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O55766

- RPB1_IIV6

UniProt

O55766 - RPB1_IIV6

Protein

Probable DNA-directed RNA polymerase II subunit RPB1 homolog

Gene

IIV6-176R

Organism
Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Component of the DNA-dependent RNA polymerase that catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit By similarity.By similarity

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi62 – 621Zinc 1By similarity
    Metal bindingi65 – 651Zinc 1By similarity
    Metal bindingi72 – 721Zinc 1By similarity
    Metal bindingi75 – 751Zinc 1By similarity
    Metal bindingi102 – 1021Zinc 2By similarity
    Metal bindingi105 – 1051Zinc 2By similarity
    Metal bindingi142 – 1421Zinc 2By similarity
    Metal bindingi588 – 5881Magnesium; catalyticBy similarity
    Metal bindingi590 – 5901Magnesium; catalyticBy similarity
    Metal bindingi592 – 5921Magnesium; catalyticBy similarity

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. DNA-directed RNA polymerase activity Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Transcription

    Keywords - Ligandi

    Magnesium, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA-directed RNA polymerase II subunit RPB1 homolog (EC:2.7.7.6)
    Gene namesi
    ORF Names:IIV6-176R
    OrganismiInvertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
    Taxonomic identifieri176652 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeIridovirus
    Virus hostiAcheta domesticus (House cricket) [TaxID: 6997]
    Chilo suppressalis (striped riceborer) [TaxID: 168631]
    Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999]
    Gryllus campestris [TaxID: 58607]
    Spodoptera frugiperda (Fall armyworm) [TaxID: 7108]
    ProteomesiUP000001359: Genome

    Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymerase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10261026Probable DNA-directed RNA polymerase II subunit RPB1 homologPRO_0000377495Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO55766.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RNA polymerase beta' chain family.Curated

    Family and domain databases

    InterProiIPR000722. RNA_pol_asu.
    IPR006592. RNA_pol_N.
    IPR007080. RNA_pol_Rpb1_1.
    IPR007066. RNA_pol_Rpb1_3.
    IPR007083. RNA_pol_Rpb1_4.
    IPR007081. RNA_pol_Rpb1_5.
    [Graphical view]
    PfamiPF04997. RNA_pol_Rpb1_1. 2 hits.
    PF00623. RNA_pol_Rpb1_2. 2 hits.
    PF04983. RNA_pol_Rpb1_3. 1 hit.
    PF05000. RNA_pol_Rpb1_4. 1 hit.
    PF04998. RNA_pol_Rpb1_5. 1 hit.
    [Graphical view]
    SMARTiSM00663. RPOLA_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O55766-1 [UniParc]FASTAAdd to Basket

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    MSANNNMESE IKEIESISFG MMSSEDIRQM SSFEVKTAKI SSTNLLETVH     50
    DPKSGPIGSA PCETCHQNEW DCPGHFGHIE LNVPIIHPLF INHVVNILKI 100
    FCWKCNEFLL TKDHLELNNI LKLEKEKKFN AVLEKIKKCD RCVHCTTPRA 150
    DYKLVLNDIT YKTIYRTFSY QGGAVKTARD KKLNESREIV SAEMVKKIFD 200
    NIKLEYVEML GISHPKDFCL EVFPVIPSCC RPHEVQDGNI NDDDLTYQLM 250
    EIVKNNSMIG AIKLEKESME KQYPECLKVK EILLLSNVEK QKKEIDDFLK 300
    KPIKNGLKTK KKINKEEITP LDQYLKLHDK YVKYVNNLKF RIETYCNNSQ 350
    GKATHATTGR AIKGLRERLT GKEGQIRNNL LGKRCEMSAR TVIGPDPTLK 400
    IDEVIVPKEI AQSLTFPDFV NKHNIDRLTK LVNSGNAIRL VKKNESGQEI 450
    KINLAAAINN HGTPLQHDDI IKRPKITNNH EEKHNYEEKH NFDTFETIVI 500
    KDPKNFVLKE GDILFRNNFQ QKVVLPSKKF IKLEEGWIVH RYLQNGDILV 550
    LNRQPTLHKA SMMALRVKIM DVKTFKFNLA CTKPYNADFD GDEMNAHAPQ 600
    SEESKAELFT LSTPKQCIMS CQSGKPNLTI VQDSLTGAYL MSKENNNDAT 650
    LTNGEFNDIL MVLTQNDEYN GDVVDYFLKR KEDVSNTLKK LGFSGTVLNG 700
    KGLLSLLFPN DLYINEEDLK INRGVIYDGC LTKKYLSSTE SSLIKILYKE 750
    YGVETCATFL NNIQFLTNRW LMISSFSIHA GDCIKQKEVL GTVEQCLMES 800
    EKIKMTTQNP FIREQKIMQT LSNAKDVGMK IAKDALKRDN VNLHAQNNFL 850
    TTVESGSKGD HLNIAQITSL LGQQITEGQR VKPLLSNGKR TLPHYILKEE 900
    NNDTEHFHDL LEEYESQGFI SSSFAQGLNP KEFFFHCMAG RQGVCDTAMS 950
    TATSGYIMRR NVKLTEDIKV AYDGTVQDTR GRRFQMAYGE LGYDPSKLVK 1000
    VNGKPEVCNI ARLVNKLNCN FEDNIK 1026
    Length:1,026
    Mass (Da):116,963
    Last modified:June 1, 1998 - v1
    Checksum:iC66698CBCE18BC7B
    GO

