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O55196 (ENAM_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Enamelin
Gene names
Name:Enam
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1274 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Tissue specificity

Expressed in developing teeth.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3838 Potential
Chain39 – 12741236Enamelin
PRO_0000021175

Amino acid modifications

Modified residue1961Phosphoserine By similarity
Modified residue2191Phosphoserine By similarity
Glycosylation1301N-linked (GlcNAc...) Potential
Glycosylation2521N-linked (GlcNAc...) Potential
Glycosylation2591N-linked (GlcNAc...) Potential
Glycosylation2691N-linked (GlcNAc...) Potential
Glycosylation3001N-linked (GlcNAc...) Potential
Glycosylation10661N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O55196 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: F9DBD1CC9D327143

FASTA1,274140,954
        10         20         30         40         50         60 
MLLLQCRNPT SPPKPCGLVP NVKMSLLVFL GLLGVSAAMP FQMPMPRMPG FSSKSEEMMR 

        70         80         90        100        110        120 
YNQFNFMNAP PMMPMGPYGN GMPMPPHMPP QYPPYQMPMW PPPVPNGWQQ PPMPNFPSKT 

       130        140        150        160        170        180 
DQTQETAKPN QTNPQEPQPQ KQPLKEPPNE AARAKDDAQP PQPFPPFGNG LYPYPQPPWP 

       190        200        210        220        230        240 
IPQRGPPTAF GRPKFSNEEG NPYYAFFGYH GFGGRPYYSE EMFEDYEKPK EKDPPKPEDP 

       250        260        270        280        290        300 
PPDDPPPEAS TNSTVPDANA TQSIPEGGND TSPIGNTGPG PNAGNNPTVQ NGVFPPPKVN 

       310        320        330        340        350        360 
VSGQGVPKSQ IPWRPSQPNI YENYPYPNYP SERQWQTTGT QGPRQNGPGY RNPQVERGPQ 

       370        380        390        400        410        420 
WNSFAWEGKQ ATRPGNPTYG KPPSPTSGVN YAGNPVHFGR NLPGPNKPFV GANPASNKPF 

       430        440        450        460        470        480 
VGANPASNKP FVGANPASNK PFVGANPASN KPFVGANPAS NKPYVGANPA SNKPFIGANP 

       490        500        510        520        530        540 
AANKPSIGTN PAANKPSIGT NPAANKPFVR NNVGANKPFV GTNPSSNQPF LRSNQASNKP 

       550        560        570        580        590        600 
FMRSNQASNK PFVGTNVASV GPKQVTVSHN MKTQNPKEKS LGQKERTVTP TKDASNPWRS 

       610        620        630        640        650        660 
AKQYGINNPN YNLPRSEGSM VGPNFNSFDQ QENSYFSKGA SKRVPSPNIQ IQSQNLPKGI 

       670        680        690        700        710        720 
ALEPRRTPFQ SETKKPELKH GTHQPAYPKK IPSPTRKHFP AERNTWNRQK ILPPLKEDYG 

       730        740        750        760        770        780 
RQDENLRHPS YGSRGNIFYH EYTNPYHNEK SQYIKSNPWD KSSPSTMMRP ENPQYTMTSL 

       790        800        810        820        830        840 
DQKETEQYNE EDPIDPNEDE SFPGQSRWGD EEMNFKGNPT VRQYEGEHYA STLAKEYLPY 

       850        860        870        880        890        900 
SLSNPPKPSE DFPYSEFYPW NPQETFPIYN PGPTIAPPVD PRSYYVNNAI GQEESTLFPS 

       910        920        930        940        950        960 
WTSWDHRNQA ERQKESEPYF NRNVWDQSIN LHKSNIPNHP YSTTSPARFP KDPTWFEGEN 

       970        980        990       1000       1010       1020 
LNYDLQITSL SPPEREQLAF PDFLPQSYPT GQNEAHLFHQ SQRGSCCIGG STGHKDNVLA 

      1030       1040       1050       1060       1070       1080 
LQDYTSSYGL PPRKNQETSP VHTESSYIKY ARPNVSPASI LPSQRNISEN KLTAESPNPS 

      1090       1100       1110       1120       1130       1140 
PFGDGVPTVR KNTPYSGKNQ LETGIVAFSE ASSSQPKNTP CLKSDLGGDR RDVLKQFFEG 

      1150       1160       1170       1180       1190       1200 
SQLSERTAGL TPEQLVIGIP DKGSGPDSIQ SEVQGKEGEM QQQRPPTIMK LPCFGSNSKF 

      1210       1220       1230       1240       1250       1260 
HSSTTGPPIN NRRPTLLNGA LSTPTESPNT LVGLATREQL KSINVDKLNA DEHTTLESFQ 

      1270 
GTSPQDQGCL LLQA 

« Hide

References

« Hide 'large scale' references
[1]"Murine enamelin: cDNA and derived protein sequences."
Hu C.-C., Simmer J.P., Bartlett J.D., Nanci A., Qian Q., Zhang C., Ryu O.H., Xue J., Fukae M., Uchida T., McDougall M.
Connect. Tissue Res. 39:47-61(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Swiss Webster.
Tissue: Enamel epithelium.
[2]"Phosphoproteomic analysis of the developing mouse brain."
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.
Mol. Cell. Proteomics 3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U82698 mRNA. Translation: AAB94312.1.
CCDSCCDS19400.1.
PIRT37193.
RefSeqNP_059496.1. NM_017468.3.
UniGeneMm.8014.

3D structure databases

ProteinModelPortalO55196.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000031222.

PTM databases

PhosphoSiteO55196.

Proteomic databases

PRIDEO55196.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000031222; ENSMUSP00000031222; ENSMUSG00000029286.
GeneID13801.
KEGGmmu:13801.
UCSCuc008xzt.2. mouse.

Organism-specific databases

CTD10117.
MGIMGI:1333772. Enam.

Phylogenomic databases

eggNOGNOG41206.
HOGENOMHOG000112367.
HOVERGENHBG005585.
InParanoidO55196.
OMAYYSEEMF.
OrthoDBEOG751NDP.
PhylomeDBO55196.
TreeFamTF337278.

Gene expression databases

BgeeO55196.
CleanExMM_ENAM.
GenevestigatorO55196.

Family and domain databases

InterProIPR015673. Enamelin.
[Graphical view]
PANTHERPTHR16784. PTHR16784. 1 hit.
PfamPF15362. Enamelin. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio284568.
PROO55196.
SOURCESearch...

Entry information

Entry nameENAM_MOUSE
AccessionPrimary (citable) accession number: O55196
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot