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O55233

- CER1_MOUSE

UniProt

O55233 - CER1_MOUSE

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Protein

Cerberus

Gene

Cer1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part, through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak.4 Publications

GO - Molecular functioni

  1. morphogen activity Source: Ensembl
  2. protein homodimerization activity Source: BHF-UCL

GO - Biological processi

  1. anterior/posterior axis specification Source: MGI
  2. anterior/posterior pattern specification Source: MGI
  3. bone mineralization Source: Ensembl
  4. cell migration involved in gastrulation Source: MGI
  5. cellular response to BMP stimulus Source: BHF-UCL
  6. determination of dorsal identity Source: Ensembl
  7. gastrulation Source: MGI
  8. growth plate cartilage chondrocyte proliferation Source: BHF-UCL
  9. negative regulation of activin receptor signaling pathway Source: BHF-UCL
  10. negative regulation of BMP signaling pathway Source: MGI
  11. negative regulation of cell proliferation Source: MGI
  12. negative regulation of mesoderm development Source: BHF-UCL
  13. nervous system development Source: Ensembl
  14. sequestering of BMP in extracellular matrix Source: BHF-UCL
  15. signal transduction involved in regulation of gene expression Source: MGI
  16. ureteric bud development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

ReactomeiREACT_199125. Regulation of signaling by NODAL.
REACT_220505. Signaling by BMP.

Names & Taxonomyi

Protein namesi
Recommended name:
Cerberus
Alternative name(s):
Cerberus-like protein
Short name:
Cer-l
Cerberus-related protein
Gene namesi
Name:Cer1
Synonyms:Cerl, Cerr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1201414. Cer1.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: MGI
  2. extracellular space Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717By similarityAdd
BLAST
Chaini18 – 272255CerberusPRO_0000006712Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi162 ↔ 209PROSITE-ProRule annotation
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi176 ↔ 223PROSITE-ProRule annotation
Disulfide bondi186 ↔ 239PROSITE-ProRule annotation
Disulfide bondi190 ↔ 241PROSITE-ProRule annotation
Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO55233.

PTM databases

PhosphoSiteiO55233.

Expressioni

Developmental stagei

At E6.5., early and mid-streak stage embryos, was expressed in the anterior visceral endoderm. The expression domain extended from the extraembryonic-embryonic junction to approximately two thirds of the way down the epiblast. By the mid-streak to late streak stage, expressed in the anterior visceral endoderm but was also expressed in the definitive endoderm emanating from the anterior portion of the primitive streak. By the neural plate stage at E7.5 expression was present throughout the anterior definitive endoderm layer including both the midline and anterior lateral endoderm. At the early headfold stage expression was reduced in the anterior lateral region and expression was seen primarily in the foregut endoderm. In early E8.5 embryos expression was restricted to the two most recently formed somites. In E9 and E9.5 embryos expression continued in the two newest formed somites and also in the anterior presomitic mesoderm.3 Publications

Gene expression databases

BgeeiO55233.
CleanExiMM_CER1.
ExpressionAtlasiO55233. differential.
GenevestigatoriO55233.

Interactioni

Subunit structurei

Forms monomers and predominantly dimers.

Protein-protein interaction databases

BioGridi198677. 1 interaction.
STRINGi10090.ENSMUSP00000102858.

Structurei

3D structure databases

ProteinModelPortaliO55233.
SMRiO55233. Positions 162-242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini162 – 24685CTCKPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the DAN family.Curated
Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40714.
GeneTreeiENSGT00530000063926.
HOGENOMiHOG000231309.
HOVERGENiHBG050902.
InParanoidiO55233.
KOiK01645.
OMAiCFGKCGS.
OrthoDBiEOG7VX8X6.
PhylomeDBiO55233.
TreeFamiTF106445.

