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O55241

- OREX_MOUSE

UniProt

O55241 - OREX_MOUSE

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Protein

Orexin

Gene

Hcrt

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.

GO - Biological processi

  1. eating behavior Source: Ensembl
  2. negative regulation of DNA replication Source: Ensembl
  3. negative regulation of potassium ion transport Source: Ensembl
  4. negative regulation of transmission of nerve impulse Source: Ensembl
  5. neuropeptide signaling pathway Source: UniProtKB-KW
  6. phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  7. positive regulation of calcium ion transport Source: Ensembl
  8. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  9. positive regulation of transmission of nerve impulse Source: Ensembl
  10. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  11. regulation of excitatory postsynaptic membrane potential Source: Ensembl
  12. regulation of neurotransmitter secretion Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Orexin
Alternative name(s):
Hypocretin
Short name:
Hcrt
Cleaved into the following 2 chains:
Alternative name(s):
Hypocretin-1
Short name:
Hcrt1
Alternative name(s):
Hypocretin-2
Short name:
Hcrt2
Gene namesi
Name:Hcrt
Synonyms:Ox, Ppox
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1202306. Hcrt.

Subcellular locationi

Rough endoplasmic reticulum By similarity. Cytoplasmic vesicle By similarity. Cell junctionsynapse By similarity
Note: Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses.By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. endoplasmic reticulum Source: UniProtKB-KW
  3. perinuclear region of cytoplasm Source: MGI
  4. secretory granule Source: Ensembl
  5. synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endoplasmic reticulum, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232By similarityAdd
BLAST
Peptidei33 – 6533Orexin-APRO_0000020264Add
BLAST
Peptidei69 – 9628Orexin-BPRO_0000020265Add
BLAST
Propeptidei97 – 13034PRO_0000020266Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331Pyrrolidone carboxylic acidBy similarity
Disulfide bondi38 ↔ 44By similarity
Disulfide bondi39 ↔ 46By similarity
Modified residuei65 – 651Leucine amideBy similarity
Modified residuei96 – 961Methionine amideBy similarity

Post-translational modificationi

Specific enzymatic cleavages at paired basic residues yield the different active peptides.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PRIDEiO55241.

Expressioni

Tissue specificityi

Restricted to neuronal cell bodies of the dorsal and lateral hypothalamus.

Gene expression databases

BgeeiO55241.
CleanExiMM_HCRT.
MM_PPOX.
ExpressionAtlasiO55241. baseline.
GenevestigatoriO55241.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057578.

Structurei

3D structure databases

ProteinModelPortaliO55241.
SMRiO55241. Positions 33-65, 71-96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the orexin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG70925.
HOGENOMiHOG000230990.
HOVERGENiHBG000256.
InParanoidiO55241.
KOiK05246.
OMAiELEPHPC.
PhylomeDBiO55241.
TreeFamiTF330756.

Family and domain databases

InterProiIPR001704. Orexin.
[Graphical view]
PANTHERiPTHR15173. PTHR15173. 1 hit.
PfamiPF02072. Orexin. 1 hit.
[Graphical view]
PIRSFiPIRSF037824. Orexin. 1 hit.
PRINTSiPR01091. OREXINPP.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55241 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNFPSTKVPW AAVTLLLLLL LPPALLSLGV DAQPLPDCCR QKTCSCRLYE
60 70 80 90 100
LLHGAGNHAA GILTLGKRRP GPPGLQGRLQ RLLQANGNHA AGILTMGRRA
110 120 130
GAELEPHPCS GRGCPTVTTT ALAPRGGSGV
Length:130
Mass (Da):13,503
Last modified:June 1, 1998 - v1
Checksum:iD3C223F9EE835F1C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF041242 mRNA. Translation: AAC40040.1.
AF019566 mRNA. Translation: AAC02934.1.
CCDSiCCDS25436.1.
RefSeqiNP_034540.1. NM_010410.2.
UniGeneiMm.10096.

Genome annotation databases

EnsembliENSMUST00000055083; ENSMUSP00000057578; ENSMUSG00000045471.
GeneIDi15171.
KEGGimmu:15171.
UCSCiuc007lmg.1. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

Qui dort dine - Issue 15 of October 2001

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF041242 mRNA. Translation: AAC40040.1 .
AF019566 mRNA. Translation: AAC02934.1 .
CCDSi CCDS25436.1.
RefSeqi NP_034540.1. NM_010410.2.
UniGenei Mm.10096.

3D structure databases

ProteinModelPortali O55241.
SMRi O55241. Positions 33-65, 71-96.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000057578.

Proteomic databases

PRIDEi O55241.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000055083 ; ENSMUSP00000057578 ; ENSMUSG00000045471 .
GeneIDi 15171.
KEGGi mmu:15171.
UCSCi uc007lmg.1. mouse.

Organism-specific databases

CTDi 3060.
MGIi MGI:1202306. Hcrt.

Phylogenomic databases

eggNOGi NOG70925.
HOGENOMi HOG000230990.
HOVERGENi HBG000256.
InParanoidi O55241.
KOi K05246.
OMAi ELEPHPC.
PhylomeDBi O55241.
TreeFami TF330756.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 287686.
PROi O55241.
SOURCEi Search...

Gene expression databases

Bgeei O55241.
CleanExi MM_HCRT.
MM_PPOX.
ExpressionAtlasi O55241. baseline.
Genevestigatori O55241.

Family and domain databases

InterProi IPR001704. Orexin.
[Graphical view ]
PANTHERi PTHR15173. PTHR15173. 1 hit.
Pfami PF02072. Orexin. 1 hit.
[Graphical view ]
PIRSFi PIRSF037824. Orexin. 1 hit.
PRINTSi PR01091. OREXINPP.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  3. "Hypocretin/orexin, sleep and narcolepsy."
    Hungs M., Mignot E.
    Bioessays 23:397-408(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  4. "To eat or to sleep? Orexin in the regulation of feeding and wakefulness."
    Willie J.T., Chemelli R.M., Sinton C.M., Yanagisawa M.
    Annu. Rev. Neurosci. 24:429-458(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiOREX_MOUSE
AccessioniPrimary (citable) accession number: O55241
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3