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Protein

5,6-dihydroxyindole-2-carboxylic acid oxidase

Gene

TYRP1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.By similarity

Cofactori

Cu2+By similarityNote: Binds 2 copper ions per subunit.By similarity

Pathwayi: melanin biosynthesis

This protein is involved in the pathway melanin biosynthesis, which is part of Pigment biosynthesis.
View all proteins of this organism that are known to be involved in the pathway melanin biosynthesis and in Pigment biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi191Copper ABy similarity1
Metal bindingi214Copper ABy similarity1
Metal bindingi223Copper ABy similarity1
Metal bindingi376Copper BBy similarity1
Metal bindingi380Copper BBy similarity1
Metal bindingi403Copper BBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Melanin biosynthesis

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00785.

Names & Taxonomyi

Protein namesi
Recommended name:
5,6-dihydroxyindole-2-carboxylic acid oxidase (EC:1.14.18.-)
Short name:
DHICA oxidase
Alternative name(s):
Tyrosinase-related protein 1
Short name:
TRP-1
Short name:
TRP1
Gene namesi
Name:TYRP1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Melanosome membrane By similarity; Single-pass type I membrane protein By similarity
  • Melanosome By similarity

  • Note: Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 478Lumenal, melanosomeSequence analysisAdd BLAST455
Transmembranei479 – 499HelicalSequence analysisAdd BLAST21
Topological domaini500 – 535CytoplasmicSequence analysisAdd BLAST36

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003589124 – 5355,6-dihydroxyindole-2-carboxylic acid oxidaseAdd BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi95N-linked (GlcNAc...)Sequence analysis1
Glycosylationi103N-linked (GlcNAc...)Sequence analysis1
Glycosylationi180N-linked (GlcNAc...)Sequence analysis1
Glycosylationi303N-linked (GlcNAc...)Sequence analysis1
Glycosylationi349N-linked (GlcNAc...)Sequence analysis1
Glycosylationi384N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO57405.

Interactioni

Subunit structurei

Tyrosinase, TYRP1 and TYRP2 may form a multienzyme complex.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037537.

Structurei

3D structure databases

ProteinModelPortaliO57405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEEB. Eukaryota.
ENOG410XSJD. LUCA.
HOGENOMiHOG000118376.
HOVERGENiHBG003553.
InParanoidiO57405.
PhylomeDBiO57405.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR015559. DiOHindole_carboxylic_A_Oxase.
IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PANTHERiPTHR11474:SF3. PTHR11474:SF3. 2 hits.
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O57405-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLPMLLLVS LPLLLNMFKP AEAQFPRQCA TIESLRSGMC CPDYFPVFGP
60 70 80 90 100
GSDQCGVSTG RGRCVQVTVD SRPHGPQYIH DGRDDREQWP IRFFNQTCRC
110 120 130 140 150
NGNFSGYNCG SCRPGWTGPT CSQQINIVRR NLLDLSTEER RRFVNALHQA
160 170 180 190 200
KVTIHPDIVI ATRRREEIFG PDGNTPQFEN ISIYNYFVWS HYYSVRKTFL
210 220 230 240 250
GAGQQSFERV DFSHEGPAFV TWHRYHLLQL ERDMQNMLQD STFGLPYWNF
260 270 280 290 300
ATGQNTCDIC SDDLMGARSN FDVSLISQNS IFSTWRVLCE SIEDYDSLGT
310 320 330 340 350
ICNSTEGGPI RRNPAGNVAR PMVQRLPEPE DVPQCLEVGI FDTPPFYSNS
360 370 380 390 400
TDSFRNTVEG YSDPSGKYDP AVRSLHNLAH LFLNGTGGQT HLSPNDPIFV
410 420 430 440 450
LLHTFTDAVF DEWLRRYSAD ISTYPLENAP IGHNREYNMV PFWPPVTNNE
460 470 480 490 500
MFVTAPENLG YSYDIEWPGP LRVTEMITIA IVTALVLVAI IFAAAACIVR
510 520 530
AKKNRDELHQ PLLTDQYQHY SDDYDGIATP SQSVV
Length:535
Mass (Da):60,595
Last modified:June 1, 1998 - v1
Checksum:i96AA3EAB5AF1AC47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003631 mRNA. Translation: AAC00213.1.
UniGeneiGga.541.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003631 mRNA. Translation: AAC00213.1.
UniGeneiGga.541.

3D structure databases

ProteinModelPortaliO57405.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037537.

Proteomic databases

PaxDbiO57405.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IEEB. Eukaryota.
ENOG410XSJD. LUCA.
HOGENOMiHOG000118376.
HOVERGENiHBG003553.
InParanoidiO57405.
PhylomeDBiO57405.

Enzyme and pathway databases

UniPathwayiUPA00785.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR015559. DiOHindole_carboxylic_A_Oxase.
IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PANTHERiPTHR11474:SF3. PTHR11474:SF3. 2 hits.
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTYRP1_CHICK
AccessioniPrimary (citable) accession number: O57405
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.