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Protein

Enamelin

Gene

Enam

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation.By similarity

GO - Biological processi

  • amelogenesis Source: MGI
  • biomineral tissue development Source: UniProtKB-KW
  • odontogenesis of dentin-containing tooth Source: MGI
Complete GO annotation...

Keywords - Biological processi

Biomineralization

Names & Taxonomyi

Protein namesi
Recommended name:
Enamelin
Gene namesi
Name:Enam
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1333772. Enam.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3838Sequence AnalysisAdd
BLAST
Chaini39 – 12741236EnamelinPRO_0000021175Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
Modified residuei196 – 1961PhosphoserineBy similarity
Modified residuei219 – 2191PhosphoserineBy similarity
Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi259 – 2591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1066 – 10661N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Phosphorylated by FAM20C in vitro.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiO55196.

PTM databases

PhosphoSiteiO55196.

Expressioni

Tissue specificityi

Expressed in developing teeth.1 Publication

Gene expression databases

BgeeiO55196.
CleanExiMM_ENAM.
ExpressionAtlasiO55196. baseline and differential.
GenevisibleiO55196. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031222.

Structurei

3D structure databases

ProteinModelPortaliO55196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41206.
GeneTreeiENSGT00440000037826.
HOGENOMiHOG000112367.
HOVERGENiHBG005585.
InParanoidiO55196.
OMAiENSYYPR.
OrthoDBiEOG751NDP.
PhylomeDBiO55196.
TreeFamiTF337278.

Family and domain databases

InterProiIPR015673. Enamelin.
[Graphical view]
PANTHERiPTHR16784. PTHR16784. 1 hit.
PfamiPF15362. Enamelin. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55196-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLQCRNPT SPPKPCGLVP NVKMSLLVFL GLLGVSAAMP FQMPMPRMPG
60 70 80 90 100
FSSKSEEMMR YNQFNFMNAP PMMPMGPYGN GMPMPPHMPP QYPPYQMPMW
110 120 130 140 150
PPPVPNGWQQ PPMPNFPSKT DQTQETAKPN QTNPQEPQPQ KQPLKEPPNE
160 170 180 190 200
AARAKDDAQP PQPFPPFGNG LYPYPQPPWP IPQRGPPTAF GRPKFSNEEG
210 220 230 240 250
NPYYAFFGYH GFGGRPYYSE EMFEDYEKPK EKDPPKPEDP PPDDPPPEAS
260 270 280 290 300
TNSTVPDANA TQSIPEGGND TSPIGNTGPG PNAGNNPTVQ NGVFPPPKVN
310 320 330 340 350
VSGQGVPKSQ IPWRPSQPNI YENYPYPNYP SERQWQTTGT QGPRQNGPGY
360 370 380 390 400
RNPQVERGPQ WNSFAWEGKQ ATRPGNPTYG KPPSPTSGVN YAGNPVHFGR
410 420 430 440 450
NLPGPNKPFV GANPASNKPF VGANPASNKP FVGANPASNK PFVGANPASN
460 470 480 490 500
KPFVGANPAS NKPYVGANPA SNKPFIGANP AANKPSIGTN PAANKPSIGT
510 520 530 540 550
NPAANKPFVR NNVGANKPFV GTNPSSNQPF LRSNQASNKP FMRSNQASNK
560 570 580 590 600
PFVGTNVASV GPKQVTVSHN MKTQNPKEKS LGQKERTVTP TKDASNPWRS
610 620 630 640 650
AKQYGINNPN YNLPRSEGSM VGPNFNSFDQ QENSYFSKGA SKRVPSPNIQ
660 670 680 690 700
IQSQNLPKGI ALEPRRTPFQ SETKKPELKH GTHQPAYPKK IPSPTRKHFP
710 720 730 740 750
AERNTWNRQK ILPPLKEDYG RQDENLRHPS YGSRGNIFYH EYTNPYHNEK
760 770 780 790 800
SQYIKSNPWD KSSPSTMMRP ENPQYTMTSL DQKETEQYNE EDPIDPNEDE
810 820 830 840 850
SFPGQSRWGD EEMNFKGNPT VRQYEGEHYA STLAKEYLPY SLSNPPKPSE
860 870 880 890 900
DFPYSEFYPW NPQETFPIYN PGPTIAPPVD PRSYYVNNAI GQEESTLFPS
910 920 930 940 950
WTSWDHRNQA ERQKESEPYF NRNVWDQSIN LHKSNIPNHP YSTTSPARFP
960 970 980 990 1000
KDPTWFEGEN LNYDLQITSL SPPEREQLAF PDFLPQSYPT GQNEAHLFHQ
1010 1020 1030 1040 1050
SQRGSCCIGG STGHKDNVLA LQDYTSSYGL PPRKNQETSP VHTESSYIKY
1060 1070 1080 1090 1100
ARPNVSPASI LPSQRNISEN KLTAESPNPS PFGDGVPTVR KNTPYSGKNQ
1110 1120 1130 1140 1150
LETGIVAFSE ASSSQPKNTP CLKSDLGGDR RDVLKQFFEG SQLSERTAGL
1160 1170 1180 1190 1200
TPEQLVIGIP DKGSGPDSIQ SEVQGKEGEM QQQRPPTIMK LPCFGSNSKF
1210 1220 1230 1240 1250
HSSTTGPPIN NRRPTLLNGA LSTPTESPNT LVGLATREQL KSINVDKLNA
1260 1270
DEHTTLESFQ GTSPQDQGCL LLQA
Length:1,274
Mass (Da):140,954
Last modified:June 1, 1998 - v1
Checksum:iF9DBD1CC9D327143
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82698 mRNA. Translation: AAB94312.1.
CCDSiCCDS19400.1.
PIRiT37193.
RefSeqiNP_059496.1. NM_017468.3.
UniGeneiMm.8014.

Genome annotation databases

EnsembliENSMUST00000031222; ENSMUSP00000031222; ENSMUSG00000029286.
GeneIDi13801.
KEGGimmu:13801.
UCSCiuc008xzt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82698 mRNA. Translation: AAB94312.1.
CCDSiCCDS19400.1.
PIRiT37193.
RefSeqiNP_059496.1. NM_017468.3.
UniGeneiMm.8014.

3D structure databases

ProteinModelPortaliO55196.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031222.

PTM databases

PhosphoSiteiO55196.

Proteomic databases

PRIDEiO55196.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031222; ENSMUSP00000031222; ENSMUSG00000029286.
GeneIDi13801.
KEGGimmu:13801.
UCSCiuc008xzt.2. mouse.

Organism-specific databases

CTDi10117.
MGIiMGI:1333772. Enam.

Phylogenomic databases

eggNOGiNOG41206.
GeneTreeiENSGT00440000037826.
HOGENOMiHOG000112367.
HOVERGENiHBG005585.
InParanoidiO55196.
OMAiENSYYPR.
OrthoDBiEOG751NDP.
PhylomeDBiO55196.
TreeFamiTF337278.

Miscellaneous databases

NextBioi284568.
PROiO55196.
SOURCEiSearch...

Gene expression databases

BgeeiO55196.
CleanExiMM_ENAM.
ExpressionAtlasiO55196. baseline and differential.
GenevisibleiO55196. MM.

Family and domain databases

InterProiIPR015673. Enamelin.
[Graphical view]
PANTHERiPTHR16784. PTHR16784. 1 hit.
PfamiPF15362. Enamelin. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Swiss Webster.
    Tissue: Enamel epithelium.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.

Entry informationi

Entry nameiENAM_MOUSE
AccessioniPrimary (citable) accession number: O55196
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: July 22, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.