Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

5,6-dihydroxyindole-2-carboxylic acid oxidase

Gene

TYRP1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid.

Cofactori

Cu2+By similarityNote: Binds 2 copper ions per subunit.By similarity

Pathwayi: melanin biosynthesis

This protein is involved in the pathway melanin biosynthesis, which is part of Pigment biosynthesis.
View all proteins of this organism that are known to be involved in the pathway melanin biosynthesis and in Pigment biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi191 – 1911Copper ABy similarity
Metal bindingi214 – 2141Copper ABy similarity
Metal bindingi223 – 2231Copper ABy similarity
Metal bindingi376 – 3761Copper BBy similarity
Metal bindingi380 – 3801Copper BBy similarity
Metal bindingi403 – 4031Copper BBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Melanin biosynthesis

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00785.

Names & Taxonomyi

Protein namesi
Recommended name:
5,6-dihydroxyindole-2-carboxylic acid oxidase (EC:1.14.18.-)
Short name:
DHICA oxidase
Alternative name(s):
Tyrosinase-related protein 1
Short name:
TRP-1
Short name:
TRP1
Gene namesi
Name:TYRP1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 478455Lumenal, melanosomeSequence analysisAdd
BLAST
Transmembranei479 – 49921HelicalSequence analysisAdd
BLAST
Topological domaini500 – 53536CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 5355125,6-dihydroxyindole-2-carboxylic acid oxidasePRO_0000035891Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence analysis
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence analysis
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence analysis
Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence analysis
Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence analysis
Glycosylationi384 – 3841N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO57405.

Interactioni

Subunit structurei

Tyrosinase, TYRP1 and TYRP2 may form a multienzyme complex.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037537.

Structurei

3D structure databases

ProteinModelPortaliO57405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEEB. Eukaryota.
ENOG410XSJD. LUCA.
HOGENOMiHOG000118376.
HOVERGENiHBG003553.
InParanoidiO57405.
PhylomeDBiO57405.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR015559. DiOHindole_carboxylic_A_Oxase.
IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PANTHERiPTHR11474:SF3. PTHR11474:SF3. 2 hits.
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O57405-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLPMLLLVS LPLLLNMFKP AEAQFPRQCA TIESLRSGMC CPDYFPVFGP
60 70 80 90 100
GSDQCGVSTG RGRCVQVTVD SRPHGPQYIH DGRDDREQWP IRFFNQTCRC
110 120 130 140 150
NGNFSGYNCG SCRPGWTGPT CSQQINIVRR NLLDLSTEER RRFVNALHQA
160 170 180 190 200
KVTIHPDIVI ATRRREEIFG PDGNTPQFEN ISIYNYFVWS HYYSVRKTFL
210 220 230 240 250
GAGQQSFERV DFSHEGPAFV TWHRYHLLQL ERDMQNMLQD STFGLPYWNF
260 270 280 290 300
ATGQNTCDIC SDDLMGARSN FDVSLISQNS IFSTWRVLCE SIEDYDSLGT
310 320 330 340 350
ICNSTEGGPI RRNPAGNVAR PMVQRLPEPE DVPQCLEVGI FDTPPFYSNS
360 370 380 390 400
TDSFRNTVEG YSDPSGKYDP AVRSLHNLAH LFLNGTGGQT HLSPNDPIFV
410 420 430 440 450
LLHTFTDAVF DEWLRRYSAD ISTYPLENAP IGHNREYNMV PFWPPVTNNE
460 470 480 490 500
MFVTAPENLG YSYDIEWPGP LRVTEMITIA IVTALVLVAI IFAAAACIVR
510 520 530
AKKNRDELHQ PLLTDQYQHY SDDYDGIATP SQSVV
Length:535
Mass (Da):60,595
Last modified:June 1, 1998 - v1
Checksum:i96AA3EAB5AF1AC47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003631 mRNA. Translation: AAC00213.1.
UniGeneiGga.541.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003631 mRNA. Translation: AAC00213.1.
UniGeneiGga.541.

3D structure databases

ProteinModelPortaliO57405.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037537.

Proteomic databases

PaxDbiO57405.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IEEB. Eukaryota.
ENOG410XSJD. LUCA.
HOGENOMiHOG000118376.
HOVERGENiHBG003553.
InParanoidiO57405.
PhylomeDBiO57405.

Enzyme and pathway databases

UniPathwayiUPA00785.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR015559. DiOHindole_carboxylic_A_Oxase.
IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PANTHERiPTHR11474:SF3. PTHR11474:SF3. 2 hits.
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The cloning and sequencing of a cDNA coding for chick tyrosinase-related protein-1."
    April C.S., Jackson I.J., Kidson S.H.
    Biochim. Biophys. Acta 1395:7-12(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Black Australorp X New Hampshire red.
    Tissue: Neural crest.

Entry informationi

Entry nameiTYRP1_CHICK
AccessioniPrimary (citable) accession number: O57405
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: June 1, 1998
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.