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Protein

Kelch repeat protein F3

Gene

MVA031L

Organism
Vaccinia virus (strain Ankara) (VACV)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

Might have a role in the suppression of host immune response.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch repeat protein F3
Gene namesi
Ordered Locus Names:MVA031L, ACAM3000_MVA_031
OrganismiVaccinia virus (strain Ankara) (VACV)
Taxonomic identifieri126794 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476Kelch repeat protein F3PRO_0000119165Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO57174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 9081BTBPROSITE-ProRule annotationAdd
BLAST
Domaini125 – 21894BACKAdd
BLAST
Repeati269 – 31547Kelch 1Add
BLAST
Repeati316 – 35944Kelch 2Add
BLAST
Repeati361 – 40444Kelch 3Add
BLAST
Repeati406 – 44338Kelch 4Add
BLAST
Repeati444 – 47633Kelch 5Add
BLAST

Sequence similaritiesi

Belongs to the poxviruses Kelch family.Curated
Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 5 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
SMARTiSM00612. Kelch. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O57174-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIFVNTVYC KNILALSMTK KFKTIIDAIG GNIIVNSTIL KKLSPYFRTH
60 70 80 90 100
LRQKYTKNKD PVTRVCLDLD IHSLTSIVIY SYTGKVYIDS HNVVNLLRAS
110 120 130 140 150
ILTSVEFIIY TCINFILRDF RKEYCVECYM MGIEYGLSNL LCHTKNFIAK
160 170 180 190 200
HFLELEDDII DNFDYLSMKL ILESDELNVP DEDFVIKWYI KRRNKLGNLL
210 220 230 240 250
LLIKNVIRSN YLSPRGINNV KWILDCTKIF HCDKQPRKSY KYPFIEYPMN
260 270 280 290 300
MDQIIDIFHM CTSTHVGEVV YLIGGWMNNE IHNNAIAVNY ISNNWIPIPP
310 320 330 340 350
MNSPRLYASG IPANNKLYVV GGLPNPTSVE RWFHGDAAWV NMPSLLKPRC
360 370 380 390 400
NPAVASINNV IYVMGGHSET DTTTEYLLPN HDQWQFGPST YYPHYKSCAL
410 420 430 440 450
VFGRRLFLVG RNAEFYCESS NTWTLIDDPI YPRDNPELII VDNKLLLIGG
460 470
FYRESYIDTI EVYNHHTYSW NIWDGK
Length:476
Mass (Da):55,299
Last modified:June 1, 1998 - v1
Checksum:i3D2891458BDB42FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94848 Genomic DNA. Translation: AAB96414.1.
AY603355 Genomic DNA. Translation: AAT10429.1.
PIRiT30781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94848 Genomic DNA. Translation: AAB96414.1.
AY603355 Genomic DNA. Translation: AAT10429.1.
PIRiT30781.

3D structure databases

ProteinModelPortaliO57174.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
SMARTiSM00612. Kelch. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genomic sequence of the modified vaccinia Ankara strain: comparison with other orthopoxviruses."
    Antoine G., Scheiflinger F., Dorner F., Falkner F.G.
    Virology 244:365-396(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Esposito J.J., Frace M., Sammons S.A., Olsen-Rasmussen M.S., Osborne J., Khristova M., Wohlhueter R.M.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate Acambis 3000.

Entry informationi

Entry nameiF3_VACCA
AccessioniPrimary (citable) accession number: O57174
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: June 1, 1998
Last modified: January 20, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.