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O55242

- SGMR1_MOUSE

UniProt

O55242 - SGMR1_MOUSE

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Protein

Sigma non-opioid intracellular receptor 1

Gene

Sigmar1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration.6 Publications

GO - Molecular functioni

  1. opioid receptor activity Source: Ensembl
  2. receptor activity Source: MGI

GO - Biological processi

  1. lipid transport Source: UniProtKB-KW
  2. nervous system development Source: Ensembl
  3. regulation of neuron apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sigma non-opioid intracellular receptor 1
Alternative name(s):
Sigma 1-type opioid receptor
Short name:
Sigma1-receptor
Short name:
Sigma1R
Gene namesi
Name:Sigmar1
Synonyms:Oprs1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1195268. Sigmar1.

Subcellular locationi

Nucleus inner membrane. Nucleus outer membrane. Endoplasmic reticulum membrane. Lipid droplet. Cell junction. Cell membrane. Cell projectiongrowth cone
Note: Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand-binding.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99CytoplasmicSequence Analysis
Transmembranei10 – 3021HelicalSequence AnalysisAdd
BLAST
Topological domaini31 – 8050ExtracellularSequence AnalysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence AnalysisAdd
BLAST
Topological domaini102 – 223122CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cell projection Source: UniProtKB-KW
  3. endoplasmic reticulum Source: UniProtKB-KW
  4. integral component of membrane Source: UniProtKB-KW
  5. lipid particle Source: UniProtKB-KW
  6. nuclear envelope Source: Ensembl
  7. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Endoplasmic reticulum, Lipid droplet, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice display decreased hypermotility response induced by (+)SKF-10047 challenge and reduced formalin-induced pain.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Sigma non-opioid intracellular receptor 1PRO_0000268653Add
BLAST

Proteomic databases

MaxQBiO55242.
PaxDbiO55242.
PRIDEiO55242.

PTM databases

PhosphoSiteiO55242.

Expressioni

Tissue specificityi

Widely expressed with higher expression in liver, brain, kidney and thymus. Expressed throughout the brain with higher expression within cerebral cortex, hippocampus and cerebellum. Within the hippocampus expressed in cornu ammonis pyramidal neurons, the granular cells of the dentate gyrus as well as interneurons. Within the cerebellum, expressed in Purkinje cell bodies. Expressed by neural retina, retinal pigment epithelial cells and lens.4 Publications

Gene expression databases

BgeeiO55242.
CleanExiMM_OPRS1.
ExpressionAtlasiO55242. baseline and differential.
GenevestigatoriO55242.

Interactioni

Subunit structurei

Interacts with KCNA4 (By similarity). Forms a ternary complex with ANK2 and ITPR3. The complex is disrupted by agonists.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
I79_019946G3I8R93EBI-1557700,EBI-988311From a different organism.
Kcna2P631413EBI-1557700,EBI-644033

Protein-protein interaction databases

IntActiO55242. 2 interactions.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 87Targeting to lipid droplets
Regioni118 – 14831Mediates ligand-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the ERG2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG296707.
GeneTreeiENSGT00390000012082.
HOGENOMiHOG000211245.
HOVERGENiHBG058220.
InParanoidiO55242.
OMAiFYTLRAY.
OrthoDBiEOG7GFB5Z.
PhylomeDBiO55242.
TreeFamiTF300106.

