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O57328

- FZD1_CHICK

UniProt

O57328 - FZD1_CHICK

Protein

Frizzled-1

Gene

FZD1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. PDZ domain binding Source: RefGenome
    3. Wnt-activated receptor activity Source: RefGenome
    4. Wnt-protein binding Source: RefGenome

    GO - Biological processi

    1. axonogenesis Source: RefGenome
    2. brain development Source: RefGenome
    3. epithelial cell differentiation Source: RefGenome
    4. gonad development Source: RefGenome
    5. G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: RefGenome
    6. lung alveolus development Source: RefGenome
    7. negative regulation of BMP signaling pathway Source: RefGenome
    8. negative regulation of canonical Wnt signaling pathway Source: RefGenome
    9. vasculature development Source: RefGenome
    10. Wnt signaling pathway, calcium modulating pathway Source: RefGenome

    Keywords - Molecular functioni

    Developmental protein, G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Frizzled-1
    Short name:
    Fz-1
    Short name:
    cFz-1
    Gene namesi
    Name:FZD1
    Synonyms:FZ1
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. apical part of cell Source: RefGenome
    2. cytoplasm Source: RefGenome
    3. integral component of membrane Source: UniProtKB-KW
    4. neuron projection membrane Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4848Sequence AnalysisAdd
    BLAST
    Chaini49 – 592544Frizzled-1PRO_0000012976Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi70 ↔ 131PROSITE-ProRule annotation
    Disulfide bondi78 ↔ 124PROSITE-ProRule annotation
    Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi115 ↔ 152PROSITE-ProRule annotation
    Disulfide bondi141 ↔ 181PROSITE-ProRule annotation
    Disulfide bondi145 ↔ 169PROSITE-ProRule annotation
    Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi533 – 5331N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO57328.

    Expressioni

    Tissue specificityi

    Expressed in the lens, otic placode (medial wall of the vesicle) and in epibranchial placode. Also expressed in the developing somites (dermomyotome).

    Developmental stagei

    Somites and placodal expression appears at stage 9. At this stage, more obvious expression is detected in the neural tube (midbrain and rostral hindbrain), and persists through about stage 15. Strongly expressed in the ectoderm and around the otic placodes at stage 12. At stage 16, otic expression declines, expression in epibranchial placodes begins and peaks at stage 20. Expression in the lens of the eye is first seen at about stage 15, more evident at stage 16. At stage 17, seen in the ectoderm and mesenchyme of the limb primordia. Detected at stage 20 in the lip of the optic cup, in the mesenchyme surrounding the eye, in the ectoderm overlying the lens and in the ectoderm caudal and ventral of the olfactory placodes. From stages 20-30, expressed in cartilage and in the dermomyotomes and migrating sclerotomal cells forming vertebrae.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000014736.

    Structurei

    3D structure databases

    ProteinModelPortaliO57328.
    SMRiO57328. Positions 68-185.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini49 – 271223ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 30311CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini325 – 35127ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini373 – 39422CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini416 – 43823ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini460 – 48526CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini507 – 54640ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini568 – 59225CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei272 – 29221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei304 – 32421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei352 – 37221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei395 – 41521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei439 – 45921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei486 – 50621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei547 – 56721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini65 – 184120FZPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi570 – 5756Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity
    Motifi590 – 5923PDZ-binding

    Domaini

    Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
    The FZ domain is involved in binding with Wnt ligands.By similarity

    Sequence similaritiesi

    Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG257258.
    HOGENOMiHOG000233236.
    HOVERGENiHBG006977.
    InParanoidiO57328.
    KOiK02432.
    PhylomeDBiO57328.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR026548. FZD1.
    IPR017981. GPCR_2-like.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF81. PTHR11309:SF81. 1 hit.
    PfamiPF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view]
    PRINTSiPR00489. FRIZZLED.
    SMARTiSM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O57328-1 [UniParc]FASTAAdd to Basket

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    MAERRGPAGG GSGEVGGGRR AGGDRCPRRP PALPLLLLLW AAALPAGGQP    50
    AAQPAALSER GISIPDHGYC QPISIPLCTD IAYNQTIMPN LLGHTNQEDA 100
    GLEVHQFYPL VKVQCSAELK FFLCSMYAPV CTVLEQALPP CRSLCERARQ 150
    GCEALMNKFG FQWPDTLRCE KFPVHGAGEL CVGQNASERG TPTPALRPES 200
    WTSNPHRGGG AGGSGPGEAR GRFSCPRALK VPSYLNYRFL GEKDCGAPCE 250
    PGRLYGLMYF GPEELRFSRT WIGIWSVLCC ASTLFTVLTY LVDMKRFSYP 300
    ERPIIFLSGC YTAVAVAYIA GFLLEERVVC NERFAEDGSR TVAQGTKREG 350
    CTILFMMLYF FGMASSIWWV ILSLTWFLAA GMKWGHEAIE ANSQYFHLAA 400
    WAVPAIKTIT ILALGQVDGD VLSGVCFVGI NNVDALRGFV LAPLFVYLFI 450
    GTSFLLAGFV SLFRIRTIMK HDGTKTEKLE KLMVRIGIFS VLYTVPATIV 500
    IACYFYEQAF REQWERSWVT QSCKSYAIPC PNNHSSHHPP MSPDFTVFMI 550
    KYLMTLIVGI TSGFWIWSGK TLNSWRKFYT RLTNSKQGET TV 592
    Length:592
    Mass (Da):65,491
    Last modified:June 1, 1998 - v1
    Checksum:i933E76063CA6109D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031830 mRNA. Translation: AAB87968.1.
    AF224314 mRNA. Translation: AAF61094.1.
    RefSeqiNP_001025508.1. NM_001030337.1.
    UniGeneiGga.4087.

    Genome annotation databases

    GeneIDi374062.
    KEGGigga:374062.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031830 mRNA. Translation: AAB87968.1 .
    AF224314 mRNA. Translation: AAF61094.1 .
    RefSeqi NP_001025508.1. NM_001030337.1.
    UniGenei Gga.4087.

    3D structure databases

    ProteinModelPortali O57328.
    SMRi O57328. Positions 68-185.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000014736.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PaxDbi O57328.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 374062.
    KEGGi gga:374062.

    Organism-specific databases

    CTDi 8321.

    Phylogenomic databases

    eggNOGi NOG257258.
    HOGENOMi HOG000233236.
    HOVERGENi HBG006977.
    InParanoidi O57328.
    KOi K02432.
    PhylomeDBi O57328.

    Miscellaneous databases

    NextBioi 20813584.
    PROi O57328.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR026548. FZD1.
    IPR017981. GPCR_2-like.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF81. PTHR11309:SF81. 1 hit.
    Pfami PF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view ]
    PRINTSi PR00489. FRIZZLED.
    SMARTi SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of Wnt and Frizzled genes during chick limb bud development."
      Kengaku M., Twombly V., Tabin C.
      Cold Spring Harb. Symp. Quant. Biol. 62:421-429(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Limb bud.
    2. "Characterization of avian frizzled genes in cranial placode development."
      Stark M.R., Biggs J.J., Schoenwolf G.C., Rao M.S.
      Mech. Dev. 93:195-200(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 307-592.

    Entry informationi

    Entry nameiFZD1_CHICK
    AccessioniPrimary (citable) accession number: O57328
    Secondary accession number(s): Q9IA07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 5, 2001
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3