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Protein

Amino acid transporter

Gene

sEAAT2A

Organism
Ambystoma tigrinum (Eastern tiger salamander)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

SymportUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Amino acid transporterUniRule annotation
Gene namesi
Name:sEAAT2AImported
OrganismiAmbystoma tigrinum (Eastern tiger salamander)Imported
Taxonomic identifieri8305 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaAmbystomatidaeAmbystoma

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 64HelicalUniRule annotationAdd BLAST24
Transmembranei84 – 108HelicalUniRule annotationAdd BLAST25
Transmembranei120 – 143HelicalUniRule annotationAdd BLAST24
Transmembranei240 – 259HelicalUniRule annotationAdd BLAST20
Transmembranei280 – 304HelicalUniRule annotationAdd BLAST25
Transmembranei316 – 338HelicalUniRule annotationAdd BLAST23
Transmembranei345 – 368HelicalUniRule annotationAdd BLAST24
Transmembranei448 – 470HelicalUniRule annotationAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliO57322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

HOVERGENiHBG000080.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 2 hits.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O57322-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTEGANNM PKQVEVRMSE SHLTADEIHP MNKCLKIWKK LTGNLLLTLT
60 70 80 90 100
VLGVIMGALC GGLLRMASPI HPDIVMVIGF PGDILMRMLK MLILPLVISS
110 120 130 140 150
LITGLSGLDA KASGRLGTRA MVYYMVTTVI AAILGVILVL AIHPGNPKLR
160 170 180 190 200
EQMGQGQKND EVSSLDAFLD LIRNLFPENL VQACFQQIQT VTKKVVVQPP
210 220 230 240 250
PEEPSNITES LLALVNTTLN ETTEEVKVIL KKGLEFKDGM NVLGLIGFFI
260 270 280 290 300
AFGISMGKMG EQARLMVDFF NILNEIVMKL VTMIMWYSPL GIACLICGKI
310 320 330 340 350
IAIADLELVA RQLGMYMVTV IVGLIIHGAI FLPLIYFAIT RKNPFTFFVG
360 370 380 390 400
IFQAWITALG TASSAGTLPV TFRCLEENLH IDKRVTRFVL PVGATINMDG
410 420 430 440 450
TALYEAVAAI FIAQMNGIVL DGGQIITVSL TATLASVGAA SIPSAGLVTM
460 470 480 490 500
LLILTAVGLP TQDISLLVAV DWFLDRMRTS VNVVGDSFGA GIVYHLSRAE
510 520 530 540 550
LEEIDAQHAQ QEIEMTKTQS VYDDMKNHRE NNSNQCAYTA HNSVVVDECK
560 570
VTLANNGKAA DYNAIEEEPL DVTVETKNL
Length:579
Mass (Da):62,969
Last modified:June 1, 1998 - v1
Checksum:i2D6E3214E82623A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018257 mRNA. Translation: AAB88287.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018257 mRNA. Translation: AAB88287.1.

3D structure databases

ProteinModelPortaliO57322.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000080.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 2 hits.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO57322_AMBTI
AccessioniPrimary (citable) accession number: O57322
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: October 5, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.