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Protein

Interleukin-1-binding protein

Gene

MVA184R

Organism
Vaccinia virus (strain Ankara) (VACV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Binds interleukin-1 and possibly interleukin-6. Could prevent these cytokines reaching their natural receptors. In consequence the inflammatory response would be diminished and virus replication enhanced.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1-binding protein
Alternative name(s):
Protein B16
Gene namesi
Ordered Locus Names:MVA184R, ACAM3000_MVA_184
OrganismiVaccinia virus (strain Ankara) (VACV)
Taxonomic identifieri126794 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 326308Interleukin-1-binding proteinPRO_0000015461Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi48 ↔ 99PROSITE-ProRule annotation
Glycosylationi80 – 801N-linked (GlcNAc...); by hostSequence analysis
Glycosylationi103 – 1031N-linked (GlcNAc...); by hostSequence analysis
Glycosylationi113 – 1131N-linked (GlcNAc...); by hostSequence analysis
Disulfide bondi143 ↔ 194PROSITE-ProRule annotation
Glycosylationi206 – 2061N-linked (GlcNAc...); by hostSequence analysis
Glycosylationi237 – 2371N-linked (GlcNAc...); by hostSequence analysis
Disulfide bondi242 ↔ 309PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliO57261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 11592Ig-like 1Add
BLAST
Domaini122 – 21291Ig-like 2Add
BLAST
Domaini221 – 322102Ig-like 3Add
BLAST

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR004078. IL-1-bd.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR013151. Immunoglobulin.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF00047. ig. 1 hit.
[Graphical view]
PRINTSiPR01540. INTRLEUKN1BP.
PR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O57261-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILPVIFLS IFFYSSFVQT FNAPECIDKG QYFASFMELE NEPVILPCPQ
60 70 80 90 100
INTLSSGYNI LDILWEKRGA DNDRIIPIDN GSNMLILNPT QSDSGIYICI
110 120 130 140 150
TTNETYCDMM SLNLTIVSVS ESNIDLISYP QIVNERSTGE MVCPNINAFI
160 170 180 190 200
ASNVNADIIW SGHRRLRNKR LKQRTPGIIT IEDVRKNDAG YYTCVLEYIY
210 220 230 240 250
GGKTYNVTRI VKLEVRDKII PSTMQLPEGV VTSIGSNLTI ACRVSLRPPT
260 270 280 290 300
TDADVFWISN GMYYEEDDGD GDGRISVANK IYMTDKRRVI TSRLNINPVK
310 320
EEDATTFTCM AFTIPSISKT VTVSIT
Length:326
Mass (Da):36,595
Last modified:June 1, 1998 - v1
Checksum:iDC44B776EA235F0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94848 Genomic DNA. Translation: AAB96555.1.
AY603355 Genomic DNA. Translation: AAT10580.1.
PIRiT37450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94848 Genomic DNA. Translation: AAB96555.1.
AY603355 Genomic DNA. Translation: AAT10580.1.
PIRiT37450.

3D structure databases

ProteinModelPortaliO57261.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR004078. IL-1-bd.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR013151. Immunoglobulin.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF00047. ig. 1 hit.
[Graphical view]
PRINTSiPR01540. INTRLEUKN1BP.
PR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genomic sequence of the modified vaccinia Ankara strain: comparison with other orthopoxviruses."
    Antoine G., Scheiflinger F., Dorner F., Falkner F.G.
    Virology 244:365-396(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Esposito J.J., Frace M., Sammons S.A., Olsen-Rasmussen M.S., Osborne J., Khristova M., Wohlhueter R.M.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate Acambis 3000.

Entry informationi

Entry nameiIL1BP_VACCA
AccessioniPrimary (citable) accession number: O57261
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: June 1, 1998
Last modified: May 11, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.