SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O57328

- FZD1_CHICK

UniProt

O57328 - FZD1_CHICK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Frizzled-1
Gene
FZD1, FZ1
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. PDZ domain binding Source: RefGenome
  3. Wnt-activated receptor activity Source: RefGenome
  4. Wnt-protein binding Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: RefGenome
  2. Wnt signaling pathway, calcium modulating pathway Source: RefGenome
  3. axonogenesis Source: RefGenome
  4. brain development Source: RefGenome
  5. epithelial cell differentiation Source: RefGenome
  6. gonad development Source: RefGenome
  7. lung alveolus development Source: RefGenome
  8. negative regulation of BMP signaling pathway Source: RefGenome
  9. negative regulation of canonical Wnt signaling pathway Source: RefGenome
  10. vasculature development Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-1
Short name:
Fz-1
Short name:
cFz-1
Gene namesi
Name:FZD1
Synonyms:FZ1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini49 – 271223Extracellular Reviewed prediction
Add
BLAST
Transmembranei272 – 29221Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini293 – 30311Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei304 – 32421Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini325 – 35127Extracellular Reviewed prediction
Add
BLAST
Transmembranei352 – 37221Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini373 – 39422Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei395 – 41521Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini416 – 43823Extracellular Reviewed prediction
Add
BLAST
Transmembranei439 – 45921Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini460 – 48526Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei486 – 50621Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini507 – 54640Extracellular Reviewed prediction
Add
BLAST
Transmembranei547 – 56721Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini568 – 59225Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical part of cell Source: RefGenome
  2. cytoplasm Source: RefGenome
  3. integral component of membrane Source: UniProtKB-KW
  4. neuron projection membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4848 Reviewed prediction
Add
BLAST
Chaini49 – 592544Frizzled-1
PRO_0000012976Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi70 ↔ 131 By similarity
Disulfide bondi78 ↔ 124 By similarity
Glycosylationi84 – 841N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi115 ↔ 152 By similarity
Disulfide bondi141 ↔ 181 By similarity
Disulfide bondi145 ↔ 169 By similarity
Glycosylationi185 – 1851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi533 – 5331N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO57328.

Expressioni

Tissue specificityi

Expressed in the lens, otic placode (medial wall of the vesicle) and in epibranchial placode. Also expressed in the developing somites (dermomyotome).

Developmental stagei

Somites and placodal expression appears at stage 9. At this stage, more obvious expression is detected in the neural tube (midbrain and rostral hindbrain), and persists through about stage 15. Strongly expressed in the ectoderm and around the otic placodes at stage 12. At stage 16, otic expression declines, expression in epibranchial placodes begins and peaks at stage 20. Expression in the lens of the eye is first seen at about stage 15, more evident at stage 16. At stage 17, seen in the ectoderm and mesenchyme of the limb primordia. Detected at stage 20 in the lip of the optic cup, in the mesenchyme surrounding the eye, in the ectoderm overlying the lens and in the ectoderm caudal and ventral of the olfactory placodes. From stages 20-30, expressed in cartilage and in the dermomyotomes and migrating sclerotomal cells forming vertebrae.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000014736.

Structurei

3D structure databases

ProteinModelPortaliO57328.
SMRiO57328. Positions 68-185.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 184120FZ
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi570 – 5756Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members By similarity
Motifi590 – 5923PDZ-binding

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway By similarity.
The FZ domain is involved in binding with Wnt ligands By similarity.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257258.
HOGENOMiHOG000233236.
HOVERGENiHBG006977.
InParanoidiO57328.
KOiK02432.
PhylomeDBiO57328.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026548. FZD1.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF81. PTHR11309:SF81. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O57328-1 [UniParc]FASTAAdd to Basket

« Hide

MAERRGPAGG GSGEVGGGRR AGGDRCPRRP PALPLLLLLW AAALPAGGQP    50
AAQPAALSER GISIPDHGYC QPISIPLCTD IAYNQTIMPN LLGHTNQEDA 100
GLEVHQFYPL VKVQCSAELK FFLCSMYAPV CTVLEQALPP CRSLCERARQ 150
GCEALMNKFG FQWPDTLRCE KFPVHGAGEL CVGQNASERG TPTPALRPES 200
WTSNPHRGGG AGGSGPGEAR GRFSCPRALK VPSYLNYRFL GEKDCGAPCE 250
PGRLYGLMYF GPEELRFSRT WIGIWSVLCC ASTLFTVLTY LVDMKRFSYP 300
ERPIIFLSGC YTAVAVAYIA GFLLEERVVC NERFAEDGSR TVAQGTKREG 350
CTILFMMLYF FGMASSIWWV ILSLTWFLAA GMKWGHEAIE ANSQYFHLAA 400
WAVPAIKTIT ILALGQVDGD VLSGVCFVGI NNVDALRGFV LAPLFVYLFI 450
GTSFLLAGFV SLFRIRTIMK HDGTKTEKLE KLMVRIGIFS VLYTVPATIV 500
IACYFYEQAF REQWERSWVT QSCKSYAIPC PNNHSSHHPP MSPDFTVFMI 550
KYLMTLIVGI TSGFWIWSGK TLNSWRKFYT RLTNSKQGET TV 592
Length:592
Mass (Da):65,491
Last modified:June 1, 1998 - v1
Checksum:i933E76063CA6109D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF031830 mRNA. Translation: AAB87968.1.
AF224314 mRNA. Translation: AAF61094.1.
RefSeqiNP_001025508.1. NM_001030337.1.
UniGeneiGga.4087.

Genome annotation databases

GeneIDi374062.
KEGGigga:374062.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF031830 mRNA. Translation: AAB87968.1 .
AF224314 mRNA. Translation: AAF61094.1 .
RefSeqi NP_001025508.1. NM_001030337.1.
UniGenei Gga.4087.

3D structure databases

ProteinModelPortali O57328.
SMRi O57328. Positions 68-185.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000014736.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PaxDbi O57328.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 374062.
KEGGi gga:374062.

Organism-specific databases

CTDi 8321.

Phylogenomic databases

eggNOGi NOG257258.
HOGENOMi HOG000233236.
HOVERGENi HBG006977.
InParanoidi O57328.
KOi K02432.
PhylomeDBi O57328.

Miscellaneous databases

NextBioi 20813584.
PROi O57328.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026548. FZD1.
IPR017981. GPCR_2-like.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
PTHR11309:SF81. PTHR11309:SF81. 1 hit.
Pfami PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view ]
PRINTSi PR00489. FRIZZLED.
SMARTi SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of Wnt and Frizzled genes during chick limb bud development."
    Kengaku M., Twombly V., Tabin C.
    Cold Spring Harb. Symp. Quant. Biol. 62:421-429(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Limb bud.
  2. "Characterization of avian frizzled genes in cranial placode development."
    Stark M.R., Biggs J.J., Schoenwolf G.C., Rao M.S.
    Mech. Dev. 93:195-200(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 307-592.

Entry informationi

Entry nameiFZD1_CHICK
AccessioniPrimary (citable) accession number: O57328
Secondary accession number(s): Q9IA07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi