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O55196

- ENAM_MOUSE

UniProt

O55196 - ENAM_MOUSE

Protein

Enamelin

Gene

Enam

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation.

    GO - Biological processi

    1. amelogenesis Source: MGI
    2. biomineral tissue development Source: UniProtKB-KW
    3. odontogenesis of dentin-containing tooth Source: MGI

    Keywords - Biological processi

    Biomineralization

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Enamelin
    Gene namesi
    Name:Enam
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1333772. Enam.

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3838Sequence AnalysisAdd
    BLAST
    Chaini39 – 12741236EnamelinPRO_0000021175Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
    Modified residuei196 – 1961PhosphoserineBy similarity
    Modified residuei219 – 2191PhosphoserineBy similarity
    Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi259 – 2591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1066 – 10661N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiO55196.

    PTM databases

    PhosphoSiteiO55196.

    Expressioni

    Tissue specificityi

    Expressed in developing teeth.

    Gene expression databases

    BgeeiO55196.
    CleanExiMM_ENAM.
    GenevestigatoriO55196.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000031222.

    Structurei

    3D structure databases

    ProteinModelPortaliO55196.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG41206.
    HOGENOMiHOG000112367.
    HOVERGENiHBG005585.
    InParanoidiO55196.
    OMAiYYSEEMF.
    OrthoDBiEOG751NDP.
    PhylomeDBiO55196.
    TreeFamiTF337278.

    Family and domain databases

    InterProiIPR015673. Enamelin.
    [Graphical view]
    PANTHERiPTHR16784. PTHR16784. 1 hit.
    PfamiPF15362. Enamelin. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O55196-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLLQCRNPT SPPKPCGLVP NVKMSLLVFL GLLGVSAAMP FQMPMPRMPG     50
    FSSKSEEMMR YNQFNFMNAP PMMPMGPYGN GMPMPPHMPP QYPPYQMPMW 100
    PPPVPNGWQQ PPMPNFPSKT DQTQETAKPN QTNPQEPQPQ KQPLKEPPNE 150
    AARAKDDAQP PQPFPPFGNG LYPYPQPPWP IPQRGPPTAF GRPKFSNEEG 200
    NPYYAFFGYH GFGGRPYYSE EMFEDYEKPK EKDPPKPEDP PPDDPPPEAS 250
    TNSTVPDANA TQSIPEGGND TSPIGNTGPG PNAGNNPTVQ NGVFPPPKVN 300
    VSGQGVPKSQ IPWRPSQPNI YENYPYPNYP SERQWQTTGT QGPRQNGPGY 350
    RNPQVERGPQ WNSFAWEGKQ ATRPGNPTYG KPPSPTSGVN YAGNPVHFGR 400
    NLPGPNKPFV GANPASNKPF VGANPASNKP FVGANPASNK PFVGANPASN 450
    KPFVGANPAS NKPYVGANPA SNKPFIGANP AANKPSIGTN PAANKPSIGT 500
    NPAANKPFVR NNVGANKPFV GTNPSSNQPF LRSNQASNKP FMRSNQASNK 550
    PFVGTNVASV GPKQVTVSHN MKTQNPKEKS LGQKERTVTP TKDASNPWRS 600
    AKQYGINNPN YNLPRSEGSM VGPNFNSFDQ QENSYFSKGA SKRVPSPNIQ 650
    IQSQNLPKGI ALEPRRTPFQ SETKKPELKH GTHQPAYPKK IPSPTRKHFP 700
    AERNTWNRQK ILPPLKEDYG RQDENLRHPS YGSRGNIFYH EYTNPYHNEK 750
    SQYIKSNPWD KSSPSTMMRP ENPQYTMTSL DQKETEQYNE EDPIDPNEDE 800
    SFPGQSRWGD EEMNFKGNPT VRQYEGEHYA STLAKEYLPY SLSNPPKPSE 850
    DFPYSEFYPW NPQETFPIYN PGPTIAPPVD PRSYYVNNAI GQEESTLFPS 900
    WTSWDHRNQA ERQKESEPYF NRNVWDQSIN LHKSNIPNHP YSTTSPARFP 950
    KDPTWFEGEN LNYDLQITSL SPPEREQLAF PDFLPQSYPT GQNEAHLFHQ 1000
    SQRGSCCIGG STGHKDNVLA LQDYTSSYGL PPRKNQETSP VHTESSYIKY 1050
    ARPNVSPASI LPSQRNISEN KLTAESPNPS PFGDGVPTVR KNTPYSGKNQ 1100
    LETGIVAFSE ASSSQPKNTP CLKSDLGGDR RDVLKQFFEG SQLSERTAGL 1150
    TPEQLVIGIP DKGSGPDSIQ SEVQGKEGEM QQQRPPTIMK LPCFGSNSKF 1200
    HSSTTGPPIN NRRPTLLNGA LSTPTESPNT LVGLATREQL KSINVDKLNA 1250
    DEHTTLESFQ GTSPQDQGCL LLQA 1274
    Length:1,274
    Mass (Da):140,954
    Last modified:June 1, 1998 - v1
    Checksum:iF9DBD1CC9D327143
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U82698 mRNA. Translation: AAB94312.1.
    CCDSiCCDS19400.1.
    PIRiT37193.
    RefSeqiNP_059496.1. NM_017468.3.
    UniGeneiMm.8014.

    Genome annotation databases

    EnsembliENSMUST00000031222; ENSMUSP00000031222; ENSMUSG00000029286.
    GeneIDi13801.
    KEGGimmu:13801.
    UCSCiuc008xzt.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U82698 mRNA. Translation: AAB94312.1 .
    CCDSi CCDS19400.1.
    PIRi T37193.
    RefSeqi NP_059496.1. NM_017468.3.
    UniGenei Mm.8014.

    3D structure databases

    ProteinModelPortali O55196.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000031222.

    PTM databases

    PhosphoSitei O55196.

    Proteomic databases

    PRIDEi O55196.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031222 ; ENSMUSP00000031222 ; ENSMUSG00000029286 .
    GeneIDi 13801.
    KEGGi mmu:13801.
    UCSCi uc008xzt.2. mouse.

    Organism-specific databases

    CTDi 10117.
    MGIi MGI:1333772. Enam.

    Phylogenomic databases

    eggNOGi NOG41206.
    HOGENOMi HOG000112367.
    HOVERGENi HBG005585.
    InParanoidi O55196.
    OMAi YYSEEMF.
    OrthoDBi EOG751NDP.
    PhylomeDBi O55196.
    TreeFami TF337278.

    Miscellaneous databases

    NextBioi 284568.
    PROi O55196.
    SOURCEi Search...

    Gene expression databases

    Bgeei O55196.
    CleanExi MM_ENAM.
    Genevestigatori O55196.

    Family and domain databases

    InterProi IPR015673. Enamelin.
    [Graphical view ]
    PANTHERi PTHR16784. PTHR16784. 1 hit.
    Pfami PF15362. Enamelin. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Swiss Webster.
      Tissue: Enamel epithelium.
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.

    Entry informationi

    Entry nameiENAM_MOUSE
    AccessioniPrimary (citable) accession number: O55196
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3