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Protein

Fibroblast growth factor 8

Gene

fgf8a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis (PubMed:19164561).By similarity1 Publication

GO - Biological processi

  • animal organ morphogenesis Source: ZFIN
  • anterior/posterior pattern specification Source: ZFIN
  • brain development Source: ZFIN
  • cardiac ventricle morphogenesis Source: ZFIN
  • cardioblast differentiation Source: ZFIN
  • cartilage development Source: ZFIN
  • cell fate specification Source: ZFIN
  • cerebellum development Source: ZFIN
  • cerebellum formation Source: ZFIN
  • cilium assembly Source: ZFIN
  • determination of dorsal identity Source: ZFIN
  • determination of left/right symmetry Source: ZFIN
  • dorsal/ventral pattern formation Source: ZFIN
  • ectodermal placode formation Source: ZFIN
  • embryonic camera-type eye development Source: ZFIN
  • embryonic heart tube development Source: ZFIN
  • embryonic pattern specification Source: ZFIN
  • embryonic retina morphogenesis in camera-type eye Source: ZFIN
  • endoderm development Source: ZFIN
  • fibroblast growth factor receptor signaling pathway Source: InterPro
  • heart morphogenesis Source: ZFIN
  • hindbrain development Source: ZFIN
  • inner ear development Source: ZFIN
  • Kupffer's vesicle development Source: ZFIN
  • locus ceruleus development Source: ZFIN
  • mesoderm development Source: ZFIN
  • midbrain development Source: ZFIN
  • midbrain-hindbrain boundary development Source: ZFIN
  • midbrain-hindbrain boundary morphogenesis Source: ZFIN
  • negative regulation of endodermal cell fate specification Source: ZFIN
  • neuron differentiation Source: ZFIN
  • neuron fate specification Source: ZFIN
  • notochord development Source: ZFIN
  • oligodendrocyte differentiation Source: ZFIN
  • otic placode formation Source: ZFIN
  • otic vesicle development Source: ZFIN
  • otic vesicle formation Source: ZFIN
  • paraxial mesoderm development Source: ZFIN
  • peripheral nervous system development Source: ZFIN
  • pharyngeal system development Source: ZFIN
  • positive regulation of cell migration Source: ZFIN
  • positive regulation of somitomeric trunk muscle development Source: BHF-UCL
  • positive regulation of Wnt signaling pathway Source: ZFIN
  • regulation of bone remodeling Source: ZFIN
  • retina development in camera-type eye Source: ZFIN
  • rhombomere 5 development Source: ZFIN
  • rhombomere 6 development Source: ZFIN
  • skeletal system morphogenesis Source: ZFIN
  • somite development Source: ZFIN
  • somitogenesis Source: ZFIN
  • striated muscle cell differentiation Source: ZFIN
  • taste bud formation Source: ZFIN
  • thyroid gland development Source: ZFIN
  • ventricular cardiac muscle cell differentiation Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiR-DRE-109704. PI3K Cascade.
R-DRE-1257604. PIP3 activates AKT signaling.
R-DRE-190322. FGFR4 ligand binding and activation.
R-DRE-190371. FGFR3b ligand binding and activation.
R-DRE-190372. FGFR3c ligand binding and activation.
R-DRE-190373. FGFR1c ligand binding and activation.
R-DRE-190375. FGFR2c ligand binding and activation.
R-DRE-5654219. Phospholipase C-mediated cascade: FGFR1.
R-DRE-5654221. Phospholipase C-mediated cascade, FGFR2.
R-DRE-5654227. Phospholipase C-mediated cascade, FGFR3.
R-DRE-5654228. Phospholipase C-mediated cascade, FGFR4.
R-DRE-5654687. Downstream signaling of activated FGFR1.
R-DRE-5654688. SHC-mediated cascade:FGFR1.
R-DRE-5654689. PI-3K cascade:FGFR1.
R-DRE-5654693. FRS-mediated FGFR1 signaling.
R-DRE-5654695. PI-3K cascade:FGFR2.
R-DRE-5654699. SHC-mediated cascade:FGFR2.
R-DRE-5654700. FRS-mediated FGFR2 signaling.
R-DRE-5654704. SHC-mediated cascade:FGFR3.
R-DRE-5654706. FRS-mediated FGFR3 signaling.
R-DRE-5654710. PI-3K cascade:FGFR3.
R-DRE-5654712. FRS-mediated FGFR4 signaling.
R-DRE-5654719. SHC-mediated cascade:FGFR4.
R-DRE-5654720. PI-3K cascade:FGFR4.
R-DRE-5654726. Negative regulation of FGFR1 signaling.
R-DRE-5654727. Negative regulation of FGFR2 signaling.
R-DRE-5654732. Negative regulation of FGFR3 signaling.
R-DRE-5654733. Negative regulation of FGFR4 signaling.
R-DRE-5658623. FGFRL1 modulation of FGFR1 signaling.
R-DRE-5673001. RAF/MAP kinase cascade.
R-DRE-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 8
Short name:
FGF-8
Gene namesi
Name:fgf8aImported
Synonyms:fgf-8Imported, fgf8Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 13

Organism-specific databases

ZFINiZDB-GENE-990415-72. fgf8a.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

  • extracellular space Source: ZFIN
  • lysosome Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Morpholino knockdown of the protein causes a dramatic loss of cilia in Kupffer's vesicle.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27UniRule annotationAdd BLAST27
ChainiPRO_500141981628 – 210Fibroblast growth factor 8UniRule annotationAdd BLAST183

Proteomic databases

PaxDbiO57341.

