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O55196

- ENAM_MOUSE

UniProt

O55196 - ENAM_MOUSE

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Protein
Enamelin
Gene
Enam
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation.

GO - Biological processi

  1. amelogenesis Source: MGI
  2. biomineral tissue development Source: UniProtKB-KW
  3. odontogenesis of dentin-containing tooth Source: MGI
Complete GO annotation...

Keywords - Biological processi

Biomineralization

Names & Taxonomyi

Protein namesi
Recommended name:
Enamelin
Gene namesi
Name:Enam
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1333772. Enam.

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3838 Reviewed prediction
Add
BLAST
Chaini39 – 12741236Enamelin
PRO_0000021175Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi130 – 1301N-linked (GlcNAc...) Reviewed prediction
Modified residuei196 – 1961Phosphoserine By similarity
Modified residuei219 – 2191Phosphoserine By similarity
Glycosylationi252 – 2521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi259 – 2591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi269 – 2691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi300 – 3001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1066 – 10661N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiO55196.

PTM databases

PhosphoSiteiO55196.

Expressioni

Tissue specificityi

Expressed in developing teeth.

Gene expression databases

BgeeiO55196.
CleanExiMM_ENAM.
GenevestigatoriO55196.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031222.

Structurei

3D structure databases

ProteinModelPortaliO55196.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41206.
HOGENOMiHOG000112367.
HOVERGENiHBG005585.
InParanoidiO55196.
OMAiYYSEEMF.
OrthoDBiEOG751NDP.
PhylomeDBiO55196.
TreeFamiTF337278.

Family and domain databases

InterProiIPR015673. Enamelin.
[Graphical view]
PANTHERiPTHR16784. PTHR16784. 1 hit.
PfamiPF15362. Enamelin. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55196-1 [UniParc]FASTAAdd to Basket

« Hide

MLLLQCRNPT SPPKPCGLVP NVKMSLLVFL GLLGVSAAMP FQMPMPRMPG     50
FSSKSEEMMR YNQFNFMNAP PMMPMGPYGN GMPMPPHMPP QYPPYQMPMW 100
PPPVPNGWQQ PPMPNFPSKT DQTQETAKPN QTNPQEPQPQ KQPLKEPPNE 150
AARAKDDAQP PQPFPPFGNG LYPYPQPPWP IPQRGPPTAF GRPKFSNEEG 200
NPYYAFFGYH GFGGRPYYSE EMFEDYEKPK EKDPPKPEDP PPDDPPPEAS 250
TNSTVPDANA TQSIPEGGND TSPIGNTGPG PNAGNNPTVQ NGVFPPPKVN 300
VSGQGVPKSQ IPWRPSQPNI YENYPYPNYP SERQWQTTGT QGPRQNGPGY 350
RNPQVERGPQ WNSFAWEGKQ ATRPGNPTYG KPPSPTSGVN YAGNPVHFGR 400
NLPGPNKPFV GANPASNKPF VGANPASNKP FVGANPASNK PFVGANPASN 450
KPFVGANPAS NKPYVGANPA SNKPFIGANP AANKPSIGTN PAANKPSIGT 500
NPAANKPFVR NNVGANKPFV GTNPSSNQPF LRSNQASNKP FMRSNQASNK 550
PFVGTNVASV GPKQVTVSHN MKTQNPKEKS LGQKERTVTP TKDASNPWRS 600
AKQYGINNPN YNLPRSEGSM VGPNFNSFDQ QENSYFSKGA SKRVPSPNIQ 650
IQSQNLPKGI ALEPRRTPFQ SETKKPELKH GTHQPAYPKK IPSPTRKHFP 700
AERNTWNRQK ILPPLKEDYG RQDENLRHPS YGSRGNIFYH EYTNPYHNEK 750
SQYIKSNPWD KSSPSTMMRP ENPQYTMTSL DQKETEQYNE EDPIDPNEDE 800
SFPGQSRWGD EEMNFKGNPT VRQYEGEHYA STLAKEYLPY SLSNPPKPSE 850
DFPYSEFYPW NPQETFPIYN PGPTIAPPVD PRSYYVNNAI GQEESTLFPS 900
WTSWDHRNQA ERQKESEPYF NRNVWDQSIN LHKSNIPNHP YSTTSPARFP 950
KDPTWFEGEN LNYDLQITSL SPPEREQLAF PDFLPQSYPT GQNEAHLFHQ 1000
SQRGSCCIGG STGHKDNVLA LQDYTSSYGL PPRKNQETSP VHTESSYIKY 1050
ARPNVSPASI LPSQRNISEN KLTAESPNPS PFGDGVPTVR KNTPYSGKNQ 1100
LETGIVAFSE ASSSQPKNTP CLKSDLGGDR RDVLKQFFEG SQLSERTAGL 1150
TPEQLVIGIP DKGSGPDSIQ SEVQGKEGEM QQQRPPTIMK LPCFGSNSKF 1200
HSSTTGPPIN NRRPTLLNGA LSTPTESPNT LVGLATREQL KSINVDKLNA 1250
DEHTTLESFQ GTSPQDQGCL LLQA 1274
Length:1,274
Mass (Da):140,954
Last modified:June 1, 1998 - v1
Checksum:iF9DBD1CC9D327143
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82698 mRNA. Translation: AAB94312.1.
CCDSiCCDS19400.1.
PIRiT37193.
RefSeqiNP_059496.1. NM_017468.3.
UniGeneiMm.8014.

Genome annotation databases

EnsembliENSMUST00000031222; ENSMUSP00000031222; ENSMUSG00000029286.
GeneIDi13801.
KEGGimmu:13801.
UCSCiuc008xzt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82698 mRNA. Translation: AAB94312.1 .
CCDSi CCDS19400.1.
PIRi T37193.
RefSeqi NP_059496.1. NM_017468.3.
UniGenei Mm.8014.

3D structure databases

ProteinModelPortali O55196.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000031222.

PTM databases

PhosphoSitei O55196.

Proteomic databases

PRIDEi O55196.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031222 ; ENSMUSP00000031222 ; ENSMUSG00000029286 .
GeneIDi 13801.
KEGGi mmu:13801.
UCSCi uc008xzt.2. mouse.

Organism-specific databases

CTDi 10117.
MGIi MGI:1333772. Enam.

Phylogenomic databases

eggNOGi NOG41206.
HOGENOMi HOG000112367.
HOVERGENi HBG005585.
InParanoidi O55196.
OMAi YYSEEMF.
OrthoDBi EOG751NDP.
PhylomeDBi O55196.
TreeFami TF337278.

Miscellaneous databases

NextBioi 284568.
PROi O55196.
SOURCEi Search...

Gene expression databases

Bgeei O55196.
CleanExi MM_ENAM.
Genevestigatori O55196.

Family and domain databases

InterProi IPR015673. Enamelin.
[Graphical view ]
PANTHERi PTHR16784. PTHR16784. 1 hit.
Pfami PF15362. Enamelin. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster.
    Tissue: Enamel epithelium.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.

Entry informationi

Entry nameiENAM_MOUSE
AccessioniPrimary (citable) accession number: O55196
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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