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Protein

C3a anaphylatoxin chemotactic receptor

Gene

C3ar1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

GO - Molecular functioni

  • complement component C3a binding Source: RGD
  • complement component C3a receptor activity Source: RGD
  • G-protein coupled receptor activity Source: GO_Central

GO - Biological processi

  • cell chemotaxis Source: GO_Central
  • complement receptor mediated signaling pathway Source: RGD
  • inflammatory response Source: GO_Central
  • leukocyte migration Source: GO_Central
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • positive regulation of cell migration Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of DNA biosynthetic process Source: RGD
  • positive regulation of glomerular mesangial cell proliferation Source: RGD
  • positive regulation of smooth muscle cell proliferation Source: RGD
  • regulation of blood pressure Source: RGD
  • tolerance induction to nonself antigen Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C3a anaphylatoxin chemotactic receptor
Short name:
C3AR
Short name:
C3a-R
Gene namesi
Name:C3ar1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620537 C3ar1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 46Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini47 – 57CytoplasmicSequence analysisAdd BLAST11
Transmembranei58 – 80Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini81 – 96ExtracellularSequence analysisAdd BLAST16
Transmembranei97 – 118Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini119 – 139CytoplasmicSequence analysisAdd BLAST21
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 329ExtracellularSequence analysisAdd BLAST169
Transmembranei330 – 349Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini350 – 366CytoplasmicSequence analysisAdd BLAST17
Transmembranei367 – 389Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini390 – 406ExtracellularSequence analysisAdd BLAST17
Transmembranei407 – 427Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini428 – 473CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692051 – 473C3a anaphylatoxin chemotactic receptorAdd BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 172PROSITE-ProRule annotation
Modified residuei174SulfotyrosineBy similarity1
Modified residuei184SulfotyrosineBy similarity1
Glycosylationi201N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei308SulfotyrosineBy similarity1
Modified residuei448PhosphoserineBy similarity1
Modified residuei452PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

PaxDbiO55197
PRIDEiO55197

PTM databases

PhosphoSitePlusiO55197

Interactioni

GO - Molecular functioni

  • complement component C3a binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012216

Structurei

3D structure databases

ProteinModelPortaliO55197
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUVF Eukaryota
ENOG410YBJQ LUCA
HOGENOMiHOG000261616
HOVERGENiHBG002433
InParanoidiO55197
KOiK04009
PhylomeDBiO55197

Family and domain databases

InterProiView protein in InterPro
IPR001644 Anaphtx_C3AR1
IPR002234 Anphylx_rcpt
IPR000826 Formyl_rcpt-rel
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24225 PTHR24225, 1 hit
PTHR24225:SF28 PTHR24225:SF28, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 2 hits
PRINTSiPR01104 ANPHYLATOXNR
PR01060 C3ANPHYLTXNR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O55197-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESFTADTNS TDLHSRPLFK PQDIASMVIL SLTCLLGLPG NGLVLWVAGV
60 70 80 90 100
KMKRTVNTVW FLHLTLADFL CCLSLPFSVA HLILRGHWPY GLFLCKLIPS
110 120 130 140 150
VIILNMFASV FLLTAISLDR CLMVHKPIWC QNHRSVRTAF AVCGCVWVVT
160 170 180 190 200
FVMCIPVFVY RDLLVVDDYS VCGYNFDSSR AYDYWDYMYN SHLPEINPPD
210 220 230 240 250
NSTGHVDDRT APSSSVPARD LWTATTALQS QTFHTSPEDP FSQDSASQQP
260 270 280 290 300
HYGGKPPTVL IATIPGGFPV EDHKSNTLNT GAFLSAHTEP SLTASSSPLY
310 320 330 340 350
AHDFPDDYFD QLMYGNHAWT PQVAITISRL VVGFLVPFFI MITCYSLIVF
360 370 380 390 400
RMRKTNLTKS RNKTLRVAVA VVTVFFVCWI PYHIVGILLV ITDQESALRE
410 420 430 440 450
VVLPWDHMSI ALASANSCFN PFLYALLGKD FRKKARQSVK GILEAAFSEE
460 470
LTHSTSCTQD KAPSKRNHMS TDV
Length:473
Mass (Da):52,896
Last modified:June 1, 1998 - v1
Checksum:i722F16F6F4B16451
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86379 mRNA Translation: AAC40071.1
PIRiJC5835
RefSeqiNP_114449.1, NM_032060.1
UniGeneiRn.226511
Rn.9772

Genome annotation databases

GeneIDi84007
KEGGirno:84007
UCSCiRGD:620537 rat

Similar proteinsi

Entry informationi

Entry nameiC3AR_RAT
AccessioniPrimary (citable) accession number: O55197
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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