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Protein
Submitted name:

RT-IN

Gene

gag-pro-pol

Organism
Mason-Pfizer monkey virus (MPMV) (Simian Mason-Pfizer virus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation

Cofactori

Mg2+SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl proteaseSAAS annotation, EndonucleaseSAAS annotation, Hydrolase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed DNA polymeraseSAAS annotation, Transferase

Keywords - Biological processi

DNA integration, DNA recombinationSAAS annotation, Viral genome integrationSAAS annotation, Virus entry into host cell

Keywords - Ligandi

DNA-bindingSAAS annotation, MagnesiumSAAS annotation, Metal-binding, Zinc

Protein family/group databases

MEROPSiA02.009.

Names & Taxonomyi

Protein namesi
Submitted name:
RT-INImported
Gene namesi
Name:gag-pro-polImported
OrganismiMason-Pfizer monkey virus (MPMV) (Simian Mason-Pfizer virus)Imported
Taxonomic identifieri11855 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeBetaretrovirus
Virus hostiMacaca mulatta (Rhesus macaque) [TaxID: 9544]

Subcellular locationi

  • Virion SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinUniRule annotation, Virion

Structurei

3D structure databases

ProteinModelPortaliO56224.
SMRiO56224. Positions 1-100, 574-605, 632-744, 760-866.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini549 – 56214CCHC-typeInterPro annotationAdd
BLAST
Domaini780 – 85677Peptidase A2InterPro annotationAdd
BLAST
Domaini867 – 91347G-patchInterPro annotationAdd
BLAST
Domaini959 – 1147189Reverse transcriptaseInterPro annotationAdd
BLAST
Domaini1361 – 1492132RNase HInterPro annotationAdd
BLAST
Domaini1496 – 153742Integrase-typeInterPro annotationAdd
BLAST
Domaini1550 – 1719170Integrase catalyticInterPro annotationAdd
BLAST
Domaini1716 – 176550Integrase-type DNA-bindingInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 reverse transcriptase domain.UniRule annotation
Contains CCHC-type zinc fingers.SAAS annotation
Contains RNase H domain.SAAS annotation
Contains integrase catalytic domain.SAAS annotation
Contains integrase-type DNA-binding domain.SAAS annotation
Contains integrase-type zinc finger.SAAS annotation
Contains peptidase A2 domain.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Zinc-fingerSAAS annotation

