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Protein

CD70 antigen

Gene

Cd70

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-MMU-5669034. TNFs bind their physiological receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
CD70 antigen
Alternative name(s):
CD27 ligand
Short name:
CD27-L
Tumor necrosis factor ligand superfamily member 7
CD_antigen: CD70
Gene namesi
Name:Cd70
Synonyms:Cd27l, Cd27lg, Tnfsf7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1195273. Cd70.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23CytoplasmicSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini45 – 195ExtracellularSequence analysisAdd BLAST151

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854981 – 195CD70 antigenAdd BLAST195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi135 ↔ 153Sequence analysis
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO55237.
PRIDEiO55237.

PTM databases

PhosphoSitePlusiO55237.

Expressioni

Tissue specificityi

Very low level of expression. Detected in splenocytes and thymocytes.

Inductioni

By IL-2 and concanavalin A (Con A).

Gene expression databases

BgeeiENSMUSG00000019489.
CleanExiMM_CD70.
ExpressionAtlasiO55237. baseline and differential.
GenevisibleiO55237. MM.

Interactioni

Subunit structurei

Homotrimer.Curated

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019633.

Structurei

3D structure databases

ProteinModelPortaliO55237.
SMRiO55237.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY7F. Eukaryota.
ENOG41119T2. LUCA.
GeneTreeiENSGT00390000006744.
HOGENOMiHOG000070045.
HOVERGENiHBG054184.
InParanoidiO55237.
KOiK05470.
OMAiQVTLANC.
OrthoDBiEOG091G0QAO.
PhylomeDBiO55237.
TreeFamiTF338269.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiView protein in InterPro
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
PfamiView protein in Pfam
PF00229. TNF. 1 hit.
SMARTiView protein in SMART
SM00207. TNF. 1 hit.
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiView protein in PROSITE
PS50049. TNF_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O55237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEEGRPCPW VRWSGTAFQR QWPWLLLVVF ITVFCCWFHC SGLLSKQQQR
60 70 80 90 100
LLEHPEPHTA ELQLNLTVPR KDPTLRWGAG PALGRSFTHG PELEEGHLRI
110 120 130 140 150
HQDGLYRLHI QVTLANCSSP GSTLQHRATL AVGICSPAAH GISLLRGRFG
160 170 180 190
QDCTVALQRL TYLVHGDVLC TNLTLPLLPS RNADETFFGV QWICP
Length:195
Mass (Da):21,919
Last modified:June 1, 1998 - v1
Checksum:iBD14671A2C8E26C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13637, Y13638 Genomic DNA. Translation: CAA73977.1.
Y13636 mRNA. Translation: CAA73976.1.
U78091 mRNA. Translation: AAD00274.1.
CCDSiCCDS28927.1.
RefSeqiNP_035747.1. NM_011617.2.
UniGeneiMm.42228.

Genome annotation databases

EnsembliENSMUST00000019633; ENSMUSP00000019633; ENSMUSG00000019489.
GeneIDi21948.
KEGGimmu:21948.
UCSCiuc008dee.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiCD70_MOUSE
AccessioniPrimary (citable) accession number: O55237
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 1, 1998
Last modified: August 30, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families