Family and domain databases

InterProiIPR006716. ERG2_sigma1_rcpt-like.
IPR028545. SIGMAR1.
[Graphical view]
PANTHERiPTHR10868. PTHR10868. 1 hit.
PfamiPF04622. ERG2_Sigma1R. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O55242-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPWAAGRRWA WITLILTIIA VLIQAAWLWL GTQNFVFSRE EIAQLARQYA
60 70 80 90 100
GLDHELAFSR LIVELRRLHP GHVLPDEELQ WVFVNAGGWM GAMCILHASL
110 120 130 140 150
SEYVLLFGTA LGSHGHSGRY WAEISDTIIS GTFHQWKEGT TKSEVFYPGE
160 170 180 190 200
TVVHGPGEAT ALEWGPNTWM VEYGRGVIPS TLFFALADTF FSTQDYLTLF
210 220
YTLRAYARGL RLELTTYLFG QDS
Length:223
Mass (Da):25,250
Last modified:June 1, 1998 - v1
Checksum:i54BB2F14472E3512
GO
Isoform 2 (identifier: O55242-2) [UniParc]FASTAAdd to Basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     118-148: Missing.

Show »
Length:192
Mass (Da):21,633
Checksum:i6C75160BF446D3BC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti192 – 1921S → G in AAF64281. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei118 – 14831Missing in isoform 2. 1 PublicationVSP_021987Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030198 mRNA. Translation: AAC39951.1.
AF030199 Genomic DNA. Translation: AAB97683.1.
AF004927 mRNA. Translation: AAC33306.1.
AF226605 mRNA. Translation: AAF64281.1.
AK154300 mRNA. Translation: BAE32499.1.
AK159886 mRNA. Translation: BAE35455.1.
BC002000 mRNA. Translation: AAH02000.1.
BC019930 mRNA. Translation: AAH19930.1.
CCDSiCCDS18070.1. [O55242-1]
CCDS71362.1. [O55242-2]
PIRiJC5815.
RefSeqiNP_001273467.1. NM_001286538.1.
NP_001273468.1. NM_001286539.1. [O55242-2]
NP_001273469.1. NM_001286540.1.
NP_001273470.1. NM_001286541.1.
NP_001273480.1. NM_001286551.1.
NP_035144.1. NM_011014.3. [O55242-1]
UniGeneiMm.425181.

Genome annotation databases

EnsembliENSMUST00000059354; ENSMUSP00000056027; ENSMUSG00000036078. [O55242-1]
ENSMUST00000071561; ENSMUSP00000071492; ENSMUSG00000036078. [O55242-2]
GeneIDi18391.
KEGGimmu:18391.
UCSCiuc008sjk.1. mouse. [O55242-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030198 mRNA. Translation: AAC39951.1 .
AF030199 Genomic DNA. Translation: AAB97683.1 .
AF004927 mRNA. Translation: AAC33306.1 .
AF226605 mRNA. Translation: AAF64281.1 .
AK154300 mRNA. Translation: BAE32499.1 .
AK159886 mRNA. Translation: BAE35455.1 .
BC002000 mRNA. Translation: AAH02000.1 .
BC019930 mRNA. Translation: AAH19930.1 .
CCDSi CCDS18070.1. [O55242-1 ]
CCDS71362.1. [O55242-2 ]
PIRi JC5815.
RefSeqi NP_001273467.1. NM_001286538.1.
NP_001273468.1. NM_001286539.1. [O55242-2 ]
NP_001273469.1. NM_001286540.1.
NP_001273470.1. NM_001286541.1.
NP_001273480.1. NM_001286551.1.
NP_035144.1. NM_011014.3. [O55242-1 ]
UniGenei Mm.425181.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O55242. 2 interactions.

Chemistry

BindingDBi O55242.
ChEMBLi CHEMBL2095192.

PTM databases

PhosphoSitei O55242.

Proteomic databases

MaxQBi O55242.
PaxDbi O55242.
PRIDEi O55242.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000059354 ; ENSMUSP00000056027 ; ENSMUSG00000036078 . [O55242-1 ]
ENSMUST00000071561 ; ENSMUSP00000071492 ; ENSMUSG00000036078 . [O55242-2 ]
GeneIDi 18391.
KEGGi mmu:18391.
UCSCi uc008sjk.1. mouse. [O55242-1 ]

Organism-specific databases

CTDi 10280.
MGIi MGI:1195268. Sigmar1.

