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O57184

- PAP1_VACCA

UniProt

O57184 - PAP1_VACCA

Protein

Poly(A) polymerase catalytic subunit

Gene

PAPL

Organism
Vaccinia virus (strain Ankara) (VACV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Polymerase that creates the 3'-poly(A) tail of mRNA's.

    Catalytic activityi

    ATP + RNA(n) = diphosphate + RNA(n+1).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei202 – 2021By similarity
    Active sitei204 – 2041By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. polynucleotide adenylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    mRNA processing, Transcription

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
    Alternative name(s):
    Poly(A) polymerase large subunit
    Short name:
    PAP-L
    VP55
    Gene namesi
    Name:PAPL
    Ordered Locus Names:MVA048L, ACAM3000_MVA_048
    OrganismiVaccinia virus (strain Ankara) (VACV)
    Taxonomic identifieri126794 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 479479Poly(A) polymerase catalytic subunitPRO_0000099105Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.

    Structurei

    3D structure databases

    ProteinModelPortaliO57184.
    SMRiO57184. Positions 12-479.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR024231. Pox_polyA_pol_nucTrfase.
    IPR004976. Poxvirus_polyA_pol_cat.
    IPR024397. Poxvirus_polyA_pol_cat_C.
    IPR024398. Poxvirus_polyA_pol_cat_N.
    [Graphical view]
    PfamiPF03296. Pox_polyA_pol. 1 hit.
    PF12629. Pox_polyA_pol_C. 1 hit.
    PF12630. Pox_polyA_pol_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015693. VAC-48L_nuct. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O57184-1 [UniParc]FASTAAdd to Basket

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    MNRNPDQNTF PNITLKIIET YLGRVPSVNE YHMLKLQARN IQKITVFNKD    50
    IFVSLVKKNK KRFFSDVDTS ASEIKDRILS YFSKQTQTYN IGKLFTIIEL 100
    QSVLVTTYTD ILGVLTIKAP NVISSKISYN VTSMEELARD MLNSMNVAVI 150
    DKAKVMGRHN VSSLVKNVNK LMEEYLRRHN KSCICYGSYS LYLINPNIRY 200
    GDIDILQTNS RTFLIDLAFL IKFITGNNII LSKIPYLRNY MVIKDENDNH 250
    IIDSFNIRQD TMNVVPKIFI DNIYIVDPTF QLLNMIKMFS QIDRLEDLSK 300
    DPEKFNARMA TMLEYVRYTH GIVFDGKRNN MPMKCIIDEN NRIVTVTTKD 350
    YFSFKKCLVY LDENVLSSDI LDLNADTSCD FESVTNSVYL IHDNIMYTYF 400
    SNTILLSDKG KVHEISARGL CAHILLYQML TSGEYKQCLS DLLNSMMNRD 450
    KIPIYSHTER DKKPGRHGFI NIEKDIIVF 479
    Length:479
    Mass (Da):55,566
    Last modified:June 1, 1998 - v1
    Checksum:iC90B9FE5EB62B6DB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U94848 Genomic DNA. Translation: AAB96426.1.
    AY603355 Genomic DNA. Translation: AAT10446.1.
    PIRiT30794.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U94848 Genomic DNA. Translation: AAB96426.1 .
    AY603355 Genomic DNA. Translation: AAT10446.1 .
    PIRi T30794.

    3D structure databases

    ProteinModelPortali O57184.
    SMRi O57184. Positions 12-479.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR024231. Pox_polyA_pol_nucTrfase.
    IPR004976. Poxvirus_polyA_pol_cat.
    IPR024397. Poxvirus_polyA_pol_cat_C.
    IPR024398. Poxvirus_polyA_pol_cat_N.
    [Graphical view ]
    Pfami PF03296. Pox_polyA_pol. 1 hit.
    PF12629. Pox_polyA_pol_C. 1 hit.
    PF12630. Pox_polyA_pol_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015693. VAC-48L_nuct. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genomic sequence of the modified vaccinia Ankara strain: comparison with other orthopoxviruses."
      Antoine G., Scheiflinger F., Dorner F., Falkner F.G.
      Virology 244:365-396(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Esposito J.J., Frace M., Sammons S.A., Olsen-Rasmussen M.S., Osborne J., Khristova M., Wohlhueter R.M.
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Isolate Acambis 3000.

    Entry informationi

    Entry nameiPAP1_VACCA
    AccessioniPrimary (citable) accession number: O57184
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3