Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O55766

- RPB1_IIV6

UniProt

O55766 - RPB1_IIV6

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable DNA-directed RNA polymerase II subunit RPB1 homolog

Gene

IIV6-176R

Organism
Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Component of the DNA-dependent RNA polymerase that catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit By similarity.By similarity

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621Zinc 1By similarity
Metal bindingi65 – 651Zinc 1By similarity
Metal bindingi72 – 721Zinc 1By similarity
Metal bindingi75 – 751Zinc 1By similarity
Metal bindingi102 – 1021Zinc 2By similarity
Metal bindingi105 – 1051Zinc 2By similarity
Metal bindingi142 – 1421Zinc 2By similarity
Metal bindingi588 – 5881Magnesium; catalyticBy similarity
Metal bindingi590 – 5901Magnesium; catalyticBy similarity
Metal bindingi592 – 5921Magnesium; catalyticBy similarity

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. DNA-directed RNA polymerase activity Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA-directed RNA polymerase II subunit RPB1 homolog (EC:2.7.7.6)
Gene namesi
ORF Names:IIV6-176R
OrganismiInvertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
Taxonomic identifieri176652 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeIridovirus
Virus hostiAcheta domesticus (House cricket) [TaxID: 6997]
Chilo suppressalis (striped riceborer) [TaxID: 168631]
Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999]
Gryllus campestris [TaxID: 58607]
Spodoptera frugiperda (Fall armyworm) [TaxID: 7108]
ProteomesiUP000001359: Genome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10261026Probable DNA-directed RNA polymerase II subunit RPB1 homologPRO_0000377495Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO55766.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.Curated

Family and domain databases

InterProiIPR000722. RNA_pol_asu.
IPR006592. RNA_pol_N.
IPR007080. RNA_pol_Rpb1_1.
IPR007066. RNA_pol_Rpb1_3.
IPR007083. RNA_pol_Rpb1_4.
IPR007081. RNA_pol_Rpb1_5.
[Graphical view]
PfamiPF04997. RNA_pol_Rpb1_1. 2 hits.
PF00623. RNA_pol_Rpb1_2. 2 hits.
PF04983. RNA_pol_Rpb1_3. 1 hit.
PF05000. RNA_pol_Rpb1_4. 1 hit.
PF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view]
SMARTiSM00663. RPOLA_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O55766-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSANNNMESE IKEIESISFG MMSSEDIRQM SSFEVKTAKI SSTNLLETVH
60 70 80 90 100
DPKSGPIGSA PCETCHQNEW DCPGHFGHIE LNVPIIHPLF INHVVNILKI
110 120 130 140 150
FCWKCNEFLL TKDHLELNNI LKLEKEKKFN AVLEKIKKCD RCVHCTTPRA
160 170 180 190 200
DYKLVLNDIT YKTIYRTFSY QGGAVKTARD KKLNESREIV SAEMVKKIFD
210 220 230 240 250
NIKLEYVEML GISHPKDFCL EVFPVIPSCC RPHEVQDGNI NDDDLTYQLM
260 270 280 290 300
EIVKNNSMIG AIKLEKESME KQYPECLKVK EILLLSNVEK QKKEIDDFLK
310 320 330 340 350
KPIKNGLKTK KKINKEEITP LDQYLKLHDK YVKYVNNLKF RIETYCNNSQ
360 370 380 390 400
GKATHATTGR AIKGLRERLT GKEGQIRNNL LGKRCEMSAR TVIGPDPTLK
410 420 430 440 450
IDEVIVPKEI AQSLTFPDFV NKHNIDRLTK LVNSGNAIRL VKKNESGQEI
460 470 480 490 500
KINLAAAINN HGTPLQHDDI IKRPKITNNH EEKHNYEEKH NFDTFETIVI
510 520 530 540 550
KDPKNFVLKE GDILFRNNFQ QKVVLPSKKF IKLEEGWIVH RYLQNGDILV
560 570 580 590 600
LNRQPTLHKA SMMALRVKIM DVKTFKFNLA CTKPYNADFD GDEMNAHAPQ
610 620 630 640 650
SEESKAELFT LSTPKQCIMS CQSGKPNLTI VQDSLTGAYL MSKENNNDAT
660 670 680 690 700
LTNGEFNDIL MVLTQNDEYN GDVVDYFLKR KEDVSNTLKK LGFSGTVLNG
710 720 730 740 750
KGLLSLLFPN DLYINEEDLK INRGVIYDGC LTKKYLSSTE SSLIKILYKE
760 770 780 790 800
YGVETCATFL NNIQFLTNRW LMISSFSIHA GDCIKQKEVL GTVEQCLMES
810 820 830 840 850
EKIKMTTQNP FIREQKIMQT LSNAKDVGMK IAKDALKRDN VNLHAQNNFL
860 870 880 890 900
TTVESGSKGD HLNIAQITSL LGQQITEGQR VKPLLSNGKR TLPHYILKEE
910 920 930 940 950
NNDTEHFHDL LEEYESQGFI SSSFAQGLNP KEFFFHCMAG RQGVCDTAMS
960 970 980 990 1000
TATSGYIMRR NVKLTEDIKV AYDGTVQDTR GRRFQMAYGE LGYDPSKLVK
1010 1020
VNGKPEVCNI ARLVNKLNCN FEDNIK
Length:1,026
Mass (Da):116,963
Last modified:June 1, 1998 - v1
Checksum:iC66698CBCE18BC7B
GO

