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Protein

Excitatory amino acid transporter 1

Gene

SLC1A3

Organism
Ambystoma tigrinum (Eastern tiger salamander)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Excitatory amino acid transporter 1
Alternative name(s):
SEAAT1
Gene namesi
Name:SLC1A3
Synonyms:EAAT1
OrganismiAmbystoma tigrinum (Eastern tiger salamander)
Taxonomic identifieri8305 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaAmbystomatidaeAmbystoma

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47CytoplasmicSequence analysisAdd BLAST47
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Transmembranei123 – 145HelicalSequence analysisAdd BLAST23
Topological domaini146 – 238ExtracellularSequence analysisAdd BLAST93
Transmembranei239 – 261HelicalSequence analysisAdd BLAST23
Transmembranei282 – 303HelicalSequence analysisAdd BLAST22
Transmembranei320 – 341HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002020601 – 543Excitatory amino acid transporter 1Add BLAST543

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi206N-linked (GlcNAc...)Sequence analysis1
Glycosylationi217N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliO57321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG000080.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 2 hits.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O57321-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKSNGEDPR AGSRMERFQQ GVRQRTLLAK KKVQNITKDD VKGFLKRNGF
60 70 80 90 100
VLFTVIAVVV GSILGFSVRS YHMTFRELKY FSFPGELLMR MLQMLVLPLI
110 120 130 140 150
VSSLVTGMAA LDSKASGKMG LRAVVYYMTT TVIAVFIGIV IVIIVHPGKG
160 170 180 190 200
TKEHMHREGK IEPVTAADAF LDLIRNMFPP NMVEACFKQF KTSYEKKIFK
210 220 230 240 250
VTMPANETAV MTSVLNNVSE AMETLTKMRE EMIPVPGAVN GVNALGLVVF
260 270 280 290 300
SMCFGLVIGN MKEQGKALKD FFDSLNEAIM RLVAVIMWYA PIGILFLIAG
310 320 330 340 350
KIAEMEDMGV VGGQLGMYTV TVIIGLLIHA VIVLPLLYFA VTRKNPWVFI
360 370 380 390 400
GGILQALITA LGTSSSSATL PITFKCLEEN NKVDKRVTRF VLPVGATINM
410 420 430 440 450
DGTALYEALA AIFIAQVNNY DLNFGQILTI SITATAASIG AAGIPQAGLV
460 470 480 490 500
TMVIVLTSVG LPTDDITLII AVDWFLDRLR TTTNVLGDSL GAGIVEHLSR
510 520 530 540
HELQSGDAEM GNSVIEENEM KKPYQLVSQE NELEKPIDSE TKM
Length:543
Mass (Da):59,395
Last modified:June 1, 1998 - v1
Checksum:i6B495796FE581FFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018256 mRNA. Translation: AAB88286.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018256 mRNA. Translation: AAB88286.1.

3D structure databases

ProteinModelPortaliO57321.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000080.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 2 hits.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEAA1_AMBTI
AccessioniPrimary (citable) accession number: O57321
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: July 6, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.