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O55259

- O55259_HHV1

UniProt

O55259 - O55259_HHV1

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Protein
Submitted name:

Thymidine kinase

Gene

UL23

Organism
Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. thymidine kinase activity Source: InterPro

GO - Biological processi

  1. TMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Thymidine kinaseImported
Submitted name:
UL23Imported
Gene namesi
Name:UL23Imported
OrganismiHuman herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)Imported
Taxonomic identifieri10298 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Family & Domainsi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

O55259-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MASYPCHQHA SAFDQAARSR GHSNRRTALR PRRQQEATEV RPEQKMPTLL
60 70 80 90 100
RVYIDGPHGM GKTTTTQLLV ALGSRDDIVY VPEPMTYWRV LGASETIANI
110 120 130 140 150
YTTQHRLDQG EISAGDAAVV MTSAQITMGM PYAVTDAVLA PHIGGEAGSS
160 170 180 190 200
HAPPPALTLI FDRHPIAALL CYPAARYLMG SMTPQAVLAF VALIPPTLPG
210 220 230 240 250
TNIVLGALPE DRHIDRLAKR QRPGERLDLA MLAAIRRVYG LLANTVRYLQ
260 270 280 290 300
CGGSWREDWG QLSGTALTPQ GAEPQSNAGP RPHIGETLFT LFRAPELLAP
310 320 330 340 350
NGDLYNVFAW ALDVLAKRLR PMHVFILDYD QSPAGCRDAL LQLTSGMVQT
360 370
HVTTPGSIPT ICDLARTFAR EMGEAH
Length:376
Mass (Da):41,010
Last modified:October 1, 2001 - v2
Checksum:i9CCFAB1D218030BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ895546 Genomic DNA. Translation: AFU56940.1.
KM222720 Genomic DNA. Translation: AIR95818.1.
AB009254 Genomic DNA. Translation: BAA23729.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ895546 Genomic DNA. Translation: AFU56940.1 .
KM222720 Genomic DNA. Translation: AIR95818.1 .
AB009254 Genomic DNA. Translation: BAA23729.2 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00693. Herpes_TK. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Analysis of the relationship between cellular thymidine kinase activity and virulence of thymidine kinase-negative herpes simplex virus types 1 and 2."
    Suzutani T., Koyano S., Takada M., Yoshida I., Azuma M.
    Microbiol. Immunol. 39:787-794(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: VR-3Imported.
  2. Suzutani T.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: VR-3Imported.
  3. "Longitudinal study on oral shedding of herpes simplex virus 1 and varicella-zoster virus in individuals infected with HIV."
    van Velzen M., Ouwendijk W.J., Selke S., Pas S.D., van Loenen F.B., Osterhaus A.D., Wald A., Verjans G.M.
    J. Med. Virol. 85:1669-1677(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 5Imported.
  4. "Genome sequence of the anterograde-spread defective HSV-1 strain McIntyre."
    Szpara M.L., Tafuri Y., Parsons L., Engel E.A., Enquist L.W.
    Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MacIntyreImported.

Entry informationi

Entry nameiO55259_HHV1
AccessioniPrimary (citable) accession number: O55259
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: October 1, 2001
Last modified: November 26, 2014
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)