Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thyrotropin subunit beta

Gene

TSHB

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Indispensable for the control of thyroid structure and metabolism.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-GGA-209822. Glycoprotein hormones.
R-GGA-209968. Thyroxine biosynthesis.
R-GGA-375281. Hormone ligand-binding receptors.
R-GGA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Thyrotropin subunit beta
Alternative name(s):
Thyroid-stimulating hormone subunit beta
Short name:
TSH-B
Short name:
TSH-beta
Thyrotropin beta chain
Gene namesi
Name:TSHB
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 26

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000001175617 – 134Thyrotropin subunit betaAdd BLAST118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi22 ↔ 72By similarity
Disulfide bondi36 ↔ 87By similarity
Disulfide bondi39 ↔ 125By similarity
Glycosylationi43N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi47 ↔ 103By similarity
Disulfide bondi51 ↔ 105By similarity
Disulfide bondi108 ↔ 115By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO57340.

Expressioni

Gene expression databases

BgeeiENSGALG00000002550.
ExpressionAtlasiO57340. differential.

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000004015.

Structurei

3D structure databases

ProteinModelPortaliO57340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXJG. Eukaryota.
ENOG410YSY0. LUCA.
GeneTreeiENSGT00390000010115.
HOGENOMiHOG000116098.
HOVERGENiHBG006698.
InParanoidiO57340.
KOiK05251.
OMAiTNYCTKP.
OrthoDBiEOG091G0XFH.
PhylomeDBiO57340.
TreeFamiTF332940.

Family and domain databases

CDDicd00069. GHB_like. 1 hit.
Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O57340-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPFFMMSLL FGLTFGQTAS VCAPSEYTIH VEKRECAYCL AINTTICAGF
60 70 80 90 100
CMTRDSNGKK LLLKSALSQN VCTYKEMFYQ TALIPGCPHH TIPYYSYPVA
110 120 130
ISCKCGKCNT DYSDCVHEKV RTNYCTKPQK LCNM
Length:134
Mass (Da):15,065
Last modified:June 1, 1998 - v1
Checksum:i3D2429DB4EAC07EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033495 mRNA. Translation: AAB88127.1.
RefSeqiNP_990394.1. NM_205063.2.
XP_015154381.1. XM_015298895.1.
XP_015154382.1. XM_015298896.1.
UniGeneiGga.551.

Genome annotation databases

EnsembliENSGALT00000004024; ENSGALP00000004015; ENSGALG00000002550.
GeneIDi395937.
KEGGigga:395937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033495 mRNA. Translation: AAB88127.1.
RefSeqiNP_990394.1. NM_205063.2.
XP_015154381.1. XM_015298895.1.
XP_015154382.1. XM_015298896.1.
UniGeneiGga.551.

3D structure databases

ProteinModelPortaliO57340.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000004015.

Proteomic databases

PaxDbiO57340.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000004024; ENSGALP00000004015; ENSGALG00000002550.
GeneIDi395937.
KEGGigga:395937.

Organism-specific databases

CTDi7252.

Phylogenomic databases

eggNOGiENOG410IXJG. Eukaryota.
ENOG410YSY0. LUCA.
GeneTreeiENSGT00390000010115.
HOGENOMiHOG000116098.
HOVERGENiHBG006698.
InParanoidiO57340.
KOiK05251.
OMAiTNYCTKP.
OrthoDBiEOG091G0XFH.
PhylomeDBiO57340.
TreeFamiTF332940.

Enzyme and pathway databases

ReactomeiR-GGA-209822. Glycoprotein hormones.
R-GGA-209968. Thyroxine biosynthesis.
R-GGA-375281. Hormone ligand-binding receptors.
R-GGA-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiO57340.

Gene expression databases

BgeeiENSGALG00000002550.
ExpressionAtlasiO57340. differential.

Family and domain databases

CDDicd00069. GHB_like. 1 hit.
Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSHB_CHICK
AccessioniPrimary (citable) accession number: O57340
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.