Phylogenomic databases

eggNOGi NOG296707.
GeneTreei ENSGT00390000012082.
HOGENOMi HOG000211245.
HOVERGENi HBG058220.
InParanoidi O55242.
OMAi FYTLRAY.
OrthoDBi EOG7GFB5Z.
PhylomeDBi O55242.
TreeFami TF300106.

Miscellaneous databases

ChiTaRSi Sigmar1. mouse.
NextBioi 293992.
PROi O55242.
SOURCEi Search...

Gene expression databases

Bgeei O55242.
CleanExi MM_OPRS1.
ExpressionAtlasi O55242. baseline and differential.
Genevestigatori O55242.

Family and domain databases

InterProi IPR006716. ERG2_sigma1_rcpt-like.
IPR028545. SIGMAR1.
[Graphical view ]
PANTHERi PTHR10868. PTHR10868. 1 hit.
Pfami PF04622. ERG2_Sigma1R. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and structural analysis of the cDNA and the gene encoding the murine type 1 sigma receptor."
    Seth P., Leibach F.H., Ganapathy V.
    Biochem. Biophys. Res. Commun. 241:535-540(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), FUNCTION.
    Strain: 129/Sv and C57BL/6.
    Tissue: Kidney.
  2. "Cloning and characterization of a mouse sigma1 receptor."
    Pan Y.-X., Mei J., Xu J., Wan B.-L., Zuckerman A., Pasternak G.W.
    J. Neurochem. 70:2279-2285(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Brain.
  3. Wang L.-M., Shelness G.S., Childers S.R., Mach R.H., Wheeler K.T.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: C3H/HeJ.
    Tissue: Mammary gland.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J and NOD.
    Tissue: Dendritic cell and Osteoclast.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Liver and Mammary tumor.
  6. "Expression of the purported sigma(1) (sigma(1)) receptor in the mammalian brain and its possible relevance in deficits induced by antagonism of the NMDA receptor complex as revealed using an antisense strategy."
    Kitaichi K., Chabot J.-G., Moebius F.F., Flandorfer A., Glossmann H., Quirion R.
    J. Chem. Neuroanat. 20:375-387(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "Expression pattern of the type 1 sigma receptor in the brain and identity of critical anionic amino acid residues in the ligand-binding domain of the receptor."
    Seth P., Ganapathy M.E., Conway S.J., Bridges C.D., Smith S.B., Casellas P., Ganapathy V.
    Biochim. Biophys. Acta 1540:59-67(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. Cited for: TISSUE SPECIFICITY.
  9. "Regulating ankyrin dynamics: roles of sigma-1 receptors."
    Hayashi T., Su T.-P.
    Proc. Natl. Acad. Sci. U.S.A. 98:491-496(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ANK2 AND ITPR3, SUBCELLULAR LOCATION.
  10. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  11. "Sigma-1 receptors (sigma(1) binding sites) form raft-like microdomains and target lipid droplets on the endoplasmic reticulum: roles in endoplasmic reticulum lipid compartmentalization and export."
    Hayashi T., Su T.-P.
    J. Pharmacol. Exp. Ther. 306:718-725(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  12. "Involvement of kappa-opioid receptors and sigma receptors in memory function demonstrated using an antisense strategy."
    Hiramatsu M., Hoshino T.
    Brain Res. 1030:247-255(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. "Formalin-induced pain is reduced in sigma(1) receptor knockout mice."
    Cendan C.M., Pujalte J.M., Portillo-Salido E., Montoliu L., Baeyens J.M.
    Eur. J. Pharmacol. 511:73-74(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiSGMR1_MOUSE
AccessioniPrimary (citable) accession number: O55242
Secondary accession number(s): Q9JKU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 1998
Last modified: November 26, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Depletion by RNAi enhances kappa-type opioid receptor-mediated analgesia and prevents the memory-improving effects of (-)- and (+)-pentazocine.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3