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O55241

- OREX_MOUSE

UniProt

O55241 - OREX_MOUSE

Protein

Orexin

Gene

Hcrt

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.

    GO - Biological processi

    1. eating behavior Source: Ensembl
    2. negative regulation of DNA replication Source: Ensembl
    3. negative regulation of potassium ion transport Source: Ensembl
    4. negative regulation of transmission of nerve impulse Source: Ensembl
    5. neuropeptide signaling pathway Source: UniProtKB-KW
    6. phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
    7. positive regulation of calcium ion transport Source: Ensembl
    8. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    9. positive regulation of transmission of nerve impulse Source: Ensembl
    10. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
    11. regulation of excitatory postsynaptic membrane potential Source: Ensembl
    12. regulation of neurotransmitter secretion Source: Ensembl

    Keywords - Molecular functioni

    Neuropeptide

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orexin
    Alternative name(s):
    Hypocretin
    Short name:
    Hcrt
    Cleaved into the following 2 chains:
    Alternative name(s):
    Hypocretin-1
    Short name:
    Hcrt1
    Alternative name(s):
    Hypocretin-2
    Short name:
    Hcrt2
    Gene namesi
    Name:Hcrt
    Synonyms:Ox, Ppox
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1202306. Hcrt.

    Subcellular locationi

    Rough endoplasmic reticulum By similarity. Cytoplasmic vesicle By similarity. Cell junctionsynapse By similarity
    Note: Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. perinuclear region of cytoplasm Source: MGI
    3. rough endoplasmic reticulum Source: UniProtKB-SubCell
    4. secretory granule Source: Ensembl
    5. synapse Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasmic vesicle, Endoplasmic reticulum, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232By similarityAdd
    BLAST
    Peptidei33 – 6533Orexin-APRO_0000020264Add
    BLAST
    Peptidei69 – 9628Orexin-BPRO_0000020265Add
    BLAST
    Propeptidei97 – 13034PRO_0000020266Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei33 – 331Pyrrolidone carboxylic acidBy similarity
    Disulfide bondi38 ↔ 44By similarity
    Disulfide bondi39 ↔ 46By similarity
    Modified residuei65 – 651Leucine amideBy similarity
    Modified residuei96 – 961Methionine amideBy similarity

    Post-translational modificationi

    Specific enzymatic cleavages at paired basic residues yield the different active peptides.

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues, Disulfide bond, Pyrrolidone carboxylic acid

    Proteomic databases

    PRIDEiO55241.

    Expressioni

    Tissue specificityi

    Restricted to neuronal cell bodies of the dorsal and lateral hypothalamus.

    Gene expression databases

    BgeeiO55241.
    CleanExiMM_HCRT.
    MM_PPOX.
    GenevestigatoriO55241.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000057578.

    Structurei

    3D structure databases

    ProteinModelPortaliO55241.
    SMRiO55241. Positions 33-65, 71-96.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the orexin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG70925.
    HOGENOMiHOG000230990.
    HOVERGENiHBG000256.
    InParanoidiO55241.
    KOiK05246.
    OMAiELEPHPC.
    PhylomeDBiO55241.
    TreeFamiTF330756.

    Family and domain databases

    InterProiIPR001704. Orexin.
    [Graphical view]
    PANTHERiPTHR15173. PTHR15173. 1 hit.
    PfamiPF02072. Orexin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037824. Orexin. 1 hit.
    PRINTSiPR01091. OREXINPP.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O55241-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNFPSTKVPW AAVTLLLLLL LPPALLSLGV DAQPLPDCCR QKTCSCRLYE    50
    LLHGAGNHAA GILTLGKRRP GPPGLQGRLQ RLLQANGNHA AGILTMGRRA 100
    GAELEPHPCS GRGCPTVTTT ALAPRGGSGV 130
    Length:130
    Mass (Da):13,503
    Last modified:June 1, 1998 - v1
    Checksum:iD3C223F9EE835F1C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041242 mRNA. Translation: AAC40040.1.
    AF019566 mRNA. Translation: AAC02934.1.
    CCDSiCCDS25436.1.
    RefSeqiNP_034540.1. NM_010410.2.
    UniGeneiMm.10096.

    Genome annotation databases

    EnsembliENSMUST00000055083; ENSMUSP00000057578; ENSMUSG00000045471.
    GeneIDi15171.
    KEGGimmu:15171.
    UCSCiuc007lmg.1. mouse.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Qui dort dine - Issue 15 of October 2001

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041242 mRNA. Translation: AAC40040.1 .
    AF019566 mRNA. Translation: AAC02934.1 .
    CCDSi CCDS25436.1.
    RefSeqi NP_034540.1. NM_010410.2.
    UniGenei Mm.10096.

    3D structure databases

    ProteinModelPortali O55241.
    SMRi O55241. Positions 33-65, 71-96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000057578.

    Proteomic databases

    PRIDEi O55241.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000055083 ; ENSMUSP00000057578 ; ENSMUSG00000045471 .
    GeneIDi 15171.
    KEGGi mmu:15171.
    UCSCi uc007lmg.1. mouse.

    Organism-specific databases

    CTDi 3060.
    MGIi MGI:1202306. Hcrt.

    Phylogenomic databases

    eggNOGi NOG70925.
    HOGENOMi HOG000230990.
    HOVERGENi HBG000256.
    InParanoidi O55241.
    KOi K05246.
    OMAi ELEPHPC.
    PhylomeDBi O55241.
    TreeFami TF330756.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 287686.
    PROi O55241.
    SOURCEi Search...

    Gene expression databases

    Bgeei O55241.
    CleanExi MM_HCRT.
    MM_PPOX.
    Genevestigatori O55241.

    Family and domain databases

    InterProi IPR001704. Orexin.
    [Graphical view ]
    PANTHERi PTHR15173. PTHR15173. 1 hit.
    Pfami PF02072. Orexin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037824. Orexin. 1 hit.
    PRINTSi PR01091. OREXINPP.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    3. "Hypocretin/orexin, sleep and narcolepsy."
      Hungs M., Mignot E.
      Bioessays 23:397-408(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    4. "To eat or to sleep? Orexin in the regulation of feeding and wakefulness."
      Willie J.T., Chemelli R.M., Sinton C.M., Yanagisawa M.
      Annu. Rev. Neurosci. 24:429-458(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiOREX_MOUSE
    AccessioniPrimary (citable) accession number: O55241
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3