Reviewed,
UniProtKB/Swiss-Prot O55241 (OREX_MOUSE)
Last modified
January 19, 2010.
Version 74.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Orexin Alternative name(s): Hypocretin Short name=Hcrt Cleaved into the following 2 chains: 1- Recommended name: Orexin-A Alternative name(s): Hypocretin-1 Short name=Hcrt1 2- Recommended name: Orexin-B Alternative name(s): Hypocretin-2 Short name=Hcrt2 | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 130 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. |
| Subcellular location | Rough endoplasmic reticulum By similarity. Cytoplasmic vesicle By similarity. Cell junction › synapse By similarity. Note: Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses By similarity. |
| Tissue specificity | Restricted to neuronal cell bodies of the dorsal and lateral hypothalamus. |
| Post-translational modification | Specific enzymatic cleavages at paired basic residues yield the different active peptides. |
| Sequence similarities | Belongs to the orexin family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell junction Cytoplasmic vesicle Endoplasmic reticulum Synapse |
| Domain | Signal |
| Molecular function | Neuropeptide |
| PTM | Amidation Cleavage on pair of basic residues Disulfide bond Pyrrolidone carboxylic acid |
| Gene Ontology (GO) | |
| Biological process | neuropeptide signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cell junction Inferred from electronic annotation. Source: UniProtKB-KW perinuclear region of cytoplasmInferred from direct assay. Source: MGI rough endoplasmic reticulumInferred from electronic annotation. Source: UniProtKB-SubCell synapseInferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 32 | 32 | By similarity | ||||||||
| Peptide | 33 – 65 | 33 | Orexin-A | PRO_0000020264 | |||||||
| Peptide | 69 – 96 | 28 | Orexin-B | PRO_0000020265 | |||||||
| Propeptide | 97 – 130 | 34 | PRO_0000020266 | ||||||||
Amino acid modifications | |||||||||||
| Modified residue | 33 | 1 | Pyrrolidone carboxylic acid By similarity | ||||||||
| Modified residue | 65 | 1 | Leucine amide By similarity | ||||||||
| Modified residue | 96 | 1 | Methionine amide By similarity | ||||||||
| Disulfide bond | 38 ↔ 44 | By similarity | |||||||||
| Disulfide bond | 39 ↔ 46 | By similarity | |||||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF041242 mRNA. Translation: AAC40040.1. AF019566 mRNA. Translation: AAC02934.1. |
| IPI | IPI00116749. |
| RefSeq | NP_034540.1. |
| UniGene | Mm.10096 |
3D structure databases | |
| SMR | O55241. Positions 33-65, 71-96. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | O55241. |
Proteomic databases | |
| PRIDE | O55241. |
Genome annotation databases | |
| Ensembl | ENSMUST00000055083; ENSMUSP00000057578; ENSMUSG00000045471; Mus musculus. [Genome view] |
| GeneID | 15171. |
| KEGG | mmu:15171. |
| UCSC | uc007lmg.1. mouse. |
Organism-specific databases | |
| CTD | 15171. |
| MGI | MGI:1202306. Hcrt. |
Phylogenomic databases | |
| eggNOG | roNOG17366. |
| HOGENOM | HBG279250. |
| HOVERGEN | O55241. |
| InParanoid | O55241. |
| PhylomeDB | O55241. |
Gene expression databases | |
| ArrayExpress | O55241. |
| Bgee | O55241. |
| CleanEx | MM_HCRT. MM_PPOX. |
| Genevestigator | O55241. |
| GermOnline | ENSMUSG00000045471. Mus musculus. |
Family and domain databases | |
| InterPro | IPR001704. Orexin. [Graphical view] |
| PANTHER | PTHR15173. Orexin. 1 hit. |
| Pfam | PF02072. Orexin. 1 hit. [Graphical view] |
| PRINTS | PR01091. OREXINPP. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 287686. |
| SOURCE | Search... |
Entry information
| Entry name | OREX_MOUSE | ||||||||
| Accession | Primary (citable) accession number: O55241 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| Protein Spotlight Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