Family and domain databases

Gene3Di1.10.10.200. 1 hit.
1.10.1200.30. 1 hit.
1.10.375.10. 1 hit.
2.40.70.10. 1 hit.
2.70.40.10. 1 hit.
3.30.420.10. 2 hits.
4.10.60.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR003322. B_retro_matrix.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR000467. G_patch_dom.
IPR000721. Gag_p24.
IPR001037. Integrase_C_retrovir.
IPR001584. Integrase_cat-core.
IPR017856. Integrase_Zn-bd_dom-like_N.
IPR003308. Integrase_Zn-bd_dom_N.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR018061. Retropepsins.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
IPR010661. RVT_thumb.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
PF01585. G-patch. 1 hit.
PF02337. Gag_p10. 1 hit.
PF00607. Gag_p24. 1 hit.
PF00552. IN_DBD_C. 1 hit.
PF02022. Integrase_Zn. 1 hit.
PF00075. RNase_H. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
PF06817. RVT_thumb. 1 hit.
[Graphical view]
ProDomiPD004265. B_retro_matrix_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00443. G_patch. 1 hit.
SM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF46919. SSF46919. 1 hit.
SSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF50122. SSF50122. 1 hit.
SSF50630. SSF50630. 1 hit.
SSF51283. SSF51283. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50174. G_PATCH. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS51027. INTEGRASE_DBD. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
PS50158. ZF_CCHC. 1 hit.
PS50876. ZF_INTEGRASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O56224-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQELSQHER YVEQLKQALK TRGVKVKYAD LLKFFDFVKD TCPWFPQEGT
60 70 80 90 100
IDIKRWRRVG DCFQDYYNTF GPEKVPVTAF SYWNLIKELI DKKEVNPQVM
110 120 130 140 150
AAVAQTEEIL KSNSQTDLTK TSQNPDLDLI SLDSDDEGAK SSSLQDKGLS
160 170 180 190 200
STKKPKRFPV LLTAQTSKDP EDPNPSEVDW DGLEDEAAKY HNPDWPPFLT
210 220 230 240 250
RPPPYNKATP SAPTVMAVVN PKEELKEKIA QLEEQIKLEE LHQALISKLQ
260 270 280 290 300
KLKTGNETVT HPDTAGGLSR TPHWPGQHIP KGKCCASREK EEQIPKDIFP
310 320 330 340 350
VTETVDGQGQ AWRHHNGFDF AVIKELKTAA SQYGATAPYT LAIVESVADN
360 370 380 390 400
WLTPTDWNTL VRAVLSGGDH LLWKSEFFEN CRDTAKRNQQ AGNGWDFDML
410 420 430 440 450
TGSGNYSSTD AQMQYDPGLF AQIQAAATKA WRKLPVKGDP GASLTGVKQG
460 470 480 490 500
PDEPFADFVH RLITTAGRIF GSAEAGVDYV KQLAYENANP ACQAAIRPYR
510 520 530 540 550
KKTDLTGYIR LCSDIGPSYQ QGLAMAAAFS GQTVKDFLNN KNKEKGGCCF
560 570 580 590 600
KCGKKGHFAK NCHEHAHNNA EPKVPGLCPR CKRGKHWANE CKSKTDNQGN
610 620 630 640 650
PIPPHQGNRV EGPAPGPETS LWGSQLCSSQ QKQPISKLTR ATPGSAGLDL
660 670 680 690 700
CSTSHTVLTP EMGPQALSTG IYGPLPPNTF GLILGRSSIT MKGLQVYPGV
710 720 730 740 750
IDNDYTGEIK IMAKAVNNIV TVSQGNRIAQ LILLPLIETD NKVQQPYRGQ
760 770 780 790 800
GSFGSSDIYW VQPITCQKPS LTLWLDDKMF TGLIDTGADV TIIKLEDWPP
810 820 830 840 850
NWPITDTLTN LRGIGQSNNP KQSSKYLTWR DKENNSGLIK PFVIPNLPVN
860 870 880 890 900
LWGRDLLSQM KIMMCSPNDI VTAQMLAQGY SPGKGLGKKE NGILHPIPNQ
910 920 930 940 950
GQSNKKGFGN FLTAAIDILA PQQCAEPITW KSDEPVWVDQ WPLTNDKLAA
960 970 980 990 1000
AQQLVQEQLE AGHITESSSP WNTPIFVIKK KSGKWRLLQD LRAVNATMVL
1010 1020 1030 1040 1050
MGALQPGLPS PVAIPQGYLK IIIDLKDCFF SIPLHPSDQK RFAFSLPSTN
1060 1070 1080 1090 1100
FKEPMQRFQW KVLPQGMANS PTLCQKYVAT AIHKVRHAWK QMYIIHYMDD
1110 1120 1130 1140 1150
ILIAGKDGQQ VLQCFDQLKQ ELTAAGLHIA PEKVQLQDPY TYLGFELNGP
1160 1170 1180 1190 1200
KITNQKAVIR KDKLQTLNDF QKLLGDINWL RPYLKLTTGD LKPLFDTLKG
1210 1220 1230 1240 1250
DSDPNSHRSL SKEALASLEK VETAIAEQFV THINYSLPLI FLIFNTALTP
1260 1270 1280 1290 1300
TGLFWQDNPI MWIHLPASPK KVLLPYYDAI ADLIILGRDH SKKYFGIEPS
1310 1320 1330 1340 1350
TIIQPYSKSQ IDWLMQNTEM WPIACASFVG ILDNHYPPNK LIQFCKLHTF
1360 1370 1380 1390 1400
VFPQIISKTP LNNALLVFTD GSSTGMAAYT LTDTTIKFQT NLNSAQLVEL
1410 1420 1430 1440 1450
QALIAVLSAF PNQPLNIYTD SAYLAHSIPL LETVAQIKHI SETAKLFLQC
1460 1470 1480 1490 1500
QQLIYNRSIP FYIGHVRAHS GLPGPIAQGN QRADLATKIV ASNINTNLES
1510 1520 1530 1540 1550
AQNAHTLHHL NAQTLRLMFN IPREQARQIV KQCPICVTYL PVPHLGVNPR
1560 1570 1580 1590 1600
GLFPNMIWQM DVTHYSEFGN LKYIHVSIDT FSGFLLATLQ TGETTKHVIT
1610 1620 1630 1640 1650
HLLHCFSIIG LPKQIKTDNG PGYTSKNFQE FCSTLQIKHI TGIPYNPQGQ
1660 1670 1680 1690 1700
GIVERAHLSL KTTIEKIKKG EWYPRKGTPR NILNHALFIL NFLNLDDQNK
1710 1720 1730 1740 1750
SAADRFWHNN PKKQFAMVKW KDPLDNTWHG PDPVLIWGRG SVCVYSQTYD
1760 1770
AARWLPERLV RQVSNNNQSR E
Length:1,771
Mass (Da):198,014
Last modified:December 1, 2001 - v2
Checksum:iBE8BEAB195B4E833
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033815 Genomic RNA. Translation: AAC82576.1.
RefSeqiNP_056891.1. NC_001550.1.

