Probable DNA-directed RNA polymerase II subunit RPB1 homolog - Invertebrate iridescent virus 6 (IIV-6)

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Reviewed, UniProtKB/Swiss-Prot O55766 (RPB1_IIV6)

Last modified September 22, 2009. Version 54. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
Probable DNA-directed RNA polymerase II subunit RPB1 homolog
EC=2.7.7.6

Gene names

ORF Names:

IIV6-176R

Organism

Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)

Taxonomic identifier

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Iridoviridae › Iridovirus

Virus host

Acheta domesticus (House cricket) [TaxID: 6997]
Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999]
Spodoptera frugiperda (Fall armyworm) [TaxID: 7108]
Gryllus campestris [TaxID: 58607]
Chilo suppressalis (striped riceborer) [TaxID: 168631]

Protein attributes

Sequence length	1026 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Component of the DNA-dependent RNA polymerase that catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit By similarity.
Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
Sequence similarities	Belongs to the RNA polymerase beta' chain family. Contains 1 C2H2-type zinc finger.
Sequence caution	The sequence AAB33907.1 differs from that shown. Reason: Frameshift at position 39.

Ontologies

Keywords
Biological process	Transcription
Cellular component	DNA-directed RNA polymerase
Domain	Zinc-finger
Ligand	Magnesium Metal-binding Zinc
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Virus reference strain
Gene Ontology (GO)
Biological process	transcription Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1026

Probable DNA-directed RNA polymerase II subunit RPB1 homolog

PRO_0000377495

Regions

Zinc finger

17

C2H2-type By similarity

Sites

Metal binding

1

Zinc 1 By similarity

Metal binding

1

Zinc 1 By similarity

Metal binding

1

Zinc 1 By similarity

Metal binding

1

Zinc 1 By similarity

Metal binding

1

Zinc 2 By similarity

Metal binding

1

Zinc 2 By similarity

Metal binding

1

Zinc 2 By similarity

Metal binding

1

Magnesium; catalytic By similarity

Metal binding

1

Magnesium; catalytic By similarity

Metal binding

1

Magnesium; catalytic By similarity

Experimental info

Sequence conflict

1

I → N Ref.1

Sequence conflict

1

I → N in AAB33907. Ref.2

Sequence conflict

2

LT → N Ref.1

Sequence conflict

2

LT → N in AAB33907. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

O55766-1 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: C66698CBCE18BC7B
Show »

1,026

116,963

        10         20         30         40         50         60 
MSANNNMESE IKEIESISFG MMSSEDIRQM SSFEVKTAKI SSTNLLETVH DPKSGPIGSA 

        70         80         90        100        110        120 
PCETCHQNEW DCPGHFGHIE LNVPIIHPLF INHVVNILKI FCWKCNEFLL TKDHLELNNI 

       130        140        150        160        170        180 
LKLEKEKKFN AVLEKIKKCD RCVHCTTPRA DYKLVLNDIT YKTIYRTFSY QGGAVKTARD 

       190        200        210        220        230        240 
KKLNESREIV SAEMVKKIFD NIKLEYVEML GISHPKDFCL EVFPVIPSCC RPHEVQDGNI 

       250        260        270        280        290        300 
NDDDLTYQLM EIVKNNSMIG AIKLEKESME KQYPECLKVK EILLLSNVEK QKKEIDDFLK 

       310        320        330        340        350        360 
KPIKNGLKTK KKINKEEITP LDQYLKLHDK YVKYVNNLKF RIETYCNNSQ GKATHATTGR 

       370        380        390        400        410        420 
AIKGLRERLT GKEGQIRNNL LGKRCEMSAR TVIGPDPTLK IDEVIVPKEI AQSLTFPDFV 

       430        440        450        460        470        480 
NKHNIDRLTK LVNSGNAIRL VKKNESGQEI KINLAAAINN HGTPLQHDDI IKRPKITNNH 

       490        500        510        520        530        540 
EEKHNYEEKH NFDTFETIVI KDPKNFVLKE GDILFRNNFQ QKVVLPSKKF IKLEEGWIVH 