Expressioni

Developmental stagei

Expressed in Kupffer's vesicle.1 Publication

Gene expression databases

BgeeiENSDARG00000003399.
ExpressionAtlasiO57341. baseline and differential.

Interactioni

Subunit structurei

Monomer (By similarity). Homodimer (By similarity).By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000018653.

Structurei

3D structure databases

ProteinModelPortaliO57341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heparin-binding growth factors family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00730000110785.
HOVERGENiHBG005659.
KOiK04358.
OMAiAATGFYI.
OrthoDBiEOG091G0NQH.
TreeFamiTF331233.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiIPR008996. Cytokine_IL1-like.
IPR028249. FGF8.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF3. PTHR11486:SF3. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O57341-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLIPSRLSY LFLHLFAFCY YAQVTIQSPP NFTQHVSEQS KVTDRVSRRL
60 70 80 90 100
IRTYQLYSRT SGKHVQVLAN KKINAMAEDG DVHAKLIVET DTFGSRVRIK
110 120 130 140 150
GAETGFYICM NRRGKLIGKK NGLGKDCIFT EIVLENNYTA LQNVKYEGWY
160 170 180 190 200
MAFTRKGRPR KGSKTRQHQR EVHFMKRLPK GHQIAEHRPF DFINYPFNRR
210
TKRTRYSGER
Length:210
Mass (Da):24,697
Last modified:June 1, 1998 - v1
Checksum:i9D9CA5B8E18A435A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83H → C in AAH86718 (Ref. 3) Curated1
Sequence conflicti83H → C in AAI65018 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051365 mRNA. Translation: AAC41302.1.
AF034264 mRNA. Translation: AAC60303.1.
BC086718 mRNA. Translation: AAH86718.1.
BC165018 mRNA. Translation: AAI65018.1.
AB256522 Genomic DNA. Translation: BAF34588.1.
CR925797 Genomic DNA. No translation available.
RefSeqiNP_571356.2. NM_131281.2.
UniGeneiDr.478.

Genome annotation databases

EnsembliENSDART00000025583; ENSDARP00000018653; ENSDARG00000003399.
GeneIDi30538.
KEGGidre:30538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051365 mRNA. Translation: AAC41302.1.
AF034264 mRNA. Translation: AAC60303.1.
BC086718 mRNA. Translation: AAH86718.1.
BC165018 mRNA. Translation: AAI65018.1.
AB256522 Genomic DNA. Translation: BAF34588.1.
CR925797 Genomic DNA. No translation available.
RefSeqiNP_571356.2. NM_131281.2.
UniGeneiDr.478.

3D structure databases

ProteinModelPortaliO57341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000018653.

Proteomic databases

PaxDbiO57341.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000025583; ENSDARP00000018653; ENSDARG00000003399.
GeneIDi30538.
KEGGidre:30538.

Organism-specific databases

CTDi30538.
ZFINiZDB-GENE-990415-72. fgf8a.

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00730000110785.
HOVERGENiHBG005659.
KOiK04358.
OMAiAATGFYI.
OrthoDBiEOG091G0NQH.
TreeFamiTF331233.

Enzyme and pathway databases

ReactomeiR-DRE-109704. PI3K Cascade.
R-DRE-1257604. PIP3 activates AKT signaling.
R-DRE-190322. FGFR4 ligand binding and activation.
R-DRE-190371. FGFR3b ligand binding and activation.
R-DRE-190372. FGFR3c ligand binding and activation.
R-DRE-190373. FGFR1c ligand binding and activation.
R-DRE-190375. FGFR2c ligand binding and activation.
R-DRE-5654219. Phospholipase C-mediated cascade: FGFR1.
R-DRE-5654221. Phospholipase C-mediated cascade, FGFR2.
R-DRE-5654227. Phospholipase C-mediated cascade, FGFR3.
R-DRE-5654228. Phospholipase C-mediated cascade, FGFR4.
R-DRE-5654687. Downstream signaling of activated FGFR1.
R-DRE-5654688. SHC-mediated cascade:FGFR1.
R-DRE-5654689. PI-3K cascade:FGFR1.
R-DRE-5654693. FRS-mediated FGFR1 signaling.
R-DRE-5654695. PI-3K cascade:FGFR2.
R-DRE-5654699. SHC-mediated cascade:FGFR2.
R-DRE-5654700. FRS-mediated FGFR2 signaling.
R-DRE-5654704. SHC-mediated cascade:FGFR3.
R-DRE-5654706. FRS-mediated FGFR3 signaling.
R-DRE-5654710. PI-3K cascade:FGFR3.
R-DRE-5654712. FRS-mediated FGFR4 signaling.
R-DRE-5654719. SHC-mediated cascade:FGFR4.
R-DRE-5654720. PI-3K cascade:FGFR4.
R-DRE-5654726. Negative regulation of FGFR1 signaling.
R-DRE-5654727. Negative regulation of FGFR2 signaling.
R-DRE-5654732. Negative regulation of FGFR3 signaling.
R-DRE-5654733. Negative regulation of FGFR4 signaling.
R-DRE-5658623. FGFRL1 modulation of FGFR1 signaling.
R-DRE-5673001. RAF/MAP kinase cascade.
R-DRE-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Miscellaneous databases

PROiO57341.

Gene expression databases

BgeeiENSDARG00000003399.
ExpressionAtlasiO57341. baseline and differential.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiIPR008996. Cytokine_IL1-like.
IPR028249. FGF8.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF3. PTHR11486:SF3. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGF8A_DANRE
AccessioniPrimary (citable) accession number: O57341
Secondary accession number(s): Q5PRC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2015
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.