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O57328 (FZD1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Frizzled-1

Short name=Fz-1
Short name=cFz-1
Gene names
Name:FZD1
Synonyms:FZ1
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length592 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Subcellular location

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Expressed in the lens, otic placode (medial wall of the vesicle) and in epibranchial placode. Also expressed in the developing somites (dermomyotome).

Developmental stage

Somites and placodal expression appears at stage 9. At this stage, more obvious expression is detected in the neural tube (midbrain and rostral hindbrain), and persists through about stage 15. Strongly expressed in the ectoderm and around the otic placodes at stage 12. At stage 16, otic expression declines, expression in epibranchial placodes begins and peaks at stage 20. Expression in the lens of the eye is first seen at about stage 15, more evident at stage 16. At stage 17, seen in the ectoderm and mesenchyme of the limb primordia. Detected at stage 20 in the lip of the optic cup, in the mesenchyme surrounding the eye, in the ectoderm overlying the lens and in the ectoderm caudal and ventral of the olfactory placodes. From stages 20-30, expressed in cartilage and in the dermomyotomes and migrating sclerotomal cells forming vertebrae.

Domain

Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway By similarity.

The FZ domain is involved in binding with Wnt ligands By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor Fz/Smo family.

Contains 1 FZ (frizzled) domain.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentCell membrane
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionDevelopmental protein
G-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger

Inferred from Biological aspect of Ancestor. Source: RefGenome

Wnt signaling pathway, calcium modulating pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

axonogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

brain development

Inferred from Biological aspect of Ancestor. Source: RefGenome

embryo development

Inferred from Biological aspect of Ancestor. Source: RefGenome

epithelial cell differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

gonad development

Inferred from Biological aspect of Ancestor. Source: RefGenome

lung alveolus development

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of BMP signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of canonical Wnt signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

vasculature development

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Cellular_componentapical part of cell

Inferred from Biological aspect of Ancestor. Source: RefGenome

cytoplasm

Inferred from Biological aspect of Ancestor. Source: RefGenome

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

neuron projection membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionG-protein coupled receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

PDZ domain binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Wnt-activated receptor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Wnt-protein binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4848 Potential
Chain49 – 592544Frizzled-1
PRO_0000012976

Regions

Topological domain49 – 271223Extracellular Potential
Transmembrane272 – 29221Helical; Name=1; Potential
Topological domain293 – 30311Cytoplasmic Potential
Transmembrane304 – 32421Helical; Name=2; Potential
Topological domain325 – 35127Extracellular Potential
Transmembrane352 – 37221Helical; Name=3; Potential
Topological domain373 – 39422Cytoplasmic Potential
Transmembrane395 – 41521Helical; Name=4; Potential
Topological domain416 – 43823Extracellular Potential
Transmembrane439 – 45921Helical; Name=5; Potential
Topological domain460 – 48526Cytoplasmic Potential
Transmembrane486 – 50621Helical; Name=6; Potential
Topological domain507 – 54640Extracellular Potential
Transmembrane547 – 56721Helical; Name=7; Potential
Topological domain568 – 59225Cytoplasmic Potential
Domain65 – 184120FZ
Motif570 – 5756Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members By similarity
Motif590 – 5923PDZ-binding

Amino acid modifications

Glycosylation841N-linked (GlcNAc...) Potential
Glycosylation1851N-linked (GlcNAc...) Potential
Glycosylation5331N-linked (GlcNAc...) Potential
Disulfide bond70 ↔ 131 By similarity
Disulfide bond78 ↔ 124 By similarity
Disulfide bond115 ↔ 152 By similarity
Disulfide bond141 ↔ 181 By similarity
Disulfide bond145 ↔ 169 By similarity

Sequences

Sequence LengthMass (Da)Tools
O57328 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 933E76063CA6109D

FASTA59265,491
        10         20         30         40         50         60 
MAERRGPAGG GSGEVGGGRR AGGDRCPRRP PALPLLLLLW AAALPAGGQP AAQPAALSER 

        70         80         90        100        110        120 
GISIPDHGYC QPISIPLCTD IAYNQTIMPN LLGHTNQEDA GLEVHQFYPL VKVQCSAELK 

       130        140        150        160        170        180 
FFLCSMYAPV CTVLEQALPP CRSLCERARQ GCEALMNKFG FQWPDTLRCE KFPVHGAGEL 

       190        200        210        220        230        240 
CVGQNASERG TPTPALRPES WTSNPHRGGG AGGSGPGEAR GRFSCPRALK VPSYLNYRFL 

       250        260        270        280        290        300 
GEKDCGAPCE PGRLYGLMYF GPEELRFSRT WIGIWSVLCC ASTLFTVLTY LVDMKRFSYP 

       310        320        330        340        350        360 
ERPIIFLSGC YTAVAVAYIA GFLLEERVVC NERFAEDGSR TVAQGTKREG CTILFMMLYF 

       370        380        390        400        410        420 
FGMASSIWWV ILSLTWFLAA GMKWGHEAIE ANSQYFHLAA WAVPAIKTIT ILALGQVDGD 

       430        440        450        460        470        480 
VLSGVCFVGI NNVDALRGFV LAPLFVYLFI GTSFLLAGFV SLFRIRTIMK HDGTKTEKLE 

       490        500        510        520        530        540 
KLMVRIGIFS VLYTVPATIV IACYFYEQAF REQWERSWVT QSCKSYAIPC PNNHSSHHPP 

       550        560        570        580        590 
MSPDFTVFMI KYLMTLIVGI TSGFWIWSGK TLNSWRKFYT RLTNSKQGET TV 

« Hide

References

[1]"Expression of Wnt and Frizzled genes during chick limb bud development."
Kengaku M., Twombly V., Tabin C.
Cold Spring Harb. Symp. Quant. Biol. 62:421-429(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Limb bud.
[2]"Characterization of avian frizzled genes in cranial placode development."
Stark M.R., Biggs J.J., Schoenwolf G.C., Rao M.S.
Mech. Dev. 93:195-200(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 307-592.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF031830 mRNA. Translation: AAB87968.1.
AF224314 mRNA. Translation: AAF61094.1.
RefSeqNP_001025508.1. NM_001030337.1.
UniGeneGga.4087.

3D structure databases

ProteinModelPortalO57328.
SMRO57328. Positions 68-185.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000014736.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PaxDbO57328.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID374062.
KEGGgga:374062.

Organism-specific databases

CTD8321.

Phylogenomic databases

eggNOGNOG257258.
HOGENOMHOG000233236.
HOVERGENHBG006977.
InParanoidO57328.
KOK02432.
PhylomeDBO57328.

Family and domain databases

Gene3D1.10.2000.10. 1 hit.
InterProIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026548. FZD1.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF33. PTHR11309:SF33. 1 hit.
PfamPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSPR00489. FRIZZLED.
SMARTSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMSSF63501. SSF63501. 1 hit.
PROSITEPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20813584.
PROO57328.

Entry information

Entry nameFZD1_CHICK
AccessionPrimary (citable) accession number: O57328
Secondary accession number(s): Q9IA07
Entry history
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: June 1, 1998
Last modified: April 16, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries