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Protein

Probable DNA-directed RNA polymerase II subunit RPB1 homolog

Gene

IIV6-176R

Organism
Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the DNA-dependent RNA polymerase that catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit (By similarity).By similarity

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62Zinc 1By similarity1
Metal bindingi65Zinc 1By similarity1
Metal bindingi72Zinc 1By similarity1
Metal bindingi75Zinc 1By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi105Zinc 2By similarity1
Metal bindingi142Zinc 2By similarity1
Metal bindingi588Magnesium; catalyticBy similarity1
Metal bindingi590Magnesium; catalyticBy similarity1
Metal bindingi592Magnesium; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA-directed RNA polymerase II subunit RPB1 homolog (EC:2.7.7.6)
Gene namesi
ORF Names:IIV6-176R
OrganismiInvertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
Taxonomic identifieri176652 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeIridovirus
Virus hostiAcheta domesticus (House cricket) [TaxID: 6997]
Chilo suppressalis (Asiatic rice borer moth) [TaxID: 168631]
Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999]
Gryllus campestris [TaxID: 58607]
Spodoptera frugiperda (Fall armyworm) [TaxID: 7108]
Proteomesi
  • UP000001359 Componenti: Genome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003774951 – 1026Probable DNA-directed RNA polymerase II subunit RPB1 homologAdd BLAST1026

Structurei

3D structure databases

ProteinModelPortaliO55766.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.Curated

Phylogenomic databases

KOiK03006.

Family and domain databases

InterProiIPR000722. RNA_pol_asu.
IPR006592. RNA_pol_N.
IPR007080. RNA_pol_Rpb1_1.
IPR007066. RNA_pol_Rpb1_3.
IPR007083. RNA_pol_Rpb1_4.
IPR007081. RNA_pol_Rpb1_5.
[Graphical view]
PfamiPF04997. RNA_pol_Rpb1_1. 1 hit.
PF00623. RNA_pol_Rpb1_2. 2 hits.
PF04983. RNA_pol_Rpb1_3. 1 hit.
PF05000. RNA_pol_Rpb1_4. 1 hit.
PF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view]
SMARTiSM00663. RPOLA_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O55766-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSANNNMESE IKEIESISFG MMSSEDIRQM SSFEVKTAKI SSTNLLETVH
60 70 80 90 100
DPKSGPIGSA PCETCHQNEW DCPGHFGHIE LNVPIIHPLF INHVVNILKI
110 120 130 140 150
FCWKCNEFLL TKDHLELNNI LKLEKEKKFN AVLEKIKKCD RCVHCTTPRA
160 170 180 190 200
DYKLVLNDIT YKTIYRTFSY QGGAVKTARD KKLNESREIV SAEMVKKIFD
210 220 230 240 250
NIKLEYVEML GISHPKDFCL EVFPVIPSCC RPHEVQDGNI NDDDLTYQLM
260 270 280 290 300
EIVKNNSMIG AIKLEKESME KQYPECLKVK EILLLSNVEK QKKEIDDFLK
310 320 330 340 350
KPIKNGLKTK KKINKEEITP LDQYLKLHDK YVKYVNNLKF RIETYCNNSQ
360 370 380 390 400
GKATHATTGR AIKGLRERLT GKEGQIRNNL LGKRCEMSAR TVIGPDPTLK
410 420 430 440 450
IDEVIVPKEI AQSLTFPDFV NKHNIDRLTK LVNSGNAIRL VKKNESGQEI
460 470 480 490 500
KINLAAAINN HGTPLQHDDI IKRPKITNNH EEKHNYEEKH NFDTFETIVI
510 520 530 540 550
KDPKNFVLKE GDILFRNNFQ QKVVLPSKKF IKLEEGWIVH RYLQNGDILV
560 570 580 590 600
LNRQPTLHKA SMMALRVKIM DVKTFKFNLA CTKPYNADFD GDEMNAHAPQ
610 620 630 640 650
SEESKAELFT LSTPKQCIMS CQSGKPNLTI VQDSLTGAYL MSKENNNDAT
660 670 680 690 700
LTNGEFNDIL MVLTQNDEYN GDVVDYFLKR KEDVSNTLKK LGFSGTVLNG
710 720 730 740 750
KGLLSLLFPN DLYINEEDLK INRGVIYDGC LTKKYLSSTE SSLIKILYKE
760 770 780 790 800
YGVETCATFL NNIQFLTNRW LMISSFSIHA GDCIKQKEVL GTVEQCLMES
810 820 830 840 850
EKIKMTTQNP FIREQKIMQT LSNAKDVGMK IAKDALKRDN VNLHAQNNFL
860 870 880 890 900
TTVESGSKGD HLNIAQITSL LGQQITEGQR VKPLLSNGKR TLPHYILKEE
910 920 930 940 950
NNDTEHFHDL LEEYESQGFI SSSFAQGLNP KEFFFHCMAG RQGVCDTAMS
960 970 980 990 1000
TATSGYIMRR NVKLTEDIKV AYDGTVQDTR GRRFQMAYGE LGYDPSKLVK
1010 1020
VNGKPEVCNI ARLVNKLNCN FEDNIK
Length:1,026
Mass (Da):116,963
Last modified:June 1, 1998 - v1
Checksum:iC66698CBCE18BC7B
GO

Sequence cautioni

The sequence AAB33907 differs from that shown. Reason: Frameshift at position 39.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti452I → N (PubMed:7698884).Curated1
Sequence conflicti452I → N in AAB33907 (PubMed:8021587).Curated1
Sequence conflicti651 – 652LT → N (PubMed:7698884).Curated2
Sequence conflicti651 – 652LT → N in AAB33907 (PubMed:8021587).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75674 Genomic DNA. Translation: AAB33907.1. Frameshift.
AF303741 Genomic DNA. Translation: AAB94477.1.
PIRiT03179.
RefSeqiNP_149639.1. NC_003038.1.

Genome annotation databases

GeneIDi1733004.
KEGGivg:1733004.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75674 Genomic DNA. Translation: AAB33907.1. Frameshift.
AF303741 Genomic DNA. Translation: AAB94477.1.
PIRiT03179.
RefSeqiNP_149639.1. NC_003038.1.

3D structure databases

ProteinModelPortaliO55766.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1733004.
KEGGivg:1733004.

Phylogenomic databases

KOiK03006.

Family and domain databases

InterProiIPR000722. RNA_pol_asu.
IPR006592. RNA_pol_N.
IPR007080. RNA_pol_Rpb1_1.
IPR007066. RNA_pol_Rpb1_3.
IPR007083. RNA_pol_Rpb1_4.
IPR007081. RNA_pol_Rpb1_5.
[Graphical view]
PfamiPF04997. RNA_pol_Rpb1_1. 1 hit.
PF00623. RNA_pol_Rpb1_2. 2 hits.
PF04983. RNA_pol_Rpb1_3. 1 hit.
PF05000. RNA_pol_Rpb1_4. 1 hit.
PF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view]
SMARTiSM00663. RPOLA_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPB1_IIV6
AccessioniPrimary (citable) accession number: O55766
Secondary accession number(s): Q89506
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 1, 1998
Last modified: October 5, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.