       550        560        570        580        590        600 
RYLQNGDILV LNRQPTLHKA SMMALRVKIM DVKTFKFNLA CTKPYNADFD GDEMNAHAPQ 

       610        620        630        640        650        660 
SEESKAELFT LSTPKQCIMS CQSGKPNLTI VQDSLTGAYL MSKENNNDAT LTNGEFNDIL 

       670        680        690        700        710        720 
MVLTQNDEYN GDVVDYFLKR KEDVSNTLKK LGFSGTVLNG KGLLSLLFPN DLYINEEDLK 

       730        740        750        760        770        780 
INRGVIYDGC LTKKYLSSTE SSLIKILYKE YGVETCATFL NNIQFLTNRW LMISSFSIHA 

       790        800        810        820        830        840 
GDCIKQKEVL GTVEQCLMES EKIKMTTQNP FIREQKIMQT LSNAKDVGMK IAKDALKRDN 

       850        860        870        880        890        900 
VNLHAQNNFL TTVESGSKGD HLNIAQITSL LGQQITEGQR VKPLLSNGKR TLPHYILKEE 

       910        920        930        940        950        960 
NNDTEHFHDL LEEYESQGFI SSSFAQGLNP KEFFFHCMAG RQGVCDTAMS TATSGYIMRR 

       970        980        990       1000       1010       1020 
NVKLTEDIKV AYDGTVQDTR GRRFQMAYGE LGYDPSKLVK VNGKPEVCNI ARLVNKLNCN 


FEDNIK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of the primary structure and the coding capacity of the genome of insect iridescent virus type 6 between the genome coordinates 0.310 and 0.347 (7990 bp)." Sonntag K.-C., Schnitzler P., Janssen W., Darai G. Intervirology 37:287-297(1994) [PubMed: 7698884] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Insect iridescent virus type 6 encodes a polypeptide related to the largest subunit of eukaryotic RNA polymerase II." Schnitzler P., Sonntag K.-C., Muller M., Janssen W., Bugert J.J., Koonin E.V., Darai G. J. Gen. Virol. 75:1557-1567(1994) [PubMed: 8021587] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Analysis of the first complete DNA sequence of an invertebrate iridovirus: coding strategy of the genome of Chilo iridescent virus." Jakob N.J., Mueller K., Bahr U., Darai G. Virology 286:182-196(2001) [PubMed: 11448171] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes." Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R. Virol. J. 4:11-11(2007) [PubMed: 17239238] [Abstract] Cited for: GENOME REANNOTATION.

Cross-references

Sequence databases
	S75674 Genomic DNA. Translation: AAB33907.1. Frameshift. AF303741 Genomic DNA. Translation: AAB94477.1.
PIR	T03179.
RefSeq	NP_149639.1.
3D structure databases
HSSP	HSSP built from PDB template 1I6H based on UniProtKB P04050.
ModBase	Search...
Genome annotation databases
GeneID	1733004.
Family and domain databases
InterPro	IPR000722. RNA_pol_asu. IPR006592. RNA_pol_N. IPR007080. RNA_pol_Rpb1_1. IPR007066. RNA_pol_Rpb1_3. IPR007083. RNA_pol_Rpb1_4. IPR007081. RNA_pol_Rpb1_5. [Graphical view]
Gene3D	G3DSA:2.40.40.30. RNA_pol_A. 1 hit. G3DSA:3.90.1120.10. RNA_pol_Rpb1_1. 1 hit.
Pfam	PF04997. RNA_pol_Rpb1_1. 2 hits. PF00623. RNA_pol_Rpb1_2. 1 hit. PF04983. RNA_pol_Rpb1_3. 1 hit. PF05000. RNA_pol_Rpb1_4. 1 hit. PF04998. RNA_pol_Rpb1_5. 1 hit. [Graphical view]
SMART	SM00663. RPOLA_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RPB1_IIV6

Accession

Primary (citable) accession number: O55766
Secondary accession number(s): Q89506

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2009
Last sequence update:	June 1, 1998
Last modified:	September 22, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents