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O55233

- CER1_MOUSE

UniProt

O55233 - CER1_MOUSE

Protein

Cerberus

Gene

Cer1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part, through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak.4 Publications

    GO - Molecular functioni

    1. morphogen activity Source: Ensembl
    2. protein homodimerization activity Source: BHF-UCL

    GO - Biological processi

    1. anterior/posterior axis specification Source: MGI
    2. anterior/posterior pattern specification Source: MGI
    3. bone mineralization Source: Ensembl
    4. cell migration involved in gastrulation Source: MGI
    5. cellular response to BMP stimulus Source: BHF-UCL
    6. determination of dorsal identity Source: Ensembl
    7. gastrulation Source: MGI
    8. growth plate cartilage chondrocyte proliferation Source: BHF-UCL
    9. negative regulation of activin receptor signaling pathway Source: BHF-UCL
    10. negative regulation of BMP signaling pathway Source: MGI
    11. negative regulation of cell proliferation Source: MGI
    12. negative regulation of mesoderm development Source: BHF-UCL
    13. nervous system development Source: Ensembl
    14. sequestering of BMP in extracellular matrix Source: BHF-UCL
    15. signal transduction involved in regulation of gene expression Source: MGI
    16. ureteric bud development Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine

    Enzyme and pathway databases

    ReactomeiREACT_199125. Regulation of signaling by NODAL.
    REACT_220505. Signaling by BMP.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cerberus
    Alternative name(s):
    Cerberus-like protein
    Short name:
    Cer-l
    Cerberus-related protein
    Gene namesi
    Name:Cer1
    Synonyms:Cerl, Cerr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1201414. Cer1.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: MGI
    2. extracellular space Source: BHF-UCL

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717By similarityAdd
    BLAST
    Chaini18 – 272255CerberusPRO_0000006712Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi162 ↔ 209PROSITE-ProRule annotation
    Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi176 ↔ 223PROSITE-ProRule annotation
    Disulfide bondi186 ↔ 239PROSITE-ProRule annotation
    Disulfide bondi190 ↔ 241PROSITE-ProRule annotation
    Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiO55233.

    PTM databases

    PhosphoSiteiO55233.

    Expressioni

    Developmental stagei

    At E6.5., early and mid-streak stage embryos, was expressed in the anterior visceral endoderm. The expression domain extended from the extraembryonic-embryonic junction to approximately two thirds of the way down the epiblast. By the mid-streak to late streak stage, expressed in the anterior visceral endoderm but was also expressed in the definitive endoderm emanating from the anterior portion of the primitive streak. By the neural plate stage at E7.5 expression was present throughout the anterior definitive endoderm layer including both the midline and anterior lateral endoderm. At the early headfold stage expression was reduced in the anterior lateral region and expression was seen primarily in the foregut endoderm. In early E8.5 embryos expression was restricted to the two most recently formed somites. In E9 and E9.5 embryos expression continued in the two newest formed somites and also in the anterior presomitic mesoderm.3 Publications

    Gene expression databases

    BgeeiO55233.
    CleanExiMM_CER1.
    GenevestigatoriO55233.

    Interactioni

    Subunit structurei

    Forms monomers and predominantly dimers.

    Protein-protein interaction databases

    BioGridi198677. 1 interaction.
    STRINGi10090.ENSMUSP00000102858.

    Structurei

    3D structure databases

    ProteinModelPortaliO55233.
    SMRiO55233. Positions 162-242.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini162 – 24685CTCKPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the DAN family.Curated
    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40714.
    GeneTreeiENSGT00530000063926.
    HOGENOMiHOG000231309.
    HOVERGENiHBG050902.
    InParanoidiO55233.
    KOiK01645.
    OMAiCFGKCGS.
    OrthoDBiEOG7VX8X6.
    PhylomeDBiO55233.
    TreeFamiTF106445.

