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O55242

- SGMR1_MOUSE

UniProt

O55242 - SGMR1_MOUSE

Protein

Sigma non-opioid intracellular receptor 1

Gene

Sigmar1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration.6 Publications

    GO - Molecular functioni

    1. opioid receptor activity Source: Ensembl
    2. protein binding Source: IntAct
    3. receptor activity Source: MGI

    GO - Biological processi

    1. lipid transport Source: UniProtKB-KW
    2. nervous system development Source: Ensembl
    3. regulation of neuron apoptotic process Source: UniProtKB

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Lipid transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sigma non-opioid intracellular receptor 1
    Alternative name(s):
    Sigma 1-type opioid receptor
    Short name:
    Sigma1-receptor
    Short name:
    Sigma1R
    Gene namesi
    Name:Sigmar1
    Synonyms:Oprs1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1195268. Sigmar1.

    Subcellular locationi

    Nucleus inner membrane. Nucleus outer membrane. Endoplasmic reticulum membrane. Lipid droplet. Cell junction. Cell membrane. Cell projectiongrowth cone
    Note: Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand-binding.

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-SubCell
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. growth cone Source: UniProtKB-SubCell
    4. integral component of membrane Source: UniProtKB-KW
    5. lipid particle Source: UniProtKB-SubCell
    6. nuclear inner membrane Source: UniProtKB-SubCell
    7. nuclear outer membrane Source: UniProtKB-SubCell
    8. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Endoplasmic reticulum, Lipid droplet, Membrane, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Mice display decreased hypermotility response induced by (+)SKF-10047 challenge and reduced formalin-induced pain.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 223223Sigma non-opioid intracellular receptor 1PRO_0000268653Add
    BLAST

    Proteomic databases

    PaxDbiO55242.
    PRIDEiO55242.

    PTM databases

    PhosphoSiteiO55242.

    Expressioni

    Tissue specificityi

    Widely expressed with higher expression in liver, brain, kidney and thymus. Expressed throughout the brain with higher expression within cerebral cortex, hippocampus and cerebellum. Within the hippocampus expressed in cornu ammonis pyramidal neurons, the granular cells of the dentate gyrus as well as interneurons. Within the cerebellum, expressed in Purkinje cell bodies. Expressed by neural retina, retinal pigment epithelial cells and lens.4 Publications

    Gene expression databases

    ArrayExpressiO55242.
    BgeeiO55242.
    CleanExiMM_OPRS1.
    GenevestigatoriO55242.

    Interactioni

    Subunit structurei

    Interacts with KCNA4 By similarity. Forms a ternary complex with ANK2 and ITPR3. The complex is disrupted by agonists.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    I79_019946G3I8R93EBI-1557700,EBI-988311From a different organism.
    Kcna2P631413EBI-1557700,EBI-644033

    Protein-protein interaction databases

    IntActiO55242. 2 interactions.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 99CytoplasmicSequence Analysis
    Topological domaini31 – 8050ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini102 – 223122CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei81 – 10121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 87Targeting to lipid droplets
    Regioni118 – 14831Mediates ligand-bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ERG2 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG296707.
    GeneTreeiENSGT00390000012082.
    HOGENOMiHOG000211245.
    HOVERGENiHBG058220.
    InParanoidiO55242.
    OMAiFYTLRAY.
    OrthoDBiEOG7GFB5Z.
    PhylomeDBiO55242.
    TreeFamiTF300106.

