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Protein

Thymidine kinase

Gene

UL23

Organism
Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors.UniRule annotation

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. TMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:UL23Imported
OrganismiHuman herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)Imported
Taxonomic identifieri10298 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Structurei

3D structure databases

ProteinModelPortaliO55259.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae thymidine kinase family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

O55259-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASYPCHQHA SAFDQAARSR GHSNRRTALR PRRQQEATEV RPEQKMPTLL
60 70 80 90 100
RVYIDGPHGM GKTTTTQLLV ALGSRDDIVY VPEPMTYWRV LGASETIANI
110 120 130 140 150
YTTQHRLDQG EISAGDAAVV MTSAQITMGM PYAVTDAVLA PHIGGEAGSS
160 170 180 190 200
HAPPPALTLI FDRHPIAALL CYPAARYLMG SMTPQAVLAF VALIPPTLPG
210 220 230 240 250
TNIVLGALPE DRHIDRLAKR QRPGERLDLA MLAAIRRVYG LLANTVRYLQ
260 270 280 290 300
CGGSWREDWG QLSGTALTPQ GAEPQSNAGP RPHIGETLFT LFRAPELLAP
310 320 330 340 350
NGDLYNVFAW ALDVLAKRLR PMHVFILDYD QSPAGCRDAL LQLTSGMVQT
360 370
HVTTPGSIPT ICDLARTFAR EMGEAH
Length:376
Mass (Da):41,010
Last modified:October 1, 2001 - v2
Checksum:i9CCFAB1D218030BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ895546 Genomic DNA. Translation: AFU56940.1.
KM222720 Genomic DNA. Translation: AIR95818.1.
AB009254 Genomic DNA. Translation: BAA23729.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ895546 Genomic DNA. Translation: AFU56940.1.
KM222720 Genomic DNA. Translation: AIR95818.1.
AB009254 Genomic DNA. Translation: BAA23729.2.

3D structure databases

ProteinModelPortaliO55259.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Analysis of the relationship between cellular thymidine kinase activity and virulence of thymidine kinase-negative herpes simplex virus types 1 and 2."
    Suzutani T., Koyano S., Takada M., Yoshida I., Azuma M.
    Microbiol. Immunol. 39:787-794(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: VR-3Imported.
  2. Suzutani T.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: VR-3Imported.
  3. "Longitudinal study on oral shedding of herpes simplex virus 1 and varicella-zoster virus in individuals infected with HIV."
    van Velzen M., Ouwendijk W.J., Selke S., Pas S.D., van Loenen F.B., Osterhaus A.D., Wald A., Verjans G.M.
    J. Med. Virol. 85:1669-1677(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 5Imported.
  4. "Genome sequence of the anterograde-spread defective HSV-1 strain McIntyre."
    Szpara M.L., Tafuri Y., Parsons L., Engel E.A., Enquist L.W.
    Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MacIntyreImported.

Entry informationi

Entry nameiO55259_HHV1
AccessioniPrimary (citable) accession number: O55259
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: October 1, 2001
Last modified: March 4, 2015
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.