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O55208 (FIGLA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Factor in the germline alpha

Short name=FIGalpha
Alternative name(s):
Transcription factor FIGa
Gene names
Name:Figla
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length194 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Germ-line specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters. Ref.2

Subunit structure

Heterodimer with TCF3/isoform E12

Subcellular location

Nucleus Probable.

Tissue specificity

Expressed only in the oocytes within the ovary and at lower level in the testis. Found in the resting oocytes of the primordial follicle cells, at the periphery of the ovary and in the hilar region. Also detected in growing oocytes, but at lower levels.

Developmental stage

Detected as early as embryonic day 13, shortly after the onset of sexual dimorphism of the gonads. Dramatically increases at the end of the embryonic development and peaks at 2 dpp, a time in ovarian development at which oocytes have become enclosed in primordial follicles. Decreases markedly by 7 and 14 days after birth. Persists, but at low level, in adult females. Not detected in male embryos, but detected in adult testes. Ref.2

Disruption phenotype

Females display a defect in the formation of primordial follicles leading to infertility. Although embryonic gonadogenesis appeared normal, primordial follicles were not formed at birth, and massive depletion of oocytes resulted in shrunken ovaries and female sterility. Null females do not express ZP1, ZP2 or ZP3. Since its expression is oocyte-specific in females, Figla is a plausible candidate gene for primary ovarian failure in otherwise phenotypically normal women. The gene for Figla null males have normal fertility. Ref.2

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 194194Factor in the germline alpha
PRO_0000127180

Regions

Domain59 – 11153bHLH

Sequences

Sequence LengthMass (Da)Tools
O55208 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: B12137E37AF22723

FASTA19421,529
        10         20         30         40         50         60 
MDTAPASPEP FLVTPQAEVL EELIQAQMGP LPRLAAICRL KRLPSGGYST TDDLHLVLER 

        70         80         90        100        110        120 
RRVANAKERE RIKNLNRGFA KLKALVPFLP QSRKPSKVDI LKGATEYIQI LGCVLEEAKV 

       130        140        150        160        170        180 
SEKQSPEEQT HSGRPSDPHV SSTRELLGNA TQPTSCASGL KKEEEGPWAY AGHSEPLYSY 

       190 
HQSTVPETRS YFTH 

« Hide

References

[1]"FIGalpha, a germ cell specific transcription factor involved in the coordinate expression of the zona pellucida genes."
Liang L.-F., Soyal S.M., Dean J.
Development 124:4939-4947(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.
[2]"FIGalpha, a germ cell-specific transcription factor required for ovarian follicle formation."
Soyal S.M., Amleh A., Dean J.
Development 127:4645-4654(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DISRUPTION PHENOTYPE, FUNCTION, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U91840 mRNA. Translation: AAB97139.1.
RefSeqNP_036143.1. NM_012013.1.
UniGeneMm.8024.

3D structure databases

ProteinModelPortalO55208.
SMRO55208. Positions 72-117.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000032070.

PTM databases

PhosphoSiteO55208.

Proteomic databases

PRIDEO55208.

Protocols and materials databases

DNASU26910.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032070; ENSMUSP00000032070; ENSMUSG00000030001.
GeneID26910.
KEGGmmu:26910.
UCSCuc009crb.1. mouse.

Organism-specific databases

CTD344018.
MGIMGI:1349421. Figla.

Phylogenomic databases

eggNOGNOG316826.
GeneTreeENSGT00440000033552.
HOGENOMHOG000112589.
HOVERGENHBG051616.
InParanoidO55208.
KOK09066.
OMAEEGPWAD.
OrthoDBEOG7KH9MK.
PhylomeDBO55208.
TreeFamTF351992.

Gene expression databases

BgeeO55208.
CleanExMM_FIGLA.
GenevestigatorO55208.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
[Graphical view]
PfamPF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio304781.
PROO55208.
SOURCESearch...

Entry information

Entry nameFIGLA_MOUSE
AccessionPrimary (citable) accession number: O55208
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 1998
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot