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Protein

Chondroadherin

Gene

Chad

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha2beta1. May play an important role in the regulation of chondrocyte growth and proliferation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • bone development Source: MGI
  • cytokine-mediated signaling pathway Source: GO_Central
  • negative regulation of bone trabecula formation Source: MGI
  • negative regulation of JAK-STAT cascade Source: GO_Central
  • negative regulation of protein kinase activity Source: GO_Central
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Chondroadherin
Alternative name(s):
Cartilage leucine-rich protein
Gene namesi
Name:Chad
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1096866. Chad.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 358338ChondroadherinPRO_0000032774Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi22 ↔ 37By similarity
Glycosylationi143 – 1431O-linked (GalNAc...)Sequence analysis
Disulfide bondi303 ↔ 345By similarity
Disulfide bondi305 ↔ 325By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO55226.
PRIDEiO55226.

PTM databases

PhosphoSiteiO55226.

Expressioni

Tissue specificityi

Cartilage.

Gene expression databases

BgeeiENSMUSG00000039084.
CleanExiMM_CHAD.
ExpressionAtlasiO55226. baseline and differential.
GenevisibleiO55226. MM.

Interactioni

Subunit structurei

Mostly monomeric. Interacts with collagen type II (By similarity).By similarity

Protein-protein interaction databases

IntActiO55226. 1 interaction.
MINTiMINT-4090771.
STRINGi10090.ENSMUSP00000047844.

Structurei

3D structure databases

ProteinModelPortaliO55226.
SMRiO55226. Positions 22-348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 5030LRRNTAdd
BLAST
Repeati51 – 7222LRR 1Add
BLAST
Repeati75 – 9622LRR 2Add
BLAST
Repeati99 – 12022LRR 3Add
BLAST
Repeati123 – 14422LRR 4Add
BLAST
Repeati147 – 16822LRR 5Add
BLAST
Repeati171 – 19222LRR 6Add
BLAST
Repeati195 – 21622LRR 7Add
BLAST
Repeati219 – 24022LRR 8Add
BLAST
Repeati244 – 26522LRR 9Add
BLAST
Repeati268 – 28922LRR 10Add
BLAST
Domaini299 – 34749LRRCTAdd
BLAST

Sequence similaritiesi

Contains 10 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000013150.
HOVERGENiHBG005324.
InParanoidiO55226.
KOiK06248.
OMAiAFRGCKF.
OrthoDBiEOG091G0AYL.
PhylomeDBiO55226.
TreeFamiTF332659.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55226-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARALLFSLV FLAILLPALA ACPQNCHCHG DLQHVICDKV GLQKIPKVSE
60 70 80 90 100
TTKLLNLQRN NFPVLAANSF RTMPNLVSLH LQHCNIREVA AGAFRGLKQL
110 120 130 140 150
IYLYLSHNDI RVLRAGAFDD LTELTYLYLD HNKVSELPRG LLSPLVNLFI
160 170 180 190 200
LQLNNNKIRE LRAGAFQGAK DLRWLYLSEN ALSSLQPGSL DDVENLAKFH
210 220 230 240 250
LDKNQLSSYP SAALSKLRVV EELKLSHNPL KSIPDNAFQS FGRYLETLWL
260 270 280 290 300
DNTNLEKFSD AAFSGVTTLK HVHLDNNRLN QLPSSFPFDN LETLTLTNNP
310 320 330 340 350
WKCTCQLRGL RRWLEAKASR PDATCSSPAK FKGQRIRDTD ALRSCKSPTK

RSKKAGRH
Length:358
Mass (Da):40,349
Last modified:June 1, 1998 - v1
Checksum:i6A062FCEBF84A078
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96626 Genomic DNA. Translation: AAC39963.1.
BC012672 mRNA. Translation: AAH12672.1.
CCDSiCCDS25260.1.
RefSeqiNP_031715.1. NM_007689.4.
UniGeneiMm.440523.

Genome annotation databases

EnsembliENSMUST00000040418; ENSMUSP00000047844; ENSMUSG00000039084.
GeneIDi12643.
KEGGimmu:12643.
UCSCiuc007kzd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96626 Genomic DNA. Translation: AAC39963.1.
BC012672 mRNA. Translation: AAH12672.1.
CCDSiCCDS25260.1.
RefSeqiNP_031715.1. NM_007689.4.
UniGeneiMm.440523.

3D structure databases

ProteinModelPortaliO55226.
SMRiO55226. Positions 22-348.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO55226. 1 interaction.
MINTiMINT-4090771.
STRINGi10090.ENSMUSP00000047844.

PTM databases

PhosphoSiteiO55226.

Proteomic databases

PaxDbiO55226.
PRIDEiO55226.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040418; ENSMUSP00000047844; ENSMUSG00000039084.
GeneIDi12643.
KEGGimmu:12643.
UCSCiuc007kzd.1. mouse.

Organism-specific databases

CTDi1101.
MGIiMGI:1096866. Chad.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000013150.
HOVERGENiHBG005324.
InParanoidiO55226.
KOiK06248.
OMAiAFRGCKF.
OrthoDBiEOG091G0AYL.
PhylomeDBiO55226.
TreeFamiTF332659.

Miscellaneous databases

PROiO55226.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039084.
CleanExiMM_CHAD.
ExpressionAtlasiO55226. baseline and differential.
GenevisibleiO55226. MM.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHAD_MOUSE
AccessioniPrimary (citable) accession number: O55226
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.