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Protein

Orexin

Gene

Hcrt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiREACT_329572. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
REACT_347934. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Orexin
Alternative name(s):
Hypocretin
Short name:
Hcrt
Cleaved into the following 2 chains:
Alternative name(s):
Hypocretin-1
Short name:
Hcrt1
Alternative name(s):
Hypocretin-2
Short name:
Hcrt2
Gene namesi
Name:Hcrt
Synonyms:Ox, Ppox
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1202306. Hcrt.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endoplasmic reticulum, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232By similarityAdd
BLAST
Peptidei33 – 6533Orexin-APRO_0000020264Add
BLAST
Peptidei69 – 9628Orexin-BPRO_0000020265Add
BLAST
Propeptidei97 – 13034PRO_0000020266Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331Pyrrolidone carboxylic acidBy similarity
Disulfide bondi38 ↔ 44By similarity
Disulfide bondi39 ↔ 46By similarity
Modified residuei65 – 651Leucine amideBy similarity
Modified residuei96 – 961Methionine amideBy similarity

Post-translational modificationi

Specific enzymatic cleavages at paired basic residues yield the different active peptides.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PRIDEiO55241.

Expressioni

Tissue specificityi

Restricted to neuronal cell bodies of the dorsal and lateral hypothalamus.

Gene expression databases

BgeeiO55241.
CleanExiMM_HCRT.
MM_PPOX.
ExpressionAtlasiO55241. baseline.
GenevisibleiO55241. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057578.

Structurei

3D structure databases

ProteinModelPortaliO55241.
SMRiO55241. Positions 33-65, 71-96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the orexin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG70925.
GeneTreeiENSGT00390000014272.
HOGENOMiHOG000230990.
HOVERGENiHBG000256.
InParanoidiO55241.
KOiK05246.
OMAiKVSWATV.
PhylomeDBiO55241.
TreeFamiTF330756.

Family and domain databases

InterProiIPR001704. Orexin.
[Graphical view]
PANTHERiPTHR15173:SF2. PTHR15173:SF2. 1 hit.
PfamiPF02072. Orexin. 1 hit.
[Graphical view]
PIRSFiPIRSF037824. Orexin. 1 hit.
PRINTSiPR01091. OREXINPP.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55241-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFPSTKVPW AAVTLLLLLL LPPALLSLGV DAQPLPDCCR QKTCSCRLYE
60 70 80 90 100
LLHGAGNHAA GILTLGKRRP GPPGLQGRLQ RLLQANGNHA AGILTMGRRA
110 120 130
GAELEPHPCS GRGCPTVTTT ALAPRGGSGV
Length:130
Mass (Da):13,503
Last modified:June 1, 1998 - v1
Checksum:iD3C223F9EE835F1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041242 mRNA. Translation: AAC40040.1.
AF019566 mRNA. Translation: AAC02934.1.
CCDSiCCDS25436.1.
RefSeqiNP_034540.1. NM_010410.2.
UniGeneiMm.10096.

Genome annotation databases

EnsembliENSMUST00000055083; ENSMUSP00000057578; ENSMUSG00000045471.
GeneIDi15171.
KEGGimmu:15171.
UCSCiuc007lmg.1. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

Qui dort dine - Issue 15 of October 2001

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041242 mRNA. Translation: AAC40040.1.
AF019566 mRNA. Translation: AAC02934.1.
CCDSiCCDS25436.1.
RefSeqiNP_034540.1. NM_010410.2.
UniGeneiMm.10096.

3D structure databases

ProteinModelPortaliO55241.
SMRiO55241. Positions 33-65, 71-96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057578.

Proteomic databases

PRIDEiO55241.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055083; ENSMUSP00000057578; ENSMUSG00000045471.
GeneIDi15171.
KEGGimmu:15171.
UCSCiuc007lmg.1. mouse.

Organism-specific databases

CTDi3060.
MGIiMGI:1202306. Hcrt.

Phylogenomic databases

eggNOGiNOG70925.
GeneTreeiENSGT00390000014272.
HOGENOMiHOG000230990.
HOVERGENiHBG000256.
InParanoidiO55241.
KOiK05246.
OMAiKVSWATV.
PhylomeDBiO55241.
TreeFamiTF330756.

Enzyme and pathway databases

ReactomeiREACT_329572. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
REACT_347934. G alpha (q) signalling events.

Miscellaneous databases

NextBioi287686.
PROiO55241.
SOURCEiSearch...

Gene expression databases

BgeeiO55241.
CleanExiMM_HCRT.
MM_PPOX.
ExpressionAtlasiO55241. baseline.
GenevisibleiO55241. MM.

Family and domain databases

InterProiIPR001704. Orexin.
[Graphical view]
PANTHERiPTHR15173:SF2. PTHR15173:SF2. 1 hit.
PfamiPF02072. Orexin. 1 hit.
[Graphical view]
PIRSFiPIRSF037824. Orexin. 1 hit.
PRINTSiPR01091. OREXINPP.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  3. "Hypocretin/orexin, sleep and narcolepsy."
    Hungs M., Mignot E.
    Bioessays 23:397-408(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  4. "To eat or to sleep? Orexin in the regulation of feeding and wakefulness."
    Willie J.T., Chemelli R.M., Sinton C.M., Yanagisawa M.
    Annu. Rev. Neurosci. 24:429-458(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiOREX_MOUSE
AccessioniPrimary (citable) accession number: O55241
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: July 22, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.