Family and domain databases

InterProiIPR016860. Cerberus.
IPR006207. Cys_knot_C.
IPR004133. DAN.
[Graphical view]
PfamiPF03045. DAN. 1 hit.
[Graphical view]
PIRSFiPIRSF027807. Cerberus. 1 hit.
SMARTiSM00041. CT. 1 hit.
[Graphical view]
PROSITEiPS01225. CTCK_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55233-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHLLLVQLLV LLPLGKADLC VDGCQSQGSL SFPLLERGRR DLHVANHEEA
60 70 80 90 100
EDKPDLFVAV PHLMGTSLAG EGQRQRGKML SRLGRFWKKP ETEFYPPRDV
110 120 130 140 150
ESDHVSSGMQ AVTQPADGRK VERSPLQEEA KRFWHRFMFR KGPAFQGVIL
160 170 180 190 200
PIKSHEVHWE TCRTVPFNQT IAHEDCQKVV VQNNLCFGKC SSIRFPGEGA
210 220 230 240 250
DAHSFCSHCS PTKFTTVHLM LNCTSPTPVV KMVMQVEECQ CMVKTERGEE
260 270
RLLLAGSQGS FIPGLPASKT NP
Length:272
Mass (Da):30,431
Last modified:June 1, 1998 - v1
Checksum:iDD0842A2619AF057
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti220 – 2201M → R in AAB71838. (PubMed:9431803)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF012244 Genomic DNA. Translation: AAB71838.1.
AF035579 mRNA. Translation: AAC02430.1.
AF031896 mRNA. Translation: AAC24461.1.
CCDSiCCDS18295.1.
RefSeqiNP_034017.1. NM_009887.2.
UniGeneiMm.6780.

Genome annotation databases

EnsembliENSMUST00000048430; ENSMUSP00000048607; ENSMUSG00000038192.
GeneIDi12622.
KEGGimmu:12622.
UCSCiuc008tkl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF012244 Genomic DNA. Translation: AAB71838.1 .
AF035579 mRNA. Translation: AAC02430.1 .
AF031896 mRNA. Translation: AAC24461.1 .
CCDSi CCDS18295.1.
RefSeqi NP_034017.1. NM_009887.2.
UniGenei Mm.6780.

3D structure databases

ProteinModelPortali O55233.
SMRi O55233. Positions 162-242.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198677. 1 interaction.
STRINGi 10090.ENSMUSP00000102858.

PTM databases

PhosphoSitei O55233.

Proteomic databases

PRIDEi O55233.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000048430 ; ENSMUSP00000048607 ; ENSMUSG00000038192 .
GeneIDi 12622.
KEGGi mmu:12622.
UCSCi uc008tkl.2. mouse.

Organism-specific databases

CTDi 9350.
MGIi MGI:1201414. Cer1.

Phylogenomic databases

eggNOGi NOG40714.
GeneTreei ENSGT00530000063926.
HOGENOMi HOG000231309.
HOVERGENi HBG050902.
InParanoidi O55233.
KOi K01645.
OMAi CFGKCGS.
OrthoDBi EOG7VX8X6.
PhylomeDBi O55233.
TreeFami TF106445.

Enzyme and pathway databases

Reactomei REACT_199125. Regulation of signaling by NODAL.
REACT_220505. Signaling by BMP.

Miscellaneous databases

NextBioi 281790.
PROi O55233.
SOURCEi Search...

Gene expression databases

Bgeei O55233.
CleanExi MM_CER1.
ExpressionAtlasi O55233. differential.
Genevestigatori O55233.

Family and domain databases

InterProi IPR016860. Cerberus.
IPR006207. Cys_knot_C.
IPR004133. DAN.
[Graphical view ]
Pfami PF03045. DAN. 1 hit.
[Graphical view ]
PIRSFi PIRSF027807. Cerberus. 1 hit.
SMARTi SM00041. CT. 1 hit.
[Graphical view ]
PROSITEi PS01225. CTCK_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula."
    Belo J.A., Bouwmeester T., Leyns L., Kertesz N., Gallo M., Follettie M., De Robertis E.M.
    Mech. Dev. 68:45-57(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
    Strain: 129/SvJ.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, GLYCOSYLATION.
  3. "Expression of the mouse cerberus-related gene, Cerr1, suggests a role in anterior neural induction and somitogenesis."
    Shawlot W., Deng J.M., Behringer R.R.
    Proc. Natl. Acad. Sci. U.S.A. 95:6198-6203(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
  4. "Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks."
    Perea-Gomez A., Vella F.D., Shawlot W., Oulad-Abdelghani M., Chazaud C., Meno C., Pfister V., Chen L., Robertson E., Hamada H., Behringer R.R., Ang S.L.
    Dev. Cell 3:745-756(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiCER1_MOUSE
AccessioniPrimary (citable) accession number: O55233
Secondary accession number(s): O35213
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3