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O56831 (NSP1_ROTF6) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Non-structural protein 1

Short name=NSP1
Alternative name(s):
NCVP2
Non-structural RNA-binding protein 53
Short name=NS53
OrganismRotavirus A (isolate Cat/Japan/FRV64/1989 G3-P5B[3]-Ix-Rx-Cx-Mx-A9-Nx-Tx-E3-Hx) (RV-A)
Taxonomic identifier39010 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusunclassified rotaviruses
Virus hostFelis catus (Cat) (Felis silvestris catus) [TaxID: 9685]

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Seems to induce the proteasome-dependent degradation of IRF3, IRF5 and IRF7, thereby antagonizing the cellular interferon response and establishment of the antiviral state. Binds and targets IRF3 early post-infection and suppresses IRF3 nuclear translocation By similarity.

Subunit structure

Interacts (via C-terminus) with host IRF3; this interaction leads to IRF3 degradation. Interacts with host IRF7; this interaction leads to IRF7 degradation By similarity.

Subcellular location

Host cytoplasmhost cytoskeleton By similarity.

Domain

The zinc-finger domain is important, but not sufficient for binding and degrading IRF3. It is sometimes described as a RING zinc-finger, but it is atypical and it is unclear whether it is related with ubiquitin ligase activity By similarity.

Sequence similarities

Belongs to the rotavirus A NSP1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 492492Non-structural protein 1
PRO_0000369066

Regions

Zinc finger42 – 7938 Potential
Region1 – 8181RNA-binding By similarity
Region82 – 17695Important for cytoskeleton localization By similarity
Region314 – 492179Interaction with IRF3 By similarity

Sequences

Sequence LengthMass (Da)Tools
O56831 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 81F3760E3BC6F573

FASTA49257,754
        10         20         30         40         50         60 
MATFKDACFH YRKITKLNRE LLRIGANSVW IPVSSNKIKG WCIECCQLTE LTFCHGCSLA 

        70         80         90        100        110        120 
HVCQWCIQNK RCFLDNEPHL LKLRSFESPI TKEKLQCIID LYNLLFPINP GIINRFKKIV 

       130        140        150        160        170        180 
NQRKCRNEFE QSWYNQLLFP ITLNAAVFKF HSREVYVFGL YEGSSSCIDL PYRIVNCIDL 

       190        200        210        220        230        240 
YDRLLLDQIN FERMSSLPAS LQSVYANKYF KLSRLPSMKL KQIYYSDFSK QNLINKCKIK 

       250        260        270        280        290        300 
SRIVLRNLTE FTWDSQVSLH NDVINNKEKI LTALSTSSLK RFETHDLNLG RVKADIFELG 

       310        320        330        340        350        360 
HHCKPNYISS NHWQPASKVS QCRWCNVKYV FRNMDWKMES MYNELLSFIQ ACYKSNVNVG 

       370        380        390        400        410        420 
NCSSIESAYP LVKDMLWHSI TKYIDQTIEK LFNVMNPVKV DGQQVISFHW QIDVALYIHI 

       430        440        450        460        470        480 
KMILKTETLP FAFTLNQFRS IIKGIVNQWY DVTELDYLPL CTEQTDKLVK LEEEGKISEE 

       490 
HELLISDSED DD 

« Hide

References

[1]"Interspecies sharing of two distinct nonstructural protein 1 alleles among human and animal rotaviruses as revealed by dot blot hybridization."
Fujiwara Y., Nakagomi O.
J. Clin. Microbiol. 35:2703-2705(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D78362 mRNA. Translation: BAA24411.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002148. Rotavirus_NSP1.
[Graphical view]
PfamPF00981. Rota_NS53. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNSP1_ROTF6
AccessionPrimary (citable) accession number: O56831
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 1, 1998
Last modified: February 19, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families