Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O55766 (RPB1_IIV6) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable DNA-directed RNA polymerase II subunit RPB1 homolog

EC=2.7.7.6
Gene names
ORF Names:IIV6-176R
OrganismInvertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus) [Reference proteome]
Taxonomic identifier176652 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageIridoviridaeIridovirus
Virus hostAcheta domesticus (House cricket) [TaxID: 6997]
Chilo suppressalis (striped riceborer) [TaxID: 168631]
Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999]
Gryllus campestris [TaxID: 58607]
Spodoptera frugiperda (Fall armyworm) [TaxID: 7108]

Protein attributes

Sequence length1026 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the DNA-dependent RNA polymerase that catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit By similarity.

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Sequence similarities

Belongs to the RNA polymerase beta' chain family.

Sequence caution

The sequence AAB33907.1 differs from that shown. Reason: Frameshift at position 39.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10261026Probable DNA-directed RNA polymerase II subunit RPB1 homolog
PRO_0000377495

Sites

Metal binding621Zinc 1 By similarity
Metal binding651Zinc 1 By similarity
Metal binding721Zinc 1 By similarity
Metal binding751Zinc 1 By similarity
Metal binding1021Zinc 2 By similarity
Metal binding1051Zinc 2 By similarity
Metal binding1421Zinc 2 By similarity
Metal binding5881Magnesium; catalytic By similarity
Metal binding5901Magnesium; catalytic By similarity
Metal binding5921Magnesium; catalytic By similarity

Experimental info

Sequence conflict4521I → N Ref.1
Sequence conflict4521I → N in AAB33907. Ref.2
Sequence conflict651 – 6522LT → N Ref.1
Sequence conflict651 – 6522LT → N in AAB33907. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O55766 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: C66698CBCE18BC7B

FASTA1,026116,963
        10         20         30         40         50         60 
MSANNNMESE IKEIESISFG MMSSEDIRQM SSFEVKTAKI SSTNLLETVH DPKSGPIGSA 

        70         80         90        100        110        120 
PCETCHQNEW DCPGHFGHIE LNVPIIHPLF INHVVNILKI FCWKCNEFLL TKDHLELNNI 

       130        140        150        160        170        180 
LKLEKEKKFN AVLEKIKKCD RCVHCTTPRA DYKLVLNDIT YKTIYRTFSY QGGAVKTARD 

       190        200        210        220        230        240 
KKLNESREIV SAEMVKKIFD NIKLEYVEML GISHPKDFCL EVFPVIPSCC RPHEVQDGNI 

       250        260        270        280        290        300 
NDDDLTYQLM EIVKNNSMIG AIKLEKESME KQYPECLKVK EILLLSNVEK QKKEIDDFLK 

       310        320        330        340        350        360 
KPIKNGLKTK KKINKEEITP LDQYLKLHDK YVKYVNNLKF RIETYCNNSQ GKATHATTGR 

       370        380        390        400        410        420 
AIKGLRERLT GKEGQIRNNL LGKRCEMSAR TVIGPDPTLK IDEVIVPKEI AQSLTFPDFV 

       430        440        450        460        470        480 
NKHNIDRLTK LVNSGNAIRL VKKNESGQEI KINLAAAINN HGTPLQHDDI IKRPKITNNH 

       490        500        510        520        530        540 
EEKHNYEEKH NFDTFETIVI KDPKNFVLKE GDILFRNNFQ QKVVLPSKKF IKLEEGWIVH 

       550        560        570        580        590        600 
RYLQNGDILV LNRQPTLHKA SMMALRVKIM DVKTFKFNLA CTKPYNADFD GDEMNAHAPQ 

       610        620        630        640        650        660 
SEESKAELFT LSTPKQCIMS CQSGKPNLTI VQDSLTGAYL MSKENNNDAT LTNGEFNDIL 

       670        680        690        700        710        720 
MVLTQNDEYN GDVVDYFLKR KEDVSNTLKK LGFSGTVLNG KGLLSLLFPN DLYINEEDLK 

       730        740        750        760        770        780 
INRGVIYDGC LTKKYLSSTE SSLIKILYKE YGVETCATFL NNIQFLTNRW LMISSFSIHA 

       790        800        810        820        830        840 
GDCIKQKEVL GTVEQCLMES EKIKMTTQNP FIREQKIMQT LSNAKDVGMK IAKDALKRDN 

       850        860        870        880        890        900 
VNLHAQNNFL TTVESGSKGD HLNIAQITSL LGQQITEGQR VKPLLSNGKR TLPHYILKEE 

       910        920        930        940        950        960 
NNDTEHFHDL LEEYESQGFI SSSFAQGLNP KEFFFHCMAG RQGVCDTAMS TATSGYIMRR 

       970        980        990       1000       1010       1020 
NVKLTEDIKV AYDGTVQDTR GRRFQMAYGE LGYDPSKLVK VNGKPEVCNI ARLVNKLNCN 


FEDNIK 

« Hide

References

« Hide 'large scale' references
[1]"Identification of the primary structure and the coding capacity of the genome of insect iridescent virus type 6 between the genome coordinates 0.310 and 0.347 (7990 bp)."
Sonntag K.-C., Schnitzler P., Janssen W., Darai G.
Intervirology 37:287-297(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Insect iridescent virus type 6 encodes a polypeptide related to the largest subunit of eukaryotic RNA polymerase II."
Schnitzler P., Sonntag K.-C., Muller M., Janssen W., Bugert J.J., Koonin E.V., Darai G.
J. Gen. Virol. 75:1557-1567(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Analysis of the first complete DNA sequence of an invertebrate iridovirus: coding strategy of the genome of Chilo iridescent virus."
Jakob N.J., Mueller K., Bahr U., Darai G.
Virology 286:182-196(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes."
Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R.
Virol. J. 4:11-11(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S75674 Genomic DNA. Translation: AAB33907.1. Frameshift.
AF303741 Genomic DNA. Translation: AAB94477.1.
PIRT03179.
RefSeqNP_149639.1. NC_003038.1.

3D structure databases

ProteinModelPortalO55766.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1733004.

Family and domain databases

InterProIPR000722. RNA_pol_asu.
IPR006592. RNA_pol_N.
IPR007080. RNA_pol_Rpb1_1.
IPR007066. RNA_pol_Rpb1_3.
IPR007083. RNA_pol_Rpb1_4.
IPR007081. RNA_pol_Rpb1_5.
[Graphical view]
PfamPF04997. RNA_pol_Rpb1_1. 2 hits.
PF00623. RNA_pol_Rpb1_2. 2 hits.
PF04983. RNA_pol_Rpb1_3. 1 hit.
PF05000. RNA_pol_Rpb1_4. 1 hit.
PF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view]
SMARTSM00663. RPOLA_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRPB1_IIV6
AccessionPrimary (citable) accession number: O55766
Secondary accession number(s): Q89506
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 1, 1998
Last modified: February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families