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Protein

Amino acid transporter

Gene

sEAAT5B

Organism
Ambystoma tigrinum (Eastern tiger salamander)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

SymportUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Amino acid transporterUniRule annotation
Gene namesi
Name:sEAAT5BImported
OrganismiAmbystoma tigrinum (Eastern tiger salamander)Imported
Taxonomic identifieri8305 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaAmbystomatidaeAmbystoma

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5422HelicalUniRule annotationAdd
BLAST
Transmembranei109 – 12820HelicalUniRule annotationAdd
BLAST
Transmembranei232 – 25221HelicalUniRule annotationAdd
BLAST
Transmembranei272 – 29322HelicalUniRule annotationAdd
BLAST
Transmembranei305 – 33127HelicalUniRule annotationAdd
BLAST
Transmembranei343 – 36826HelicalUniRule annotationAdd
BLAST
Transmembranei380 – 40526HelicalUniRule annotationAdd
BLAST
Transmembranei417 – 43418HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliO57325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

HOVERGENiHBG000080.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 2 hits.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O57325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWERIKKALL NNFPFSLADV VTWLRNYWKK NGLLTLSMLS VITGCLIGFL
60 70 80 90 100
LRALELSDQE KQYFSFPGEL LMRMLKMLIL PLITSSLMSG LATMDSKVCG
110 120 130 140 150
KMGLITITYY LWTTFLAVAV GIILVICIHP GAAAQKEEHL GGKPILSSAD
160 170 180 190 200
ALLDLIRNMF PANLIEASFQ QYRTVLIPVV KSQDTKFLKK SLSFIYFAPD
210 220 230 240 250
DKNPEIHRPV LLEITPSPQM SYKTRPGTNT EMNVLGIVIF SATIGLLLGK
260 270 280 290 300
MGDRGAPLVN VCQCLNEAVM KIVSVAVWYF PFGIVFLIAG KILDMEDPAT
310 320 330 340 350
IGKKLGLYAI TVMAGLFIHG VILLPLLYLI FTKKNPFPFI QGILQALLIA
360 370 380 390 400
LATSSSSATL PITLKCLLEN NGIDRRVARF VLPVGATINM DGTALYEAVA
410 420 430 440 450
AIFIAQVNEY DLDMGQIITI SITATAASIG AAGIPQSGLV TMVIVLTSVG
460 470 480 490 500
LPTDDITLIV AVDWALDRFR TMTNVLGDAL AAGIVAHICR REFAALPEKQ
510 520 530 540
NLLTTAEPCS NTQRRPITKE HEVMEIIEEA LAERTGIHYN VCQV
Length:544
Mass (Da):59,610
Last modified:June 1, 1998 - v1
Checksum:iD609DDFA44E010D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018260 mRNA. Translation: AAB88290.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018260 mRNA. Translation: AAB88290.1.

3D structure databases

ProteinModelPortaliO57325.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000080.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 2 hits.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Excitatory amino acid transporters of the salamander retina: identification, localization, and function."
    Eliasof S., Arriza J.L., Leighton B.H., Kavanaugh M.P., Amara S.G.
    J. Neurosci. 18:698-712(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO57325_AMBTI
AccessioniPrimary (citable) accession number: O57325
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: November 11, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.