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Protein

Fibroblast growth factor 8

Gene

fgf8a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis (PubMed:19164561).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • animal organ morphogenesis Source: ZFIN
  • anterior/posterior pattern specification Source: ZFIN
  • brain development Source: ZFIN
  • cardiac ventricle morphogenesis Source: ZFIN
  • cardioblast differentiation Source: ZFIN
  • cartilage development Source: ZFIN
  • cell fate specification Source: ZFIN
  • cerebellum development Source: ZFIN
  • cerebellum formation Source: ZFIN
  • cilium assembly Source: ZFIN
  • determination of dorsal identity Source: ZFIN
  • determination of left/right symmetry Source: ZFIN
  • dorsal/ventral pattern formation Source: ZFIN
  • ectodermal placode formation Source: ZFIN
  • embryonic camera-type eye development Source: ZFIN
  • embryonic heart tube development Source: ZFIN
  • embryonic neurocranium morphogenesis Source: ZFIN
  • embryonic pattern specification Source: ZFIN
  • embryonic retina morphogenesis in camera-type eye Source: ZFIN
  • endoderm development Source: ZFIN
  • fibroblast growth factor receptor signaling pathway Source: InterPro
  • heart morphogenesis Source: ZFIN
  • hindbrain development Source: ZFIN
  • inner ear development Source: ZFIN
  • Kupffer's vesicle development Source: ZFIN
  • locus ceruleus development Source: ZFIN
  • mesoderm development Source: ZFIN
  • midbrain development Source: ZFIN
  • midbrain-hindbrain boundary development Source: ZFIN
  • midbrain-hindbrain boundary morphogenesis Source: ZFIN
  • negative regulation of endodermal cell fate specification Source: ZFIN
  • neuron differentiation Source: ZFIN
  • neuron fate specification Source: ZFIN
  • notochord development Source: ZFIN
  • oligodendrocyte differentiation Source: ZFIN
  • otic placode formation Source: ZFIN
  • otic vesicle development Source: ZFIN
  • otic vesicle formation Source: ZFIN
  • paraxial mesoderm development Source: ZFIN
  • peripheral nervous system development Source: ZFIN
  • pharyngeal system development Source: ZFIN
  • positive regulation of cell migration Source: ZFIN
  • positive regulation of somitomeric trunk muscle development Source: BHF-UCL
  • positive regulation of Wnt signaling pathway Source: ZFIN
  • regulation of bone remodeling Source: ZFIN
  • retina development in camera-type eye Source: ZFIN
  • rhombomere 5 development Source: ZFIN
  • rhombomere 6 development Source: ZFIN
  • skeletal system morphogenesis Source: ZFIN
  • somite development Source: ZFIN
  • somitogenesis Source: ZFIN
  • striated muscle cell differentiation Source: ZFIN
  • taste bud formation Source: ZFIN
  • thyroid gland development Source: ZFIN
  • ventricular cardiac muscle cell differentiation Source: ZFIN

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-DRE-109704 PI3K Cascade
R-DRE-1257604 PIP3 activates AKT signaling
R-DRE-190322 FGFR4 ligand binding and activation
R-DRE-190371 FGFR3b ligand binding and activation
R-DRE-190372 FGFR3c ligand binding and activation
R-DRE-190373 FGFR1c ligand binding and activation
R-DRE-190375 FGFR2c ligand binding and activation
R-DRE-5654219 Phospholipase C-mediated cascade: FGFR1
R-DRE-5654221 Phospholipase C-mediated cascade, FGFR2
R-DRE-5654227 Phospholipase C-mediated cascade, FGFR3
R-DRE-5654228 Phospholipase C-mediated cascade, FGFR4
R-DRE-5654687 Downstream signaling of activated FGFR1
R-DRE-5654688 SHC-mediated cascade:FGFR1
R-DRE-5654689 PI-3K cascade:FGFR1
R-DRE-5654693 FRS-mediated FGFR1 signaling
R-DRE-5654695 PI-3K cascade:FGFR2
R-DRE-5654699 SHC-mediated cascade:FGFR2
R-DRE-5654700 FRS-mediated FGFR2 signaling
R-DRE-5654704 SHC-mediated cascade:FGFR3
R-DRE-5654706 FRS-mediated FGFR3 signaling
R-DRE-5654710 PI-3K cascade:FGFR3
R-DRE-5654712 FRS-mediated FGFR4 signaling
R-DRE-5654719 SHC-mediated cascade:FGFR4
R-DRE-5654720 PI-3K cascade:FGFR4
R-DRE-5654726 Negative regulation of FGFR1 signaling
R-DRE-5654727 Negative regulation of FGFR2 signaling
R-DRE-5654732 Negative regulation of FGFR3 signaling
R-DRE-5654733 Negative regulation of FGFR4 signaling
R-DRE-5658623 FGFRL1 modulation of FGFR1 signaling
R-DRE-5673001 RAF/MAP kinase cascade
R-DRE-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 8
Short name:
FGF-8
Gene namesi
Name:fgf8aImported
Synonyms:fgf-8Imported, fgf8Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 13

Organism-specific databases

ZFINiZDB-GENE-990415-72 fgf8a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Morpholino knockdown of the protein causes a dramatic loss of cilia in Kupffer's vesicle.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27UniRule annotationAdd BLAST27
ChainiPRO_500141981628 – 210Fibroblast growth factor 8UniRule annotationAdd BLAST183

Proteomic databases

PaxDbiO57341

Expressioni

Developmental stagei

Expressed in Kupffer's vesicle.1 Publication

Gene expression databases

BgeeiENSDARG00000003399
ExpressionAtlasiO57341 baseline and differential

Interactioni

Subunit structurei

Monomer (By similarity). Homodimer (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000018653

Structurei

3D structure databases

ProteinModelPortaliO57341
SMRiO57341
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heparin-binding growth factors family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00730000110785
HOVERGENiHBG005659
KOiK04358
OrthoDBiEOG091G0NQH
TreeFamiTF331233

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028249 FGF8
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 2 hits
PTHR11486:SF3 PTHR11486:SF3, 2 hits
PfamiView protein in Pfam
PF00167 FGF, 1 hit
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O57341-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLIPSRLSY LFLHLFAFCY YAQVTIQSPP NFTQHVSEQS KVTDRVSRRL
60 70 80 90 100
IRTYQLYSRT SGKHVQVLAN KKINAMAEDG DVHAKLIVET DTFGSRVRIK
110 120 130 140 150
GAETGFYICM NRRGKLIGKK NGLGKDCIFT EIVLENNYTA LQNVKYEGWY
160 170 180 190 200
MAFTRKGRPR KGSKTRQHQR EVHFMKRLPK GHQIAEHRPF DFINYPFNRR
210
TKRTRYSGER
Length:210
Mass (Da):24,697
Last modified:June 1, 1998 - v1
Checksum:i9D9CA5B8E18A435A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83H → C in AAH86718 (Ref. 3) Curated1
Sequence conflicti83H → C in AAI65018 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051365 mRNA Translation: AAC41302.1
AF034264 mRNA Translation: AAC60303.1
BC086718 mRNA Translation: AAH86718.1
BC165018 mRNA Translation: AAI65018.1
AB256522 Genomic DNA Translation: BAF34588.1
CR925797 Genomic DNA No translation available.
RefSeqiNP_571356.2, NM_131281.2
UniGeneiDr.478

Genome annotation databases

EnsembliENSDART00000025583; ENSDARP00000018653; ENSDARG00000003399
GeneIDi30538
KEGGidre:30538

Similar proteinsi

Entry informationi

Entry nameiFGF8A_DANRE
AccessioniPrimary (citable) accession number: O57341
Secondary accession number(s): Q5PRC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2015
Last sequence update: June 1, 1998
Last modified: March 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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