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O57329 (FZD7_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Frizzled-7

Short name=Fz-7
Short name=cFz-7
Gene names
Name:FZD7
Synonyms:FZ7
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length567 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Subcellular location

Membrane; Multi-pass membrane protein By similarity. Cell membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Expressed broadly in cranial ectoderm. Also expressed in the developing somites and in other cranial placodes, including the olfactory, lens, otic placodes (lateral half of the vesicle) and epibranchial placodes. Low level of expression in all the mesoderm derivatives in the limb buds.

Developmental stage

First detected as stage 6 in the forming neural tube and somites, but not in trunk surface ectoderm. By stage 8, expression persists in the cranial ectoderm and is up-regulated in the presomptive olfactory placodes. By stages 11-12, expression declines in the neural tube, but not in the cranial ectoderm; in somites, expressed all along the rostral-caudal axis as well as in presegmental mesenchyme caudal to the developing somites. Lens and otic placode expression first visible at stage 12, strongest at stages 13-16. Detected uniformly in ectoderm and mesenchyme of the limb primordia at stage 17. By stage 18, decrease of ectodermal, otic, lens and olfactory placode expression; expression appears in the epibranchial placodes. By stages 22-30, highest levels in the most distal mesoderm of the autopod, in the ventricular zone of the neural tube from the forebrain to the spinal cord, in the dermomyotomes and the tail buds.

Domain

Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway By similarity.

The FZ domain is involved in binding with Wnt ligands By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor Fz/Smo family.

Contains 1 FZ (frizzled) domain.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentCell membrane
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionDevelopmental protein
G-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger

Inferred from Biological aspect of Ancestor. Source: RefGenome

Wnt signaling pathway, calcium modulating pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

axonogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

brain development

Inferred from Biological aspect of Ancestor. Source: RefGenome

canonical Wnt signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

epithelial cell differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

gonad development

Inferred from Biological aspect of Ancestor. Source: RefGenome

vasculature development

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Cellular_componentapical part of cell

Inferred from Biological aspect of Ancestor. Source: RefGenome

cytoplasm

Inferred from Biological aspect of Ancestor. Source: RefGenome

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

neuron projection membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionG-protein coupled receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

PDZ domain binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Wnt-activated receptor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Wnt-protein binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Potential
Chain32 – 567536Frizzled-7
PRO_0000012998

Regions

Topological domain32 – 250219Extracellular Potential
Transmembrane251 – 27121Helical; Name=1; Potential
Topological domain272 – 28211Cytoplasmic Potential
Transmembrane283 – 30321Helical; Name=2; Potential
Topological domain304 – 33027Extracellular Potential
Transmembrane331 – 35121Helical; Name=3; Potential
Topological domain352 – 37322Cytoplasmic Potential
Transmembrane374 – 39421Helical; Name=4; Potential
Topological domain395 – 41723Extracellular Potential
Transmembrane418 – 43821Helical; Name=5; Potential
Topological domain439 – 46426Cytoplasmic Potential
Transmembrane465 – 48521Helical; Name=6; Potential
Topological domain486 – 52136Extracellular Potential
Transmembrane522 – 54221Helical; Name=7; Potential
Topological domain543 – 56725Cytoplasmic Potential
Domain42 – 161120FZ
Motif545 – 5506Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members By similarity
Motif565 – 5673PDZ-binding

Amino acid modifications

Glycosylation611N-linked (GlcNAc...) Potential
Glycosylation1621N-linked (GlcNAc...) Potential
Disulfide bond47 ↔ 108 By similarity
Disulfide bond55 ↔ 101 By similarity
Disulfide bond92 ↔ 129 By similarity
Disulfide bond118 ↔ 158 By similarity
Disulfide bond122 ↔ 146 By similarity

Experimental info

Sequence conflict34 – 352HE → QD in AAF61097. Ref.2
Sequence conflict4801V → L in AAF61097. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O57329 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 3EFF0381FC899BC3

FASTA56762,811
        10         20         30         40         50         60 
MRPAAGEAGA GLRWLGLAAL LAALLGTPCA AAHHEDKAIS VPDHGFCQPI SIPLCTDIAY 

        70         80         90        100        110        120 
NQTILPNLLG HTNQEDAGLE VHQFYPLVKV QCSAELKFFL CSMYAPVCTV LEQAIPPCRS 

       130        140        150        160        170        180 
LCERARQGCE ALMNKFGFQW PERLRCENFP VHGAGEICVG QNTSDAPPGP GGAGGRGATA 

       190        200        210        220        230        240 
QPTAGYLPDL LTPPQPAAGF SFSCPRQLKV PPYLGYRFLG ERDCGAPCEP GRPNGLMYFK 

       250        260        270        280        290        300 
EAEVRFARLW VGVWSVLCCA STLFTVLTYL VDMRRFSYPE RPIIFLSGCY FMVAVAYAAG 

       310        320        330        340        350        360 
FLLEERVVCL ERFSEDGYRT VAQGTKKEGC TILFMILYFF GMASSIWWVI LSLTWFLAAG 

       370        380        390        400        410        420 
MKWGHEAIEA NSQYFHLAAW AVPAVKTITI LAMGQVDGDV LSGVCYVGIY SVDSLRGFVL 

       430        440        450        460        470        480 
APLFVYLFIG TSFLLAGFVS LFRIRTIMKH DGTKTEKLEK LMVRIGVFSV LYTVPATIVV 

       490        500        510        520        530        540 
ACYFYEQAFR STWEKTWLLQ TCKTYAVPCP SHFAPMSPDF TVFMIKYLMT MIVGITTGFW 

       550        560 
IWSGKTLQSW RRFYHRLSTG SKGETAV 

« Hide

References

[1]"Expression of Wnt and Frizzled genes during chick limb bud development."
Kengaku M., Twombly V., Tabin C.
Cold Spring Harb. Symp. Quant. Biol. 62:421-429(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Limb bud.
[2]"Characterization of avian frizzled genes in cranial placode development."
Stark M.R., Biggs J.J., Schoenwolf G.C., Rao M.S.
Mech. Dev. 93:195-200(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF031831 mRNA. Translation: AAB87969.1.
AF224317 mRNA. Translation: AAF61097.1.
RefSeqNP_989552.1. NM_204221.2.
UniGeneGga.110.

3D structure databases

ProteinModelPortalO57329.
SMRO57329. Positions 45-162.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSI93.001.
GPCRDBSearch...

Proteomic databases

PaxDbO57329.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID374060.
KEGGgga:374060.

Organism-specific databases

CTD8324.

Phylogenomic databases

eggNOGNOG257258.
HOGENOMHOG000233237.
HOVERGENHBG006977.
InParanoidO57329.
KOK02432.
PhylomeDBO57329.

Family and domain databases

Gene3D1.10.2000.10. 1 hit.
InterProIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026552. FZD7.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF31. PTHR11309:SF31. 1 hit.
PfamPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSPR00489. FRIZZLED.
SMARTSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMSSF63501. SSF63501. 1 hit.
PROSITEPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20813582.
PROO57329.

Entry information

Entry nameFZD7_CHICK
AccessionPrimary (citable) accession number: O57329
Secondary accession number(s): Q9IA04
Entry history
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries