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O55208

- FIGLA_MOUSE

UniProt

O55208 - FIGLA_MOUSE

Protein

Factor in the germline alpha

Gene

Figla

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Germ-line specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters.1 Publication

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: Ensembl
    2. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. oogenesis Source: UniProtKB-KW
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Oogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Factor in the germline alpha
    Short name:
    FIGalpha
    Alternative name(s):
    Transcription factor FIGa
    Gene namesi
    Name:Figla
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1349421. Figla.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Females display a defect in the formation of primordial follicles leading to infertility. Although embryonic gonadogenesis appeared normal, primordial follicles were not formed at birth, and massive depletion of oocytes resulted in shrunken ovaries and female sterility. Null females do not express ZP1, ZP2 or ZP3. Since its expression is oocyte-specific in females, Figla is a plausible candidate gene for primary ovarian failure in otherwise phenotypically normal women. The gene for Figla null males have normal fertility.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 194194Factor in the germline alphaPRO_0000127180Add
    BLAST

    Proteomic databases

    PRIDEiO55208.

    PTM databases

    PhosphoSiteiO55208.

    Expressioni

    Tissue specificityi

    Expressed only in the oocytes within the ovary and at lower level in the testis. Found in the resting oocytes of the primordial follicle cells, at the periphery of the ovary and in the hilar region. Also detected in growing oocytes, but at lower levels.

    Developmental stagei

    Detected as early as embryonic day 13, shortly after the onset of sexual dimorphism of the gonads. Dramatically increases at the end of the embryonic development and peaks at 2 dpp, a time in ovarian development at which oocytes have become enclosed in primordial follicles. Decreases markedly by 7 and 14 days after birth. Persists, but at low level, in adult females. Not detected in male embryos, but detected in adult testes.1 Publication

    Gene expression databases

    BgeeiO55208.
    CleanExiMM_FIGLA.
    GenevestigatoriO55208.

    Interactioni

    Subunit structurei

    Heterodimer with TCF3/isoform E12.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000032070.

    Structurei

    3D structure databases

    ProteinModelPortaliO55208.
    SMRiO55208. Positions 55-117.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini59 – 11153bHLHPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG316826.
    GeneTreeiENSGT00440000033552.
    HOGENOMiHOG000112589.
    HOVERGENiHBG051616.
    InParanoidiO55208.
    KOiK09066.
    OMAiSKKQDPD.
    OrthoDBiEOG7KH9MK.
    PhylomeDBiO55208.
    TreeFamiTF351992.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O55208-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTAPASPEP FLVTPQAEVL EELIQAQMGP LPRLAAICRL KRLPSGGYST    50
    TDDLHLVLER RRVANAKERE RIKNLNRGFA KLKALVPFLP QSRKPSKVDI 100
    LKGATEYIQI LGCVLEEAKV SEKQSPEEQT HSGRPSDPHV SSTRELLGNA 150
    TQPTSCASGL KKEEEGPWAY AGHSEPLYSY HQSTVPETRS YFTH 194
    Length:194
    Mass (Da):21,529
    Last modified:June 1, 1998 - v1
    Checksum:iB12137E37AF22723
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U91840 mRNA. Translation: AAB97139.1.
    CCDSiCCDS20307.1.
    RefSeqiNP_036143.1. NM_012013.1.
    UniGeneiMm.8024.

    Genome annotation databases

    EnsembliENSMUST00000032070; ENSMUSP00000032070; ENSMUSG00000030001.
    GeneIDi26910.
    KEGGimmu:26910.
    UCSCiuc009crb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U91840 mRNA. Translation: AAB97139.1 .
    CCDSi CCDS20307.1.
    RefSeqi NP_036143.1. NM_012013.1.
    UniGenei Mm.8024.

    3D structure databases

    ProteinModelPortali O55208.
    SMRi O55208. Positions 55-117.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000032070.

    PTM databases

    PhosphoSitei O55208.

    Proteomic databases

    PRIDEi O55208.

    Protocols and materials databases

    DNASUi 26910.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032070 ; ENSMUSP00000032070 ; ENSMUSG00000030001 .
    GeneIDi 26910.
    KEGGi mmu:26910.
    UCSCi uc009crb.1. mouse.

    Organism-specific databases

    CTDi 344018.
    MGIi MGI:1349421. Figla.

    Phylogenomic databases

    eggNOGi NOG316826.
    GeneTreei ENSGT00440000033552.
    HOGENOMi HOG000112589.
    HOVERGENi HBG051616.
    InParanoidi O55208.
    KOi K09066.
    OMAi SKKQDPD.
    OrthoDBi EOG7KH9MK.
    PhylomeDBi O55208.
    TreeFami TF351992.

    Miscellaneous databases

    NextBioi 304781.
    PROi O55208.
    SOURCEi Search...

    Gene expression databases

    Bgeei O55208.
    CleanExi MM_FIGLA.
    Genevestigatori O55208.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "FIGalpha, a germ cell specific transcription factor involved in the coordinate expression of the zona pellucida genes."
      Liang L.-F., Soyal S.M., Dean J.
      Development 124:4939-4947(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.
    2. "FIGalpha, a germ cell-specific transcription factor required for ovarian follicle formation."
      Soyal S.M., Amleh A., Dean J.
      Development 127:4645-4654(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DISRUPTION PHENOTYPE, FUNCTION, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiFIGLA_MOUSE
    AccessioniPrimary (citable) accession number: O55208
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3