Genome annotation databases

GeneIDi2746973.

Keywords - Coding sequence diversityi

Ribosomal frameshiftingSAAS annotation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033815 Genomic RNA. Translation: AAC82576.1.
RefSeqiNP_056891.1. NC_001550.1.

3D structure databases

ProteinModelPortaliO56224.
SMRiO56224. Positions 1-100, 574-605, 632-744, 760-866.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiA02.009.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2746973.

Family and domain databases

Gene3Di1.10.10.200. 1 hit.
1.10.1200.30. 1 hit.
1.10.375.10. 1 hit.
2.40.70.10. 1 hit.
2.70.40.10. 1 hit.
3.30.420.10. 2 hits.
4.10.60.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR003322. B_retro_matrix.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR000467. G_patch_dom.
IPR000721. Gag_p24.
IPR001037. Integrase_C_retrovir.
IPR001584. Integrase_cat-core.
IPR017856. Integrase_Zn-bd_dom-like_N.
IPR003308. Integrase_Zn-bd_dom_N.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR018061. Retropepsins.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
IPR010661. RVT_thumb.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
PF01585. G-patch. 1 hit.
PF02337. Gag_p10. 1 hit.
PF00607. Gag_p24. 1 hit.
PF00552. IN_DBD_C. 1 hit.
PF02022. Integrase_Zn. 1 hit.
PF00075. RNase_H. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
PF06817. RVT_thumb. 1 hit.
[Graphical view]
ProDomiPD004265. B_retro_matrix_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00443. G_patch. 1 hit.
SM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF46919. SSF46919. 1 hit.
SSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF50122. SSF50122. 1 hit.
SSF50630. SSF50630. 1 hit.
SSF51283. SSF51283. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50174. G_PATCH. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS51027. INTEGRASE_DBD. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
PS50158. ZF_CCHC. 1 hit.
PS50876. ZF_INTEGRASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Appendix 2: Retroviral taxonomy, protein structure, sequences, and genetic maps."
    Petropoulos C.J.
    (In) Coffin, J.M. (eds.); RETROVIRUSES, pp.757-0, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, NY, USA (1997)
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Chappey C.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO56224_MPMV
AccessioniPrimary (citable) accession number: O56224
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Multifunctional enzymeSAAS annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.