    Family and domain databases

    InterProiIPR006716. ERG2_sigma1_rcpt-like.
    IPR028545. SIGMAR1.
    [Graphical view]
    PANTHERiPTHR10868. PTHR10868. 1 hit.
    PfamiPF04622. ERG2_Sigma1R. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O55242-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPWAAGRRWA WITLILTIIA VLIQAAWLWL GTQNFVFSRE EIAQLARQYA    50
    GLDHELAFSR LIVELRRLHP GHVLPDEELQ WVFVNAGGWM GAMCILHASL 100
    SEYVLLFGTA LGSHGHSGRY WAEISDTIIS GTFHQWKEGT TKSEVFYPGE 150
    TVVHGPGEAT ALEWGPNTWM VEYGRGVIPS TLFFALADTF FSTQDYLTLF 200
    YTLRAYARGL RLELTTYLFG QDS 223
    Length:223
    Mass (Da):25,250
    Last modified:June 1, 1998 - v1
    Checksum:i54BB2F14472E3512
    GO
    Isoform 2 (identifier: O55242-2) [UniParc]FASTAAdd to Basket

    Also known as: Beta

    The sequence of this isoform differs from the canonical sequence as follows:
         118-148: Missing.

    Show »
    Length:192
    Mass (Da):21,633
    Checksum:i6C75160BF446D3BC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti192 – 1921S → G in AAF64281. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei118 – 14831Missing in isoform 2. 1 PublicationVSP_021987Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030198 mRNA. Translation: AAC39951.1.
    AF030199 Genomic DNA. Translation: AAB97683.1.
    AF004927 mRNA. Translation: AAC33306.1.
    AF226605 mRNA. Translation: AAF64281.1.
    AK154300 mRNA. Translation: BAE32499.1.
    AK159886 mRNA. Translation: BAE35455.1.
    BC002000 mRNA. Translation: AAH02000.1.
    BC019930 mRNA. Translation: AAH19930.1.
    CCDSiCCDS18070.1. [O55242-1]
    CCDS71362.1. [O55242-2]
    PIRiJC5815.
    RefSeqiNP_001273467.1. NM_001286538.1.
    NP_001273468.1. NM_001286539.1. [O55242-2]
    NP_001273469.1. NM_001286540.1.
    NP_001273470.1. NM_001286541.1.
    NP_001273480.1. NM_001286551.1.
    NP_035144.1. NM_011014.3. [O55242-1]
    UniGeneiMm.425181.

    Genome annotation databases

    EnsembliENSMUST00000059354; ENSMUSP00000056027; ENSMUSG00000036078. [O55242-1]
    ENSMUST00000071561; ENSMUSP00000071492; ENSMUSG00000036078. [O55242-2]
    GeneIDi18391.
    KEGGimmu:18391.
    UCSCiuc008sjk.1. mouse. [O55242-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030198 mRNA. Translation: AAC39951.1 .
    AF030199 Genomic DNA. Translation: AAB97683.1 .
    AF004927 mRNA. Translation: AAC33306.1 .
    AF226605 mRNA. Translation: AAF64281.1 .
    AK154300 mRNA. Translation: BAE32499.1 .
    AK159886 mRNA. Translation: BAE35455.1 .
    BC002000 mRNA. Translation: AAH02000.1 .
    BC019930 mRNA. Translation: AAH19930.1 .
    CCDSi CCDS18070.1. [O55242-1 ]
    CCDS71362.1. [O55242-2 ]
    PIRi JC5815.
    RefSeqi NP_001273467.1. NM_001286538.1.
    NP_001273468.1. NM_001286539.1. [O55242-2 ]
    NP_001273469.1. NM_001286540.1.
    NP_001273470.1. NM_001286541.1.
    NP_001273480.1. NM_001286551.1.
    NP_035144.1. NM_011014.3. [O55242-1 ]
    UniGenei Mm.425181.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O55242. 2 interactions.

    Chemistry

    BindingDBi O55242.
    ChEMBLi CHEMBL3465.

    PTM databases

    PhosphoSitei O55242.

    Proteomic databases

    PaxDbi O55242.
    PRIDEi O55242.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000059354 ; ENSMUSP00000056027 ; ENSMUSG00000036078 . [O55242-1 ]
    ENSMUST00000071561 ; ENSMUSP00000071492 ; ENSMUSG00000036078 . [O55242-2 ]
    GeneIDi 18391.
    KEGGi mmu:18391.
    UCSCi uc008sjk.1. mouse. [O55242-1 ]

    Organism-specific databases

    CTDi 10280.
    MGIi MGI:1195268. Sigmar1.