    Family and domain databases

    InterProiIPR016860. Cerberus.
    IPR006207. Cys_knot_C.
    IPR004133. DAN.
    [Graphical view]
    PfamiPF03045. DAN. 1 hit.
    [Graphical view]
    PIRSFiPIRSF027807. Cerberus. 1 hit.
    SMARTiSM00041. CT. 1 hit.
    [Graphical view]
    PROSITEiPS01225. CTCK_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O55233-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHLLLVQLLV LLPLGKADLC VDGCQSQGSL SFPLLERGRR DLHVANHEEA    50
    EDKPDLFVAV PHLMGTSLAG EGQRQRGKML SRLGRFWKKP ETEFYPPRDV 100
    ESDHVSSGMQ AVTQPADGRK VERSPLQEEA KRFWHRFMFR KGPAFQGVIL 150
    PIKSHEVHWE TCRTVPFNQT IAHEDCQKVV VQNNLCFGKC SSIRFPGEGA 200
    DAHSFCSHCS PTKFTTVHLM LNCTSPTPVV KMVMQVEECQ CMVKTERGEE 250
    RLLLAGSQGS FIPGLPASKT NP 272
    Length:272
    Mass (Da):30,431
    Last modified:June 1, 1998 - v1
    Checksum:iDD0842A2619AF057
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti220 – 2201M → R in AAB71838. (PubMed:9431803)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF012244 Genomic DNA. Translation: AAB71838.1.
    AF035579 mRNA. Translation: AAC02430.1.
    AF031896 mRNA. Translation: AAC24461.1.
    CCDSiCCDS18295.1.
    RefSeqiNP_034017.1. NM_009887.2.
    UniGeneiMm.6780.

    Genome annotation databases

    EnsembliENSMUST00000048430; ENSMUSP00000048607; ENSMUSG00000038192.
    GeneIDi12622.
    KEGGimmu:12622.
    UCSCiuc008tkl.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF012244 Genomic DNA. Translation: AAB71838.1 .
    AF035579 mRNA. Translation: AAC02430.1 .
    AF031896 mRNA. Translation: AAC24461.1 .
    CCDSi CCDS18295.1.
    RefSeqi NP_034017.1. NM_009887.2.
    UniGenei Mm.6780.

    3D structure databases

    ProteinModelPortali O55233.
    SMRi O55233. Positions 162-242.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198677. 1 interaction.
    STRINGi 10090.ENSMUSP00000102858.

    PTM databases

    PhosphoSitei O55233.

    Proteomic databases

    PRIDEi O55233.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000048430 ; ENSMUSP00000048607 ; ENSMUSG00000038192 .
    GeneIDi 12622.
    KEGGi mmu:12622.
    UCSCi uc008tkl.2. mouse.

    Organism-specific databases

    CTDi 9350.
    MGIi MGI:1201414. Cer1.

    Phylogenomic databases

    eggNOGi NOG40714.
    GeneTreei ENSGT00530000063926.
    HOGENOMi HOG000231309.
    HOVERGENi HBG050902.
    InParanoidi O55233.
    KOi K01645.
    OMAi CFGKCGS.
    OrthoDBi EOG7VX8X6.
    PhylomeDBi O55233.
    TreeFami TF106445.

    Enzyme and pathway databases

    Reactomei REACT_199125. Regulation of signaling by NODAL.
    REACT_220505. Signaling by BMP.

    Miscellaneous databases

    NextBioi 281790.
    PROi O55233.
    SOURCEi Search...

    Gene expression databases

    Bgeei O55233.
    CleanExi MM_CER1.
    Genevestigatori O55233.

    Family and domain databases

    InterProi IPR016860. Cerberus.
    IPR006207. Cys_knot_C.
    IPR004133. DAN.
    [Graphical view ]
    Pfami PF03045. DAN. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF027807. Cerberus. 1 hit.
    SMARTi SM00041. CT. 1 hit.
    [Graphical view ]
    PROSITEi PS01225. CTCK_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula."
      Belo J.A., Bouwmeester T., Leyns L., Kertesz N., Gallo M., Follettie M., De Robertis E.M.
      Mech. Dev. 68:45-57(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
      Strain: 129/SvJ.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, GLYCOSYLATION.
    3. "Expression of the mouse cerberus-related gene, Cerr1, suggests a role in anterior neural induction and somitogenesis."
      Shawlot W., Deng J.M., Behringer R.R.
      Proc. Natl. Acad. Sci. U.S.A. 95:6198-6203(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
    4. "Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks."
      Perea-Gomez A., Vella F.D., Shawlot W., Oulad-Abdelghani M., Chazaud C., Meno C., Pfister V., Chen L., Robertson E., Hamada H., Behringer R.R., Ang S.L.
      Dev. Cell 3:745-756(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiCER1_MOUSE
    AccessioniPrimary (citable) accession number: O55233
    Secondary accession number(s): O35213
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3