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Protein

Proteasome subunit beta type

Gene

psmb6

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine proteaseUniRule annotation

Protein family/group databases

MEROPSiT01.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta typeUniRule annotation (EC:3.4.25.1UniRule annotation)
Gene namesi
Name:psmb6Imported
Synonyms:YImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-990415-216. psmb6.

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleus UniRule annotation
  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation, ProteasomeUniRule annotationImported

PTM / Processingi

Proteomic databases

PaxDbiO57332.
PRIDEiO57332.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.UniRule annotation

Protein-protein interaction databases

STRINGi7955.ENSDARP00000025226.

Structurei

3D structure databases

ProteinModelPortaliO57332.
SMRiO57332. Positions 24-221.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0174. Eukaryota.
ENOG410XS23. LUCA.
HOGENOMiHOG000091079.
HOVERGENiHBG000123.
KOiK02738.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O57332-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTLNNYND LCPDWTQREV STGTTIMAVE FDGGVVMGAD SRTTTGAYIA
60 70 80 90 100
NRVTDKLTPI HDRIFCCRSG SAADTQAIAD AVTYQLGFHS IELDEAPLVQ
110 120 130 140 150
TAASLFRDMC YRYREELMAG IIVAGWDRRR GGQVYTVPVG GMLTRQPVSV
160 170 180 190 200
GGSGSSYIYG YVDSNYRSGM SKEECLKFTA GALTLPMERD GSSGGVVRLA
210 220
VISEQGVERQ AILGNQLPQF STV
Length:223
Mass (Da):24,123
Last modified:June 1, 1998 - v1
Checksum:i1B7258CAD584B897
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032392 mRNA. Translation: AAB87681.1.
RefSeqiNP_571227.1. NM_131152.1.
UniGeneiDr.11843.

Genome annotation databases

GeneIDi30388.
KEGGidre:30388.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032392 mRNA. Translation: AAB87681.1.
RefSeqiNP_571227.1. NM_131152.1.
UniGeneiDr.11843.

3D structure databases

ProteinModelPortaliO57332.
SMRiO57332. Positions 24-221.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000025226.

Protein family/group databases

MEROPSiT01.010.

Proteomic databases

PaxDbiO57332.
PRIDEiO57332.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi30388.
KEGGidre:30388.

Organism-specific databases

CTDi5694.
ZFINiZDB-GENE-990415-216. psmb6.

Phylogenomic databases

eggNOGiKOG0174. Eukaryota.
ENOG410XS23. LUCA.
HOGENOMiHOG000091079.
HOVERGENiHBG000123.
KOiK02738.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Linkage of LMP, TAP, and RING3 with Mhc class I rather than class II genes in the zebrafish."
    Takami K., Zaleska-Rutczynska Z., Figueroa F., Klein J.
    J. Immunol. 159:6052-6060(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO57332_DANRE
AccessioniPrimary (citable) accession number: O57332
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.