Reviewed,
UniProtKB/Swiss-Prot O55716 (RIR1_IIV6)
Last modified
July 28, 2009.
Version 54.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ribonucleoside-diphosphate reductase large subunit EC=1.17.4.1 Alternative name(s): Ribonucleotide reductase large subunit Cleaved into the following chain: 1- Recommended name: IIV-6 RIR1 intein | ||
| Gene names |
| ||
| Organism | Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus) | ||
| Taxonomic identifier | 176652 [NCBI] | ||
| Taxonomic lineage | Viruses › dsDNA viruses, no RNA stage › Iridoviridae › Iridovirus | ||
| Virus host | Acheta domesticus (House cricket) [TaxID: 6997] Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999] Spodoptera frugiperda (Fall armyworm) [TaxID: 7108] Gryllus campestris [TaxID: 58607] Chilo suppressalis (striped riceborer) [TaxID: 168631] |
Protein attributes
| Sequence length | 959 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity. |
| Catalytic activity | 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. |
| Pathway | |
| Subunit structure | Heterodimer of a large and a small chain By similarity. |
| Sequence similarities | Belongs to the ribonucleoside diphosphate reductase large chain family. Contains 1 DOD-type homing endonuclease domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | DNA replication |
| Molecular function | Oxidoreductase |
| PTM | Autocatalytic cleavage Protein splicing |
| Technical term | Complete proteome Virus reference strain |
| Gene Ontology (GO) | |
| Biological process | DNA replication Inferred from electronic annotation. Source: UniProtKB-KW intein-mediated protein splicingInferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | ribonucleoside-diphosphate reductase complex Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: InterPro endonuclease activityInferred from electronic annotation. Source: InterPro protein bindingInferred from electronic annotation. Source: InterPro ribonucleoside-diphosphate reductase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 271 | 271 | Ribonucleoside-diphosphate reductase large subunit, 1st part | PRO_0000376951 | |||||
| Chain | 272 – 611 | 340 | IIV-6 RIR1 intein Potential | PRO_0000376952 | |||||
| Chain | 612 – 959 | 348 | Ribonucleoside-diphosphate reductase large subunit, 2nd part | PRO_0000377536 | |||||
Regions | |||||||||
| Domain | 378 – 508 | 131 | DOD-type homing endonuclease | ||||||
Sites | |||||||||
| Active site | 84 | 1 | Hydrogen atom transfer By similarity | ||||||
| Active site | 270 | 1 | Proton acceptor By similarity | ||||||
| Active site | 611 | 1 | Proton acceptor By similarity | ||||||
| Active site | 613 | 1 | Proton acceptor By similarity | ||||||
| Active site | 626 | 1 | Hydrogen atom transfer By similarity | ||||||
| Active site | 890 | 1 | Electron transfer By similarity | ||||||
| Active site | 891 | 1 | Electron transfer By similarity | ||||||
| Site | 91 | 1 | Allosteric effector binding By similarity | ||||||
| Site | 120 | 1 | Allosteric effector binding By similarity | ||||||
| Site | 955 | 1 | Interacts with thioredoxin/glutaredoxin By similarity | ||||||
| Site | 958 | 1 | Interacts with thioredoxin/glutaredoxin By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Analysis of the first complete DNA sequence of an invertebrate iridovirus: coding strategy of the genome of Chilo iridescent virus." Jakob N.J., Mueller K., Bahr U., Darai G. Virology 286:182-196(2001) [PubMed: 11448171] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | "Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes." Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R. Virol. J. 4:11-11(2007) [PubMed: 17239238] [Abstract] Cited for: GENOME REANNOTATION. |
Cross-references
Sequence databases | |
|---|---|
| AF303741 Genomic DNA. Translation: AAB94427.1. | |
| PIR | T03053. |
| RefSeq | NP_149548.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1733256. |
Family and domain databases | |
| InterPro | IPR003586. Hedgehog_hint_C. IPR003587. Hedgehog_hint_N. IPR006142. INTEIN. IPR004042. Intein_endonuc. IPR006141. Intein_splicing_site. IPR013509. Ribncl_Rdtase_lsu_N. IPR000788. Ribncl_red_lg_C. [Graphical view] |
| PANTHER | PTHR11573. Ribncl_red_lg_C. 1 hit. |
| Pfam | PF02867. Ribonuc_red_lgC. 4 hits. PF00317. Ribonuc_red_lgN. 1 hit. [Graphical view] |
| PRINTS | PR00379. INTEIN. |
| SMART | SM00305. HintC. 1 hit. SM00306. HintN. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01445. intein_Nterm. 1 hit. |
| PROSITE | PS50818. INTEIN_C_TER. False negative. PS50819. INTEIN_ENDONUCLEASE. 1 hit. PS50817. INTEIN_N_TER. 1 hit. PS00089. RIBORED_LARGE. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | RIR1_IIV6 | ||||||||
| Accession | Primary (citable) accession number: O55716 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Virus (Virus annotation project) | ||||||||
Relevant documents
| Intein-containing proteins List of intein-containing protein entries |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


