRGKR NTYSDCPQKI TCPYCPRVFS WASSLQRHML THTDSQADTE
1210 1220 1230 1240 1250
APATGGEVLD LTSCEKEQPE EVSELPGSEC SPQEEQKADS PPAEEDAEEK
1260 1270 1280 1290 1300
ADEYEEGPEE DSVSNKSLDL NFASKLMDFK LAESDQSAGS SSQTERKHAC
1310 1320 1330 1340 1350
DVCGKTFKFA GALSRHKKAH IREDRKDERS SEDESKSIQD DAGAPSMQDS
1360 1370 1380 1390 1400
GLEQEESPMD LKVVESPLDC EATGKENEES ESISEGEGTE RKSTEKSSDD
1410 1420 1430 1440 1450
KIPKTDEAKS TAKADKRKKV CTVCNKRFWS LQDLTRHMRS HTGERPYKCQ
1460 1470 1480 1490 1500
TCERTFTLKH SLVRHQRIHQ KVKNTRNHGK ESDKEETQSR CGEDSENESS
1510 1520 1530 1540 1550
HSGTNPISEN ECDFAGVVGS HPSGTRSRKE SLVGAAKDVP CEEERPSGQG
1560 1570 1580 1590 1600
ATADLVEPAK STQKQPAKDQ EPRGSSELER PSGFIQDLLE MHNKKSPMNH
1610
ILASADSTPQ LLGVE
Length:1,615
Mass (Da):178,389
Last modified:July 10, 2007 - v2
Checksum:i4D22E8480E55874B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti837L → S in strain: Leghorn. 1 Publication1
Natural varianti932W → C in strain: Leghorn. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013754 mRNA. Translation: AAB96584.1.
AF221559 mRNA. Translation: AAF71241.1.
AF221560 mRNA. Translation: AAF71242.1.
PIRiJC6510.
RefSeqiNP_990380.1. NM_205049.1.
UniGeneiGga.1491.

Genome annotation databases

GeneIDi395920.
KEGGigga:395920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013754 mRNA. Translation: AAB96584.1.
AF221559 mRNA. Translation: AAF71241.1.
AF221560 mRNA. Translation: AAF71242.1.
PIRiJC6510.
RefSeqiNP_990380.1. NM_205049.1.
UniGeneiGga.1491.

3D structure databases

ProteinModelPortaliO57415.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020854.

Proteomic databases

PaxDbiO57415.
PRIDEiO57415.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395920.
KEGGigga:395920.

Organism-specific databases

CTDi6239.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000154195.
HOVERGENiHBG108418.
InParanoidiO57415.
KOiK20210.
PhylomeDBiO57415.

Miscellaneous databases

PROiO57415.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 15 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRREB1_CHICK
AccessioniPrimary (citable) accession number: O57415
Secondary accession number(s): Q9I861
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: November 30, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.