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Protein

C3a anaphylatoxin chemotactic receptor

Gene

C3ar1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

GO - Molecular functioni

  • C3a anaphylatoxin receptor activity Source: RGD
  • complement component C3a binding Source: RGD

GO - Biological processi

  • chemotaxis Source: UniProtKB-KW
  • complement receptor mediated signaling pathway Source: RGD
  • positive regulation of cell migration Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of DNA biosynthetic process Source: RGD
  • positive regulation of glomerular mesangial cell proliferation Source: RGD
  • positive regulation of smooth muscle cell proliferation Source: RGD
  • regulation of blood pressure Source: RGD
  • tolerance induction to nonself antigen Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C3a anaphylatoxin chemotactic receptor
Short name:
C3AR
Short name:
C3a-R
Gene namesi
Name:C3ar1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620537. C3ar1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence analysisAdd
BLAST
Transmembranei24 – 4623Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 5711CytoplasmicSequence analysisAdd
BLAST
Transmembranei58 – 8023Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini81 – 9616ExtracellularSequence analysisAdd
BLAST
Transmembranei97 – 11822Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini119 – 13921CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini161 – 329169ExtracellularSequence analysisAdd
BLAST
Transmembranei330 – 34920Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini350 – 36617CytoplasmicSequence analysisAdd
BLAST
Transmembranei367 – 38923Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini390 – 40617ExtracellularSequence analysisAdd
BLAST
Transmembranei407 – 42721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini428 – 47346CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473C3a anaphylatoxin chemotactic receptorPRO_0000069205Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence analysis
Disulfide bondi95 ↔ 172PROSITE-ProRule annotation
Modified residuei174 – 1741SulfotyrosineBy similarity
Modified residuei184 – 1841SulfotyrosineBy similarity
Glycosylationi201 – 2011N-linked (GlcNAc...)Sequence analysis
Modified residuei308 – 3081SulfotyrosineBy similarity
Modified residuei448 – 4481PhosphoserineBy similarity
Modified residuei452 – 4521PhosphothreonineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

PaxDbiO55197.
PRIDEiO55197.

PTM databases

PhosphoSiteiO55197.

Interactioni

GO - Molecular functioni

  • complement component C3a binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012216.

Structurei

3D structure databases

ProteinModelPortaliO55197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUVF. Eukaryota.
ENOG410YBJQ. LUCA.
HOGENOMiHOG000261616.
HOVERGENiHBG002433.
InParanoidiO55197.
KOiK04009.
PhylomeDBiO55197.

Family and domain databases

InterProiIPR001644. Anaphtx_C3AR1.
IPR002234. Anphylx_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 2 hits.
PTHR24225:SF28. PTHR24225:SF28. 2 hits.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR01104. ANPHYLATOXNR.
PR01060. C3ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O55197-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESFTADTNS TDLHSRPLFK PQDIASMVIL SLTCLLGLPG NGLVLWVAGV
60 70 80 90 100
KMKRTVNTVW FLHLTLADFL CCLSLPFSVA HLILRGHWPY GLFLCKLIPS
110 120 130 140 150
VIILNMFASV FLLTAISLDR CLMVHKPIWC QNHRSVRTAF AVCGCVWVVT
160 170 180 190 200
FVMCIPVFVY RDLLVVDDYS VCGYNFDSSR AYDYWDYMYN SHLPEINPPD
210 220 230 240 250
NSTGHVDDRT APSSSVPARD LWTATTALQS QTFHTSPEDP FSQDSASQQP
260 270 280 290 300
HYGGKPPTVL IATIPGGFPV EDHKSNTLNT GAFLSAHTEP SLTASSSPLY
310 320 330 340 350
AHDFPDDYFD QLMYGNHAWT PQVAITISRL VVGFLVPFFI MITCYSLIVF
360 370 380 390 400
RMRKTNLTKS RNKTLRVAVA VVTVFFVCWI PYHIVGILLV ITDQESALRE
410 420 430 440 450
VVLPWDHMSI ALASANSCFN PFLYALLGKD FRKKARQSVK GILEAAFSEE
460 470
LTHSTSCTQD KAPSKRNHMS TDV
Length:473
Mass (Da):52,896
Last modified:June 1, 1998 - v1
Checksum:i722F16F6F4B16451
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86379 mRNA. Translation: AAC40071.1.
PIRiJC5835.
RefSeqiNP_114449.1. NM_032060.1.
UniGeneiRn.226511.
Rn.9772.

Genome annotation databases

GeneIDi84007.
KEGGirno:84007.
UCSCiRGD:620537. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86379 mRNA. Translation: AAC40071.1.
PIRiJC5835.
RefSeqiNP_114449.1. NM_032060.1.
UniGeneiRn.226511.
Rn.9772.

3D structure databases

ProteinModelPortaliO55197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012216.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiO55197.

Proteomic databases

PaxDbiO55197.
PRIDEiO55197.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi84007.
KEGGirno:84007.
UCSCiRGD:620537. rat.

Organism-specific databases

CTDi719.
RGDi620537. C3ar1.

Phylogenomic databases

eggNOGiENOG410IUVF. Eukaryota.
ENOG410YBJQ. LUCA.
HOGENOMiHOG000261616.
HOVERGENiHBG002433.
InParanoidiO55197.
KOiK04009.
PhylomeDBiO55197.

Miscellaneous databases

PROiO55197.

Family and domain databases

InterProiIPR001644. Anaphtx_C3AR1.
IPR002234. Anphylx_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 2 hits.
PTHR24225:SF28. PTHR24225:SF28. 2 hits.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR01104. ANPHYLATOXNR.
PR01060. C3ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of rat C3a receptor: differential expression of rat C3a and C5a receptors by LPS stimulation."
    Fukuoka Y., Ember J.A., Hugli T.E.
    Biochem. Biophys. Res. Commun. 242:663-668(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Lung.

Entry informationi

Entry nameiC3AR_RAT
AccessioniPrimary (citable) accession number: O55197
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.