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Protein

5,6-dihydroxyindole-2-carboxylic acid oxidase

Gene

TYRP1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.By similarity

Cofactori

Cu2+By similarityNote: Binds 2 copper ions per subunit.By similarity

Pathwayi: melanin biosynthesis

This protein is involved in the pathway melanin biosynthesis, which is part of Pigment biosynthesis.
View all proteins of this organism that are known to be involved in the pathway melanin biosynthesis and in Pigment biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi191Copper ABy similarity1
Metal bindingi214Copper ABy similarity1
Metal bindingi223Copper ABy similarity1
Metal bindingi376Copper BBy similarity1
Metal bindingi380Copper BBy similarity1
Metal bindingi403Copper BBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processMelanin biosynthesis
LigandCopper, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00785

Names & Taxonomyi

Protein namesi
Recommended name:
5,6-dihydroxyindole-2-carboxylic acid oxidase (EC:1.14.18.-)
Short name:
DHICA oxidase
Alternative name(s):
Tyrosinase-related protein 11 Publication
Short name:
TRP-11 Publication
Short name:
TRP1
Gene namesi
Name:TYRP1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 478Lumenal, melanosomeSequence analysisAdd BLAST455
Transmembranei479 – 499HelicalSequence analysisAdd BLAST21
Topological domaini500 – 535CytoplasmicSequence analysisAdd BLAST36

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003589124 – 5355,6-dihydroxyindole-2-carboxylic acid oxidaseAdd BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 40By similarity
Disulfide bondi41 ↔ 64By similarity
Disulfide bondi55 ↔ 98By similarity
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi100 ↔ 109By similarity
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi112 ↔ 121By similarity
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi257 ↔ 260By similarity
Disulfide bondi289 ↔ 302By similarity
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi349N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi384N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO57405
PRIDEiO57405

Interactioni

Subunit structurei

Tyrosinase, TYRP1 and TYRP2 may form a multienzyme complex.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037537

Structurei

3D structure databases

ProteinModelPortaliO57405
SMRiO57405
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEEB Eukaryota
ENOG410XSJD LUCA
HOGENOMiHOG000118376
HOVERGENiHBG003553
InParanoidiO57405
PhylomeDBiO57405

Family and domain databases

Gene3Di1.10.1280.10, 1 hit
InterProiView protein in InterPro
IPR002227 Tyrosinase_Cu-bd
IPR008922 Unchr_di-copper_centre
PfamiView protein in Pfam
PF00264 Tyrosinase, 1 hit
PRINTSiPR00092 TYROSINASE
SUPFAMiSSF48056 SSF48056, 1 hit
PROSITEiView protein in PROSITE
PS00497 TYROSINASE_1, 1 hit
PS00498 TYROSINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O57405-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLPMLLLVS LPLLLNMFKP AEAQFPRQCA TIESLRSGMC CPDYFPVFGP
60 70 80 90 100
GSDQCGVSTG RGRCVQVTVD SRPHGPQYIH DGRDDREQWP IRFFNQTCRC
110 120 130 140 150
NGNFSGYNCG SCRPGWTGPT CSQQINIVRR NLLDLSTEER RRFVNALHQA
160 170 180 190 200
KVTIHPDIVI ATRRREEIFG PDGNTPQFEN ISIYNYFVWS HYYSVRKTFL
210 220 230 240 250
GAGQQSFERV DFSHEGPAFV TWHRYHLLQL ERDMQNMLQD STFGLPYWNF
260 270 280 290 300
ATGQNTCDIC SDDLMGARSN FDVSLISQNS IFSTWRVLCE SIEDYDSLGT
310 320 330 340 350
ICNSTEGGPI RRNPAGNVAR PMVQRLPEPE DVPQCLEVGI FDTPPFYSNS
360 370 380 390 400
TDSFRNTVEG YSDPSGKYDP AVRSLHNLAH LFLNGTGGQT HLSPNDPIFV
410 420 430 440 450
LLHTFTDAVF DEWLRRYSAD ISTYPLENAP IGHNREYNMV PFWPPVTNNE
460 470 480 490 500
MFVTAPENLG YSYDIEWPGP LRVTEMITIA IVTALVLVAI IFAAAACIVR
510 520 530
AKKNRDELHQ PLLTDQYQHY SDDYDGIATP SQSVV
Length:535
Mass (Da):60,595
Last modified:June 1, 1998 - v1
Checksum:i96AA3EAB5AF1AC47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003631 mRNA Translation: AAC00213.1
UniGeneiGga.541

Similar proteinsi

Entry informationi

Entry nameiTYRP1_CHICK
AccessioniPrimary (citable) accession number: O57405
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health