Sequence cautioni

The sequence AAB33907.1 differs from that shown. Reason: Frameshift at position 39.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti452 – 4521I → N(PubMed:7698884)Curated
Sequence conflicti452 – 4521I → N in AAB33907. (PubMed:8021587)Curated
Sequence conflicti651 – 6522LT → N(PubMed:7698884)Curated
Sequence conflicti651 – 6522LT → N in AAB33907. (PubMed:8021587)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S75674 Genomic DNA. Translation: AAB33907.1. Frameshift.
AF303741 Genomic DNA. Translation: AAB94477.1.
PIRiT03179.
RefSeqiNP_149639.1. NC_003038.1.

Genome annotation databases

GeneIDi1733004.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S75674 Genomic DNA. Translation: AAB33907.1 . Frameshift.
AF303741 Genomic DNA. Translation: AAB94477.1 .
PIRi T03179.
RefSeqi NP_149639.1. NC_003038.1.

3D structure databases

ProteinModelPortali O55766.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1733004.

Family and domain databases

InterProi IPR000722. RNA_pol_asu.
IPR006592. RNA_pol_N.
IPR007080. RNA_pol_Rpb1_1.
IPR007066. RNA_pol_Rpb1_3.
IPR007083. RNA_pol_Rpb1_4.
IPR007081. RNA_pol_Rpb1_5.
[Graphical view ]
Pfami PF04997. RNA_pol_Rpb1_1. 2 hits.
PF00623. RNA_pol_Rpb1_2. 2 hits.
PF04983. RNA_pol_Rpb1_3. 1 hit.
PF05000. RNA_pol_Rpb1_4. 1 hit.
PF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view ]
SMARTi SM00663. RPOLA_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the primary structure and the coding capacity of the genome of insect iridescent virus type 6 between the genome coordinates 0.310 and 0.347 (7990 bp)."
    Sonntag K.-C., Schnitzler P., Janssen W., Darai G.
    Intervirology 37:287-297(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Insect iridescent virus type 6 encodes a polypeptide related to the largest subunit of eukaryotic RNA polymerase II."
    Schnitzler P., Sonntag K.-C., Muller M., Janssen W., Bugert J.J., Koonin E.V., Darai G.
    J. Gen. Virol. 75:1557-1567(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Analysis of the first complete DNA sequence of an invertebrate iridovirus: coding strategy of the genome of Chilo iridescent virus."
    Jakob N.J., Mueller K., Bahr U., Darai G.
    Virology 286:182-196(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes."
    Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R.
    Virol. J. 4:11-11(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.

Entry informationi

Entry nameiRPB1_IIV6
AccessioniPrimary (citable) accession number: O55766
Secondary accession number(s): Q89506
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 1, 1998
Last modified: October 1, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3