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Protein

Factor in the germline alpha

Gene

Figla

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Germ-line specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters.1 Publication

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  3. transcription factor binding Source: UniProtKB

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. oogenesis Source: UniProtKB-KW
  3. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Oogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Factor in the germline alpha
Short name:
FIGalpha
Alternative name(s):
Transcription factor FIGa
Gene namesi
Name:Figla
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1349421. Figla.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Females display a defect in the formation of primordial follicles leading to infertility. Although embryonic gonadogenesis appeared normal, primordial follicles were not formed at birth, and massive depletion of oocytes resulted in shrunken ovaries and female sterility. Null females do not express ZP1, ZP2 or ZP3. Since its expression is oocyte-specific in females, Figla is a plausible candidate gene for primary ovarian failure in otherwise phenotypically normal women. The gene for Figla null males have normal fertility.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194Factor in the germline alphaPRO_0000127180Add
BLAST

Proteomic databases

PRIDEiO55208.

PTM databases

PhosphoSiteiO55208.

Expressioni

Tissue specificityi

Expressed only in the oocytes within the ovary and at lower level in the testis. Found in the resting oocytes of the primordial follicle cells, at the periphery of the ovary and in the hilar region. Also detected in growing oocytes, but at lower levels.

Developmental stagei

Detected as early as embryonic day 13, shortly after the onset of sexual dimorphism of the gonads. Dramatically increases at the end of the embryonic development and peaks at 2 dpp, a time in ovarian development at which oocytes have become enclosed in primordial follicles. Decreases markedly by 7 and 14 days after birth. Persists, but at low level, in adult females. Not detected in male embryos, but detected in adult testes.1 Publication

Gene expression databases

BgeeiO55208.
CleanExiMM_FIGLA.
ExpressionAtlasiO55208. baseline and differential.
GenevestigatoriO55208.

Interactioni

Subunit structurei

Heterodimer with TCF3/isoform E12.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032070.

Structurei

3D structure databases

ProteinModelPortaliO55208.
SMRiO55208. Positions 55-117.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 11153bHLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG316826.
GeneTreeiENSGT00440000033552.
HOGENOMiHOG000112589.
HOVERGENiHBG051616.
InParanoidiO55208.
KOiK09066.
OMAiEEGPWAD.
OrthoDBiEOG7KH9MK.
PhylomeDBiO55208.
TreeFamiTF351992.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O55208-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTAPASPEP FLVTPQAEVL EELIQAQMGP LPRLAAICRL KRLPSGGYST
60 70 80 90 100
TDDLHLVLER RRVANAKERE RIKNLNRGFA KLKALVPFLP QSRKPSKVDI
110 120 130 140 150
LKGATEYIQI LGCVLEEAKV SEKQSPEEQT HSGRPSDPHV SSTRELLGNA
160 170 180 190
TQPTSCASGL KKEEEGPWAY AGHSEPLYSY HQSTVPETRS YFTH
Length:194
Mass (Da):21,529
Last modified:June 1, 1998 - v1
Checksum:iB12137E37AF22723
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91840 mRNA. Translation: AAB97139.1.
CCDSiCCDS20307.1.
RefSeqiNP_036143.1. NM_012013.1.
UniGeneiMm.8024.

Genome annotation databases

EnsembliENSMUST00000032070; ENSMUSP00000032070; ENSMUSG00000030001.
GeneIDi26910.
KEGGimmu:26910.
UCSCiuc009crb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91840 mRNA. Translation: AAB97139.1.
CCDSiCCDS20307.1.
RefSeqiNP_036143.1. NM_012013.1.
UniGeneiMm.8024.

3D structure databases

ProteinModelPortaliO55208.
SMRiO55208. Positions 55-117.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032070.

PTM databases

PhosphoSiteiO55208.

Proteomic databases

PRIDEiO55208.

Protocols and materials databases

DNASUi26910.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032070; ENSMUSP00000032070; ENSMUSG00000030001.
GeneIDi26910.
KEGGimmu:26910.
UCSCiuc009crb.1. mouse.

Organism-specific databases

CTDi344018.
MGIiMGI:1349421. Figla.

Phylogenomic databases

eggNOGiNOG316826.
GeneTreeiENSGT00440000033552.
HOGENOMiHOG000112589.
HOVERGENiHBG051616.
InParanoidiO55208.
KOiK09066.
OMAiEEGPWAD.
OrthoDBiEOG7KH9MK.
PhylomeDBiO55208.
TreeFamiTF351992.

Miscellaneous databases

NextBioi304781.
PROiO55208.
SOURCEiSearch...

Gene expression databases

BgeeiO55208.
CleanExiMM_FIGLA.
ExpressionAtlasiO55208. baseline and differential.
GenevestigatoriO55208.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "FIGalpha, a germ cell specific transcription factor involved in the coordinate expression of the zona pellucida genes."
    Liang L.-F., Soyal S.M., Dean J.
    Development 124:4939-4947(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.
  2. "FIGalpha, a germ cell-specific transcription factor required for ovarian follicle formation."
    Soyal S.M., Amleh A., Dean J.
    Development 127:4645-4654(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DISRUPTION PHENOTYPE, FUNCTION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiFIGLA_MOUSE
AccessioniPrimary (citable) accession number: O55208
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 1998
Last modified: February 4, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.