    Phylogenomic databases

    eggNOGi NOG296707.
    GeneTreei ENSGT00390000012082.
    HOGENOMi HOG000211245.
    HOVERGENi HBG058220.
    InParanoidi O55242.
    OMAi FYTLRAY.
    OrthoDBi EOG7GFB5Z.
    PhylomeDBi O55242.
    TreeFami TF300106.

    Miscellaneous databases

    ChiTaRSi SIGMAR1. mouse.
    NextBioi 293992.
    PROi O55242.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O55242.
    Bgeei O55242.
    CleanExi MM_OPRS1.
    Genevestigatori O55242.

    Family and domain databases

    InterProi IPR006716. ERG2_sigma1_rcpt-like.
    IPR028545. SIGMAR1.
    [Graphical view ]
    PANTHERi PTHR10868. PTHR10868. 1 hit.
    Pfami PF04622. ERG2_Sigma1R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and structural analysis of the cDNA and the gene encoding the murine type 1 sigma receptor."
      Seth P., Leibach F.H., Ganapathy V.
      Biochem. Biophys. Res. Commun. 241:535-540(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), FUNCTION.
      Strain: 129/Sv and C57BL/6.
      Tissue: Kidney.
    2. "Cloning and characterization of a mouse sigma1 receptor."
      Pan Y.-X., Mei J., Xu J., Wan B.-L., Zuckerman A., Pasternak G.W.
      J. Neurochem. 70:2279-2285(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
      Strain: C57BL/6.
      Tissue: Brain.
    3. Wang L.-M., Shelness G.S., Childers S.R., Mach R.H., Wheeler K.T.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: C3H/HeJ.
      Tissue: Mammary gland.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J and NOD.
      Tissue: Dendritic cell and Osteoclast.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N.
      Tissue: Liver and Mammary tumor.
    6. "Expression of the purported sigma(1) (sigma(1)) receptor in the mammalian brain and its possible relevance in deficits induced by antagonism of the NMDA receptor complex as revealed using an antisense strategy."
      Kitaichi K., Chabot J.-G., Moebius F.F., Flandorfer A., Glossmann H., Quirion R.
      J. Chem. Neuroanat. 20:375-387(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. "Expression pattern of the type 1 sigma receptor in the brain and identity of critical anionic amino acid residues in the ligand-binding domain of the receptor."
      Seth P., Ganapathy M.E., Conway S.J., Bridges C.D., Smith S.B., Casellas P., Ganapathy V.
      Biochim. Biophys. Acta 1540:59-67(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    8. Cited for: TISSUE SPECIFICITY.
    9. "Regulating ankyrin dynamics: roles of sigma-1 receptors."
      Hayashi T., Su T.-P.
      Proc. Natl. Acad. Sci. U.S.A. 98:491-496(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ANK2 AND ITPR3, SUBCELLULAR LOCATION.
    10. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    11. "Sigma-1 receptors (sigma(1) binding sites) form raft-like microdomains and target lipid droplets on the endoplasmic reticulum: roles in endoplasmic reticulum lipid compartmentalization and export."
      Hayashi T., Su T.-P.
      J. Pharmacol. Exp. Ther. 306:718-725(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    12. "Involvement of kappa-opioid receptors and sigma receptors in memory function demonstrated using an antisense strategy."
      Hiramatsu M., Hoshino T.
      Brain Res. 1030:247-255(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    13. "Formalin-induced pain is reduced in sigma(1) receptor knockout mice."
      Cendan C.M., Pujalte J.M., Portillo-Salido E., Montoliu L., Baeyens J.M.
      Eur. J. Pharmacol. 511:73-74(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiSGMR1_MOUSE
    AccessioniPrimary (citable) accession number: O55242
    Secondary accession number(s): Q9JKU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Depletion by RNAi enhances kappa-type opioid receptor-mediated analgesia and prevents the memory-improving effects of (-)- and (+)-pentazocine.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3