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O57329

- FZD7_CHICK

UniProt

O57329 - FZD7_CHICK

Protein

Frizzled-7

Gene

FZD7

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. PDZ domain binding Source: RefGenome
    3. Wnt-activated receptor activity Source: RefGenome
    4. Wnt-protein binding Source: RefGenome

    GO - Biological processi

    1. axonogenesis Source: RefGenome
    2. brain development Source: RefGenome
    3. canonical Wnt signaling pathway Source: RefGenome
    4. epithelial cell differentiation Source: RefGenome
    5. gonad development Source: RefGenome
    6. G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: RefGenome
    7. vasculature development Source: RefGenome
    8. Wnt signaling pathway, calcium modulating pathway Source: RefGenome

    Keywords - Molecular functioni

    Developmental protein, G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Wnt signaling pathway

    Protein family/group databases

    MEROPSiI93.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Frizzled-7
    Short name:
    Fz-7
    Short name:
    cFz-7
    Gene namesi
    Name:FZD7
    Synonyms:FZ7
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity. Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. apical part of cell Source: RefGenome
    2. cytoplasm Source: RefGenome
    3. integral component of membrane Source: UniProtKB-KW
    4. neuron projection membrane Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131Sequence AnalysisAdd
    BLAST
    Chaini32 – 567536Frizzled-7PRO_0000012998Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi47 ↔ 108PROSITE-ProRule annotation
    Disulfide bondi55 ↔ 101PROSITE-ProRule annotation
    Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi92 ↔ 129PROSITE-ProRule annotation
    Disulfide bondi118 ↔ 158PROSITE-ProRule annotation
    Disulfide bondi122 ↔ 146PROSITE-ProRule annotation
    Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO57329.

    Expressioni

    Tissue specificityi

    Expressed broadly in cranial ectoderm. Also expressed in the developing somites and in other cranial placodes, including the olfactory, lens, otic placodes (lateral half of the vesicle) and epibranchial placodes. Low level of expression in all the mesoderm derivatives in the limb buds.

    Developmental stagei

    First detected as stage 6 in the forming neural tube and somites, but not in trunk surface ectoderm. By stage 8, expression persists in the cranial ectoderm and is up-regulated in the presomptive olfactory placodes. By stages 11-12, expression declines in the neural tube, but not in the cranial ectoderm; in somites, expressed all along the rostral-caudal axis as well as in presegmental mesenchyme caudal to the developing somites. Lens and otic placode expression first visible at stage 12, strongest at stages 13-16. Detected uniformly in ectoderm and mesenchyme of the limb primordia at stage 17. By stage 18, decrease of ectodermal, otic, lens and olfactory placode expression; expression appears in the epibranchial placodes. By stages 22-30, highest levels in the most distal mesoderm of the autopod, in the ventricular zone of the neural tube from the forebrain to the spinal cord, in the dermomyotomes and the tail buds.

    Structurei

    3D structure databases

    ProteinModelPortaliO57329.
    SMRiO57329. Positions 45-162.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini32 – 250219ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini272 – 28211CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini304 – 33027ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini352 – 37322CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini395 – 41723ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini439 – 46426CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini486 – 52136ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini543 – 56725CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei251 – 27121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei283 – 30321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei331 – 35121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei374 – 39421Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei418 – 43821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei465 – 48521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei522 – 54221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini42 – 161120FZPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi545 – 5506Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity
    Motifi565 – 5673PDZ-binding

    Domaini

    Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
    The FZ domain is involved in binding with Wnt ligands.By similarity

    Sequence similaritiesi

    Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG257258.
    HOGENOMiHOG000233237.
    HOVERGENiHBG006977.
    InParanoidiO57329.
    KOiK02432.
    PhylomeDBiO57329.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR026552. FZD7.
    IPR017981. GPCR_2-like.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF31. PTHR11309:SF31. 1 hit.
    PfamiPF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view]
    PRINTSiPR00489. FRIZZLED.
    SMARTiSM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O57329-1 [UniParc]FASTAAdd to Basket

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    MRPAAGEAGA GLRWLGLAAL LAALLGTPCA AAHHEDKAIS VPDHGFCQPI    50
    SIPLCTDIAY NQTILPNLLG HTNQEDAGLE VHQFYPLVKV QCSAELKFFL 100
    CSMYAPVCTV LEQAIPPCRS LCERARQGCE ALMNKFGFQW PERLRCENFP 150
    VHGAGEICVG QNTSDAPPGP GGAGGRGATA QPTAGYLPDL LTPPQPAAGF 200
    SFSCPRQLKV PPYLGYRFLG ERDCGAPCEP GRPNGLMYFK EAEVRFARLW 250
    VGVWSVLCCA STLFTVLTYL VDMRRFSYPE RPIIFLSGCY FMVAVAYAAG 300
    FLLEERVVCL ERFSEDGYRT VAQGTKKEGC TILFMILYFF GMASSIWWVI 350
    LSLTWFLAAG MKWGHEAIEA NSQYFHLAAW AVPAVKTITI LAMGQVDGDV 400
    LSGVCYVGIY SVDSLRGFVL APLFVYLFIG TSFLLAGFVS LFRIRTIMKH 450
    DGTKTEKLEK LMVRIGVFSV LYTVPATIVV ACYFYEQAFR STWEKTWLLQ 500
    TCKTYAVPCP SHFAPMSPDF TVFMIKYLMT MIVGITTGFW IWSGKTLQSW 550
    RRFYHRLSTG SKGETAV 567
    Length:567
    Mass (Da):62,811
    Last modified:June 1, 1998 - v1
    Checksum:i3EFF0381FC899BC3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti34 – 352HE → QD in AAF61097. (PubMed:10781956)Curated
    Sequence conflicti480 – 4801V → L in AAF61097. (PubMed:10781956)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031831 mRNA. Translation: AAB87969.1.
    AF224317 mRNA. Translation: AAF61097.1.
    RefSeqiNP_989552.1. NM_204221.2.
    UniGeneiGga.110.

    Genome annotation databases

    GeneIDi374060.
    KEGGigga:374060.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031831 mRNA. Translation: AAB87969.1 .
    AF224317 mRNA. Translation: AAF61097.1 .
    RefSeqi NP_989552.1. NM_204221.2.
    UniGenei Gga.110.

    3D structure databases

    ProteinModelPortali O57329.
    SMRi O57329. Positions 45-162.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I93.001.
    GPCRDBi Search...

    Proteomic databases

    PaxDbi O57329.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 374060.
    KEGGi gga:374060.

    Organism-specific databases

    CTDi 8324.

    Phylogenomic databases

    eggNOGi NOG257258.
    HOGENOMi HOG000233237.
    HOVERGENi HBG006977.
    InParanoidi O57329.
    KOi K02432.
    PhylomeDBi O57329.

    Miscellaneous databases

    NextBioi 20813582.
    PROi O57329.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR026552. FZD7.
    IPR017981. GPCR_2-like.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF31. PTHR11309:SF31. 1 hit.
    Pfami PF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view ]
    PRINTSi PR00489. FRIZZLED.
    SMARTi SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of Wnt and Frizzled genes during chick limb bud development."
      Kengaku M., Twombly V., Tabin C.
      Cold Spring Harb. Symp. Quant. Biol. 62:421-429(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Limb bud.
    2. "Characterization of avian frizzled genes in cranial placode development."
      Stark M.R., Biggs J.J., Schoenwolf G.C., Rao M.S.
      Mech. Dev. 93:195-200(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiFZD7_CHICK
    AccessioniPrimary (citable) accession number: O57329
    Secondary accession number(s): Q9IA04
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 5, 2001
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3