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Protein

Frizzled-1

Gene

FZD1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Wnt signaling pathway

Protein family/group databases

MEROPSiI93.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-1
Short name:
Fz-1
Short name:
cFz-1
Gene namesi
Name:FZD1
Synonyms:FZ1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini49 – 271223ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini293 – 30311CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei304 – 32421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini325 – 35127ExtracellularSequence AnalysisAdd
BLAST
Transmembranei352 – 37221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini373 – 39422CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei395 – 41521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini416 – 43823ExtracellularSequence AnalysisAdd
BLAST
Transmembranei439 – 45921Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini460 – 48526CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei486 – 50621Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini507 – 54640ExtracellularSequence AnalysisAdd
BLAST
Transmembranei547 – 56721Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini568 – 59225CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4848Sequence AnalysisAdd
BLAST
Chaini49 – 592544Frizzled-1PRO_0000012976Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi70 ↔ 131PROSITE-ProRule annotation
Disulfide bondi78 ↔ 124PROSITE-ProRule annotation
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi115 ↔ 152PROSITE-ProRule annotation
Disulfide bondi141 ↔ 181PROSITE-ProRule annotation
Disulfide bondi145 ↔ 169PROSITE-ProRule annotation
Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi533 – 5331N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO57328.

Expressioni

Tissue specificityi

Expressed in the lens, otic placode (medial wall of the vesicle) and in epibranchial placode. Also expressed in the developing somites (dermomyotome).

Developmental stagei

Somites and placodal expression appears at stage 9. At this stage, more obvious expression is detected in the neural tube (midbrain and rostral hindbrain), and persists through about stage 15. Strongly expressed in the ectoderm and around the otic placodes at stage 12. At stage 16, otic expression declines, expression in epibranchial placodes begins and peaks at stage 20. Expression in the lens of the eye is first seen at about stage 15, more evident at stage 16. At stage 17, seen in the ectoderm and mesenchyme of the limb primordia. Detected at stage 20 in the lip of the optic cup, in the mesenchyme surrounding the eye, in the ectoderm overlying the lens and in the ectoderm caudal and ventral of the olfactory placodes. From stages 20-30, expressed in cartilage and in the dermomyotomes and migrating sclerotomal cells forming vertebrae.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000014736.

Structurei

3D structure databases

ProteinModelPortaliO57328.
SMRiO57328. Positions 68-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 184120FZPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi570 – 5756Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity
Motifi590 – 5923PDZ-binding

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257258.
HOGENOMiHOG000233236.
HOVERGENiHBG006977.
InParanoidiO57328.
KOiK02432.
PhylomeDBiO57328.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026548. FZD1.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF81. PTHR11309:SF81. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O57328-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAERRGPAGG GSGEVGGGRR AGGDRCPRRP PALPLLLLLW AAALPAGGQP
60 70 80 90 100
AAQPAALSER GISIPDHGYC QPISIPLCTD IAYNQTIMPN LLGHTNQEDA
110 120 130 140 150
GLEVHQFYPL VKVQCSAELK FFLCSMYAPV CTVLEQALPP CRSLCERARQ
160 170 180 190 200
GCEALMNKFG FQWPDTLRCE KFPVHGAGEL CVGQNASERG TPTPALRPES
210 220 230 240 250
WTSNPHRGGG AGGSGPGEAR GRFSCPRALK VPSYLNYRFL GEKDCGAPCE
260 270 280 290 300
PGRLYGLMYF GPEELRFSRT WIGIWSVLCC ASTLFTVLTY LVDMKRFSYP
310 320 330 340 350
ERPIIFLSGC YTAVAVAYIA GFLLEERVVC NERFAEDGSR TVAQGTKREG
360 370 380 390 400
CTILFMMLYF FGMASSIWWV ILSLTWFLAA GMKWGHEAIE ANSQYFHLAA
410 420 430 440 450
WAVPAIKTIT ILALGQVDGD VLSGVCFVGI NNVDALRGFV LAPLFVYLFI
460 470 480 490 500
GTSFLLAGFV SLFRIRTIMK HDGTKTEKLE KLMVRIGIFS VLYTVPATIV
510 520 530 540 550
IACYFYEQAF REQWERSWVT QSCKSYAIPC PNNHSSHHPP MSPDFTVFMI
560 570 580 590
KYLMTLIVGI TSGFWIWSGK TLNSWRKFYT RLTNSKQGET TV
Length:592
Mass (Da):65,491
Last modified:June 1, 1998 - v1
Checksum:i933E76063CA6109D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031830 mRNA. Translation: AAB87968.1.
AF224314 mRNA. Translation: AAF61094.1.
RefSeqiNP_001025508.1. NM_001030337.1.
UniGeneiGga.4087.

Genome annotation databases

GeneIDi374062.
KEGGigga:374062.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031830 mRNA. Translation: AAB87968.1.
AF224314 mRNA. Translation: AAF61094.1.
RefSeqiNP_001025508.1. NM_001030337.1.
UniGeneiGga.4087.

3D structure databases

ProteinModelPortaliO57328.
SMRiO57328. Positions 68-185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000014736.

Protein family/group databases

MEROPSiI93.001.
GPCRDBiSearch...

Proteomic databases

PaxDbiO57328.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi374062.
KEGGigga:374062.

Organism-specific databases

CTDi8321.

Phylogenomic databases

eggNOGiNOG257258.
HOGENOMiHOG000233236.
HOVERGENiHBG006977.
InParanoidiO57328.
KOiK02432.
PhylomeDBiO57328.

Miscellaneous databases

NextBioi20813584.
PROiO57328.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026548. FZD1.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF81. PTHR11309:SF81. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of Wnt and Frizzled genes during chick limb bud development."
    Kengaku M., Twombly V., Tabin C.
    Cold Spring Harb. Symp. Quant. Biol. 62:421-429(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Limb bud.
  2. "Characterization of avian frizzled genes in cranial placode development."
    Stark M.R., Biggs J.J., Schoenwolf G.C., Rao M.S.
    Mech. Dev. 93:195-200(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 307-592.

Entry informationi

Entry nameiFZD1_CHICK
AccessioniPrimary (citable) accession number: O57328
Secondary accession number(s): Q9IA07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: June 1, 1998
Last modified: February 4, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.