    Sequence cautioni

    The sequence AAB33907.1 differs from that shown. Reason: Frameshift at position 39.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti452 – 4521I → N(PubMed:7698884)Curated
    Sequence conflicti452 – 4521I → N in AAB33907. (PubMed:8021587)Curated
    Sequence conflicti651 – 6522LT → N(PubMed:7698884)Curated
    Sequence conflicti651 – 6522LT → N in AAB33907. (PubMed:8021587)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S75674 Genomic DNA. Translation: AAB33907.1. Frameshift.
    AF303741 Genomic DNA. Translation: AAB94477.1.
    PIRiT03179.
    RefSeqiNP_149639.1. NC_003038.1.

    Genome annotation databases

    GeneIDi1733004.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S75674 Genomic DNA. Translation: AAB33907.1 . Frameshift.
    AF303741 Genomic DNA. Translation: AAB94477.1 .
    PIRi T03179.
    RefSeqi NP_149639.1. NC_003038.1.

    3D structure databases

    ProteinModelPortali O55766.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1733004.

    Family and domain databases

    InterProi IPR000722. RNA_pol_asu.
    IPR006592. RNA_pol_N.
    IPR007080. RNA_pol_Rpb1_1.
    IPR007066. RNA_pol_Rpb1_3.
    IPR007083. RNA_pol_Rpb1_4.
    IPR007081. RNA_pol_Rpb1_5.
    [Graphical view ]
    Pfami PF04997. RNA_pol_Rpb1_1. 2 hits.
    PF00623. RNA_pol_Rpb1_2. 2 hits.
    PF04983. RNA_pol_Rpb1_3. 1 hit.
    PF05000. RNA_pol_Rpb1_4. 1 hit.
    PF04998. RNA_pol_Rpb1_5. 1 hit.
    [Graphical view ]
    SMARTi SM00663. RPOLA_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the primary structure and the coding capacity of the genome of insect iridescent virus type 6 between the genome coordinates 0.310 and 0.347 (7990 bp)."
      Sonntag K.-C., Schnitzler P., Janssen W., Darai G.
      Intervirology 37:287-297(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Insect iridescent virus type 6 encodes a polypeptide related to the largest subunit of eukaryotic RNA polymerase II."
      Schnitzler P., Sonntag K.-C., Muller M., Janssen W., Bugert J.J., Koonin E.V., Darai G.
      J. Gen. Virol. 75:1557-1567(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Analysis of the first complete DNA sequence of an invertebrate iridovirus: coding strategy of the genome of Chilo iridescent virus."
      Jakob N.J., Mueller K., Bahr U., Darai G.
      Virology 286:182-196(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes."
      Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R.
      Virol. J. 4:11-11(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.

    Entry informationi

    Entry nameiRPB1_IIV6
    AccessioniPrimary (citable) accession number: O55766
    Secondary accession number(s): Q89506
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2009
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3